Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Published on 22 Sep 2025

Regional CSF volume quantification using deep learning for comparative analysis of brain atrophy in frontotemporal dementia subtypes

in Alzheimer's Disease and Related Dementias

Kyoung Yoon Lim
Soyeon Yoon
Seongbeom Park
Seongmi Kim
Kyoungmin Kim
Jehyun Ahn
Jun Pyo Kim
Hee Jin Kim
Duk L. Na
Sang Won Seo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1631640

2,156 views

Original Research

Published on 18 Sep 2025

Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis

in Alzheimer's Disease and Related Dementias

Haishou Fu
Huaqing Huang
Shuzhen Liao
Zhisen Dai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637029

3,661 views

Review

Published on 16 Sep 2025

Exercise-mediated cerebrovascular repair in Alzheimer's disease: from pathophysiology to therapeutic precision

in Alzheimer's Disease and Related Dementias

Ming Cai
Keren Cai
Ziqi Wei
Jing Zhou
Jiayi Shu
Weiyi Wang
Wanju Sun
Jingyun Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632365

3,249 views

Review

Published on 16 Sep 2025

Cerebral amyloid angiopathy: a narrative review

in Alzheimer's Disease and Related Dementias

Natalia Motzko Noto
Robert C. Speth
Lisa S. Robison

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632252

5,171 views
1 citation

Original Research

Published on 16 Sep 2025

Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers

in Alzheimer's Disease and Related Dementias

Edward Ofori
B. Blair Braden
Kewei Chen
Yi Su
Richard J. Caselli
Eric M. Reiman

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597127

2,657 views

Original Research

Published on 12 Sep 2025

Abnormal resting-state EEG neural oscillations and functional connectivity in mild cognitive impairment

in Alzheimer's Disease and Related Dementias

Yi Jiang
Zhiwei Guo
Rubing Jiao
Haoru He
Ning Jiang
Jiayuan He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640966

3,507 views
2 citations

Original Research

Published on 05 Sep 2025

The mediating role of depression on the association between physical activity and cognitive function among older adults

in Alzheimer's Disease and Related Dementias

HuanRui Zhang
Wen Tian
GuoXian Qi
XiuFang Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1470256

2,389 views

Original Research

Published on 03 Sep 2025

Associations of plasma von Willebrand Factor levels with cognitive decline and neurodegeneration in older adults without dementia

in Alzheimer's Disease and Related Dementias

Pan Fu
Meiling Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1595071

1,801 views

Original Research

Published on 29 Aug 2025

Abnormal sleep blood pressure patterns are associated with the diffusion tensor imaging along the perivascular space index in cognitively impaired individuals

in Alzheimer's Disease and Related Dementias

Mariateresa Buongiorno
Gonzalo Sánchez-Benavides
Giovanni Caruana
Andrea Elias-Mas
Cristina Artero
Natalia Cullell
Pilar Delgado
Darly Milena Giraldo
Clara Marzal-Espí
Oriol Grau-Rivera

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1578270

2,538 views

Original Research

Published on 26 Aug 2025

Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes

in Alzheimer's Disease and Related Dementias

Toshiya Takahashi
Dinh Ha Duy Thuy
Shingo Takenaka
Sayaka Ono
Maya Fukui
Yasushi Okada
Tomohiko Asada
Kan Niimi
Kaku Kimura
Akio Ikeda

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1651596

2,783 views

Review

Published on 25 Aug 2025

The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Gao Ning
Xing Fan
Du Juan
Zhao wenxue
Wang Sijia
Chen Meinei
Dong Xiaolong
Qi Yiming

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637671

3,212 views
1 citation

Original Research

Published on 22 Aug 2025

Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Ji-Woo Seok
Kahye Kim
Soonjo Hwang
Kun Ho Lee
Jaeuk U. Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592341

2,149 views

Original Research

Published on 20 Aug 2025

Virtual reality navigation for the early detection of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Sayuri Shima
Reiko Ohdake
Yasuaki Mizutani
Harutsugu Tatebe
Riki Koike
Atsushi Kasai
Epifanio Bagarinao
Kazuya Kawabata
Akihiro Ueda
Mizuki Ito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571429

2,992 views

Original Research

Published on 20 Aug 2025

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Alexander Erofeev
Egor Vinokurov
Anastasia Bol’shakova
Ilya Bezprozvanny
Olga Vlasova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1550673

2,205 views

Original Research

Published on 18 Aug 2025

Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females

in Alzheimer's Disease and Related Dementias

Tian Wang
Zisu Mao
Yuan Shang
Simona Merlini
Francesca Vitali
Jean-Paul Wiegand
Roberta Diaz Brinton

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632877

3,391 views
2 citations

Original Research

Published on 18 Aug 2025

Accurate and robust prediction of Amyloid-β brain deposition from plasma biomarkers and clinical information using machine learning

in Alzheimer's Disease and Related Dementias

Jiayuan Xu
Andrew J. Doig
Sofia Michopoulou
Petroula Proitsi
Fumie Costen
The Alzheimer's disease neuroimaging initiative

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1559459

2,006 views

Review

Published on 15 Aug 2025

Naringenin as a neurotherapeutic agent in Alzheimer’s disease: epigenetic signatures, gut microbiota alterations, and molecular neuroprotection

in Alzheimer's Disease and Related Dementias

Zhenzhen Lai
Long Ke
Wei Zhao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1647967

4,189 views
3 citations

Review

Published on 15 Aug 2025

Artificial intelligence technologies for enhancing neurofunctionalities: a comprehensive review with applications in Alzheimer’s disease research

in Alzheimer's Disease and Related Dementias

Zhirong Gu
Bin Ge
Yuanyuan Wang
Yiping Gong
Mei Qi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1609063

3,966 views

Mini Review

Published on 14 Aug 2025

Exploring efficient and effective mammalian models for Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Mitsunori Kayano

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1652754

2,876 views
1 citation

Original Research

Published on 12 Aug 2025

Local gyrification index and sulcal depth as imaging markers of cognitive decline in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Yongsik Sim
Changmin Seo
Young-gun Lee
Byoung Seok Ye
Ilwoo Lyu
Beomseok Sohn

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1635861

1,864 views

Original Research

Published on 06 Aug 2025

Effect of aspirin use on conversion risk from mild cognitive impairment to Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Bo Kyu Choi
Yeonju Jin
Hokyung Lee
Sung-Woo Kim
Sojeong Park
Ickpyo Hong
Min Seok Baek

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1603892

2,575 views
1 citation

Original Research

Published on 06 Aug 2025

Neuroinflammation-mediated YKL-40 correlates with tau pathology and predicts longitudinal cognitive impairment and brain atrophy in Alzheimer’s disease, with hypertensive dependency

in Alzheimer's Disease and Related Dementias

Ya-Yu Wang
Man Zhang
Shu-Jian Chen
Wei Miao
Zhi-Xin Wang
Ya-Jun Zhou
Si-Qi Yu
Zhong-Wu Sun
Xia Zhou
Xian-Feng Yu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1630022

2,473 views
2 citations

Original Research

Published on 06 Aug 2025

Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Hui Liu
Chenye Li
Congchen Zhai
Mei Li
Lan Ma

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566929

2,391 views

Review

Published on 06 Aug 2025

Advancement in modeling of Alzheimer’s disease: a comprehensive review of preclinical screening platforms

in Alzheimer's Disease and Related Dementias

Souvik Adak
Shivam Singh
Ridhi Jain
Abhilasha Tiwari
Binny Singh
Sumit Kumar
Ayushi Dadhwal
Avishek Chakroborty
Ashish Kumar Sharma
Ravindra Pal Singh

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1646551

3,571 views

2,205 articles

articles

Regional CSF volume quantification using deep learning for comparative analysis of brain atrophy in frontotemporal dementia subtypes

Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis

Exercise-mediated cerebrovascular repair in Alzheimer's disease: from pathophysiology to therapeutic precision

Cerebral amyloid angiopathy: a narrative review

Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers

Abnormal resting-state EEG neural oscillations and functional connectivity in mild cognitive impairment

The mediating role of depression on the association between physical activity and cognitive function among older adults

Associations of plasma von Willebrand Factor levels with cognitive decline and neurodegeneration in older adults without dementia

Abnormal sleep blood pressure patterns are associated with the diffusion tensor imaging along the perivascular space index in cognitively impaired individuals

Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes

The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer’s disease

Virtual reality navigation for the early detection of Alzheimer’s disease

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females

Accurate and robust prediction of Amyloid-β brain deposition from plasma biomarkers and clinical information using machine learning

Naringenin as a neurotherapeutic agent in Alzheimer’s disease: epigenetic signatures, gut microbiota alterations, and molecular neuroprotection

Artificial intelligence technologies for enhancing neurofunctionalities: a comprehensive review with applications in Alzheimer’s disease research

Exploring efficient and effective mammalian models for Alzheimer’s disease

Local gyrification index and sulcal depth as imaging markers of cognitive decline in Alzheimer’s disease

Effect of aspirin use on conversion risk from mild cognitive impairment to Alzheimer’s disease

Neuroinflammation-mediated YKL-40 correlates with tau pathology and predicts longitudinal cognitive impairment and brain atrophy in Alzheimer’s disease, with hypertensive dependency

Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer’s disease

Advancement in modeling of Alzheimer’s disease: a comprehensive review of preclinical screening platforms