Frontiers in Aging Neuroscience

Original Research

Published on 17 Jul 2025

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

in Neurocognitive Aging and Behavior

Mark H. Sundman
Yilin Liu
Nan-kuei Chen
Ying-hui Chou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597311

4,272 views
3 citations

Systematic Review

Published on 17 Jul 2025

Orthostatic hypotension in Parkinson’s disease: effects on clinical features and disease severity-a systematic review and meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Hui Wang
Chi Zhang
Dongxun Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612960

2,190 views

Original Research

Published on 16 Jul 2025

Brain structural MRI marker for predicting conversion to Parkinson’s disease in individuals with prodromal symptoms

in Parkinson’s Disease and Aging-related Movement Disorders

Chang-hyun Park
Uicheul Yoon
Phil Hyu Lee
Jinna Kim
Seung-Koo Lee
Na-Young Shin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579326

1,996 views

Original Research

Published on 16 Jul 2025

Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study

in Neurocognitive Aging and Behavior

Yushu Huang
Xifan Yang
Qi Wang
Adila Abula
Yue Dong
Wenyuan Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1532884

4,171 views
1 citation

Original Research

Published on 16 Jul 2025

Predictive value of pan-immune-inflammation value in the prognosis of adults with status epilepticus: a retrospective study

in Neuroinflammation and Neuropathy

Jie Fu
Yifei Chu
Chenxin Zhao
Lilei Peng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1601816

1,227 views

Original Research

Published on 16 Jul 2025

Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly

in Neurocognitive Aging and Behavior

Vivian Schultz
Benita Schmitz-Koep
Aurore Menegaux
Melissa Thalhammer
Severin Schramm
Su Hwan Kim
Claus Zimmer
Christian Sorg
Panteleimon Giannakopoulos
Marie-Louise Montandon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1542857

2,119 views

Review

Published on 16 Jul 2025

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

in Alzheimer's Disease and Related Dementias

Yanrong Yang
Hua Chen
Qibing Liu
Yang Niu
Chunyang Mao
Rui Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1623050

4,042 views
4 citations

Original Research

Published on 16 Jul 2025

Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Fenyang Chen
Tiantian Heng
Qi Feng
Rui Hua
Jiaojiao Wu
Feng Shi
Zhengluan Liao
Keyin Qiao
Zhiliang Zhang
Jianliang Miao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1621106

3,453 views
1 citation

Original Research

Published on 16 Jul 2025

Evaluation of non-motor symptoms in Parkinson’s disease using multiparametric MRI with the multiplex sequence

in Parkinson’s Disease and Aging-related Movement Disorders

He Sui
Zhanhao Mo
Feng Shi
Qing Zhou
Dan Yu
Jiaqi Wang
Lin Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602245

1,998 views
1 citation

Review

Published on 15 Jul 2025

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

in Alzheimer's Disease and Related Dementias

Amy F. T. Arnsten
Isabella Perone
Min Wang
Shengtao Yang
Stacy Uchendu
Dinara Bolat
Dibyadeep Datta

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1610350

3,048 views
1 citation

Original Research

Published on 15 Jul 2025

Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey

in Neurocognitive Aging and Behavior

Hui-Ying Fan
He-Li Sun
Yuan Feng
Qinge Zhang
Hua-Qing Xing
Qian-Hua Huang
Zhaohui Su
Teris Cheung
Chee H. Ng
Yu-Tao Xiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579560

3,087 views
1 citation

Systematic Review

Published on 11 Jul 2025

Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis

in Neurocognitive Aging and Behavior

Han Han
Jinhao Zhang
Fan Zhang
Fanghui Li
Zhijian Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1510773

12,310 views
8 citations

Original Research

Published on 11 Jul 2025

Intranasal delivery of dodecyl creatine ester alleviates motor deficits and increases dopamine levels in a 6-OHDA rat model of parkinsonism

in Parkinson’s Disease and Aging-related Movement Disorders

Clémence Disdier
Clara Lhotellier
Stéphanie Wagner
Emile Andriambeloson
Frédéric Théodoro
Alain Pruvost
Thomas Joudinaud
Henri Bénech
Aloïse Mabondzo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597263

3,033 views
1 citation

Original Research

Published on 11 Jul 2025

Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China

in Alzheimer's Disease and Related Dementias

Jianping Lu
Guoen Cai
Naian Xiao
Kunmu Zheng
Qinyong Ye
Xiaochun Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566247

1,652 views
1 citation

Review

Published on 11 Jul 2025

Stem cell extracellular vesicles: a new dawn for anti-inflammatory treatment of neurodegenerative diseases

in Neuroinflammation and Neuropathy

Miao Yu
Hongxia Ma
Xiaoyi Lai
Jiannan Wu
Mengmeng Shen
Junqiang Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592578

4,700 views
3 citations

Systematic Review

Published on 10 Jul 2025

Repetitive transcranial magnetic stimulation across neurodegenerative diseases: a systematic review and dose-response meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Yu Zhang
Yulin Wang
Ke Xu
Chengguang Zhang
Peizhu Lv
Yan Bai
Shun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1615734

3,182 views

Original Research

Published on 09 Jul 2025

Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos

in Parkinson’s Disease and Aging-related Movement Disorders

Ernesto G. Miranda-Morales
Daniel F. Ramos-Rosales
Alma C. Salas-Leal
Sergio M. Salas-Pacheco
Francisco X. Castellanos-Juárez
Edna M. Méndez-Hernández
Osmel La Llave-León
María S. Peñaherrera
Gerardo Quiñones-Canales
Oscar Arias-Carrión

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612544

1,736 views

Original Research

Published on 09 Jul 2025

Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism

in Neurocognitive Aging and Behavior

Wei Zhou
MengYue Tang
Bo Cheng
Ling Sun
HongYu Lin
Yang Fan
Nian Liu
Shushan Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566785

1,751 views

Original Research

Published on 09 Jul 2025

Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury

in Neuroinflammation and Neuropathy

Ryan P. McCann
Bethany Bowley
Monica Pessina
Qiong Yang
Hongqi Xin
Sarah A. DeVries
Mingjin Wang
Yi Zhang
Michael Chopp
Zhenggang Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1605144

3,052 views
2 citations

Mini Review

Published on 09 Jul 2025

Regulation of BBB function and pathological evolution of PD by microenvironment “spatiotemporal gradient”: unique advantages of microfluidic chips

in Neuroinflammation and Neuropathy

Sixun Yu
Lingli Jiang
Min Song
Tao Yang
Ma Yuan
Xin Chen
Haifeng Shu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599509

3,153 views
2 citations

Systematic Review

Published on 08 Jul 2025

Sedentary behavior, cognition, and brain health in older adults: a systematic review

in Neurocognitive Aging and Behavior

Marissa A. Gogniat
Junyeon Won
Carlos Cruz
Amaya Aranda
Aryan Verma
Swathi Gujral
Andrea M. Weinstein
Afsara B. Zaheed
Keith R. Cole
Kelsie M. Full

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1622049

3,862 views
4 citations

Original Research

Published on 08 Jul 2025

Altered automatic gaze processing in older adults

in Neurocognitive Aging and Behavior

Roger Koenig-Robert
Boris Barrientos
Phoebe E. Bailey
Kiley Seymour

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592763

1,688 views

Original Research

Published on 08 Jul 2025

Efficiency of structural brain networks mediates age-associated differences in executive functioning in older adults

in Neurocognitive Aging and Behavior

Geraldine Rodríguez-Nieto
Caroline Seer
Hamed Zivari Adab
Antonio Jimenez-Marin
Sima Chalavi
Amirhossein Rasooli
Jesús M. Cortés
Stefan Sunaert
Stephan P. Swinnen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1593868

1,679 views
1 citation

Original Research

Published on 07 Jul 2025

Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method

in Alzheimer's Disease and Related Dementias

Shiyu Xiao
Xuemeng Wei
Bing Han
Xiaoqian Shi
Congzhen Wei
Rumeng Liang
Jingna Sun
Zheng Zhang
Zhengang Han
Li Shen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1561831

3,249 views
2 citations

7,789 articles

articles

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

Orthostatic hypotension in Parkinson’s disease: effects on clinical features and disease severity-a systematic review and meta-analysis

Brain structural MRI marker for predicting conversion to Parkinson’s disease in individuals with prodromal symptoms

Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study

Predictive value of pan-immune-inflammation value in the prognosis of adults with status epilepticus: a retrospective study

Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer’s disease

Evaluation of non-motor symptoms in Parkinson’s disease using multiparametric MRI with the multiplex sequence

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey

Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis

Intranasal delivery of dodecyl creatine ester alleviates motor deficits and increases dopamine levels in a 6-OHDA rat model of parkinsonism

Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China

Stem cell extracellular vesicles: a new dawn for anti-inflammatory treatment of neurodegenerative diseases

Repetitive transcranial magnetic stimulation across neurodegenerative diseases: a systematic review and dose-response meta-analysis

Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos

Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism

Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury

Regulation of BBB function and pathological evolution of PD by microenvironment “spatiotemporal gradient”: unique advantages of microfluidic chips

Sedentary behavior, cognition, and brain health in older adults: a systematic review

Altered automatic gaze processing in older adults

Efficiency of structural brain networks mediates age-associated differences in executive functioning in older adults

Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method