Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Original Research

Accepted on 11 Dec 2025

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging

in Cellular and Molecular Mechanisms of Brain-aging

Ming Sun
Chao Wu
Jingjing Wu
Lixin Liu
Liang Gu
Zihao Wang
Xue Yang
Feng Xu

Frontiers in Aging Neuroscience

Original Research

Accepted on 28 Nov 2025

The aggregate proteome of C. elegans mitochondria implicates shared mechanisms of aging and Alzheimer's disease

in Cellular and Molecular Mechanisms of Brain-aging

Sonu Pahal
Akshatha Ganne
Meenakshisundaram Balasubramaniam
Sue T Griffin
Robert Joseph Shmookler Reis
Srinivas Ayyadevara

Frontiers in Aging Neuroscience

184 views

Review

Accepted on 28 Nov 2025

The Application of Fecal microbiota transplantation in Parkinson's Disease

in Cellular and Molecular Mechanisms of Brain-aging

Tianfei Luo
Boyan Wang

Frontiers in Aging Neuroscience

122 views

Mini Review

Published on 19 Nov 2025

Neuroimmune dynamics and brain aging: mechanisms and consequences

in Cellular and Molecular Mechanisms of Brain-aging

Ludmila Müller
Svetlana Di Benedetto
Viktor Müller

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1715045

888 views

Original Research

Published on 19 Nov 2025

Decanoic acid, an MCT dietary component, alleviates cognitive impairment, cellular senescence, and promotes autophagy in accelerated aging and neurotoxic mouse models induced by chronic administration of D-galactose and D-galactose/AlCl3

in Cellular and Molecular Mechanisms of Brain-aging

Shreshta Jain
Divya Vohora

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676926

962 views

Original Research

Published on 07 Nov 2025

Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease

in Cellular and Molecular Mechanisms of Brain-aging

Faruk Hossen
Javier Hung
Hamza Odeh
Grace Y. Sun
James C. Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1671986

1,833 views

Original Research

Published on 03 Nov 2025

From genomic discovery to application in age-related hearing loss: a global bibliometric and cross-ethnic analysis

in Cellular and Molecular Mechanisms of Brain-aging

Yang Lu
Jiawei Shen
Ka Ho Kairos Sou
Hsi Lu
Shuoyuan Huang
Kai Uus

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1678115

1,794 views

Review

Published on 13 Oct 2025

Copper homeostasis and cuproptosis: implications for neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Feng Tao
Mengxuan Lin
Xiang Meng
Linghui Huang
Bifang Zhuo
Siyi Jiang
Shizhe Deng
Zhihong Meng
Jiangwei Shi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688554

2,695 views

Original Research

Published on 10 Oct 2025

Asrij/OCIAD1 contributes to age-associated microglial activation and neuroinflammation in mice

in Cellular and Molecular Mechanisms of Brain-aging

Prathamesh Dongre
Madhu Ramesh
Thimmaiah Govindaraju
Maneesha S. Inamdar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1674136

1,993 views

Review

Published on 25 Sep 2025

Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Ravindran Jaganathan
Ashok Iyaswamy
Senthilkumar Krishnamoorthi
Abhimanyu Thakur
Siva Sundara Kumar Durairajan
Chuanbin Yang
Dapkupar Wankhar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627921

3,553 views

Review

Published on 19 Sep 2025

STING-mediated neuroinflammation: a therapeutic target in neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Haoqin Zhang
Ziyang He
Can Yin
Shiyi Yang
Jianqiao Li
Hong Lin
Guishan Hu
Anguo Wu
Dalian Qin
Guangqiang Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1659216

4,485 views
1 citation

Review

Published on 20 Aug 2025

Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review

in Cellular and Molecular Mechanisms of Brain-aging

Shichu Sun
Qi Zhao
Haojia He
Yujia Liu
Yuchong Nie
You Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657603

4,452 views
1 citation

Brief Research Report

Published on 19 Aug 2025

Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging

in Cellular and Molecular Mechanisms of Brain-aging

Viana Q. Pham
Melike Tutunculer
Halah Al-Dulaimi
Daniel Ardjmand
William Fleischmann
Tomas P. Bachor
Allison W. Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1634283

2,635 views

Systematic Review

Published on 18 Aug 2025

Glutamate-associated research in Parkinson’s disease: a bibliometric analysis

in Cellular and Molecular Mechanisms of Brain-aging

Yan-Jun Chen
Ming-Rong Xie
Sheng-Qiang Zhou
Fang Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569924

2,416 views

Original Research

Published on 13 Aug 2025

Gut dysbiosis is associated with increased blood–brain barrier permeability and cognitive impairment in elderlies with coronary heart disease

in Cellular and Molecular Mechanisms of Brain-aging

Lichao Di
Peiying Huang
Yeju He
Na Sun
Liwei Chi
Lining Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640761

2,149 views
1 citation

Review

Published on 07 Aug 2025

Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders

in Cellular and Molecular Mechanisms of Brain-aging

Hao Jiao
Xiuying Wang
Dahui Zhang
Shengxue Zhou
Feng Gao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592280

4,882 views