Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Published on 03 Dec 2025

Early detection of mild cognitive impairment utilizing ocular biomarker-based risk scoring nomogram

in Alzheimer's Disease and Related Dementias

Mohammed Seid Hussen
Bess Yin-Hung Lam
Wei Gao
Liping Zhou
Kai Yip Choi
Henry Ho-lung Chan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1669948

953 views

Original Research

Published on 03 Dec 2025

Validation of the robustness of blood-based biomarkers for predicting amyloid-β positivity in Chinese populations

in Alzheimer's Disease and Related Dementias

Ying Wang
Liang Cui
Feng-Feng Pan
Zhen Zhang
Lin Huang
Ya Miao
Yi-Hui Guan
Qi-Hao Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1660755

918 views

Original Research

Accepted on 02 Dec 2025

Aperiodic EEG Signatures: Unveiling the Interplay between APOE ε4 and Mild Cognitive Impairment Subtypes

in Alzheimer's Disease and Related Dementias

Joel Eyamu
Boncho Ku
Kahye Kim
Kun Ho Lee
Jaeuk Kim

Frontiers in Aging Neuroscience

304 views

Original Research

Accepted on 02 Dec 2025

Dexmedetomidine Ameliorates Cognitive and Affective Deficits by Modulating Neuroinflammation and Neurogenesis in an Alzheimer's Disease Mouse Model

in Alzheimer's Disease and Related Dementias

Mai Li
Chanyuan An
Xin Wang
Minghe Ren
Shiyu Liu
Ruixin Chen
Yuyan Guo
Jun Wang
Yulang Fei
Dafei Ma

Frontiers in Aging Neuroscience

543 views

Original Research

Published on 02 Dec 2025

Agricultural or gardening physical activity may slow neurovascular aging and prevent stroke and dementia: an experimental and cross-sectional study

in Alzheimer's Disease and Related Dementias

Kiyoshi Kikuchi
Seiya Takada
Shotaro Otsuka
Kazuki Nakanishi
Harutoshi Sakakima
Hyuma Makizako
Nobuhiro Tahara
Hisaaki Uchikado
Naoto Shiomi
Satomi Ooba

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676259

750 views

Review

Published on 01 Dec 2025

The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Fatemeh Farahani
Christelle Anaclet
Hossein Azizi
Heinrich S. Gompf

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632236

1,246 views

Original Research

Published on 01 Dec 2025

An investigation on Alzheimer’s disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure

in Alzheimer's Disease and Related Dementias

Dongmei Luo
Tenghong Lian
Ning Wei
Peng Guo
Mingyue He
Yanan Zhang
Yue Huang
Gaifen Liu
Jinghui Li
Jing Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1552535

1,101 views

Original Research

Published on 01 Dec 2025

Global, regional, and national burden of Alzheimer’s disease and other dementias from 1990 to 2021: findings from the Global Burden of Disease Study 2021

in Alzheimer's Disease and Related Dementias

Yinglei Duan
Chongfang Han
Hua Zheng
Jing Yu
Min Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1678212

963 views

Original Research

Accepted on 28 Nov 2025

HALP, PIV and SII as Novel Composite Inflammatory Indices for Early Detection and Severity Assessment of Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Chao Huang
Chenxi Lu
Shuai Liu
Fanshu Dai
Dilraba Mahmut
Hezhen Gao
Yong Ji
Biao Zhang

Frontiers in Aging Neuroscience

401 views

Hypothesis and Theory

Published on 28 Nov 2025

Are current etiological theories of Alzheimer’s disease falsifiable? An epistemological assessment

in Alzheimer's Disease and Related Dementias

Tommaso Costa
Donato Liloia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1708234

684 views

Brief Research Report

Published on 27 Nov 2025

Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration

in Alzheimer's Disease and Related Dementias

Luca Sacchi
Marina Arcaro
Giorgio Bocca
Lia Schmid
Tiziana Carandini
Laura Ghezzi
Manuela Pintus
Anna Margherita Pietroboni
Chiara Fenoglio
Maria Serpente

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688996

981 views

Original Research

Published on 27 Nov 2025

Evaluation of microcurrent as an adjunct to donepezil therapy in an Alzheimer’s disease mouse model: a pilot study

in Alzheimer's Disease and Related Dementias

Eun Ho Kim
Yoon-Jin Lee
Yong Suk Moon
Oh Dae Kwon
Dong Rak Kwon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1689593

843 views

Review

Published on 26 Nov 2025

Unvalidated efficacy and significant risks hinder clinical use of deep cervical lymphatic-venous anastomosis for Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Rui Zhang
Ying Ying Liu
Xun Xia
Xinjun Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1671741

1,174 views

Original Research

Published on 26 Nov 2025

Clinical and neuropsychological features associated with progression in subjective cognitive decline

in Alzheimer's Disease and Related Dementias

Rafael Villino-Rodríguez
Mirla M. Ríos-Rivera
Genoveva Montoya-Murillo
Jonathan Patricio Baldera
Salomón Salazar-Londoño
María Cruz Rodríguez-Oroz
Miguel Germán Borda
Adolfo Jiménez-Huete
Mario Riverol

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1680762

945 views

Systematic Review

Accepted on 25 Nov 2025

The Efficacy Versus Evidence Quality of Multicompomnent Exercise for Cognitive Health in Older Adults: An Umbrella Review

in Alzheimer's Disease and Related Dementias

Weibao Liang
Chuannan Liu
Xujie Yan
Shuting Xu
Jianmin Dai
Wenbai Huang

Frontiers in Aging Neuroscience

499 views

Original Research

Published on 24 Nov 2025

Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study

in Alzheimer's Disease and Related Dementias

Unai Torres
David Bernal
Ibai Gurrutxaga
Ainara Estanga
Pablo Martínez-Lage
Olatz Arbelaitz

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1653074

1,016 views

Original Research

Published on 24 Nov 2025

Music-induced physiological markers for detecting Alzheimer's disease using machine learning

in Alzheimer's Disease and Related Dementias

Rodrigo Lima
Gonçalo Barradas
Sergi Bermúdez i Badia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1701970

839 views

Original Research

Accepted on 21 Nov 2025

Follicle-Stimulating Hormone Linked to Cognitive Decline and Amyloid Burden in Postmenopausal Women

in Alzheimer's Disease and Related Dementias

Sheng-Min Wang
Chaiho Jeong
Yoo Hyun Um
Dong Woo Kang
Sunghwan Kim
Soyoung Lee
Chang Uk Lee
Howard J Aizenstein
Ki-hyun Baek
Hyun Kook Lim

Frontiers in Aging Neuroscience

285 views

Review

Accepted on 21 Nov 2025

Mechanisms to Medicines: Navigating Drug Repurposing Strategies in Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Sara A Khan
Khushi Raza
Prachi Tiwari
Mohamed Eltenani
Syed Arman Rabbani
Suhel Parvez

Frontiers in Aging Neuroscience

235 views

Original Research

Published on 19 Nov 2025

MRI-derived global small vessel disease burden serves as a marker of hippocampal sclerosis and clinical stage across the probable Alzheimer’s disease continuum

in Alzheimer's Disease and Related Dementias

Ya-Che Chen
Ting-Bin Chen
Hsin-Chieh Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692747

1,456 views

Original Research

Published on 19 Nov 2025

Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study

in Alzheimer's Disease and Related Dementias

Zhou Su
Mengran Liu
Jun Kuai
Tingting Yi
Yuechang Zheng
Xinran Bao
Jiyu Ji

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1630826

671 views

Mini Review

Accepted on 17 Nov 2025

LRP1 at the Crossroads of Aβ Clearance and Therapeutic Targeting in Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Yuepeng Deng
Haolin Yin
Zihao Lu
Huan Lan
Wenxiong Liu
Chao Zuo
Nanfang Pan
Xiaohe Tian
Qiyong Gong

Frontiers in Aging Neuroscience

326 views

Correction

Published on 17 Nov 2025

Correction: Current application status of non-invasive brain stimulation techniques in Alzheimer's disease: a bibliometric analysis

in Alzheimer's Disease and Related Dementias

Shan Cong
Meng Wang
Long Yan
Li Sun
Bowen Zheng
Jinying Xie
Tao Yu
Yulin Qian

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730649

772 views

Review

Published on 14 Nov 2025

Structural and microstructural changes in white and gray matter across the Alzheimer’s disease continuum

in Alzheimer's Disease and Related Dementias

Lingling Lv
Hui Guo
Zhiru Zhao
Xiongfei Zhao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1693840

1,087 views

2,205 articles

articles

Early detection of mild cognitive impairment utilizing ocular biomarker-based risk scoring nomogram

Validation of the robustness of blood-based biomarkers for predicting amyloid-β positivity in Chinese populations

Aperiodic EEG Signatures: Unveiling the Interplay between APOE ε4 and Mild Cognitive Impairment Subtypes

Dexmedetomidine Ameliorates Cognitive and Affective Deficits by Modulating Neuroinflammation and Neurogenesis in an Alzheimer's Disease Mouse Model

Agricultural or gardening physical activity may slow neurovascular aging and prevent stroke and dementia: an experimental and cross-sectional study

The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer’s disease

An investigation on Alzheimer’s disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure

Global, regional, and national burden of Alzheimer’s disease and other dementias from 1990 to 2021: findings from the Global Burden of Disease Study 2021

HALP, PIV and SII as Novel Composite Inflammatory Indices for Early Detection and Severity Assessment of Alzheimer's Disease

Are current etiological theories of Alzheimer’s disease falsifiable? An epistemological assessment

Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration

Evaluation of microcurrent as an adjunct to donepezil therapy in an Alzheimer’s disease mouse model: a pilot study

Unvalidated efficacy and significant risks hinder clinical use of deep cervical lymphatic-venous anastomosis for Alzheimer’s disease

Clinical and neuropsychological features associated with progression in subjective cognitive decline

The Efficacy Versus Evidence Quality of Multicompomnent Exercise for Cognitive Health in Older Adults: An Umbrella Review

Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study

Music-induced physiological markers for detecting Alzheimer's disease using machine learning

Follicle-Stimulating Hormone Linked to Cognitive Decline and Amyloid Burden in Postmenopausal Women

Mechanisms to Medicines: Navigating Drug Repurposing Strategies in Alzheimer's Disease

MRI-derived global small vessel disease burden serves as a marker of hippocampal sclerosis and clinical stage across the probable Alzheimer’s disease continuum

Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study

LRP1 at the Crossroads of Aβ Clearance and Therapeutic Targeting in Alzheimer's Disease

Correction: Current application status of non-invasive brain stimulation techniques in Alzheimer's disease: a bibliometric analysis

Structural and microstructural changes in white and gray matter across the Alzheimer’s disease continuum