Frontiers in Aging Neuroscience

Original Research

Published on 23 Sep 2025

The impact of ondansetron on clinical outcomes in cranial surgery patients: a propensity-matched analysis of retrospective data

in Neuroinflammation and Neuropathy

Debo Yun
Yongzhen Luo
Rui Li
Wenyong Li
Chunyou Wan
Qinjiang Huang
Jiang Du
Shiyi Zeng
Guangdong Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627353

663 views

Original Research

Published on 23 Sep 2025

Development and validation of a prognostic scoring system for cognitive decline in adults aged 50 and older in China

in Neurocognitive Aging and Behavior

Ningjie Zhang
Linglei Meng
Zhendong Qian
Ying Jin
Hua Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1664943

391 views

Original Research

Published on 23 Sep 2025

Quantitative analysis of serum metabolites in a rat model of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Anton A. Smolentsev
Darya V. Telegina
Nataliya G. Kolosova
Yuri P. Tsentalovich
Olga A. Snytnikova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1648561

838 views

Original Research

Accepted on 22 Sep 2025

Impairment of spatial orientation in the horizontal, but not the vertical plane, by ageing, cognitive decline or chronic peripheral vestibular loss

in Neurocognitive Aging and Behavior

Johannes Gerb
Vivien Oertle
Burak Onmus
Marianne Dieterich
Thomas Brandt

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1671562

Mini Review

Accepted on 22 Sep 2025

Biomarkers of Balance and Gait Deficits in FMR1 Premutation Carriers: A Mini-Review

in Parkinson’s Disease and Aging-related Movement Disorders

Leila C Moore
Nell Maltman
Jonathan S. Lee-Confer
Megan Kobel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637819

Original Research

Published on 22 Sep 2025

Regional CSF volume quantification using deep learning for comparative analysis of brain atrophy in frontotemporal dementia subtypes

in Alzheimer's Disease and Related Dementias

Kyoung Yoon Lim
Soyeon Yoon
Seongbeom Park
Seongmi Kim
Kyoungmin Kim
Jehyun Ahn
Jun Pyo Kim
Hee Jin Kim
Duk L. Na
Sang Won Seo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1631640

531 views

Review

Published on 19 Sep 2025

STING-mediated neuroinflammation: a therapeutic target in neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Haoqin Zhang
Ziyang He
Can Yin
Shiyi Yang
Jianqiao Li
Hong Lin
Guishan Hu
Anguo Wu
Dalian Qin
Guangqiang Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1659216

1,686 views

Systematic Review

Published on 19 Sep 2025

Association of brain-derived neurotrophic factor in blood and cerebrospinal fluid with Parkinson’s disease and non-motor symptoms of Parkinson’s disease: a systematic review and meta-analysis of 6655 participants

in Parkinson’s Disease and Aging-related Movement Disorders

Zhenzhen Zhao
Jiahui Sun
Youhong Liu
Miao Liu
Di Tong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1620172

919 views

Original Research

Accepted on 18 Sep 2025

Attention-based Transformer-LSTM Architecture for Early Diagnosis and Staging of Early-Stage Parkinson's Disease Using fNIRS Data

in Parkinson’s Disease and Aging-related Movement Disorders

Huan Wang
Hujun Wang
Shuyan Qie
Congxiao Wang
Nan Li
Hanming Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1677722

376 views

Original Research

Accepted on 18 Sep 2025

Clinical Validation of a Plasma-Based Antibody-Free LC-MS Method for Identifying CSF Amyloid Positivity in Mild Cognitive Impairment

in Alzheimer's Disease and Related Dementias

José Antonio Allué
Leticia Sarasa
Noelia Fandos
Ricardo Gonzalo
Rubén Sabido-Vera
Jorge Loscos
Judith Romero
Adrián Sánchez
Jose Terencio
Jordi A. Matias-Guiu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1681516

391 views

Review

Accepted on 18 Sep 2025

Role of Lipocalin-2 in Amyotrophic Lateral Sclerosis

in Neuroinflammation and Neuropathy

Zhuoya Wang
Wen Cao
Dongsheng Fan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1672903

333 views

Brief Research Report

Published on 18 Sep 2025

Beyond traditional proxies: the contribution of leisure to cognitive reserve and dementia

in Neurocognitive Aging and Behavior

Silvia Ottaviani
Luca Tagliafico
Stefania Peruzzo
Marta Ponzano
Alessio Signori
Alessio Nencioni
Fiammetta Monacelli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1600798

1,282 views

Original Research

Published on 18 Sep 2025

Association between cardiovascular disease risk, regional brain age gap, and cognition in healthy adults

in Neurocognitive Aging and Behavior

Sriya Pallapothu
Roger D. Newman-Norlund
Nicholas Riccardi
Raghav Pallapothu
Pranesh Rajesh Kannan
Leonardo Bonilha
Julius Fridriksson
Chris Rorden

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1611847

1,122 views

Original Research

Published on 18 Sep 2025

Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis

in Alzheimer's Disease and Related Dementias

Haishou Fu
Huaqing Huang
Shuzhen Liao
Zhisen Dai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637029

882 views

Review

Published on 18 Sep 2025

Understanding Parkinson’s disease: current trends and its multifaceted complications

in Parkinson’s Disease and Aging-related Movement Disorders

Sameer A. Chaudhary
Sapana Chaudhary
Sakshi Rawat

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617106

1,379 views

Review

Accepted on 17 Sep 2025

Kynurenine Pathway:A Possible New Mechanism for Exercise In the Prevention and Treatment of Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Gangqiang Li
Shuang Li
Wenhui Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617690

437 views