Frontiers in Aging Neuroscience

Original Research

Published on 13 May 2025

Assessment of the glymphatic dysfunction in amyotrophic lateral sclerosis using the diffusion tensor imaging along the perivascular spaces index: a pilot study

in Neuroinflammation and Neuropathy

Seol-Hee Baek
Woo-Suk Tae
Jin-Woo Park
Byung-Jo Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1570327

3,636 views
4 citations

Study Protocol

Published on 13 May 2025

Effects and mechanisms of acupuncture for PIGD-subtype Parkinson’s disease via integration of fMRI and gut microbiota-metabolomics analysis: protocol for a prospective randomized controlled trial

in Parkinson’s Disease and Aging-related Movement Disorders

Jili Sheng
Yingqi Xu
Tao Liu
Jianfang Zhu
Caiyun Mu
Lihao Zhai
Shanhu Xu
Hanyi Wang
Xiangzhi Liu
Tao Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1534165

3,258 views

Original Research

Published on 12 May 2025

High serum glial fibrillary acidic protein levels are associated with increased risk of post-stroke cognitive impairment

in Neurocognitive Aging and Behavior

Wanying Shan
Rui Jiang
Jing Wang
Guoli Xu
Jie Zhao
Guojie Zhai
Jiaxin Shao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1546270

2,126 views

Original Research

Published on 12 May 2025

Implications of heart rate variability measured using wearable electrocardiogram devices in diagnosing Parkinson’s disease and its association with neuroimaging biomarkers: a case-control study

in Parkinson’s Disease and Aging-related Movement Disorders

Mincheol Park
Sung-Woo Kim
Jin Yong Hong
Sung Pil Cho
Junghwan Park
Erdenebayar Urtnasan
Min Seok Baek

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1530240

3,085 views
3 citations

Study Protocol

Published on 12 May 2025

Impact of impaired intrinsic capacity on postoperative frailty in elderly patients undergoing colorectal surgery: study protocol for a single-center, prospective, cohort study

in Neurocognitive Aging and Behavior

Jirun Wang
Shaoqi Tian
Lei Zhang
Jia Liu
Yuefang Liu
Lei Zhu
Peipei Shan
Ping Zhao
Yang Zhao
Youzhuang Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1523642

3,036 views

Review

Published on 12 May 2025

Review of FUNDC1-mediated mitochondrial autophagy in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Dandan Shi
Xiaochen Guo
Ziqi Ning
Yaoyao Zhang
Fang Liu
Meixia Liu
Yun Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1544241

4,488 views
3 citations

Review

Published on 09 May 2025

Early diagnosis of Parkinson’s disease: biomarker study

in Parkinson’s Disease and Aging-related Movement Disorders

Jing Li
Mei Zhang
Chuan-Qing Yu
Min Xue
Pan-Pan Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1495769

6,120 views
5 citations

Original Research

Published on 09 May 2025

Research hotspots and future trends of insomnia in Parkinson’s disease: a bibliometric and visualization analysis from 1973 to 2024

in Parkinson’s Disease and Aging-related Movement Disorders

Xianghong Guo
Tianye Wang
Dan Wang
Jingjing Zhou
Xin Lai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1535861

2,612 views

Original Research

Published on 09 May 2025

Subregional analysis of the amygdala, thalamus, and hypothalamus at the pre-decline stage in Parkinson’s disease with later cognitive impairment

in Cellular and Molecular Mechanisms of Brain-aging

Kazuhide Seo
Genko Oyama
Toshimasa Yamamoto

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1588027

3,039 views
3 citations

Original Research

Published on 09 May 2025

Blood biomarkers as surrogate endpoints in Alzheimer’s disease research

in Alzheimer's Disease and Related Dementias

Guogen Shan
Hui Li
Yahui Zhang
Guoqiao Wang
Charles Bernick

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576373

2,385 views
3 citations

Original Research

Published on 09 May 2025

Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice

in Neurocognitive Aging and Behavior

Behroo Mirza Agha
Merrin Monteith
Jarem Earl
Keona Ganske
Tina Kaloa
Kelan J. McDonald
Abigail G. Nixon
Maleeha Panjwani
Danika Robinson
Valeria Rusnak

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1567650

6,793 views
1 citation

Original Research

Published on 09 May 2025

Obesity paradox in cognitive function: a longitudinal study of BMI and cognitive impairment in older adult Chinese population

in Neurocognitive Aging and Behavior

Jing Chen
Jun Zhang
Hao Wang
Hongliang Zhu
Jialin Fu
Chuanwei Li
Qingrong Zhang
Xingzhi Xia
He Ma
Junjun Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1543501

4,592 views
8 citations

Original Research

Published on 08 May 2025

Association between nutrition literacy and cognitive impairment among older adults in Bengbu, China

in Neurocognitive Aging and Behavior

Yan Cui
Xiaoting Hu
Xi Tian
Yuhui Sun
Bingyong Zhang
Huaqing Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1532279

2,318 views

Original Research

Published on 08 May 2025

Internet use, physical activity, and cognitive function in Chinese older adults: a cross-lagged panel analysis

in Neurocognitive Aging and Behavior

Jinfu Wang
Na Zhang
Chengxin Huang
Qinmei Wu
Jin Tong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579874

2,603 views
3 citations

Brief Research Report

Published on 07 May 2025

Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial

in Neurocognitive Aging and Behavior

Moeko Noguchi-Shinohara
Kunihiko Yokoyama
Junji Komatsu
Kazumi Masuda
Mitsunobu Kouno
Mitsuhiro Yoshita
Kenjiro Ono

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1581400

3,650 views
1 citation

Review

Published on 07 May 2025

Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Minji Zhou
Xiu'e Pang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571563

3,905 views
3 citations

Original Research

Published on 07 May 2025

The mechanism of electroacupuncture-mediated improvement in Parkinson’s disease by inhibiting ferroptosis through activating the Nrf2/GPX4 signal pathway

in Parkinson’s Disease and Aging-related Movement Disorders

Min Wang
He-Sheng Zheng
Wei-Liang Ye
Jin-Dong Mao
Kun Zhang
Le Yang
Ming-Gao Zhao
Shui-Bing Liu
Rui Liu
Yu-Mei Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1551404

3,932 views

Study Protocol

Published on 07 May 2025

Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the world-wide FINGERS network)

in Alzheimer's Disease and Related Dementias

Gessica Sala
Luca Cuffaro
Federico Emanuele Pozzi
Simona Andreoni
Chiara Bazzini
Elisa Conti
Chiara Paola Zoia
Simone Beretta
Lucio Tremolizzo
Giuseppe Bellelli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1581892

5,486 views
3 citations

Original Research

Published on 07 May 2025

Development and validation of a nomogram to predict the risk of post-stroke complex regional pain syndrome

in Neuroinflammation and Neuropathy

Qian Xie
Qing Song
Jianling Deng
Xuanling Cheng
Aiguo Xue
Shuxiong Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1577256

2,264 views

Review

Published on 02 May 2025

Applications of event-related potentials in Alzheimer’s disease: a systematic review and analysis

in Alzheimer's Disease and Related Dementias

Qian Liang
Zhilin Chen
Xiaohui Tang
Xijin Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1513049

4,195 views
1 citation

Study Protocol

Published on 01 May 2025

Protocol for detection and monitoring of post-stroke cognitive impairment through AI-powered speech analysis: a mixed methods pilot study

in Neurocognitive Aging and Behavior

Ravi Shankar
Effie Chew
Anjali Bundele
Amartya Mukhopadhyay

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1581891

4,565 views
1 citation

Original Research

Published on 01 May 2025

PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Zhen Wei
Xiaodong Pan
Xiaoli Cui
Jing Zhang
Xiaoman Dai
Yuqi Zeng
Xiaochun Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1537388

5,008 views
3 citations

Original Research

Published on 30 Apr 2025

Relationship between the hemoglobin-to-red cell distribution width ratio and post-stroke cognitive impairment: a prospective study

in Neurocognitive Aging and Behavior

Yufeng Liu
Zhe Xie
Ping Wang
Fan Liu
Liandong Zhao
Chun Chen
Qiu Ge
Mengchao Wang
Zhongwen Zhi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1552956

2,660 views
1 citation

Original Research

Published on 30 Apr 2025

Amyloid-beta peptide toxicity in the aged brain is a one-way journey into Alzheimer’s disease

in Cellular and Molecular Mechanisms of Brain-aging

Georgia Culley
Alexandre Henriques
Delphine Hardy
Alexandre Wojcinski
Adrien Chabert
Bilal El Waly
Philippe Poindron
Noelle Callizot

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569181

4,478 views
1 citation

7,794 articles

articles

Assessment of the glymphatic dysfunction in amyotrophic lateral sclerosis using the diffusion tensor imaging along the perivascular spaces index: a pilot study

Effects and mechanisms of acupuncture for PIGD-subtype Parkinson’s disease via integration of fMRI and gut microbiota-metabolomics analysis: protocol for a prospective randomized controlled trial

High serum glial fibrillary acidic protein levels are associated with increased risk of post-stroke cognitive impairment

Implications of heart rate variability measured using wearable electrocardiogram devices in diagnosing Parkinson’s disease and its association with neuroimaging biomarkers: a case-control study

Impact of impaired intrinsic capacity on postoperative frailty in elderly patients undergoing colorectal surgery: study protocol for a single-center, prospective, cohort study

Review of FUNDC1-mediated mitochondrial autophagy in Alzheimer’s disease

Early diagnosis of Parkinson’s disease: biomarker study

Research hotspots and future trends of insomnia in Parkinson’s disease: a bibliometric and visualization analysis from 1973 to 2024

Subregional analysis of the amygdala, thalamus, and hypothalamus at the pre-decline stage in Parkinson’s disease with later cognitive impairment

Blood biomarkers as surrogate endpoints in Alzheimer’s disease research

Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice

Obesity paradox in cognitive function: a longitudinal study of BMI and cognitive impairment in older adult Chinese population

Association between nutrition literacy and cognitive impairment among older adults in Bengbu, China

Internet use, physical activity, and cognitive function in Chinese older adults: a cross-lagged panel analysis

Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial

Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer’s disease

The mechanism of electroacupuncture-mediated improvement in Parkinson’s disease by inhibiting ferroptosis through activating the Nrf2/GPX4 signal pathway

Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the world-wide FINGERS network)

Development and validation of a nomogram to predict the risk of post-stroke complex regional pain syndrome

Applications of event-related potentials in Alzheimer’s disease: a systematic review and analysis

Protocol for detection and monitoring of post-stroke cognitive impairment through AI-powered speech analysis: a mixed methods pilot study

PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease

Relationship between the hemoglobin-to-red cell distribution width ratio and post-stroke cognitive impairment: a prospective study

Amyloid-beta peptide toxicity in the aged brain is a one-way journey into Alzheimer’s disease