Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Published on 23 Jun 2025

α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid

in Alzheimer's Disease and Related Dementias

Jacob Raber
Alexandra Pederson
Emily Bunnell
Nora Mattek
Nora E. Gray
Steven G. Kohama
Alison R. Weiss
Joseph F. Quinn
Henryk F. Urbanski

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599402

2,236 views

Original Research

Published on 19 Jun 2025

The effect of periodontal status in the associations between socioeconomic status and cognitive performance: a mediation analysis in older adults

in Alzheimer's Disease and Related Dementias

Heming Zhang
Hongxia Xiang
Lin Zhang
Zhiyang Chen
Wei Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1524268

2,944 views

Original Research

Published on 18 Jun 2025

Impact of cognitive decline on the physical functioning of older adults in Southern Brazil: a cross-sectional study

in Alzheimer's Disease and Related Dementias

Andréa Kruger Gonçalves
Valéria Feijó Martins
Ana Carolina Kanitz
Flávia Gomes Martinez
Leonardo Alexandre Peyré-Tartaruga
Raphael Machado Castilhos
Aline Nogueira Haas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549764

2,566 views

Original Research

Published on 17 Jun 2025

Brain microvascular calcification is increased in human donors with dementia compared to elderly controls: a pilot study

in Alzheimer's Disease and Related Dementias

Kelly A. Borges
Isabelle Lombardi
Mackenzie Sivilli
Joseph Aabye
Isabella Romano
Saud A. Nasruddin
Mugdha V. Padalkar
Daniel Moussouros
Olga V. Savinova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1557625

3,356 views
1 citation

Original Research

Published on 17 Jun 2025

Effects of West Nile virus on behavioral and cognitive performance, cortical Aβ pathology, viral loads, and immune measures of middle-aged NL-G-F/E3 and NL-G-F/E4 mice

in Alzheimer's Disease and Related Dementias

Abigail O’Niel
Christopher J. Parkins
Alexandra Pederson
Elizabeth Saltonstall
Emily Bunnell
Ria Aggarwal
Phoebe Sandholm
Kat Kessler
Henry F. Harrison
Jessica L. Smith

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1600119

3,561 views

Original Research

Published on 16 Jun 2025

A high-accuracy, low-cost blood test for Alzheimer’s disease: validating P-tau181/Aβ42 in real-world cohorts

in Alzheimer's Disease and Related Dementias

Dequan Liu
Hang Li
Qing Liu
Haiyan Li
Yuanyuan Tang
Kaiting Cheng
Tong Li
Yulan Chu
Xiaodong Jia
Wenying Yu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599761

3,811 views
1 citation

Original Research

Published on 16 Jun 2025

CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process

in Alzheimer's Disease and Related Dementias

Mikel Tainta
Mirian Ecay-Torres
Myriam Barandiaran
Ainara Estanga
Carolina López
Miren Altuna
Ane Iriondo
Jon Saldias
Maite Garcia-Sebastian
Marta Cañada

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1539711

3,942 views
1 citation

Review

Published on 13 Jun 2025

Infections with Chlamydia pneumoniae and SARS-CoV-2 and Alzheimer’s disease pathogenesis

in Alzheimer's Disease and Related Dementias

Alexa Romanella
Maegan McCall
Rachel Corwin
Alaha Abdul Faruq
Emily Lingo
Sanya Bhambhani
Christine J. Hammond
Brian J. Balin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587782

8,250 views

Original Research

Published on 04 Jun 2025

Association between sarcopenic obesity and dementia in the Chinese elderly using different definitions of obesity: evidence from the CHARLS

in Alzheimer's Disease and Related Dementias

Lang Peng
Qingwei Xiang
Ge Jia
Renyi Yin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1540272

7,649 views
2 citations

Review

Published on 02 Jun 2025

Neurobiological and therapeutic landmarks of depression associated with Alzheimer’s disease dementia

in Alzheimer's Disease and Related Dementias

Ilinca Untu
Michael Davidson
Gabriela-Dumitrita Stanciu
Jonathan Rabinowitz
Romeo-Petru Dobrin
Diana-Sabina Vieru
Bogdan-Ionel Tamba

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1584607

4,503 views

Original Research

Published on 30 May 2025

Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening

in Alzheimer's Disease and Related Dementias

Li Wu
Renxin Zhang
Yichao Wang
Shaoxing Dai
Naixue Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571783

3,275 views
1 citation

Original Research

Published on 30 May 2025

Blood essential trace elements and Alzheimer’s disease biomarkers in midlife

in Alzheimer's Disease and Related Dementias

Xin Wang
Kelly M. Bakulski
Carrie A. Karvonen-Gutierrez
Sung Kyun Park
David Morgan
Brian P. Jackson
Roger L. Albin
Henry L. Paulson

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1539749

2,536 views
2 citations

Original Research

Published on 27 May 2025

Neuropsychological and clinical variables associated with cognitive trajectories in patients with Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Marianna Riello
Monica Moroni
Stefano Bovo
Flavio Ragni
Manuela Buganza
Raffaella Di Giacopo
Marco Chierici
Lorenzo Gios
Matteo Pardini
Federico Massa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1565006

3,329 views

Original Research

Published on 15 May 2025

Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice

in Alzheimer's Disease and Related Dementias

Yejin Park
Subin Moon
Harry Jung
Songyi Park
Ju Won Kim
Dan-Gyeong Song
Yong-Ho In
Sang Won Han
Jong-Hee Sohn
Chan Hee Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579411

4,050 views
2 citations

Systematic Review

Published on 15 May 2025

Diagnostic value of olfactory function testing for Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis

in Alzheimer's Disease and Related Dementias

Yuxuan Liu
Yunpeng Cao
Hongquan Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1551939

2,474 views
2 citations

Review

Published on 14 May 2025

Iron responsive elements mRNA regulate Alzheimer’s amyloid precursor protein translation through iron sensing

in Alzheimer's Disease and Related Dementias

Mateen A. Khan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1483913

2,640 views
2 citations

Correction

Published on 14 May 2025

Corrigendum: Prebiotic effect of fructooligosaccharides from Morinda officinalis on Alzheimer's disease in rodent models by targeting the microbiota-gut-brain axis

in Alzheimer's Disease and Related Dementias

Diling Chen
Xin Yang
Jian Yang
Guoxiao Lai
Tianqiao Yong
Xiaocui Tang
Ou Shuai
Gailian Zhou
Yizhen Xie
Qingping Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1593725

1,406 views

Original Research

Published on 14 May 2025

Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults

in Alzheimer's Disease and Related Dementias

Chunhua Zhang
Bingyu Li
Kok Pin Ng
Guojuan Huang
Xijin Wang
Min Kong
Maowen Ba

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547394

2,135 views
1 citation

Original Research

Published on 14 May 2025

Unravelling the interplay: brain regional atrophy and neuropsychological function in early Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Doyun Heo
Min-Seong Kim
Yun-Jin Lee
Seon-Kyeong Kim
Yong Sung Kim
Wonjae Sung
Hee-Jin Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1508849

2,600 views

Original Research

Published on 14 May 2025

Identification and validation of pyroptosis-related genes in Alzheimer’s disease based on multi-transcriptome and machine learning

in Alzheimer's Disease and Related Dementias

Yuntai Wang
Yilin Li
Lu Zhou
Yihuan Yuan
Chuanfei Liu
Zimeng Zeng
Yuanqi Chen
Qi He
Zhuoze Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1568337

4,174 views
1 citation

Review

Published on 12 May 2025

Review of FUNDC1-mediated mitochondrial autophagy in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Dandan Shi
Xiaochen Guo
Ziqi Ning
Yaoyao Zhang
Fang Liu
Meixia Liu
Yun Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1544241

4,026 views
3 citations

Original Research

Published on 09 May 2025

Blood biomarkers as surrogate endpoints in Alzheimer’s disease research

in Alzheimer's Disease and Related Dementias

Guogen Shan
Hui Li
Yahui Zhang
Guoqiao Wang
Charles Bernick

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576373

2,069 views
1 citation

Review

Published on 07 May 2025

Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Minji Zhou
Xiu'e Pang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571563

3,560 views
3 citations

Study Protocol

Published on 07 May 2025

Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the world-wide FINGERS network)

in Alzheimer's Disease and Related Dementias

Gessica Sala
Luca Cuffaro
Federico Emanuele Pozzi
Simona Andreoni
Chiara Bazzini
Elisa Conti
Chiara Paola Zoia
Simone Beretta
Lucio Tremolizzo
Giuseppe Bellelli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1581892

4,851 views
1 citation

2,205 articles

articles

α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid

The effect of periodontal status in the associations between socioeconomic status and cognitive performance: a mediation analysis in older adults

Impact of cognitive decline on the physical functioning of older adults in Southern Brazil: a cross-sectional study

Brain microvascular calcification is increased in human donors with dementia compared to elderly controls: a pilot study

Effects of West Nile virus on behavioral and cognitive performance, cortical Aβ pathology, viral loads, and immune measures of middle-aged NL-G-F/E3 and NL-G-F/E4 mice

A high-accuracy, low-cost blood test for Alzheimer’s disease: validating P-tau181/Aβ42 in real-world cohorts

CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process

Infections with Chlamydia pneumoniae and SARS-CoV-2 and Alzheimer’s disease pathogenesis

Association between sarcopenic obesity and dementia in the Chinese elderly using different definitions of obesity: evidence from the CHARLS

Neurobiological and therapeutic landmarks of depression associated with Alzheimer’s disease dementia

Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening

Blood essential trace elements and Alzheimer’s disease biomarkers in midlife

Neuropsychological and clinical variables associated with cognitive trajectories in patients with Alzheimer's disease

Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice

Diagnostic value of olfactory function testing for Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis

Iron responsive elements mRNA regulate Alzheimer’s amyloid precursor protein translation through iron sensing

Corrigendum: Prebiotic effect of fructooligosaccharides from Morinda officinalis on Alzheimer's disease in rodent models by targeting the microbiota-gut-brain axis

Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults

Unravelling the interplay: brain regional atrophy and neuropsychological function in early Alzheimer’s disease

Identification and validation of pyroptosis-related genes in Alzheimer’s disease based on multi-transcriptome and machine learning

Review of FUNDC1-mediated mitochondrial autophagy in Alzheimer’s disease

Blood biomarkers as surrogate endpoints in Alzheimer’s disease research

Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer’s disease

Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the world-wide FINGERS network)