Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Published on 06 Aug 2025

Hippocampal vascular supply and its mediating role in systemic physiological influences on hippocampal volume

in Alzheimer's Disease and Related Dementias

Tae Kim
Javier Rasero
Anna L. Marsland
Mark R. Scudder
Tamer S. Ibrahim
Peter J. Gianaros

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1590242

2,018 views

Original Research

Published on 04 Aug 2025

Sex differences in the association of cardiometabolic risk scores and blood pressure measurements with white matter hyperintensities in diverse older adults—HABS-HD

in Alzheimer's Disease and Related Dementias

Cellas A. Hayes
Raul Vintimilla
Soumilee Chaudhuri
Michelle C. Odden

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607646

2,090 views

Original Research

Published on 28 Jul 2025

Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer’s disease progression

in Alzheimer's Disease and Related Dementias

Peng Yu
Lu Shen
Lijun Tang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1609793

2,736 views
1 citation

Original Research

Published on 24 Jul 2025

Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models

in Alzheimer's Disease and Related Dementias

Xiao Zhang
Sanoji Wijenayake
Shakhawat Hossain
Qian Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617611

2,541 views

Mini Review

Published on 24 Jul 2025

GLP-1R as a potential link between diabetes and Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Shujun Li
Nanqu Huang
Mei Wang
Wendi Huang
Jingshan Shi
Yong Luo
Juan Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1601602

3,642 views
1 citation

Review

Published on 23 Jul 2025

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

in Alzheimer's Disease and Related Dementias

Julia C. Colwell
Marina E. Emborg

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598245

2,244 views
3 citations

Original Research

Published on 23 Jul 2025

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Liangdong Zhou
Tracy A. Butler
Xiuyuan H. Wang
Samantha A. Keil
Seyed Hani Hojjati
Tsung-Wei Hu
Mélissa Savard
Firoza Z. Lussier
Pedro Rosa-Neto
Lidia Glodzik

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1613320

2,232 views

Original Research

Published on 23 Jul 2025

Altered dynamic functional network connectivity patterns in Alzheimer’s disease: insights into neural dysfunction

in Alzheimer's Disease and Related Dementias

Xuerui Pang
Yi Ji
Chenyang Hu
Yulong Dai
Panpan Hu
Xingqi Wu
Kai Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617191

2,200 views
2 citations

Review

Published on 23 Jul 2025

Advancements in multi-omics research to address challenges in Alzheimer’s disease: a systems biology approach utilizing molecular biomarkers and innovative strategies

in Alzheimer's Disease and Related Dementias

Madison Cardillo
Keyura Katam
Prashanth Suravajhala

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591796

5,273 views
4 citations

Original Research

Published on 22 Jul 2025

miR-423-5p and miR-92a-3p in Alzheimer’s disease: relationship with pathology and cognition

in Alzheimer's Disease and Related Dementias

Sang-Won Han
Young Ho Park
Jung-Min Pyun
Paula J. Bice
SangYun Kim
Andrew J. Saykin
Kwangsik Nho

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637368

2,268 views

Review

Published on 21 Jul 2025

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

in Alzheimer's Disease and Related Dementias

Bingyuan Zhou
Jing Li
Anqi Wu
Xuewei Wang
Le Cheng
Gaoshang Yang
Dahong Gao
Caifeng Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587986

3,502 views
3 citations

Review

Published on 16 Jul 2025

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

in Alzheimer's Disease and Related Dementias

Yanrong Yang
Hua Chen
Qibing Liu
Yang Niu
Chunyang Mao
Rui Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1623050

3,559 views
2 citations

Original Research

Published on 16 Jul 2025

Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Fenyang Chen
Tiantian Heng
Qi Feng
Rui Hua
Jiaojiao Wu
Feng Shi
Zhengluan Liao
Keyin Qiao
Zhiliang Zhang
Jianliang Miao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1621106

3,036 views
1 citation

Review

Published on 15 Jul 2025

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

in Alzheimer's Disease and Related Dementias

Amy F. T. Arnsten
Isabella Perone
Min Wang
Shengtao Yang
Stacy Uchendu
Dinara Bolat
Dibyadeep Datta

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1610350

2,665 views
1 citation

Original Research

Published on 11 Jul 2025

Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China

in Alzheimer's Disease and Related Dementias

Jianping Lu
Guoen Cai
Naian Xiao
Kunmu Zheng
Qinyong Ye
Xiaochun Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566247

1,490 views

Original Research

Published on 07 Jul 2025

Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method

in Alzheimer's Disease and Related Dementias

Shiyu Xiao
Xuemeng Wei
Bing Han
Xiaoqian Shi
Congzhen Wei
Rumeng Liang
Jingna Sun
Zheng Zhang
Zhengang Han
Li Shen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1561831

2,921 views
2 citations

Mini Review

Published on 04 Jul 2025

Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia

in Alzheimer's Disease and Related Dementias

Jinhuan Yue
Peng Wang
Xiang-fa Guo
Zeyi Wei
Kaiting He
Nuo Li
Xiaoling Li
Qinhong Zhang
Xiaoqing Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547965

2,517 views
1 citation

Brief Research Report

Published on 03 Jul 2025

Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Neha Singh-Reilly
Ryota Satoh
Jonathan Graff-Radford
Mary M. Machulda
Val J. Lowe
Keith A. Josephs
Jennifer L. Whitwell

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1615718

1,949 views

Original Research

Published on 02 Jul 2025

Hippocampal iron patterns in aging and mild cognitive impairment

in Alzheimer's Disease and Related Dementias

Sonja M. Kagerer
Laetitia Vionnet
Jiri M. G. van Bergen
Rafael Meyer
Anton F. Gietl
Klaas P. Pruessmann
Christoph Hock
Paul G. Unschuld

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598859

2,092 views
1 citation

Original Research

Published on 02 Jul 2025

Research hotspots and frontiers of glymphatic system and Alzheimer’s disease: a bibliometrics analysis

in Alzheimer's Disease and Related Dementias

Shichao Liu
Lvping Zhuang
Xiaochun Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579373

3,635 views

Original Research

Published on 02 Jul 2025

Serum uric acid to creatinine ratio in patients with early-onset post-stroke cognitive impairment: a retrospective cohort study

in Alzheimer's Disease and Related Dementias

Libin Liao
Weiquan Huang
Rongchao Ma
Wentong Hu
Hui Wu
Moxi Su
Dujuan Sha

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1580722

2,059 views

Original Research

Published on 27 Jun 2025

Age-sex differences in Alzheimer’s and related dementias burden and risk factors in east and Southeast Asia: results from the 2021 GBD study

in Alzheimer's Disease and Related Dementias

Tengyu Zhao
Pengyu Pan
Yuhan Zhou
Xinyue Zhang
Quan Li
Yanyan Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1562148

3,782 views
1 citation

Original Research

Published on 25 Jun 2025

Voxel- and surface-based morphometry in the cortical thickness and cortical and subcortical gray matter volume in patients with mild-to-moderate Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Kaidi Li
Dingling Xie
Zhengyong Zhang
Chunyu Fu
Chunyang Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1546977

2,356 views

Original Research

Published on 24 Jun 2025

A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling

in Alzheimer's Disease and Related Dementias

Jiahui Li
Yuan Xu
Gianfranco Balboni
Ying Xia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587219

2,384 views
1 citation

2,205 articles

articles

Hippocampal vascular supply and its mediating role in systemic physiological influences on hippocampal volume

Sex differences in the association of cardiometabolic risk scores and blood pressure measurements with white matter hyperintensities in diverse older adults—HABS-HD

Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer’s disease progression

Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models

GLP-1R as a potential link between diabetes and Alzheimer’s disease

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

Altered dynamic functional network connectivity patterns in Alzheimer’s disease: insights into neural dysfunction

Advancements in multi-omics research to address challenges in Alzheimer’s disease: a systems biology approach utilizing molecular biomarkers and innovative strategies

miR-423-5p and miR-92a-3p in Alzheimer’s disease: relationship with pathology and cognition

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer’s disease

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China

Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method

Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia

Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease

Hippocampal iron patterns in aging and mild cognitive impairment

Research hotspots and frontiers of glymphatic system and Alzheimer’s disease: a bibliometrics analysis

Serum uric acid to creatinine ratio in patients with early-onset post-stroke cognitive impairment: a retrospective cohort study

Age-sex differences in Alzheimer’s and related dementias burden and risk factors in east and Southeast Asia: results from the 2021 GBD study

Voxel- and surface-based morphometry in the cortical thickness and cortical and subcortical gray matter volume in patients with mild-to-moderate Alzheimer’s disease

A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling