Frontiers in Aging Neuroscience

Original Research

Published on 22 Sep 2025

Regional CSF volume quantification using deep learning for comparative analysis of brain atrophy in frontotemporal dementia subtypes

in Alzheimer's Disease and Related Dementias

Kyoung Yoon Lim
Soyeon Yoon
Seongbeom Park
Seongmi Kim
Kyoungmin Kim
Jehyun Ahn
Jun Pyo Kim
Hee Jin Kim
Duk L. Na
Sang Won Seo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1631640

233 views

Review

Published on 19 Sep 2025

STING-mediated neuroinflammation: a therapeutic target in neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Haoqin Zhang
Ziyang He
Can Yin
Shiyi Yang
Jianqiao Li
Hong Lin
Guishan Hu
Anguo Wu
Dalian Qin
Guangqiang Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1659216

1,470 views

Systematic Review

Published on 19 Sep 2025

Association of brain-derived neurotrophic factor in blood and cerebrospinal fluid with Parkinson’s disease and non-motor symptoms of Parkinson’s disease: a systematic review and meta-analysis of 6655 participants

in Parkinson’s Disease and Aging-related Movement Disorders

Zhenzhen Zhao
Jiahui Sun
Youhong Liu
Miao Liu
Di Tong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1620172

762 views

Original Research

Accepted on 18 Sep 2025

Attention-based Transformer-LSTM Architecture for Early Diagnosis and Staging of Early-Stage Parkinson's Disease Using fNIRS Data

in Parkinson’s Disease and Aging-related Movement Disorders

Huan Wang
Hujun Wang
Shuyan Qie
Congxiao Wang
Nan Li
Hanming Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1677722

304 views

Original Research

Accepted on 18 Sep 2025

Clinical Validation of a Plasma-Based Antibody-Free LC-MS Method for Identifying CSF Amyloid Positivity in Mild Cognitive Impairment

in Alzheimer's Disease and Related Dementias

José Antonio Allué
Leticia Sarasa
Noelia Fandos
Ricardo Gonzalo
Rubén Sabido-Vera
Jorge Loscos
Judith Romero
Adrián Sánchez
Jose Terencio
Jordi A. Matias-Guiu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1681516

332 views

Review

Accepted on 18 Sep 2025

Role of Lipocalin-2 in Amyotrophic Lateral Sclerosis

in Neuroinflammation and Neuropathy

Zhuoya Wang
Wen Cao
Dongsheng Fan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1672903

266 views

Brief Research Report

Published on 18 Sep 2025

Beyond traditional proxies: the contribution of leisure to cognitive reserve and dementia

in Neurocognitive Aging and Behavior

Silvia Ottaviani
Luca Tagliafico
Stefania Peruzzo
Marta Ponzano
Alessio Signori
Alessio Nencioni
Fiammetta Monacelli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1600798

1,119 views

Original Research

Published on 18 Sep 2025

Association between cardiovascular disease risk, regional brain age gap, and cognition in healthy adults

in Neurocognitive Aging and Behavior

Sriya Pallapothu
Roger D. Newman-Norlund
Nicholas Riccardi
Raghav Pallapothu
Pranesh Rajesh Kannan
Leonardo Bonilha
Julius Fridriksson
Chris Rorden

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1611847

981 views

Original Research

Published on 18 Sep 2025

Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis

in Alzheimer's Disease and Related Dementias

Haishou Fu
Huaqing Huang
Shuzhen Liao
Zhisen Dai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637029

746 views

Review

Published on 18 Sep 2025

Understanding Parkinson’s disease: current trends and its multifaceted complications

in Parkinson’s Disease and Aging-related Movement Disorders

Sameer A. Chaudhary
Sapana Chaudhary
Sakshi Rawat

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617106

1,193 views

Review

Accepted on 17 Sep 2025

Kynurenine Pathway:A Possible New Mechanism for Exercise In the Prevention and Treatment of Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Gangqiang Li
Shuang Li
Wenhui Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617690

377 views

Original Research

Accepted on 17 Sep 2025

In Vivo Quantification of Superficial Cortical Veins on Susceptibility-Weighted Imaging with Artificial Intelligence Image Segmentation and the Potential Mechanism of Human Cognitive Decline

in Neurocognitive Aging and Behavior

Qi Xie
Hai-Xia Xu
Ya-Jie Wang
Hui-Xian Chen
Xiao-Fang Tu
Peng-Peng Han
Jun Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1557397

327 views

Systematic Review

Accepted on 17 Sep 2025

Cognitive Changes Preceding Parkinson's Disease: A Systematic Review and Meta-analysis of Prospective Population-based Studies

in Parkinson’s Disease and Aging-related Movement Disorders

NOELIA PEÑA ARAUZO
Christoph Theyer
Florian Krismer
Atbin Djamshidian
Werner Poewe
Corinne Horlings
Beatrice Heim
Laura Zamarian
Philipp Mahlknecht

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627221

368 views

Original Research

Accepted on 17 Sep 2025

Visual attention during non-immersive virtual reality balance training in older adults with mild to moderate cognitive impairment: An eye-tracking study

in Neurocognitive Aging and Behavior

Marcos Maldonado Diaz
Gonzalo Jara- Vargas
Felipe Gonzalez-Seguel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1671477

362 views

Systematic Review

Accepted on 17 Sep 2025

Oscillatory Dynamics of Motor Learning Across Adulthood Life Span: A Systematic Review

in Neurocognitive Aging and Behavior

Amir Jahanian-Najafabadi
Elaheh Davoodi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1646172

311 views

Original Research

Published on 17 Sep 2025

Moderating effect of APOE ε4 on the association of sleep disturbance and amyloid-β pathology among cognitively normal older adults

in Neurocognitive Aging and Behavior

Shufei Feng
Jianyu Que
Qianwen Wang
Kai Yuan
Le Shi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627774

1,152 views