Frontiers in Aging Neuroscience

Original Research

Published on 23 Jul 2025

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways

Waqas Ahmad
Kyonghwan Choe
Riaz Ahmad
Tae Ju Park
Myeong Ok Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607289

4,403 views
2 citations

Review

Published on 23 Jul 2025

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

Julia C. Colwell
Marina E. Emborg

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598245

2,253 views
3 citations

Original Research

Published on 23 Jul 2025

Vulnerability of long-range inputome of basal forebrain in normal aging mice

Tingting Sun
Jiale Chen
Bimin Liu
Anan Li
Hui Gong
Xiangning Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1573906

1,861 views

Original Research

Published on 23 Jul 2025

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats

Laila S. Almassri
Kristen M. Crane
Sean R. Hergenrother
Gurveer Singh
Gillian L. Barach
Melina C. Iafrate
Joshua C. Harris
Nick Tokar
Andrew P. Ohl
Jesse W. Young

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1626021

1,927 views
2 citations

Original Research

Published on 23 Jul 2025

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

Liangdong Zhou
Tracy A. Butler
Xiuyuan H. Wang
Samantha A. Keil
Seyed Hani Hojjati
Tsung-Wei Hu
Mélissa Savard
Firoza Z. Lussier
Pedro Rosa-Neto
Lidia Glodzik

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1613320

2,246 views

Review

Published on 23 Jul 2025

Advancements in multi-omics research to address challenges in Alzheimer’s disease: a systems biology approach utilizing molecular biomarkers and innovative strategies

Madison Cardillo
Keyura Katam
Prashanth Suravajhala

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591796

5,324 views
4 citations

Original Research

Published on 23 Jul 2025

Altered dynamic functional network connectivity patterns in Alzheimer’s disease: insights into neural dysfunction

Xuerui Pang
Yi Ji
Chenyang Hu
Yulong Dai
Panpan Hu
Xingqi Wu
Kai Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617191

2,212 views
2 citations

Original Research

Published on 23 Jul 2025

Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications

David Toloza-Ramirez
Rodrigo Santibañez
Leonardo Arraño-Carrasco
Romina Zunino-Pesce
Teresa Julio-Ramos
David A. Copland
Camilo Quezada
Carolina Mendez-Orellana

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547162

2,254 views

Original Research

Published on 22 Jul 2025

Lifespan brain age prediction based on multiple EEG oscillatory features and sparse group lasso

Shiang Hu
Xue Xiang
Xiaolong Huang
Yan Lu
Xulai Zhang
Dezhong Yao
Pedro A. Valdes-Sosa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1559067

2,655 views
2 citations

Original Research

Published on 22 Jul 2025

miR-423-5p and miR-92a-3p in Alzheimer’s disease: relationship with pathology and cognition

Sang-Won Han
Young Ho Park
Jung-Min Pyun
Paula J. Bice
SangYun Kim
Andrew J. Saykin
Kwangsik Nho

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637368

2,283 views

Original Research

Published on 22 Jul 2025

Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection

Juanjuan Jiang
Tao Kang
Ronghua Ling
Yingqian Liu
Jiuai Sun
Yiming Li
Xiaoou Li
Hui Yang
Bingcang Huang
the Alzheimer’s Disease Neuroimaging Initiative

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1589018

2,236 views

Mini Review

Published on 22 Jul 2025

Sex differences in the outcomes of modifiable lifestyle factors for cognitive aging: neuroinflammation and microglia as key underlying mechanisms

Samantha G. Coleborn
Zoë M. Gilson
Yunyong Guo
Marie-Ève Tremblay

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1642043

2,639 views
1 citation

Review

Published on 21 Jul 2025

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

Bingyuan Zhou
Jing Li
Anqi Wu
Xuewei Wang
Le Cheng
Gaoshang Yang
Dahong Gao
Caifeng Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587986

3,516 views
3 citations

Original Research

Published on 21 Jul 2025

Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain

Gen Miura
Tomoyo Morita
Jihoon Park
Eiichi Naito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1501011

1,942 views

Review

Published on 18 Jul 2025

Motor symptoms of Parkinson’s disease: critical markers for early AI-assisted diagnosis

Ni Yang
Jing Liu
Dan Sun
Jiajun Ding
Lingzhi Sun
Xianghua Qi
Wei Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602426

4,738 views

Original Research

Published on 17 Jul 2025

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

Mark H. Sundman
Yilin Liu
Nan-kuei Chen
Ying-hui Chou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597311

3,637 views
3 citations

Systematic Review

Published on 17 Jul 2025

Orthostatic hypotension in Parkinson’s disease: effects on clinical features and disease severity-a systematic review and meta-analysis

Hui Wang
Chi Zhang
Dongxun Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612960

1,871 views

Original Research

Published on 16 Jul 2025

Brain structural MRI marker for predicting conversion to Parkinson’s disease in individuals with prodromal symptoms

Chang-hyun Park
Uicheul Yoon
Phil Hyu Lee
Jinna Kim
Seung-Koo Lee
Na-Young Shin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579326

1,697 views

Original Research

Published on 16 Jul 2025

Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study

Yushu Huang
Xifan Yang
Qi Wang
Adila Abula
Yue Dong
Wenyuan Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1532884

3,638 views
1 citation

Original Research

Published on 16 Jul 2025

Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly

Vivian Schultz
Benita Schmitz-Koep
Aurore Menegaux
Melissa Thalhammer
Severin Schramm
Su Hwan Kim
Claus Zimmer
Christian Sorg
Panteleimon Giannakopoulos
Marie-Louise Montandon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1542857

1,756 views

Original Research

Published on 16 Jul 2025

Predictive value of pan-immune-inflammation value in the prognosis of adults with status epilepticus: a retrospective study

Jie Fu
Yifei Chu
Chenxin Zhao
Lilei Peng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1601816

1,120 views

Review

Published on 16 Jul 2025

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

Yanrong Yang
Hua Chen
Qibing Liu
Yang Niu
Chunyang Mao
Rui Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1623050

3,570 views
2 citations

Original Research

Published on 16 Jul 2025

Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer’s disease

Fenyang Chen
Tiantian Heng
Qi Feng
Rui Hua
Jiaojiao Wu
Feng Shi
Zhengluan Liao
Keyin Qiao
Zhiliang Zhang
Jianliang Miao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1621106

3,053 views
1 citation

Original Research

Published on 16 Jul 2025

Evaluation of non-motor symptoms in Parkinson’s disease using multiparametric MRI with the multiplex sequence

He Sui
Zhanhao Mo
Feng Shi
Qing Zhou
Dan Yu
Jiaqi Wang
Lin Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602245

1,768 views