Frontiers in Aging Neuroscience

Original Research

Published on 25 Sep 2025

Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention

in Neurocognitive Aging and Behavior

Xuehua Zhou
Huiqian Yu
Yiru Wang
Kaizheng Chen
Xia Shen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1662732

1,986 views

Review

Published on 25 Sep 2025

Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Ravindran Jaganathan
Ashok Iyaswamy
Senthilkumar Krishnamoorthi
Abhimanyu Thakur
Siva Sundara Kumar Durairajan
Chuanbin Yang
Dapkupar Wankhar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627921

4,565 views
1 citation

Mini Review

Published on 25 Sep 2025

Role of store-operated Ca2+ entry and STIM2 in retinal neurodegeneration during glaucoma

in Neuroinflammation and Neuropathy

Sofiia Baranykova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657590

2,641 views

Methods

Published on 25 Sep 2025

Current application status of non-invasive brain stimulation techniques in Alzheimer’s disease: a bibliometric analysis

in Alzheimer's Disease and Related Dementias

Shan Cong
Meng Wang
Long Yan
Li Sun
Bowen Zheng
Jinying Xie
Tao Yu
Yulin Qian

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1585885

3,238 views
1 citation

Correction

Published on 25 Sep 2025

Correction: Altered dynamic functional network connectivity patterns in Alzheimer's disease: insights into neural dysfunction

in Alzheimer's Disease and Related Dementias

Xuerui Pang
Yi Ji
Chenyang Hu
Yulong Dai
Panpan Hu
Xingqi Wu
Kai Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1693649

1,307 views

Original Research

Published on 25 Sep 2025

Risk factor analysis of cognitive frailty in older adults with type 2 diabetes mellitus: a cross-sectional study

in Neurocognitive Aging and Behavior

Qingjuan Ren
Shu Niu
Lei Zhi
Hongfang Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1667405

2,589 views
1 citation

Opinion

Published on 24 Sep 2025

Regulatory mechanisms of neuro inflammation from a gender perspective: interactions among astrocytes, sex hormones, and the gut-brain axis

in Neuroinflammation and Neuropathy

Jia-Wei Shi
Xiu-Li Meng
Yu Ye
Yi-Ting Wang
He-Xuan Ding
Wen-Xu Qi
Rui Feng
Ke Zhang
Ming Lei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1675694

2,402 views

Systematic Review

Published on 24 Sep 2025

Unveiling the glymphatic system’s impact on neurodegenerative diseases: a comprehensive bibliometric analysis (2012–2024)

in Alzheimer's Disease and Related Dementias

Younian Wang
Qiangsheng Liu
Junyi Wu
Kun Meng
Lanting Zhou
Fan Ye

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598608

4,709 views
3 citations

Original Research

Published on 24 Sep 2025

Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study

in Neurocognitive Aging and Behavior

Dashan Li
Yongjie Yin
Shan Jiang
Jiuyu Yin
Luyao Yu
Nan Feng
Zhaohua Sun
Zilian Chen
Hongting Xu
Yu Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1660734

2,197 views

Original Research

Published on 24 Sep 2025

Latent profiles and correlates factors of cognitive function in older adults: a cross-sectional study

in Neurocognitive Aging and Behavior

Jin Xiang
Yan Xiong
Heting Liang
Qingyun Mao
Yumeng Zhang
Yunting Li
Zhixia Jiang
Xiaoli Yuan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1622804

2,568 views

Original Research

Published on 23 Sep 2025

The impact of ondansetron on clinical outcomes in cranial surgery patients: a propensity-matched analysis of retrospective data

in Neuroinflammation and Neuropathy

Debo Yun
Yongzhen Luo
Rui Li
Wenyong Li
Chunyou Wan
Qinjiang Huang
Jiang Du
Shiyi Zeng
Guangdong Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627353

2,401 views

Original Research

Published on 23 Sep 2025

Music elicits different gene expression responses in the buccal cavity of age-related cognitive disorders patients and healthy controls

in Neurocognitive Aging and Behavior

Alberto Gómez-Carballa
Laura Navarro
Nour El Zahraa Mallah
Xabier Bello
Sara Pischedda
Sandra Viz-Lasheras
María José Currás
Isabel Ferreirós-Vidal
Narmeen Mallah
Julián Montoto-Louzao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1622816

3,118 views
2 citations

Original Research

Published on 23 Sep 2025

Development and validation of a prognostic scoring system for cognitive decline in adults aged 50 and older in China

in Neurocognitive Aging and Behavior

Ningjie Zhang
Linglei Meng
Zhendong Qian
Ying Jin
Hua Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1664943

2,376 views

Original Research

Published on 23 Sep 2025

Quantitative analysis of serum metabolites in a rat model of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Anton A. Smolentsev
Darya V. Telegina
Nataliya G. Kolosova
Yuri P. Tsentalovich
Olga A. Snytnikova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1648561

2,648 views

Original Research

Published on 22 Sep 2025

Regional CSF volume quantification using deep learning for comparative analysis of brain atrophy in frontotemporal dementia subtypes

in Alzheimer's Disease and Related Dementias

Kyoung Yoon Lim
Soyeon Yoon
Seongbeom Park
Seongmi Kim
Kyoungmin Kim
Jehyun Ahn
Jun Pyo Kim
Hee Jin Kim
Duk L. Na
Sang Won Seo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1631640

2,435 views

Review

Published on 19 Sep 2025

STING-mediated neuroinflammation: a therapeutic target in neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Haoqin Zhang
Ziyang He
Can Yin
Shiyi Yang
Jianqiao Li
Hong Lin
Guishan Hu
Anguo Wu
Dalian Qin
Guangqiang Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1659216

5,554 views
4 citations

Systematic Review

Published on 19 Sep 2025

Association of brain-derived neurotrophic factor in blood and cerebrospinal fluid with Parkinson’s disease and non-motor symptoms of Parkinson’s disease: a systematic review and meta-analysis of 6655 participants

in Parkinson’s Disease and Aging-related Movement Disorders

Zhenzhen Zhao
Jiahui Sun
Youhong Liu
Miao Liu
Di Tong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1620172

3,572 views
2 citations

Brief Research Report

Published on 18 Sep 2025

Beyond traditional proxies: the contribution of leisure to cognitive reserve and dementia

in Neurocognitive Aging and Behavior

Silvia Ottaviani
Luca Tagliafico
Stefania Peruzzo
Marta Ponzano
Alessio Signori
Alessio Nencioni
Fiammetta Monacelli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1600798

2,933 views

Original Research

Published on 18 Sep 2025

Association between cardiovascular disease risk, regional brain age gap, and cognition in healthy adults

in Neurocognitive Aging and Behavior

Sriya Pallapothu
Roger D. Newman-Norlund
Nicholas Riccardi
Raghav Pallapothu
Pranesh Rajesh Kannan
Leonardo Bonilha
Julius Fridriksson
Chris Rorden

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1611847

3,158 views

Review

Published on 18 Sep 2025

Understanding Parkinson’s disease: current trends and its multifaceted complications

in Parkinson’s Disease and Aging-related Movement Disorders

Sameer A. Chaudhary
Sapana Chaudhary
Sakshi Rawat

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617106

8,938 views
3 citations

Original Research

Published on 18 Sep 2025

Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis

in Alzheimer's Disease and Related Dementias

Haishou Fu
Huaqing Huang
Shuzhen Liao
Zhisen Dai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637029

4,391 views

Systematic Review

Published on 17 Sep 2025

The effects of Nordic walking on cognitive function in older adults: a systematic review and meta-analysis

in Neurocognitive Aging and Behavior

Haobai Li
Ke Zhu
Jianyu Gan
Ziyi Wang
Zhikun Gao
Liangru Liu
Xiaojie Guo
Jianfeng Niu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1666449

3,323 views

Original Research

Published on 17 Sep 2025

Moderating effect of APOE ε4 on the association of sleep disturbance and amyloid-β pathology among cognitively normal older adults

in Neurocognitive Aging and Behavior

Shufei Feng
Jianyu Que
Qianwen Wang
Kai Yuan
Le Shi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627774

2,990 views

Review

Published on 16 Sep 2025

Cerebral amyloid angiopathy: a narrative review

in Alzheimer's Disease and Related Dementias

Natalia Motzko Noto
Robert C. Speth
Lisa S. Robison

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632252

6,882 views
2 citations

7,789 articles

articles

Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention

Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases

Role of store-operated Ca2+ entry and STIM2 in retinal neurodegeneration during glaucoma

Current application status of non-invasive brain stimulation techniques in Alzheimer’s disease: a bibliometric analysis

Correction: Altered dynamic functional network connectivity patterns in Alzheimer's disease: insights into neural dysfunction

Risk factor analysis of cognitive frailty in older adults with type 2 diabetes mellitus: a cross-sectional study

Regulatory mechanisms of neuro inflammation from a gender perspective: interactions among astrocytes, sex hormones, and the gut-brain axis

Unveiling the glymphatic system’s impact on neurodegenerative diseases: a comprehensive bibliometric analysis (2012–2024)

Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study

Latent profiles and correlates factors of cognitive function in older adults: a cross-sectional study

The impact of ondansetron on clinical outcomes in cranial surgery patients: a propensity-matched analysis of retrospective data

Music elicits different gene expression responses in the buccal cavity of age-related cognitive disorders patients and healthy controls

Development and validation of a prognostic scoring system for cognitive decline in adults aged 50 and older in China

Quantitative analysis of serum metabolites in a rat model of Alzheimer’s disease

Regional CSF volume quantification using deep learning for comparative analysis of brain atrophy in frontotemporal dementia subtypes

STING-mediated neuroinflammation: a therapeutic target in neurodegenerative diseases

Association of brain-derived neurotrophic factor in blood and cerebrospinal fluid with Parkinson’s disease and non-motor symptoms of Parkinson’s disease: a systematic review and meta-analysis of 6655 participants

Beyond traditional proxies: the contribution of leisure to cognitive reserve and dementia

Association between cardiovascular disease risk, regional brain age gap, and cognition in healthy adults

Understanding Parkinson’s disease: current trends and its multifaceted complications

Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis

The effects of Nordic walking on cognitive function in older adults: a systematic review and meta-analysis

Moderating effect of APOE ε4 on the association of sleep disturbance and amyloid-β pathology among cognitively normal older adults

Cerebral amyloid angiopathy: a narrative review