Frontiers in Aging Neuroscience

Original Research

Published on 28 Jul 2025

Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer’s disease progression

in Alzheimer's Disease and Related Dementias

Peng Yu
Lu Shen
Lijun Tang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1609793

3,192 views
5 citations

Original Research

Published on 28 Jul 2025

Advancing the modified face name associative memory exam in cognitive aging research: insights into connectomic correlates and task reliability

in Neurocognitive Aging and Behavior

Yilin Liu
Mark H. Sundman
Dalen Hinderaker
Allison Yu-Chin Chen
Jacob M. Green
Lisbeth G. Haaheim
Hannah M. Siu
Catherine Jezerc
Kaitlyn Lai
Carol Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592678

2,156 views

Original Research

Published on 28 Jul 2025

AI-driven precision diagnosis and treatment in Parkinson’s disease: a comprehensive review and experimental analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Bhekisipho Twala

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1638340

7,680 views
9 citations

Systematic Review

Published on 28 Jul 2025

A bibliometric analysis of the immune system and cognitive impairment: trends from 1985 to 2024

in Neuroinflammation and Neuropathy

Beibei Zou
Jinxi Xiang
Muhua Zhang
Jing Huang
Chao Feng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587575

3,796 views

Brief Research Report

Published on 25 Jul 2025

Molecular targets of neuroplasticity in ischemic stroke: insights from GEO database, single-cell analysis and immune infiltration analysis

in Cellular and Molecular Mechanisms of Brain-aging

Haoyue Yang
Zekun Li
Lu Zhang
Haifeng Zhang
Yang Liu
Wei Chen
Feng Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1561282

4,999 views
1 citation

Original Research

Published on 25 Jul 2025

Modeling and validation of wearable sensor-based gait parameters in Parkinson’s disease patients with cognitive impairment

in Parkinson’s Disease and Aging-related Movement Disorders

Guo Hong
Fengju Mao
Mingming Zhang
Fei Zhang
Xiangcheng Wang
Kang Ren
Zhonglue Chen
Xiaoguang Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1590224

2,887 views
1 citation

Review

Published on 24 Jul 2025

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Keyi Zhang
Ming Wen
Xinyue Nan
Shuaizhu Zhao
Hao Li
Yanping Ai
Houze Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1604378

5,809 views
4 citations

Original Research

Published on 24 Jul 2025

Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models

in Alzheimer's Disease and Related Dementias

Xiao Zhang
Sanoji Wijenayake
Shakhawat Hossain
Qian Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617611

2,788 views

Mini Review

Published on 24 Jul 2025

GLP-1R as a potential link between diabetes and Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Shujun Li
Nanqu Huang
Mei Wang
Wendi Huang
Jingshan Shi
Yong Luo
Juan Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1601602

4,087 views
1 citation

Review

Published on 23 Jul 2025

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

in Alzheimer's Disease and Related Dementias

Julia C. Colwell
Marina E. Emborg

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598245

2,575 views
3 citations

Original Research

Published on 23 Jul 2025

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways

in Cellular and Molecular Mechanisms of Brain-aging

Waqas Ahmad
Kyonghwan Choe
Riaz Ahmad
Tae Ju Park
Myeong Ok Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607289

5,101 views
4 citations

Original Research

Published on 23 Jul 2025

Vulnerability of long-range inputome of basal forebrain in normal aging mice

in Cellular and Molecular Mechanisms of Brain-aging

Tingting Sun
Jiale Chen
Bimin Liu
Anan Li
Hui Gong
Xiangning Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1573906

2,062 views

Original Research

Published on 23 Jul 2025

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Liangdong Zhou
Tracy A. Butler
Xiuyuan H. Wang
Samantha A. Keil
Seyed Hani Hojjati
Tsung-Wei Hu
Mélissa Savard
Firoza Z. Lussier
Pedro Rosa-Neto
Lidia Glodzik

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1613320

2,485 views

Original Research

Published on 23 Jul 2025

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats

in Cellular and Molecular Mechanisms of Brain-aging

Laila S. Almassri
Kristen M. Crane
Sean R. Hergenrother
Gurveer Singh
Gillian L. Barach
Melina C. Iafrate
Joshua C. Harris
Nick Tokar
Andrew P. Ohl
Jesse W. Young

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1626021

2,100 views
2 citations

Original Research

Published on 23 Jul 2025

Altered dynamic functional network connectivity patterns in Alzheimer’s disease: insights into neural dysfunction

in Alzheimer's Disease and Related Dementias

Xuerui Pang
Yi Ji
Chenyang Hu
Yulong Dai
Panpan Hu
Xingqi Wu
Kai Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617191

2,575 views
2 citations

Review

Published on 23 Jul 2025

Advancements in multi-omics research to address challenges in Alzheimer’s disease: a systems biology approach utilizing molecular biomarkers and innovative strategies

in Alzheimer's Disease and Related Dementias

Madison Cardillo
Keyura Katam
Prashanth Suravajhala

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591796

6,269 views
7 citations

Original Research

Published on 23 Jul 2025

Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications

in Neurocognitive Aging and Behavior

David Toloza-Ramirez
Rodrigo Santibañez
Leonardo Arraño-Carrasco
Romina Zunino-Pesce
Teresa Julio-Ramos
David A. Copland
Camilo Quezada
Carolina Mendez-Orellana

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547162

2,524 views

Original Research

Published on 22 Jul 2025

miR-423-5p and miR-92a-3p in Alzheimer’s disease: relationship with pathology and cognition

in Alzheimer's Disease and Related Dementias

Sang-Won Han
Young Ho Park
Jung-Min Pyun
Paula J. Bice
SangYun Kim
Andrew J. Saykin
Kwangsik Nho

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637368

2,573 views
1 citation

Original Research

Published on 22 Jul 2025

Lifespan brain age prediction based on multiple EEG oscillatory features and sparse group lasso

in Neurocognitive Aging and Behavior

Shiang Hu
Xue Xiang
Xiaolong Huang
Yan Lu
Xulai Zhang
Dezhong Yao
Pedro A. Valdes-Sosa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1559067

3,096 views
2 citations

Original Research

Published on 22 Jul 2025

Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection

in Neurocognitive Aging and Behavior

Juanjuan Jiang
Tao Kang
Ronghua Ling
Yingqian Liu
Jiuai Sun
Yiming Li
Xiaoou Li
Hui Yang
Bingcang Huang
the Alzheimer’s Disease Neuroimaging Initiative

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1589018

2,501 views

Mini Review

Published on 22 Jul 2025

Sex differences in the outcomes of modifiable lifestyle factors for cognitive aging: neuroinflammation and microglia as key underlying mechanisms

in Cellular and Molecular Mechanisms of Brain-aging

Samantha G. Coleborn
Zoë M. Gilson
Yunyong Guo
Marie-Ève Tremblay

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1642043

2,907 views
2 citations

Review

Published on 21 Jul 2025

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

in Alzheimer's Disease and Related Dementias

Bingyuan Zhou
Jing Li
Anqi Wu
Xuewei Wang
Le Cheng
Gaoshang Yang
Dahong Gao
Caifeng Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587986

4,201 views
5 citations

Original Research

Published on 21 Jul 2025

Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain

in Neurocognitive Aging and Behavior

Gen Miura
Tomoyo Morita
Jihoon Park
Eiichi Naito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1501011

2,264 views

Review

Published on 18 Jul 2025

Motor symptoms of Parkinson’s disease: critical markers for early AI-assisted diagnosis

in Parkinson’s Disease and Aging-related Movement Disorders

Ni Yang
Jing Liu
Dan Sun
Jiajun Ding
Lingzhi Sun
Xianghua Qi
Wei Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602426

5,454 views
1 citation

7,789 articles

articles

Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer’s disease progression

Advancing the modified face name associative memory exam in cognitive aging research: insights into connectomic correlates and task reliability

AI-driven precision diagnosis and treatment in Parkinson’s disease: a comprehensive review and experimental analysis

A bibliometric analysis of the immune system and cognitive impairment: trends from 1985 to 2024

Molecular targets of neuroplasticity in ischemic stroke: insights from GEO database, single-cell analysis and immune infiltration analysis

Modeling and validation of wearable sensor-based gait parameters in Parkinson’s disease patients with cognitive impairment

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies

Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models

GLP-1R as a potential link between diabetes and Alzheimer’s disease

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways

Vulnerability of long-range inputome of basal forebrain in normal aging mice

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats

Altered dynamic functional network connectivity patterns in Alzheimer’s disease: insights into neural dysfunction

Advancements in multi-omics research to address challenges in Alzheimer’s disease: a systems biology approach utilizing molecular biomarkers and innovative strategies

Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications

miR-423-5p and miR-92a-3p in Alzheimer’s disease: relationship with pathology and cognition

Lifespan brain age prediction based on multiple EEG oscillatory features and sparse group lasso

Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection

Sex differences in the outcomes of modifiable lifestyle factors for cognitive aging: neuroinflammation and microglia as key underlying mechanisms

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain

Motor symptoms of Parkinson’s disease: critical markers for early AI-assisted diagnosis