Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Original Research

Accepted on 04 Jul 2025

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer's-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways

in Cellular and Molecular Mechanisms of Brain-aging

Waqas Ahmad
Kyonghwan Choe
Riaz Ahmad
Tae Ju Park
Myeong Ok Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607289

Original Research

Accepted on 02 Jul 2025

Neuropeptide Y mRNA Expression in the Aging Inferior Colliculus of Fischer Brown Norway Rats

in Cellular and Molecular Mechanisms of Brain-aging

Laila S Almassri
Kristen M Crane
Sean R Hergenrother
Gurveer Singh
Gillian L Barach
Melina C Iafrate
Joshua C Harris
Nick Tokar
Andrew P Ohl
Jesse Wyatt Young

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1626021

110 views

Review

Accepted on 30 Jun 2025

NMDA Receptors in Neurodegenerative Diseases: Mechanisms and Emerging Therapeutic Strategies

in Cellular and Molecular Mechanisms of Brain-aging

Keyi Zhang
Ming Wen
Xinyue Nan
Shuaizhu Zhao
Hao Li
Houze Zhu
Yanping Ai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1604378

117 views

Review

Published on 21 May 2025

Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathways

in Cellular and Molecular Mechanisms of Brain-aging

Jihe Kang
Mei Liu
Qiang Yang
Xiangji Dang
Qun Li
Ting Wang
Bin Qiu
Yibao Zhang
Xudong Guo
Xiaoling Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1558078

2,132 views

Original Research

Published on 09 May 2025

Subregional analysis of the amygdala, thalamus, and hypothalamus at the pre-decline stage in Parkinson’s disease with later cognitive impairment

in Cellular and Molecular Mechanisms of Brain-aging

Kazuhide Seo
Genko Oyama
Toshimasa Yamamoto

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1588027

1,190 views

Original Research

Published on 30 Apr 2025

Amyloid-beta peptide toxicity in the aged brain is a one-way journey into Alzheimer’s disease

in Cellular and Molecular Mechanisms of Brain-aging

Georgia Culley
Alexandre Henriques
Delphine Hardy
Alexandre Wojcinski
Adrien Chabert
Bilal El Waly
Philippe Poindron
Noelle Callizot

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569181

2,473 views

Review

Published on 30 Apr 2025

Adenosine diphosphate-ribosylation greatly affects proteins function: a focus on neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Chaowen Huang
Huilin Xiao
Yang Yang
Jiankun Luo
Yixi Lai
Shizhen Liu
Kanmin Mao
Jialong Chen
Liling Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1575204

1,776 views

Original Research

Published on 29 Apr 2025

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation

in Cellular and Molecular Mechanisms of Brain-aging

Shveta Bathla
Dibyadeep Datta
Dinara Bolat
Elizabeth Woo
Alvaro Duque
Jon I. Arellano
Amy F. T. Arnsten
Angus C. Nairn

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549770

1,558 views

Review

Published on 29 Apr 2025

Phospholipids and peroxisomes in ferroptosis: the therapeutic target of acupuncture regulating vascular cognitive impairment and dementia

in Cellular and Molecular Mechanisms of Brain-aging

Wenyu Zhang
Ruiyu Li
Donglei Lu
Xinliang Wang
Qiuxuan Wang
Xuyang Feng
Sai Qi
Xuezhu Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1512980

2,176 views

Original Research

Published on 28 Apr 2025

NTN-1 attenuates amyloid-β-mediated microglial neuroinflammation and memory impairment via the NF-κB pathway and NLRP3 inflammasome in a rat model of Alzheimer's disease

in Cellular and Molecular Mechanisms of Brain-aging

Tianhang Wang
Yanchen Liu
Yidan Lu
Lijun Chi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1516399

1,986 views

Original Research

Published on 23 Apr 2025

The synergistic extract of Zophobas atratus and Tenebrio molitor regulates neuroplasticity and oxidative stress in a scopolamine-induced cognitive impairment model

in Cellular and Molecular Mechanisms of Brain-aging

Ngoc Buu Tran
Haesung Lee
Myoung-Geun Ji
Long Ngo Hoang
Sook-Jeong Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566621

1,929 views

Editorial

Published on 16 Apr 2025

Editorial: Similarities and differences between cellular and molecular mechanisms of normal brain aging and neurodegeneration

in Cellular and Molecular Mechanisms of Brain-aging

Anamaria Jurcau

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602391

1,300 views

Editorial

Published on 27 Mar 2025

Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Zhiquan Li
Konstantinos Palikaras
Yuan Li
Vilhelm A. Bohr

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591288

1,892 views
1 citation

Review

Published on 19 Mar 2025

Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Yulia Komleva
Kristina Shpiliukova
Nikolai Bondar
Alla Salmina
Elena Khilazheva
Sergey Illarioshkin
Michael Piradov

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1562453

1,890 views

Review

Published on 12 Feb 2025

Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

in Cellular and Molecular Mechanisms of Brain-aging

Mi-bo Tang
Yi-xuan Liu
Zheng-wei Hu
Hai-yang Luo
Shuo Zhang
Chang-he Shi
Yu-ming Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1454735

2,712 views
1 citation

Original Research

Published on 07 Feb 2025

Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

in Cellular and Molecular Mechanisms of Brain-aging

Shumin Zhao
Ranran Chen
Yi An
Yali Zhang
Cheng Ma
Ying Gao
Yanchao Lu
Fei Yang
Xue Bai
Jingjing Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1522073

1,762 views