Frontiers in Aging Neuroscience

Original Research

Published on 18 Aug 2025

Accurate and robust prediction of Amyloid-β brain deposition from plasma biomarkers and clinical information using machine learning

Jiayuan Xu
Andrew J. Doig
Sofia Michopoulou
Petroula Proitsi
Fumie Costen
The Alzheimer's disease neuroimaging initiative

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1559459

2,011 views

Review

Published on 15 Aug 2025

Naringenin as a neurotherapeutic agent in Alzheimer’s disease: epigenetic signatures, gut microbiota alterations, and molecular neuroprotection

Zhenzhen Lai
Long Ke
Wei Zhao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1647967

4,217 views
3 citations

Review

Published on 15 Aug 2025

Artificial intelligence technologies for enhancing neurofunctionalities: a comprehensive review with applications in Alzheimer’s disease research

Zhirong Gu
Bin Ge
Yuanyuan Wang
Yiping Gong
Mei Qi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1609063

3,996 views

Mini Review

Published on 14 Aug 2025

Exploring efficient and effective mammalian models for Alzheimer’s disease

Mitsunori Kayano

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1652754

2,888 views
1 citation

Original Research

Published on 14 Aug 2025

Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson’s disease with excessive daytime sleepiness

Jieyu Chen
Guoliang Jiang
Yongyun Zhu
Chunyu Liang
Chenxi Liu
Jianzhun Chen
Baiyuan Yang
Xinglong Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1645290

1,424 views

Original Research

Published on 13 Aug 2025

Age- and sex-related differences in landmark recall following a virtual spatial navigation task

Alexis N. Chargo
Cheryl L. Dahle
Naftali Raz
Ana M. Daugherty

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602945

1,434 views

Original Research

Published on 13 Aug 2025

Combinations of multimodal neuroimaging biomarkers and cognitive test scores to identify patients with cognitive impairment

Yuriko Nakaoku
Soshiro Ogata
Kiyotaka Nemoto
Chikage Kakuta
Eri Kiyoshige
Kanako Teramoto
Kiyomasa Nakatsuka
Gantsetseg Ganbaatar
Masafumi Ihara
Kunihiro Nishimura

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1650629

1,930 views

Original Research

Published on 13 Aug 2025

Gut dysbiosis is associated with increased blood–brain barrier permeability and cognitive impairment in elderlies with coronary heart disease

Lichao Di
Peiying Huang
Yeju He
Na Sun
Liwei Chi
Lining Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640761

2,378 views
2 citations

Systematic Review

Published on 13 Aug 2025

The effect of transcranial direct current stimulation on static and dynamic posture control in the elderly: a systematic review and meta-analysis

Yaru Wei
Peng Chen
Jianglong Zhan
Lulu Yin
Zhongqi Yu
Lin Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1645962

1,959 views

Perspective

Published on 12 Aug 2025

A model to address healthcare gaps and poor research participation in Hispanic patients with Parkinson's disease

M. Felice Ghilardi
Alessandro Di Rocco
Jennifer Fearday
Donna Sperlakis
Maria Lima
Nora Vanegas-Arroyave
Elisa Tatti
Marcelo Arroyave
Evelyn Stevens
Denise Hernandez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1610448

1,646 views

Mini Review

Published on 12 Aug 2025

Seeking the neural basis of neuropsychiatric symptoms in dementia: neuroimaging findings and controversies

Daichi Sone
Shunichiro Shinagawa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1633309

1,592 views

Original Research

Published on 12 Aug 2025

Local gyrification index and sulcal depth as imaging markers of cognitive decline in Alzheimer’s disease

Yongsik Sim
Changmin Seo
Young-gun Lee
Byoung Seok Ye
Ilwoo Lyu
Beomseok Sohn

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1635861

1,889 views

Original Research

Published on 12 Aug 2025

Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit

Guohua Liu
Ya Zhou
Hao Ding
Lin Chen
Lan Chen
Sufang Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607332

1,749 views

Original Research

Published on 11 Aug 2025

Increased tau-induced inflammatory responses are associated with a greater degree of atherosclerosis in progressive supranuclear palsy

Yi-Xin He
Rui Zhang
Chen Xie
Si-Fan Ji
Wen-Jing Deng
Jun-Fang Teng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1608631

1,814 views

Original Research

Published on 08 Aug 2025

Objective assessment of gait and posture symptoms in Parkinson’s disease using wearable sensors and machine learning

Lingyan Ma
Shinuan Lin
Jianing Jin
Zhan Wang
Xuemei Wang
Zhonglue Chen
Yun Ling
Fei Zhang
Kang Ren
Tao Feng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1618764

2,187 views

Clinical Trial

Published on 08 Aug 2025

Improvement of neuropsychological and cognitive functions in older adults through transcranial vibroacoustic stimulation: a double blind, randomized, comparative trial

Jang-Han Bae
Jae-Young Ha
Jai Jun Choung
Min-Woo Cho
Byung-In Oh
Kun Ho Lee
Young Chul Youn
SangYun Kim
Dong-Keun Song
Chang-Ho Shin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1526088

3,244 views
1 citation

Review

Published on 07 Aug 2025

Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders

Hao Jiao
Xiuying Wang
Dahui Zhang
Shengxue Zhou
Feng Gao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592280

5,286 views
2 citations

Review

Published on 07 Aug 2025

Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson’s disease treatment

Zimo Zang
Fang Yang
Liang Qu
Minghui Ge
Liang Tong
Lihui Xue
Xiuye Sun
Ying Hai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640389

4,020 views
3 citations

Original Research

Published on 07 Aug 2025

Latent profile analysis of loneliness among elderly people in the community and its relationship with cognitive function

Lei Yang
Rushi Yang
Tiantian Liu
Jinfeng Wang
Bo Wang
Fengxue Zhao
Yue Zhang
Ping Zhang
Hao Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1574095

2,185 views

Original Research

Published on 06 Aug 2025

Effect of aspirin use on conversion risk from mild cognitive impairment to Alzheimer’s disease

Bo Kyu Choi
Yeonju Jin
Hokyung Lee
Sung-Woo Kim
Sojeong Park
Ickpyo Hong
Min Seok Baek

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1603892

2,595 views
1 citation

Original Research

Published on 06 Aug 2025

Neuroinflammation-mediated YKL-40 correlates with tau pathology and predicts longitudinal cognitive impairment and brain atrophy in Alzheimer’s disease, with hypertensive dependency

Ya-Yu Wang
Man Zhang
Shu-Jian Chen
Wei Miao
Zhi-Xin Wang
Ya-Jun Zhou
Si-Qi Yu
Zhong-Wu Sun
Xia Zhou
Xian-Feng Yu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1630022

2,483 views
2 citations

Review

Published on 06 Aug 2025

Choline alphoscerate: insights between acquired certainties and future perspectives

Giovanni Biggio
Claudio Mencacci

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1613566

3,492 views
1 citation

Original Research

Published on 06 Aug 2025

Ginsenoside Rb1 attenuates neuroflammation via activating Wnt/β-catenin signaling pathway to exert neuroprotective effect on cerebral ischemic-reperfusion injury

Ruo-jing Liu
Xue Zhao
Yi-zhen Zhu
Ling-Ling Fu
Guo Ge
Jun-de Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1555067

2,193 views

Original Research

Published on 06 Aug 2025

Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer’s disease

Hui Liu
Chenye Li
Congchen Zhai
Mei Li
Lan Ma

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566929

2,398 views

747 Publications

volumes

Accurate and robust prediction of Amyloid-β brain deposition from plasma biomarkers and clinical information using machine learning

Naringenin as a neurotherapeutic agent in Alzheimer’s disease: epigenetic signatures, gut microbiota alterations, and molecular neuroprotection

Artificial intelligence technologies for enhancing neurofunctionalities: a comprehensive review with applications in Alzheimer’s disease research

Exploring efficient and effective mammalian models for Alzheimer’s disease

Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson’s disease with excessive daytime sleepiness

Age- and sex-related differences in landmark recall following a virtual spatial navigation task

Combinations of multimodal neuroimaging biomarkers and cognitive test scores to identify patients with cognitive impairment

Gut dysbiosis is associated with increased blood–brain barrier permeability and cognitive impairment in elderlies with coronary heart disease

The effect of transcranial direct current stimulation on static and dynamic posture control in the elderly: a systematic review and meta-analysis

A model to address healthcare gaps and poor research participation in Hispanic patients with Parkinson's disease

Seeking the neural basis of neuropsychiatric symptoms in dementia: neuroimaging findings and controversies

Local gyrification index and sulcal depth as imaging markers of cognitive decline in Alzheimer’s disease

Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit

Increased tau-induced inflammatory responses are associated with a greater degree of atherosclerosis in progressive supranuclear palsy

Objective assessment of gait and posture symptoms in Parkinson’s disease using wearable sensors and machine learning

Improvement of neuropsychological and cognitive functions in older adults through transcranial vibroacoustic stimulation: a double blind, randomized, comparative trial

Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders

Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson’s disease treatment

Latent profile analysis of loneliness among elderly people in the community and its relationship with cognitive function

Effect of aspirin use on conversion risk from mild cognitive impairment to Alzheimer’s disease

Neuroinflammation-mediated YKL-40 correlates with tau pathology and predicts longitudinal cognitive impairment and brain atrophy in Alzheimer’s disease, with hypertensive dependency

Choline alphoscerate: insights between acquired certainties and future perspectives

Ginsenoside Rb1 attenuates neuroflammation via activating Wnt/β-catenin signaling pathway to exert neuroprotective effect on cerebral ischemic-reperfusion injury

Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer’s disease