Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Original Research

Published on 22 Oct 2021

Plasma and CSF Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Cross-Sectional and Longitudinal Study

in Cellular and Molecular Mechanisms of Brain-aging

Veria Vacchiano
Andrea Mastrangelo
Corrado Zenesini
Marco Masullo
Corinne Quadalti
Patrizia Avoni
Barbara Polischi
Arianna Cherici
Sabina Capellari
Fabrizio Salvi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.753242

10,306 views
59 citations

Original Research

Published on 18 Oct 2021

Synaptic Release Potentiation at Aging Auditory Ribbon Synapses

in Cellular and Molecular Mechanisms of Brain-aging

Thibault Peineau
Séverin Belleudy
Susanna Pietropaolo
Yohan Bouleau
Didier Dulon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.756449

5,352 views
27 citations

Editorial

Published on 13 Oct 2021

Editorial: Molecular Mechanisms of Thiol-Based Redox Homeostasis and Signaling in the Brain

in Cellular and Molecular Mechanisms of Brain-aging

Bindu Diana Paul
Milos R. Filipovic

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.771877

2,497 views
4 citations

Hypothesis and Theory

Published on 13 Oct 2021

SIRT6 Through the Brain Evolution, Development, and Aging

in Cellular and Molecular Mechanisms of Brain-aging

Alfredo Garcia-Venzor
Debra Toiber

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.747989

7,791 views
20 citations

Original Research

Published on 12 Oct 2021

Selenomethionine Improves Mitochondrial Function by Upregulating Mitochondrial Selenoprotein in a Model of Alzheimer’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Chen Chen
Yao Chen
Zhong-Hao Zhang
Shi-Zheng Jia
Yu-Bin Chen
Shao-Ling Huang
Xin-Wen Xu
Guo-Li Song

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.750921

5,451 views
17 citations

Review

Published on 01 Oct 2021

Exercise-Induced Benefits for Alzheimer’s Disease by Stimulating Mitophagy and Improving Mitochondrial Function

in Cellular and Molecular Mechanisms of Brain-aging

Jiling Liang
Cenyi Wang
Hu Zhang
Jielun Huang
Juying Xie
Ning Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.755665

13,130 views
47 citations

Review

Published on 29 Sep 2021

Current Approaches and Molecular Mechanisms for Directly Reprogramming Fibroblasts Into Neurons and Dopamine Neurons

in Cellular and Molecular Mechanisms of Brain-aging

Fabin Han
Yanming Liu
Jin Huang
Xiaoping Zhang
Chuanfei Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.738529

10,626 views
19 citations

Review

Published on 28 Sep 2021

Cellular Senescence in Traumatic Brain Injury: Evidence and Perspectives

in Cellular and Molecular Mechanisms of Brain-aging

Nicole Schwab
Emily Leung
Lili-Naz Hazrati

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.742632

7,872 views
22 citations

Original Research

Published on 28 Sep 2021

Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept

in Cellular and Molecular Mechanisms of Brain-aging

Theresa Lüth
Kobi Wasner
Christine Klein
Susen Schaake
Ronnie Tse
Sandro L. Pereira
Joshua Laß
Lasse Sinkkonen
Anne Grünewald
Joanne Trinh

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.713084

9,245 views
16 citations

Systematic Review

Published on 21 Sep 2021

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

in Cellular and Molecular Mechanisms of Brain-aging

Mohammad Reza Asadi
Mehdi Hassani
Shiva Kiani
Hani Sabaie
Marziyeh Sadat Moslehian
Mohammad Kazemi
Soudeh Ghafouri-Fard
Mohammad Taheri
Maryam Rezazadeh

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.709568

7,180 views
33 citations

Review

Published on 20 Sep 2021

Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node

in Cellular and Molecular Mechanisms of Brain-aging

Yang Fang
Xifeng Wang
Danying Yang
Yimei Lu
Gen Wei
Wen Yu
Xing Liu
Qingcui Zheng
Jun Ying
Fuzhou Hua

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.738686

7,977 views
33 citations

Original Research

Published on 17 Sep 2021

Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

in Cellular and Molecular Mechanisms of Brain-aging

Claudia Salcedo
Jens V. Andersen
Kasper Tore Vinten
Lars H. Pinborg
Helle S. Waagepetersen
Kristine K. Freude
Blanca I. Aldana

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.736580

10,757 views
45 citations

Review

Published on 07 Sep 2021

Mitochondrial Dynamics: A Potential Therapeutic Target for Ischemic Stroke

in Cellular and Molecular Mechanisms of Brain-aging

Xiangyue Zhou
Hanmin Chen
Ling Wang
Cameron Lenahan
Lifei Lian
Yibo Ou
Yue He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.721428

12,460 views
60 citations

Original Research

Published on 30 Aug 2021

Efficacy of Δ9 -Tetrahydrocannabinol (THC) Alone or in Combination With a 1:1 Ratio of Cannabidiol (CBD) in Reversing the Spatial Learning Deficits in Old Mice

in Cellular and Molecular Mechanisms of Brain-aging

Prakash Nidadavolu
Andras Bilkei-Gorzo
Michael Krämer
Britta Schürmann
Michela Palmisano
Eva C. Beins
Burkhard Madea
Andreas Zimmer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.718850

10,360 views
17 citations

Original Research

Published on 23 Aug 2021

Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice

in Cellular and Molecular Mechanisms of Brain-aging

Helena Nascimento Malerba
Arthur Antonio Ruiz Pereira
Marcela Favoretto Pierrobon
Guilherme Souza Abrao
Mariana Toricelli
Eliana Hiromi Akamine
Hudson Sousa Buck
Tania Araujo Viel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.681498

3,527 views
9 citations

Original Research

Published on 13 Aug 2021

Prostaglandin E2 Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Amanda C. Rosehart
Thomas A. Longden
Nick Weir
Jackson T. Fontaine
Anne Joutel
Fabrice Dabertrand

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.695965

5,067 views
19 citations