Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Original Research

Published on 09 May 2025

Subregional analysis of the amygdala, thalamus, and hypothalamus at the pre-decline stage in Parkinson’s disease with later cognitive impairment

in Cellular and Molecular Mechanisms of Brain-aging

Kazuhide Seo
Genko Oyama
Toshimasa Yamamoto

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1588027

331 views

Review

Accepted on 05 May 2025

Exercise training exerts beneficial effects on Alzheimer's disease through multiple signaling pathways

in Cellular and Molecular Mechanisms of Brain-aging

Jihe Kang
Mei Liu
Qiang Yang
Xiangji Dang
Qun Li
Ting Wang
Bin Qiu
Yibao Zhang
Xudong Guo
Xiaoling Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1558078

Original Research

Published on 30 Apr 2025

Amyloid-beta peptide toxicity in the aged brain is a one-way journey into Alzheimer’s disease

in Cellular and Molecular Mechanisms of Brain-aging

Georgia Culley
Alexandre Henriques
Delphine Hardy
Alexandre Wojcinski
Adrien Chabert
Bilal El Waly
Philippe Poindron
Noelle Callizot

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569181

1,245 views

Review

Published on 30 Apr 2025

Adenosine diphosphate-ribosylation greatly affects proteins function: a focus on neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Chaowen Huang
Huilin Xiao
Yang Yang
Jiankun Luo
Yixi Lai
Shizhen Liu
Kanmin Mao
Jialong Chen
Liling Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1575204

1,026 views

Review

Published on 29 Apr 2025

Phospholipids and peroxisomes in ferroptosis: the therapeutic target of acupuncture regulating vascular cognitive impairment and dementia

in Cellular and Molecular Mechanisms of Brain-aging

Wenyu Zhang
Ruiyu Li
Donglei Lu
Xinliang Wang
Qiuxuan Wang
Xuyang Feng
Sai Qi
Xuezhu Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1512980

733 views

Original Research

Published on 29 Apr 2025

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation

in Cellular and Molecular Mechanisms of Brain-aging

Shveta Bathla
Dibyadeep Datta
Dinara Bolat
Elizabeth Woo
Alvaro Duque
Jon I. Arellano
Amy F. T. Arnsten
Angus C. Nairn

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549770

1,111 views

Original Research

Published on 28 Apr 2025

NTN-1 attenuates amyloid-β-mediated microglial neuroinflammation and memory impairment via the NF-κB pathway and NLRP3 inflammasome in a rat model of Alzheimer's disease

in Cellular and Molecular Mechanisms of Brain-aging

Tianhang Wang
Yanchen Liu
Yidan Lu
Lijun Chi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1516399

1,375 views

Original Research

Published on 23 Apr 2025

The synergistic extract of Zophobas atratus and Tenebrio molitor regulates neuroplasticity and oxidative stress in a scopolamine-induced cognitive impairment model

in Cellular and Molecular Mechanisms of Brain-aging

Ngoc Buu Tran
Haesung Lee
Myoung-Geun Ji
Long Ngo Hoang
Sook-Jeong Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566621

1,377 views

Editorial

Published on 16 Apr 2025

Editorial: Similarities and differences between cellular and molecular mechanisms of normal brain aging and neurodegeneration

in Cellular and Molecular Mechanisms of Brain-aging

Anamaria Jurcau

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602391

1,080 views

Editorial

Published on 27 Mar 2025

Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Zhiquan Li
Konstantinos Palikaras
Yuan Li
Vilhelm A. Bohr

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591288

1,444 views

Review

Published on 19 Mar 2025

Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Yulia Komleva
Kristina Shpiliukova
Nikolai Bondar
Alla Salmina
Elena Khilazheva
Sergey Illarioshkin
Michael Piradov

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1562453

1,286 views

Review

Published on 12 Feb 2025

Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

in Cellular and Molecular Mechanisms of Brain-aging

Mi-bo Tang
Yi-xuan Liu
Zheng-wei Hu
Hai-yang Luo
Shuo Zhang
Chang-he Shi
Yu-ming Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1454735

2,008 views
1 citation

Original Research

Published on 07 Feb 2025

Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

in Cellular and Molecular Mechanisms of Brain-aging

Shumin Zhao
Ranran Chen
Yi An
Yali Zhang
Cheng Ma
Ying Gao
Yanchao Lu
Fei Yang
Xue Bai
Jingjing Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1522073

1,455 views

Mini Review

Published on 05 Feb 2025

A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders

in Cellular and Molecular Mechanisms of Brain-aging

Birra Taha
Robert McGovern
Cornelius Lam

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1492449

1,193 views

Brief Research Report

Published on 24 Jan 2025

Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging

in Cellular and Molecular Mechanisms of Brain-aging

Maggie K. Pecsok
Heather Robinson
Ally Atkins
Monica E. Calkins
Mark A. Elliott
Arianna Mordy
Jacquelyn Stifelman
Ruben C. Gur
Paul J. Moberg
Ravi Prakash Reddy Nanga

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1535158

1,487 views

Original Research

Published on 23 Jan 2025

Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain

in Cellular and Molecular Mechanisms of Brain-aging

Saeideh Aran
Mohammad Ghasem Golmohammadi
Mohsen Sagha
Kamran Ghaedi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1498308

1,391 views