Frontiers in Aging Neuroscience

Original Research

Published on 05 Sep 2025

Explainable machine learning for early detection of Parkinson’s disease in aging populations using vocal biomarkers

Bright Egbo
Zhanbota Nigmetolla
Naveed Ahmad Khan
Prashant K. Jamwal

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1672971

3,821 views

Original Research

Published on 05 Sep 2025

The mediating role of depression on the association between physical activity and cognitive function among older adults

HuanRui Zhang
Wen Tian
GuoXian Qi
XiuFang Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1470256

2,632 views

Original Research

Published on 04 Sep 2025

Muscle strength, EEG biomarkers, and working memory as interacting predictors of cognitive function in cognitively impaired older adults

Yagang Song
Shuqi Jia
Xing Wang
Aiwei Wang
Shufan Li
Feng Ding
Tao Ma
Xueping Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1641209

2,293 views

Original Research

Published on 03 Sep 2025

Associations of plasma von Willebrand Factor levels with cognitive decline and neurodegeneration in older adults without dementia

Pan Fu
Meiling Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1595071

1,982 views

Original Research

Published on 03 Sep 2025

Corpus callosum microstructure in chimpanzees (pan troglodytes): associations with age, handedness and cognition

Maëlig Chauvel
Ivy Uszynski
Cyril Poupon
William D. Hopkins

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1611611

1,684 views

Systematic Review

Published on 03 Sep 2025

Effects of transcranial alternating current stimulation on neurophysiologic motor function in Parkinson’s patients: a systematic review and meta-analysis

Fangcheng Ye
Yinjin Shao
Guihua Wu
Miao Huang
Hui Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1621052

2,246 views

Review

Published on 02 Sep 2025

Associations between peripheral nerve stimulation and cognitive performance: insights from healthy individuals and various disease pathologies

Xing Liu
Chenyi Yang
Xinyi Wang
Zixuan Wang
Huihui Liao
Huan Liu
Miao Zhang
Lin Zhang
Haiyun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1518198

3,291 views
1 citation

Mini Review

Published on 01 Sep 2025

The estrogen–brain interface in neuroinflammation: a multidimensional mechanistic insight

Jie Lu
Tie-Jun Xian
Cheng-Jun Li
Yang Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1671552

4,301 views
7 citations

Original Research

Published on 01 Sep 2025

Dual improvement of cognitive function and auditory ability in elderly patients with hearing impairment by transcranial direct current stimulation-assisted auditory rehabilitation training

Ying Zhou
Haolun Han
Xiaoli Zhang
Yiyan Zhang
Wenbo Duan
Liyun Su
Baowei Li
Zhezhe Sun
Lei Wang
Gang Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591496

3,006 views

Original Research

Published on 29 Aug 2025

Abnormal sleep blood pressure patterns are associated with the diffusion tensor imaging along the perivascular space index in cognitively impaired individuals

Mariateresa Buongiorno
Gonzalo Sánchez-Benavides
Giovanni Caruana
Andrea Elias-Mas
Cristina Artero
Natalia Cullell
Pilar Delgado
Darly Milena Giraldo
Clara Marzal-Espí
Oriol Grau-Rivera

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1578270

2,855 views

Original Research

Published on 29 Aug 2025

Systemic inflammation versus clinical demographics: patient age surpasses the platelet-to-lymphocyte ratio in differentiating secondary trigeminal neuralgia

Zihao Zhang
Qingpei Hao
Tao Wang
Shijun Peng
Xin Chang
Yuepeng Wang
Jia Ouyang
Ruen Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1658854

1,476 views

Mini Review

Published on 29 Aug 2025

Influence of biological sex on neuroinflammatory dynamics in the aging brain

Ludmila Müller
Svetlana Di Benedetto
Viktor Müller

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670175

3,792 views
6 citations

Mini Review

Published on 29 Aug 2025

Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration

Kun Leng
Mervyn Maze
Odmara L. Barreto Chang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632947

4,033 views
4 citations

Original Research

Published on 29 Aug 2025

Association between shift work and brain age gap: a neuroimaging study using MRI-based brain age prediction algorithms

Youjin Kim
Joon Yul Choi
Evgeny Petrovskiy
Wanhyung Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1650497

2,799 views

Original Research

Published on 26 Aug 2025

Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes

Toshiya Takahashi
Dinh Ha Duy Thuy
Shingo Takenaka
Sayaka Ono
Maya Fukui
Yasushi Okada
Tomohiko Asada
Kan Niimi
Kaku Kimura
Akio Ikeda

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1651596

3,180 views

Original Research

Published on 26 Aug 2025

HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia

Joanne K. Agus
Oscar M. Muñoz Herrera
Christopher H. Rhodes
Jack Jingyuan Zheng
Chenghao Zhu
Maurice Wong
Xinyu Tang
Izumi Maezawa
Lee-Way Jin
Carlito B. Lebrilla

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1629496

2,474 views

Brief Research Report

Published on 26 Aug 2025

Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis

Thomas Rudolf Schneider
Ansgar Felbecker
Ben von Mitzlaff
Gregor Weissofner
Sarah Meier
Patrick Eggenberger
Simon Annaheim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1624307

2,276 views
1 citation

Original Research

Published on 26 Aug 2025

The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity

Ming Zhao
Jiayue Zhang
Qianqian Yang
Lei Chen
Hongjian Shen
Yingyan Pu
Wei Wei
Yi Han
Ping Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1570482

1,748 views
1 citation

Original Research

Published on 26 Aug 2025

Altered brain dynamics in post-stroke cognitive and motor dysfunction

Xiaoying Liu
Guihua Song
Xiaoyun Zhuang
Ying Zhang
Xiaoyang Wang
Yin Qin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640378

1,911 views

Original Research

Published on 26 Aug 2025

Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study

Florian U. Fischer
Bianca Kollmann
Dominik Wolf
Alexandra Sebastian
Kristel Knaepen
David Riedel
Andreas Mierau
Nicolas Ruffini
Kristina Endres
Jennifer Winter

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587395

2,175 views

Review

Published on 26 Aug 2025

Exercise as a multitarget therapy: modulating myokines, neurotrophins, and inflammation in Parkinson’s disease

Wei-Qi Li
Jia-Hua Yang
Lu-Lu Liu
Song-Tao Ding
Bin Yu
Lin Jiang
Ning Yan
Han-Deng Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1580029

3,693 views

Original Research

Published on 26 Aug 2025

Cognitive flexibility in aging: the impact of age range and task difficulty on local switch costs in task switching

Tara Radović
Sebastian Kübler
Rafael Mikolajczyk
Alexander Kluttig
Viktoria Maydych
Torsten Schubert

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1619441

2,354 views
1 citation

Review

Published on 25 Aug 2025

The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

Gao Ning
Xing Fan
Du Juan
Zhao wenxue
Wang Sijia
Chen Meinei
Dong Xiaolong
Qi Yiming

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637671

3,887 views
2 citations

Original Research

Published on 22 Aug 2025

Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer’s disease

Ji-Woo Seok
Kahye Kim
Soonjo Hwang
Kun Ho Lee
Jaeuk U. Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592341

2,503 views

7,794 Publications

volumes

Volume 17 - 2025

Explainable machine learning for early detection of Parkinson’s disease in aging populations using vocal biomarkers

The mediating role of depression on the association between physical activity and cognitive function among older adults

Muscle strength, EEG biomarkers, and working memory as interacting predictors of cognitive function in cognitively impaired older adults

Associations of plasma von Willebrand Factor levels with cognitive decline and neurodegeneration in older adults without dementia

Corpus callosum microstructure in chimpanzees (pan troglodytes): associations with age, handedness and cognition

Effects of transcranial alternating current stimulation on neurophysiologic motor function in Parkinson’s patients: a systematic review and meta-analysis

Associations between peripheral nerve stimulation and cognitive performance: insights from healthy individuals and various disease pathologies

The estrogen–brain interface in neuroinflammation: a multidimensional mechanistic insight

Dual improvement of cognitive function and auditory ability in elderly patients with hearing impairment by transcranial direct current stimulation-assisted auditory rehabilitation training

Abnormal sleep blood pressure patterns are associated with the diffusion tensor imaging along the perivascular space index in cognitively impaired individuals

Systemic inflammation versus clinical demographics: patient age surpasses the platelet-to-lymphocyte ratio in differentiating secondary trigeminal neuralgia

Influence of biological sex on neuroinflammatory dynamics in the aging brain

Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration

Association between shift work and brain age gap: a neuroimaging study using MRI-based brain age prediction algorithms

Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes

HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia

Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis

The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity

Altered brain dynamics in post-stroke cognitive and motor dysfunction

Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study

Exercise as a multitarget therapy: modulating myokines, neurotrophins, and inflammation in Parkinson’s disease

Cognitive flexibility in aging: the impact of age range and task difficulty on local switch costs in task switching

The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer’s disease