Frontiers in Aging Neuroscience

Original Research

Accepted on 02 Dec 2025

Mechanistic Insights into the Anti-Neuroinflammatory Effects of Cassia obtusifolia in Parkinson's Disease: A Network Pharmacology-Based Study

in Neuroinflammation and Neuropathy

Xinfu Lian
Yongjun Bai
Rong Xie
Wang Du
Lingbo Ma
Yuqian Jiang

Frontiers in Aging Neuroscience

127 views

Original Research

Published on 02 Dec 2025

Correlation between cerebral small vessel disease and postural instability/gait difficulty subtype in Parkinson’s disease patients

in Parkinson’s Disease and Aging-related Movement Disorders

Yingchao Ge
Wa Zhao
Xiaorong Xu
Wenchao Qiu
Peiting Liu
Minghui Zhao
Yongqing Cheng
Shouru Xue

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1686214

697 views

Original Research

Published on 02 Dec 2025

Agricultural or gardening physical activity may slow neurovascular aging and prevent stroke and dementia: an experimental and cross-sectional study

in Alzheimer's Disease and Related Dementias

Kiyoshi Kikuchi
Seiya Takada
Shotaro Otsuka
Kazuki Nakanishi
Harutoshi Sakakima
Hyuma Makizako
Nobuhiro Tahara
Hisaaki Uchikado
Naoto Shiomi
Satomi Ooba

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676259

750 views

Correction

Published on 02 Dec 2025

Correction: Visual attention during non-immersive virtual reality balance training in older adults with mild to moderate cognitive impairment: an eye-tracking study

in Neurocognitive Aging and Behavior

Marcos Maldonado-Díaz
Gonzalo Jara-Vargas
Felipe González-Seguel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1737079

556 views

Original Research

Accepted on 01 Dec 2025

Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants

in Neurocognitive Aging and Behavior

Yucheng Gu
Xiaoyuan Li
Nihong Chen
Feng Wang

Frontiers in Aging Neuroscience

151 views

Review

Published on 01 Dec 2025

The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Fatemeh Farahani
Christelle Anaclet
Hossein Azizi
Heinrich S. Gompf

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632236

1,246 views

Original Research

Published on 01 Dec 2025

Sarcopenia and cognitive impairment: a multidimensional study of clinical associations, shared genetics, and causal links

in Neurocognitive Aging and Behavior

Kemeng Zhang
Sui Huang
Mengchen Liu
Yi Zhang
Wenhan Li
Bijin Luo
Ping He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1708170

852 views

Review

Published on 01 Dec 2025

How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings

in Neurocognitive Aging and Behavior

Antonietta Pepe
Asieh Amousoltani Arani
Francesca Bracone
Augusto Di Castelnuovo
Loreto Muñoz-Venegas
Chiara Cerletti
Giovanni de Gaetano
Maria Benedetta Donati
Licia Iacoviello
Alessandro Gialluisi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1616303

1,399 views

Original Research

Published on 01 Dec 2025

An investigation on Alzheimer’s disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure

in Alzheimer's Disease and Related Dementias

Dongmei Luo
Tenghong Lian
Ning Wei
Peng Guo
Mingyue He
Yanan Zhang
Yue Huang
Gaifen Liu
Jinghui Li
Jing Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1552535

1,101 views

Original Research

Published on 01 Dec 2025

Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

in Neurocognitive Aging and Behavior

Yu Wang
Li Wang
Yunhong Du
Xiaoye Ma
Lili Sun
Xiujie Zhang
Wenli Rong
Jianwei Li
Yao Shi
Wei Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692414

722 views

Review

Published on 01 Dec 2025

Research progress on the role of microbiome-immune-neurotransmitter network in post-stroke sleep disorders

in Neuroinflammation and Neuropathy

Wanting Shi
Li Wu
Qiong Qin
Yanjing Li
Wei Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1694709

1,208 views

Original Research

Published on 01 Dec 2025

Impact of aging on the central and enteric nervous system in a Parkinson’s disease mouse model

in Parkinson’s Disease and Aging-related Movement Disorders

Solène Pradeloux
Morgane M. André
Maélie Fréchette
Mathilde Drolet
Catherine Fontaine-Lavallée
Mélissa Côté
Katherine Coulombe
Marie Rieux
Frédéric Calon
Denis Soulet

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576325

1,170 views

Original Research

Published on 01 Dec 2025

Global, regional, and national burden of Alzheimer’s disease and other dementias from 1990 to 2021: findings from the Global Burden of Disease Study 2021

in Alzheimer's Disease and Related Dementias

Yinglei Duan
Chongfang Han
Hua Zheng
Jing Yu
Min Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1678212

963 views

Original Research

Accepted on 28 Nov 2025

The aggregate proteome of C. elegans mitochondria implicates shared mechanisms of aging and Alzheimer's disease

in Cellular and Molecular Mechanisms of Brain-aging

Sonu Pahal
Akshatha Ganne
Meenakshisundaram Balasubramaniam
Sue T Griffin
Robert Joseph Shmookler Reis
Srinivas Ayyadevara

Frontiers in Aging Neuroscience

240 views

Original Research

Accepted on 28 Nov 2025

Functional Data Analysis of Heart Rate Variability from Continuous ECG Monitoring in Older Adults with and without Mild Cognitive Impairment

in Neurocognitive Aging and Behavior

Jiyue Qin
Carol Derby
Grace LIU
Cuiling Wang
Richard Sloan

Frontiers in Aging Neuroscience

308 views

Original Research

Accepted on 28 Nov 2025

HALP, PIV and SII as Novel Composite Inflammatory Indices for Early Detection and Severity Assessment of Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Chao Huang
Chenxi Lu
Shuai Liu
Fanshu Dai
Dilraba Mahmut
Hezhen Gao
Yong Ji
Biao Zhang

Frontiers in Aging Neuroscience

401 views

Review

Published on 28 Nov 2025

Development and emerging trends in gastrointestinal dysfunction of Parkinson’s disease: a decade-long bibliometric analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Yujia Sun
Haoyu Yang
Junfeng Zhang
Shan Cong
Lin Wang
Tao Yu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1712302

1,163 views

Hypothesis and Theory

Published on 28 Nov 2025

Are current etiological theories of Alzheimer’s disease falsifiable? An epistemological assessment

in Alzheimer's Disease and Related Dementias

Tommaso Costa
Donato Liloia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1708234

684 views

Original Research

Published on 28 Nov 2025

Association of white matter hyperintensity with systemic inflammation markers and cognitive assessments: a cross-sectional study via SHAP analysis

in Neuroinflammation and Neuropathy

Dewang Gao
Jiayu Lv
Xinhui Li
Wen Yong
Wenlong Yu
Lu Wang
Shangjia Ma
Hua Li
Shuaiqiang Zhang
Zi Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1667025

735 views

Original Research

Accepted on 27 Nov 2025

Machine Learning Models for the Prediction of Levodopa Response to Tremor in Parkinson's Disease

in Parkinson’s Disease and Aging-related Movement Disorders

Fangfei Li
Shinuan Lin
Rui Yan
Yusha Cui
Kang Ren
Zhonglue Chen
Lingyan Ma
Tao Feng

Frontiers in Aging Neuroscience

196 views

Original Research

Accepted on 27 Nov 2025

The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss

in Neuroinflammation and Neuropathy

Juhong Zhang
Haizhu Ma
Jing Ke
Ziyi Tang
Zhiji Chen
Guijun Yang
Li Yang
Jialin Guo
Xiaoqi Yan
Changxiu Peng

Frontiers in Aging Neuroscience

164 views

Brief Research Report

Published on 27 Nov 2025

Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration

in Alzheimer's Disease and Related Dementias

Luca Sacchi
Marina Arcaro
Giorgio Bocca
Lia Schmid
Tiziana Carandini
Laura Ghezzi
Manuela Pintus
Anna Margherita Pietroboni
Chiara Fenoglio
Maria Serpente

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688996

981 views

Original Research

Published on 27 Nov 2025

Evaluation of microcurrent as an adjunct to donepezil therapy in an Alzheimer’s disease mouse model: a pilot study

in Alzheimer's Disease and Related Dementias

Eun Ho Kim
Yoon-Jin Lee
Yong Suk Moon
Oh Dae Kwon
Dong Rak Kwon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1689593

843 views

Original Research

Published on 26 Nov 2025

Absence of the LRRK2 mutation in Emirati Parkinson’s disease patients in contrast to other Arab populations

in Parkinson’s Disease and Aging-related Movement Disorders

Vinod Metta
Anjana Soorajkumar
Tom Loney
Nasna Nassir
K. Ray Chaudhuri
Mohammed Jashim Uddin
Hani T. S. Benamer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676115

743 views

7,708 articles

articles

Mechanistic Insights into the Anti-Neuroinflammatory Effects of Cassia obtusifolia in Parkinson's Disease: A Network Pharmacology-Based Study

Correlation between cerebral small vessel disease and postural instability/gait difficulty subtype in Parkinson’s disease patients

Agricultural or gardening physical activity may slow neurovascular aging and prevent stroke and dementia: an experimental and cross-sectional study

Correction: Visual attention during non-immersive virtual reality balance training in older adults with mild to moderate cognitive impairment: an eye-tracking study

Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants

The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer’s disease

Sarcopenia and cognitive impairment: a multidimensional study of clinical associations, shared genetics, and causal links

How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings

An investigation on Alzheimer’s disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure

Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

Research progress on the role of microbiome-immune-neurotransmitter network in post-stroke sleep disorders

Impact of aging on the central and enteric nervous system in a Parkinson’s disease mouse model

Global, regional, and national burden of Alzheimer’s disease and other dementias from 1990 to 2021: findings from the Global Burden of Disease Study 2021

The aggregate proteome of C. elegans mitochondria implicates shared mechanisms of aging and Alzheimer's disease

Functional Data Analysis of Heart Rate Variability from Continuous ECG Monitoring in Older Adults with and without Mild Cognitive Impairment

HALP, PIV and SII as Novel Composite Inflammatory Indices for Early Detection and Severity Assessment of Alzheimer's Disease

Development and emerging trends in gastrointestinal dysfunction of Parkinson’s disease: a decade-long bibliometric analysis

Are current etiological theories of Alzheimer’s disease falsifiable? An epistemological assessment

Association of white matter hyperintensity with systemic inflammation markers and cognitive assessments: a cross-sectional study via SHAP analysis

Machine Learning Models for the Prediction of Levodopa Response to Tremor in Parkinson's Disease

The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss

Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration

Evaluation of microcurrent as an adjunct to donepezil therapy in an Alzheimer’s disease mouse model: a pilot study

Absence of the LRRK2 mutation in Emirati Parkinson’s disease patients in contrast to other Arab populations