Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Original Research

Published on 12 Aug 2021

Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers

in Cellular and Molecular Mechanisms of Brain-aging

Sumonto Mitra
Giorgio Turconi
Taher Darreh-Shori
Kärt Mätlik
Matilde Aquilino
Maria Eriksdotter
Jaan-Olle Andressoo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.714186

4,991 views
12 citations

Original Research

Published on 06 Aug 2021

Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice

in Cellular and Molecular Mechanisms of Brain-aging

Jian-Wei Zhu
Wei-Qiang Jia
Hui Zhou
Yi-Fei Li
Ming-Ming Zou
Zhao-Tao Wang
Bing-Shan Wu
Ru-Xiang Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.697494

5,777 views
10 citations

Original Research

Published on 04 Aug 2021

Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen’s Critical Window

in Cellular and Molecular Mechanisms of Brain-aging

Puja Sinha
Asha Rani
Ashok Kumar
Alberto Riva
Jason Orr Brant
Thomas C. Foster

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.717032

4,627 views
5 citations

Review

Published on 03 Aug 2021

Understanding Intra-Species and Inter-Species Prion Conversion and Zoonotic Potential Using Protein Misfolding Cyclic Amplification

in Cellular and Molecular Mechanisms of Brain-aging

Alexander H. Peden
Suzanne Suleiman
Marcelo A. Barria

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.716452

5,992 views
13 citations

Mini Review

Published on 02 Aug 2021

In vivo Direct Conversion of Astrocytes to Neurons Maybe a Potential Alternative Strategy for Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Youcui Wang
Xiaoqin Zhang
Fenghua Chen
Ning Song
Junxia Xie

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.689276

13,229 views
15 citations

Original Research

Published on 30 Jul 2021

A Shift in Tissue Stiffness During Hippocampal Maturation Correlates to the Pattern of Neurogenesis and Composition of the Extracellular Matrix

in Cellular and Molecular Mechanisms of Brain-aging

Youngjae Ryu
Misato Iwashita
Wonyoung Lee
Kenji Uchimura
Yoichi Kosodo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.709620

7,330 views
31 citations

Brief Research Report

Published on 30 Jul 2021

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport

in Cellular and Molecular Mechanisms of Brain-aging

Nadeeja Wijesekara
Rosemary Ahrens
Ling Wu
Tammy Langman
Anurag Tandon
Paul E. Fraser

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.665348

5,239 views
16 citations

Original Research

Published on 28 Jul 2021

Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Alpna Tyagi
Carol Mirita
Iman Shah
P. Hemachandra Reddy
Subbiah Pugazhenthi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.716616

6,725 views
17 citations

Review

Published on 15 Jul 2021

Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

in Cellular and Molecular Mechanisms of Brain-aging

Li Lei
Shuaifeng Yang
Xiaoyang Lu
Yongfa Zhang
Tao Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.698601

6,920 views
19 citations

Review

Published on 13 Jul 2021

The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain

in Cellular and Molecular Mechanisms of Brain-aging

Anna Gasiorowska
Malgorzata Wydrych
Patrycja Drapich
Maciej Zadrozny
Marta Steczkowska
Wiktor Niewiadomski
Grazyna Niewiadomska

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.654931

34,094 views
127 citations

Mini Review

Published on 12 Jul 2021

The Emerging Role of Circular RNAs in Alzheimer’s Disease and Parkinson’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Meng Zhang
Zhigang Bian

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.691512

8,413 views
35 citations

Review

Published on 08 Jul 2021

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

in Cellular and Molecular Mechanisms of Brain-aging

Irina A. Pikuleva
Nathalie Cartier

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.696778

11,380 views
62 citations

Case Report

Published on 29 Jun 2021

Case Report: A Homozygous Mutation (p.Y62X) of Phospholipase D3 May Lead to a New Leukoencephalopathy Syndrome

in Cellular and Molecular Mechanisms of Brain-aging

Yi-Hui Liu
Hai-Feng Zhang
Jie-Yuan Jin
Yan-Qiu Wei
Chen-Yu Wang
Liang-Liang Fan
Lv Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.671296

3,669 views
4 citations

Review

Published on 25 Jun 2021

Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders

in Cellular and Molecular Mechanisms of Brain-aging

Nelson de Oliveira Manzanza
Lucia Sedlackova
Raj N. Kalaria

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.690293

15,884 views
62 citations

Original Research

Published on 24 Jun 2021

Cadmium, an Environmental Contaminant, Exacerbates Alzheimer’s Pathology in the Aged Mice’s Brain

in Cellular and Molecular Mechanisms of Brain-aging

Tahir Ali
Amjad Khan
Sayed Ibrar Alam
Sareer Ahmad
Muhammad Ikram
Jun Sung Park
Hyeon Jin Lee
Myeong Ok Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.650930

6,427 views
39 citations

Mini Review

Published on 23 Jun 2021

The Role of Protein Persulfidation in Brain Aging and Neurodegeneration

in Cellular and Molecular Mechanisms of Brain-aging

Dunja Petrovic
Emilia Kouroussis
Thibaut Vignane
Milos R. Filipovic

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.674135

10,390 views
55 citations