Frontiers in Aging Neuroscience

Original Research

Published on 30 Apr 2025

Non-invasive detection of Parkinson’s disease based on speech analysis and interpretable machine learning

in Parkinson’s Disease and Aging-related Movement Disorders

Huanqing Xu
Wei Xie
Mingzhen Pang
Ya Li
Luhua Jin
Fangliang Huang
Xian Shao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1586273

6,516 views
5 citations

Original Research

Published on 30 Apr 2025

Association of low-density lipoprotein/high-density lipoprotein ratio with cognition, Alzheimer’s disease biomarkers and brain structure

in Alzheimer's Disease and Related Dementias

Zihao Zhang
Lingzhi Ma
Liangyu Huang
Yangke Zhu
Haihua Guo
Lanyang Wang
Wei Zhang
Lan Tan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1457160

3,104 views
3 citations

Review

Published on 30 Apr 2025

Adenosine diphosphate-ribosylation greatly affects proteins function: a focus on neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Chaowen Huang
Huilin Xiao
Yang Yang
Jiankun Luo
Yixi Lai
Shizhen Liu
Kanmin Mao
Jialong Chen
Liling Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1575204

3,217 views

Original Research

Published on 30 Apr 2025

Observation on prefrontal cortex activation in patients with Parkinson’s disease: a fNIRS study

in Parkinson’s Disease and Aging-related Movement Disorders

Yingqi Li
Tingting Hu
Yingpeng Wang
Jie Wang
Shuyan Qie
Congxiao Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1560315

3,126 views
2 citations

Systematic Review

Published on 30 Apr 2025

Effect of resistance training on body composition and physical function in older females with sarcopenic obesity—a systematic review and meta-analysis of randomized controlled trials

in Parkinson’s Disease and Aging-related Movement Disorders

Changsheng Guo
Ting Dai
Haoran Zhang
Meng Luo
Jing Gao
Xiaodong Feng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1495218

5,542 views
4 citations

Original Research

Published on 30 Apr 2025

Cross-frequency neuromodulation: leveraging theta-gamma coupling for cognitive rehabilitation in MCI patients

in Neurocognitive Aging and Behavior

Xiao Yuan
Zhilan Tu
Renren Li
Chenxi Pan
Jing Ma
Meng Liu
Dan Yang
Hualan Yang
Fangyun Li
Zhi Bie

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1541126

4,047 views
3 citations

Original Research

Published on 29 Apr 2025

The association between kidney function-standardized serum uric acid levels and stroke risk: insights from the National Health and Nutrition Examination Survey

in Neuroinflammation and Neuropathy

Xinmin Deng
Kunlin Kuang
Yumei Zhong
Rui Lai
Xiaofeng Lv
Shanshan Liu
Meijun Liu
Jingtao Liang
Dongdong Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1542298

3,437 views
1 citation

Original Research

Published on 29 Apr 2025

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation

in Cellular and Molecular Mechanisms of Brain-aging

Shveta Bathla
Dibyadeep Datta
Dinara Bolat
Elizabeth Woo
Alvaro Duque
Jon I. Arellano
Amy F. T. Arnsten
Angus C. Nairn

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549770

2,668 views
4 citations

Review

Published on 29 Apr 2025

Phospholipids and peroxisomes in ferroptosis: the therapeutic target of acupuncture regulating vascular cognitive impairment and dementia

in Cellular and Molecular Mechanisms of Brain-aging

Wenyu Zhang
Ruiyu Li
Donglei Lu
Xinliang Wang
Qiuxuan Wang
Xuyang Feng
Sai Qi
Xuezhu Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1512980

5,319 views
5 citations

Original Research

Published on 28 Apr 2025

Effects of off-line auricular transcutaneous vagus nerve stimulation (taVNS) on a short-term memory task: a pilot study

in Neurocognitive Aging and Behavior

Francesco Fisicaro
Klizia Cortese
Rita Bella
Manuela Pennisi
Giuseppe Lanza
Kaoru Yuasa
Yoshikazu Ugawa
Yasuo Terao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549167

5,089 views
1 citation

Original Research

Published on 28 Apr 2025

NTN-1 attenuates amyloid-β-mediated microglial neuroinflammation and memory impairment via the NF-κB pathway and NLRP3 inflammasome in a rat model of Alzheimer's disease

in Cellular and Molecular Mechanisms of Brain-aging

Tianhang Wang
Yanchen Liu
Yidan Lu
Lijun Chi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1516399

3,246 views
5 citations

Original Research

Published on 28 Apr 2025

Handgrip strength and risk of cognitive impairment across different glucose metabolism statuses: insights from the CHARLS study

in Neurocognitive Aging and Behavior

Shiqi Wang
Liangchen Li
Jia Yu
Xianli Sun
Jianqiao Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566652

6,944 views
2 citations

Original Research

Published on 28 Apr 2025

Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Sean B. Ostlund
Grace Chen
Alisa Kosheleff
Lindsay M Lueptow
Irina Zhuravka
Sally A. Frautschy
Hoa A. Lam
Nigel T. Maidment

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1572956

3,268 views
3 citations

Original Research

Published on 28 Apr 2025

A cross-sectional study of how high-frequency hearing loss impacts cognitive functions in middle-aged-to-older adults

in Neurocognitive Aging and Behavior

Dona M. P. Jayakody
Paul McIlhiney
Inge Stegeman
Robert H. Eikelboom

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1560307

3,394 views
2 citations

Brief Research Report

Published on 28 Apr 2025

Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease

in Neurocognitive Aging and Behavior

Hóngyi Zhào
Wei Wei
Fang Lv
Jie Shen
Yonghua Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569582

2,999 views

Systematic Review

Published on 28 Apr 2025

Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review

in Neurocognitive Aging and Behavior

Xinming Yang
Bo Li
Linna Wu
Ying Cui

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1515327

6,769 views
3 citations

Original Research

Published on 25 Apr 2025

Activation of GLP-1R modulates the spontaneous discharge of nigral dopaminergic neurons and motor behavior in mice with chronic MPTP Parkinson's disease

in Parkinson’s Disease and Aging-related Movement Disorders

Wen-Hong Liu
Cui Liu
Yan Xue
Xiang-Rong Sun
Xin-Yi Chen
Lei Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1529919

3,139 views
2 citations

Original Research

Published on 25 Apr 2025

Bioinformatics-driven exploration of key genes and mechanisms underlying oxidative stress in traumatic brain injury

in Neuroinflammation and Neuropathy

Bin Ren
Jifang Liang
Leifang Yang
Xiaocong Wei
Min Guo
Hong Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1531317

2,908 views
2 citations

Original Research

Published on 25 Apr 2025

Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss

in Neurocognitive Aging and Behavior

Chenyang Yuan
Tianyu Ma
Mengting Liu
Li Jiang
Gongrui Tang
Qi Hu
Tianhong Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1526519

3,675 views

Original Research

Published on 25 Apr 2025

Lower CALLY index levels indicate higher poor functional outcome risk in acute ischemic stroke patients treated with endovascular thrombectomy

in Neuroinflammation and Neuropathy

Yunnan Lu
Xiaohua Zhu
Yaojia Xu
Yongxin Li
Qingyong Dai
Xia Chang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587861

3,858 views
6 citations

Mini Review

Published on 25 Apr 2025

The potential and challenges of TREM2-targeted therapy in Alzheimer’s disease: insights from the INVOKE-2 study

in Alzheimer's Disease and Related Dementias

Ya-nan Ma
Xiqi Hu
Kenji Karako
Peipei Song
Wei Tang
Ying Xia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576020

9,226 views
16 citations

Review

Published on 24 Apr 2025

Neuroprotective effects of electroacupuncture in ischemic stroke: from mechanisms to clinical implications

in Neuroinflammation and Neuropathy

Jinxi Zhu
Xinyi Ge
Yulong Cao
Renjie Xiao
Xiao Deng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1562925

6,460 views
3 citations

Original Research

Published on 23 Apr 2025

Machine learning models based on location-radiomics enable the accurate prediction of early neurological function deterioration for acute stroke in elderly patients

in Neurocognitive Aging and Behavior

Xiaoming Fu
Chuanyang Zhang
Hongjie Huang
Changcheng Li
Miaomiao Li
XiaoRan Li
Zhijun Gao
Mingyang Peng
Hui Xu
Wenli Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1582687

2,643 views
1 citation

Systematic Review

Published on 23 Apr 2025

Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention

in Alzheimer's Disease and Related Dementias

Giulia Marafioti
Laura Culicetto
Desirèe Latella
Angela Marra
Angelo Quartarone
Viviana Lo Buono

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549134

5,660 views
5 citations

7,794 articles

articles

Non-invasive detection of Parkinson’s disease based on speech analysis and interpretable machine learning

Association of low-density lipoprotein/high-density lipoprotein ratio with cognition, Alzheimer’s disease biomarkers and brain structure

Adenosine diphosphate-ribosylation greatly affects proteins function: a focus on neurodegenerative diseases

Observation on prefrontal cortex activation in patients with Parkinson’s disease: a fNIRS study

Effect of resistance training on body composition and physical function in older females with sarcopenic obesity—a systematic review and meta-analysis of randomized controlled trials

Cross-frequency neuromodulation: leveraging theta-gamma coupling for cognitive rehabilitation in MCI patients

The association between kidney function-standardized serum uric acid levels and stroke risk: insights from the National Health and Nutrition Examination Survey

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation

Phospholipids and peroxisomes in ferroptosis: the therapeutic target of acupuncture regulating vascular cognitive impairment and dementia

Effects of off-line auricular transcutaneous vagus nerve stimulation (taVNS) on a short-term memory task: a pilot study

NTN-1 attenuates amyloid-β-mediated microglial neuroinflammation and memory impairment via the NF-κB pathway and NLRP3 inflammasome in a rat model of Alzheimer's disease

Handgrip strength and risk of cognitive impairment across different glucose metabolism statuses: insights from the CHARLS study

Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer’s disease

A cross-sectional study of how high-frequency hearing loss impacts cognitive functions in middle-aged-to-older adults

Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease

Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review

Activation of GLP-1R modulates the spontaneous discharge of nigral dopaminergic neurons and motor behavior in mice with chronic MPTP Parkinson's disease

Bioinformatics-driven exploration of key genes and mechanisms underlying oxidative stress in traumatic brain injury

Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss

Lower CALLY index levels indicate higher poor functional outcome risk in acute ischemic stroke patients treated with endovascular thrombectomy

The potential and challenges of TREM2-targeted therapy in Alzheimer’s disease: insights from the INVOKE-2 study

Neuroprotective effects of electroacupuncture in ischemic stroke: from mechanisms to clinical implications

Machine learning models based on location-radiomics enable the accurate prediction of early neurological function deterioration for acute stroke in elderly patients

Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention