Frontiers in Aging Neuroscience | Parkinson’s Disease and Aging-related Movement Disorders

Original Research

Accepted on 04 Nov 2025

VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson's disease via using molecular docking, molecular dynamic simulation and cellular model

in Parkinson’s Disease and Aging-related Movement Disorders

Mei Jiang
Xu Deng
Zijie Qiu
Yuan Fu
Zixiong Qiu
Jiankai Zhang
Hongxia Fu
Jie Li
Yao Luo
Xiaojun Cui

Frontiers in Aging Neuroscience

Original Research

Accepted on 04 Nov 2025

Multimodal MRI reveals distinct hippocampal subregional alterations in de novo Parkinson's disease across the cognitive spectrum

in Parkinson’s Disease and Aging-related Movement Disorders

Pan Chenxi
Enchun Zhao
Jingru Ren
Gaiyan Zhou
Yajie Wang
Ronggui Zhang
Yang Shen
Jiu Chen
Weiguo Liu

Frontiers in Aging Neuroscience

Original Research

Accepted on 03 Nov 2025

Absence of the LRRK2 mutation in Emirati Parkinson's disease patients in contrast to other Arab populations

in Parkinson’s Disease and Aging-related Movement Disorders

Vinod Metta
Anjana Soorajkumar
Tom Loney
Nasna Nassir
K. Ray Chaudhuri
Mohammed Jashim Uddin
Hani T. S Ben Amer

Frontiers in Aging Neuroscience

Review

Accepted on 03 Nov 2025

PARKINSON'S DISEASE PHYSIOPATHOLOGY - BEYOND THE α-SYNUCLEIN AGGREGATION - A NARRATIVE REVIEW

in Parkinson’s Disease and Aging-related Movement Disorders

Victor Fellipe Bispo Macedo
Jorge Artur Peçanha de Miranda Coelho
Vanessa Karine Bispo Macedo

Frontiers in Aging Neuroscience

Original Research

Published on 31 Oct 2025

Prevalence, associated factors and impact of mild cognitive impairment in hospitalized older adults with Parkinson’s disease: a cross-sectional study

in Parkinson’s Disease and Aging-related Movement Disorders

Siyuan Gong
Tianqi Wang
Rongzhu Tang
Wangjuan Hu
Wenjing Wang
Jia Li
Jihong Liu
Chunlian Liao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1693417

562 views

Original Research

Accepted on 29 Oct 2025

Vitamin D-Linked Vulnerability and Functional Connectivity Alterations in the Superior Frontal Gyrus Contributing to Cognitive Impairment in Parkinson's Disease

in Parkinson’s Disease and Aging-related Movement Disorders

Lingling Lv
Lixia Qin
Shenglan Hu
Changlian Tan
Haiyan Liao
Hainan Zhang
Feng Ren
Chunyu Wang

Frontiers in Aging Neuroscience

226 views

Systematic Review

Accepted on 29 Oct 2025

Effect of various acupuncture courses for upper limb motor dysfunction after ischemic stroke: A Bayesian network meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Can Wang
Pei Yu
Yuqi Tang
Yaning Liu
Jiangwei Shi
Xuhui Yang
Zihan Yin
Ling Zhao

Frontiers in Aging Neuroscience

323 views

Review

Accepted on 29 Oct 2025

Exercise Regulates Mitophagy to Alleviate Parkinsonian Neurodegeneration

in Parkinson’s Disease and Aging-related Movement Disorders

Chang Liu
Wei He
JianHua Zhang

Frontiers in Aging Neuroscience

Mini Review

Published on 29 Oct 2025

Improving recognition and management of inpatient delirium in Parkinson’s disease: evidence review and implications for clinical care

in Parkinson’s Disease and Aging-related Movement Disorders

Colin Coleman
Adrianne Smiley
Sheera Rosenfeld
Anne Brooks

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1693827

581 views

Systematic Review

Accepted on 28 Oct 2025

Effects of glucocerebrosidase gene variations on the risk of Parkinson's disease dementia: a meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Qiujie Li
Zhumei Bi
Shan Yin
Huaicheng Li
Zhongyou Liang
Minyao Wu
Jieru Quan
Weiming Liang

Frontiers in Aging Neuroscience

121 views

Original Research

Published on 28 Oct 2025

Directed brain connectivity biomarkers of healthy aging and Parkinson’s disease staging

in Parkinson’s Disease and Aging-related Movement Disorders

Tauqeer Anjum
Ali Seyfizadeh
Hao Ding
Tahir Mahmood
Rüdiger Pryss
Jens Volkmann
Dumitru Ciolac
Muthuraman Muthuraman

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1698600

640 views

Review

Published on 28 Oct 2025

Drug discovery and development for Parkinson’s disease: are preclinical models good enough?

in Parkinson’s Disease and Aging-related Movement Disorders

Alejandro Reinares-Sebastián
Noelia Esteban-García
Masahiko Takada
Inés Trigo-Damas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692592

605 views

Original Research

Published on 27 Oct 2025

Chronic kidney disease, proteinuria, and mortality risk in patients with Parkinson’s disease: a 12-year longitudinal study

in Parkinson’s Disease and Aging-related Movement Disorders

Kyoungwon Baik
Minwoong Kang
Yu Jeong Park
Su Jin Chung
Kyungmi Oh
Sung Hoon Kang
Seong-Beom Koh

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1631079

458 views

Original Research

Accepted on 24 Oct 2025

Increased Free Water in the Nucleus Basalis of Meynert is Associated with Worse Olfaction in Idiopathic Parkinson's Disease

in Parkinson’s Disease and Aging-related Movement Disorders

Kai Wei
Shuyue Wang
Cheng Zhou
Peiyu Huang
Chao Wang

Frontiers in Aging Neuroscience

382 views

Original Research

Accepted on 24 Oct 2025

Impact of aging on the central and enteric nervous system in a Parkinson's Disease Mouse Model

in Parkinson’s Disease and Aging-related Movement Disorders

Solène Pradeloux
Maélie Fréchette
Mathilde Drolet
Catherine Fontaine-Lavallée
Mélissa Côté
Katherine Coulombe
Marie Rieux
Frederic Calon
Denis Soulet

Frontiers in Aging Neuroscience

364 views

Original Research

Published on 22 Oct 2025

Gender-related differences in cognitive performance and cognitive stimulation efficacy in subjects with Parkinson’s disease and mild cognitive impairment

in Parkinson’s Disease and Aging-related Movement Disorders

Noemi Iaccino
Jolanda Buonocore
Giusi Torchia
Francesca Curcio
Fabio M. Pirrotta
Marianna Contrada
Loris Pignolo
Antonio Gambardella
Gennarina Arabia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1672084

640 views