Frontiers in Aging Neuroscience | Parkinson’s Disease and Aging-related Movement Disorders

Original Research

Published on 11 Jul 2025

Intranasal delivery of dodecyl creatine ester alleviates motor deficits and increases dopamine levels in a 6-OHDA rat model of parkinsonism

in Parkinson’s Disease and Aging-related Movement Disorders

Clémence Disdier
Clara Lhotellier
Stéphanie Wagner
Emile Andriambeloson
Frédéric Théodoro
Alain Pruvost
Thomas Joudinaud
Henri Bénech
Aloïse Mabondzo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597263

249 views

Original Research

Accepted on 10 Jul 2025

Objective Assessment of Gait and Posture Symptoms in Parkinson's Disease Using Wearable Sensors and Machine Learning

in Parkinson’s Disease and Aging-related Movement Disorders

Lingyan Ma
Shinuan Lin
Jianing Jin
Zhan Wang
Xuemei Wang
Zhonglue Chen
Yun Ling
Fei Zhang
Kang Ren
Tao Feng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1618764

Original Research

Accepted on 10 Jul 2025

Modelling and Validation of Wearable Sensor-based Gait Parameters in Parkinson's Disease Patients with Cognitive Impairment

in Parkinson’s Disease and Aging-related Movement Disorders

Guo Hong
Fengju Mao
Mingming Zhang
Fei Zhang
Xiangcheng Wang
Kang Ren
Zhonglue Chen
Xiaoguang Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1590224

Systematic Review

Published on 10 Jul 2025

Repetitive transcranial magnetic stimulation across neurodegenerative diseases: a systematic review and dose-response meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Yu Zhang
Yulin Wang
Ke Xu
Chengguang Zhang
Peizhu Lv
Yan Bai
Shun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1615734

424 views

Original Research

Published on 09 Jul 2025

Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos

in Parkinson’s Disease and Aging-related Movement Disorders

Ernesto G. Miranda-Morales
Daniel F. Ramos-Rosales
Alma C. Salas-Leal
Sergio M. Salas-Pacheco
Francisco X. Castellanos-Juárez
Edna M. Méndez-Hernández
Osmel La Llave-León
María S. Peñaherrera
Gerardo Quiñones-Canales
Oscar Arias-Carrión

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612544

296 views

Review

Accepted on 30 Jun 2025

Understanding Parkinson's Disease: Current Trends and its Multifaceted Complications

in Parkinson’s Disease and Aging-related Movement Disorders

Sameer A. Chaudhary
Sapana Chaudhary
Sakshi Rawat

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617106

242 views

Original Research

Published on 30 Jun 2025

Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson’s disease pathogenesis

in Parkinson’s Disease and Aging-related Movement Disorders

Cheng Cheng
Huijia Yang
Lulu Tian
Yang Ni
Congcong Jia
Weidong Le
Qingshan Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612389

540 views

Editorial

Published on 27 Jun 2025

Editorial: Advances in Parkinson's Disease Research: Exploring Biomarkers and Therapeutic Strategies for Halting Disease Progression

in Parkinson’s Disease and Aging-related Movement Disorders

Anastasia Bougea
Yildiz Degirmenci

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640566

602 views

Review

Accepted on 26 Jun 2025

Motor Symptoms of Parkinson's Disease: Critical Markers for Early AI-assisted Diagnosis

in Parkinson’s Disease and Aging-related Movement Disorders

Ni Yang
Jing Liu
Dan Sun
Jiajun Ding
Lingzhi Sun
Xianghua Qi
Wei Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602426

179 views

Original Research

Accepted on 25 Jun 2025

Evaluation of non-motor symptoms in Parkinson's Disease Using Multiparametric MRI with the MULTIPLEX Sequence

in Parkinson’s Disease and Aging-related Movement Disorders

He Sui
Zhanhao Mo
Feng Shi
Qing Zhou
Dan Yu
Jiaqi Wang
Lin Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602245

234 views

Original Research

Accepted on 23 Jun 2025

Brain Structural MRI Marker for Predicting Conversion to Parkinson's Disease in Individuals with Prodromal Symptoms

in Parkinson’s Disease and Aging-related Movement Disorders

Chang-hyun Park
Uicheul Yoon
Phil Hyu Lee
Jinna Kim
Seung-Koo Lee
Na-Young Shin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579326

Systematic Review

Accepted on 23 Jun 2025

Orthostatic Hypotension in Parkinson's Disease: Effects on Clinical Features and Disease Severity-A Systematic Review and Meta-Analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Hui Wang
Chi Zhang
Dongxun Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612960

136 views

Editorial

Published on 23 Jun 2025

Editorial: A comprehensive look at biomarkers in neurodegenerative diseases: from early diagnosis to treatment response assessment

in Parkinson’s Disease and Aging-related Movement Disorders

Riccardo Pascuzzo
Fulvia Palesi
Yi-Min Wan
Federico Angelo Cazzaniga

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1642793

676 views

Original Research

Published on 18 Jun 2025

Relationship between executive function and dual-task walking in people with Parkinson's disease

in Parkinson’s Disease and Aging-related Movement Disorders

Jun-Hong Zhou
Ray-Yau Wang
Yo-Tsen Liu
Shih-Jung Cheng
Hsin-Hsuan Liu
Yea-Ru Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1585524

1,345 views

Original Research

Published on 16 Jun 2025

The burden of Parkinson’s disease, 1990–2021: a systematic analysis of the Global Burden of Disease study 2021

in Parkinson’s Disease and Aging-related Movement Disorders

Xi-Chen Wu
Yi-Yue Dong
Yu-Chen Ying
Guang-Yan Chen
Qian Fan
Ping Yin
Yue-Lai Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1596392

1,731 views

Original Research

Published on 06 Jun 2025

Diffusion tensor imaging of sequential neuropathological patterns in progressive supranuclear palsy

in Parkinson’s Disease and Aging-related Movement Disorders

Lavinia A. Bârlescu
Günter U. Höglinger
Heiko Volkmann
Albert C. Ludolph
Kelly Del Tredici
Heiko Braak
the DESCRIBE-PSP Study Group
Hans-Peter Müller
Jan Kassubek
Moritz Brandt

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569302

1,948 views