Frontiers in Aging Neuroscience

Original Research

Accepted on 15 Dec 2025

The Association of Eight-Year Trajectories in Total, Cognitive-Affective, and Somatic Depressive Symptoms with Incident Stroke: A 10-Year Follow-Up Study Using HRS and ELSA Cohorts

in Neuroinflammation and Neuropathy

Haining Zhang
Jiange Chen
Yuntian Ye
Hongyi Wang
Shun Fan
Wei Zhang
An Bao
Huanan Li
Jingui Wang

Frontiers in Aging Neuroscience

102 views

Systematic Review

Published on 15 Dec 2025

Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson’s disease: a network meta-analysis of 23 RCTs

in Parkinson’s Disease and Aging-related Movement Disorders

Dongyue Li
Xinyu Lin
Haojie Li
Jian Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670825

457 views

Original Research

Accepted on 12 Dec 2025

Trends and cross-country inequalities in the global burden of Alzheimer's disease and other dementias among adults aged 65+ years, 1990-2021: a population based study with projections into 2050

in Alzheimer's Disease and Related Dementias

Sibo Liu
Guozhi Wu
Xiao Ma
Kai Xu
Xiaoyan Lan
Long Wang
Hang Li
Dean Gu
Mengxing Wang
Jinjie Liu

Frontiers in Aging Neuroscience

199 views

Original Research

Accepted on 12 Dec 2025

Development and Validation of a Prognostic Nomogram for Predicting Ventilator-Associated Pneumonia Risk in Elderly Large Vessel Occlusion Ischemic Stroke after Endovascular Therapy Patients

in Neuroinflammation and Neuropathy

Wenfei Liang
Jingling Zhu
Xiuling Yang
Xiaohua He
Guoshun Li
Zhaobang Chen
Jiasheng Zhao
Kangqiang Yang
Bin Liao
Huiquan Deng

Frontiers in Aging Neuroscience

217 views

Mini Review

Published on 12 Dec 2025

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Fanshuai Zeng
Wei Li
Liyue Yang
Lu Yao
Xinna Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692777

849 views

Original Research

Published on 12 Dec 2025

Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study

in Parkinson’s Disease and Aging-related Movement Disorders

Jun Seok Lee
Joonsang Yoo
Nak-Hoon Son
Hye Jin Byun
Sooyeoun You

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688656

609 views

Original Research

Published on 12 Dec 2025

Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

in Neurocognitive Aging and Behavior

Ondřej Rýdlo
Adéla Bubeníková
Petr Skalický
Klára Häcklová
Robért Leško
Aleš Vlasák
Hana Georgi
Ondřej Bradáč

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1725486

736 views

Review

Published on 12 Dec 2025

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

in Parkinson’s Disease and Aging-related Movement Disorders

Victor Fellipe Bispo Macedo
Vanessa Karine Bispo Macedo
Jorge Artur Peçanha de Miranda Coelho
Alana Madeiro de Melo Barboza

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1664269

758 views

Original Research

Accepted on 11 Dec 2025

Subclinical Infection Combined with Surgery-Induced Cogni-tive Dysfunction: A Novel Adult Mouse Model for Periopera-tive Neurocognitive Disorder

in Neuroinflammation and Neuropathy

Yizhe Zhang
Xiao Zhang
Wanbing Dai
Ye Liu
Xiangyang Cheng
Yeke Zhu
Lili Huang
Minghao Tang
Yongxing Yao
Xuwu Xiang

Frontiers in Aging Neuroscience

168 views

Correction

Accepted on 11 Dec 2025

Correction: Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

in Neurocognitive Aging and Behavior

Yu Wang
Li Wang
Yunhong Du
Xiaoye Ma
Lili Sun
Xiujie Zhang
Wenli Rong
Jianwei Li
Yao Shi
Wei Liu

Frontiers in Aging Neuroscience

153 views

Original Research

Accepted on 11 Dec 2025

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging

in Cellular and Molecular Mechanisms of Brain-aging

Ming Sun
Chao Wu
Jingjing Wu
Lixin Liu
Liang Gu
Zihao Wang
Xue Yang
Feng Xu

Frontiers in Aging Neuroscience

171 views

Original Research

Accepted on 11 Dec 2025

The Alterations in Brain Network Functional Gradients and Dynamic Functional Connectivity in Alzheimer's Disease:A Resting-State fMRI Study

in Alzheimer's Disease and Related Dementias

Benqin Liu
Chunbing Chen
Pan Cai
Jiaren Zhang
Yang Li
Xu Chen
Xuejin Ma
Xuetao Jiang
anjie zhang
Linfeng Song

Frontiers in Aging Neuroscience

185 views

Original Research

Accepted on 11 Dec 2025

18F-FDG PET/MR reveals specific brain metabolic features in Parkinson's disease with frailty

in Parkinson’s Disease and Aging-related Movement Disorders

Guoyang LI
Wenli Zhang
Fengju Mao
Hong Zhao
Long Zhao
Yang Yang
Chang Sun
Lu Liu
Xiangcheng Wang
Xiaoguang Luo

Frontiers in Aging Neuroscience

203 views

Original Research

Published on 11 Dec 2025

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database

in Neuroinflammation and Neuropathy

Songmei Ma
Lin Lin
Shuwen Zheng
Zhenjing Liu
Li Kong
Haiyun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599858

607 views

Systematic Review

Published on 11 Dec 2025

Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Hong Jiang
Xinling Yang
Wenxing Wang
Lin Jiang
Xiao’e Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1704039

607 views

Original Research

Published on 10 Dec 2025

Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology

in Alzheimer's Disease and Related Dementias

Che Chen
Qianfeng Shao
Sheng Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688316

689 views

Original Research

Published on 10 Dec 2025

Prognostic value of endothelial activation and stress index in mechanical thrombectomy for patients with acute ischemic stroke

in Neuroinflammation and Neuropathy

Xiaohua Zhu
Yunnan Lu
Yaojia Xu
Yongxin Li
Qingyong Dai
Xia Chang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1683690

536 views

Original Research

Published on 10 Dec 2025

Safety and efficacy of extracranial vertebral artery stenting in elderly patients with symptomatic vertebral artery stenosis

in Neuroinflammation and Neuropathy

Miao Wu
Zhiyong Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1667157

485 views

Original Research

Published on 10 Dec 2025

Amyloid pathology modulates the relationship between subsyndromal symptomatic depression and tau accumulation in non-demented older adults

in Alzheimer's Disease and Related Dementias

Jiahe Bai
Xiaonan Wei
Hongchun Wei
Yaojun Tai
Min Kong
Maowen Ba
Chunhua Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679285

568 views

Perspective

Accepted on 09 Dec 2025

AI agents in Alzheimer's Disease Management: Challenges and Future Directions

in Alzheimer's Disease and Related Dementias

Marios Krokidis
Gerasimos Grammenos
Aristidis G. Vrahatis
Konstantinos Lazaros
Themis Exarchos
PANAGIOTIS VLAMOS

Frontiers in Aging Neuroscience

193 views

Original Research

Published on 09 Dec 2025

Enhanced Parkinson's disease prediction using LDEFS feature selection and Mamdani fuzzy neural network

in Parkinson’s Disease and Aging-related Movement Disorders

M. Vijayalakshmi
B. Dhiyanesh
D. Viji
P. Saranya

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1665590

493 views

Systematic Review

Published on 09 Dec 2025

The EEG analysis and identification of Alzheimer's disease: a review

in Alzheimer's Disease and Related Dementias

Jinying Bi
Fei Wang
Fangzhou Hu
Shuai Han
Yuting Wang
Zhijian Fu
Xin Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1686628

882 views

Brief Research Report

Published on 09 Dec 2025

The cerebellar-related cognitive function is sensitive to aging: implications for early detection

in Neurocognitive Aging and Behavior

Qianying Ma
Min Pu
Meijia Li
Ling Liu
Ruilin Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679443

548 views

Original Research

Published on 09 Dec 2025

Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach

in Neurocognitive Aging and Behavior

Kevin Mekulu
Faisal Aqlan
Hui Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1681124

607 views

7,706 articles

articles

The Association of Eight-Year Trajectories in Total, Cognitive-Affective, and Somatic Depressive Symptoms with Incident Stroke: A 10-Year Follow-Up Study Using HRS and ELSA Cohorts

Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson’s disease: a network meta-analysis of 23 RCTs

Trends and cross-country inequalities in the global burden of Alzheimer's disease and other dementias among adults aged 65+ years, 1990-2021: a population based study with projections into 2050

Development and Validation of a Prognostic Nomogram for Predicting Ventilator-Associated Pneumonia Risk in Elderly Large Vessel Occlusion Ischemic Stroke after Endovascular Therapy Patients

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease

Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study

Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

Subclinical Infection Combined with Surgery-Induced Cogni-tive Dysfunction: A Novel Adult Mouse Model for Periopera-tive Neurocognitive Disorder

Correction: Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging

The Alterations in Brain Network Functional Gradients and Dynamic Functional Connectivity in Alzheimer's Disease:A Resting-State fMRI Study

18F-FDG PET/MR reveals specific brain metabolic features in Parkinson's disease with frailty

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database

Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis

Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology

Prognostic value of endothelial activation and stress index in mechanical thrombectomy for patients with acute ischemic stroke

Safety and efficacy of extracranial vertebral artery stenting in elderly patients with symptomatic vertebral artery stenosis

Amyloid pathology modulates the relationship between subsyndromal symptomatic depression and tau accumulation in non-demented older adults

AI agents in Alzheimer's Disease Management: Challenges and Future Directions

Enhanced Parkinson's disease prediction using LDEFS feature selection and Mamdani fuzzy neural network

The EEG analysis and identification of Alzheimer's disease: a review

The cerebellar-related cognitive function is sensitive to aging: implications for early detection

Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach