Frontiers in Aging Neuroscience

Review

Published on 15 Jul 2025

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

Amy F. T. Arnsten
Isabella Perone
Min Wang
Shengtao Yang
Stacy Uchendu
Dinara Bolat
Dibyadeep Datta

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1610350

2,674 views
1 citation

Original Research

Published on 15 Jul 2025

Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey

Hui-Ying Fan
He-Li Sun
Yuan Feng
Qinge Zhang
Hua-Qing Xing
Qian-Hua Huang
Zhaohui Su
Teris Cheung
Chee H. Ng
Yu-Tao Xiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579560

2,768 views
1 citation

Systematic Review

Published on 11 Jul 2025

Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis

Han Han
Jinhao Zhang
Fan Zhang
Fanghui Li
Zhijian Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1510773

10,076 views
5 citations

Original Research

Published on 11 Jul 2025

Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China

Jianping Lu
Guoen Cai
Naian Xiao
Kunmu Zheng
Qinyong Ye
Xiaochun Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566247

1,491 views

Original Research

Published on 11 Jul 2025

Intranasal delivery of dodecyl creatine ester alleviates motor deficits and increases dopamine levels in a 6-OHDA rat model of parkinsonism

Clémence Disdier
Clara Lhotellier
Stéphanie Wagner
Emile Andriambeloson
Frédéric Théodoro
Alain Pruvost
Thomas Joudinaud
Henri Bénech
Aloïse Mabondzo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597263

2,554 views

Review

Published on 11 Jul 2025

Stem cell extracellular vesicles: a new dawn for anti-inflammatory treatment of neurodegenerative diseases

Miao Yu
Hongxia Ma
Xiaoyi Lai
Jiannan Wu
Mengmeng Shen
Junqiang Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592578

4,053 views
3 citations

Systematic Review

Published on 10 Jul 2025

Repetitive transcranial magnetic stimulation across neurodegenerative diseases: a systematic review and dose-response meta-analysis

Yu Zhang
Yulin Wang
Ke Xu
Chengguang Zhang
Peizhu Lv
Yan Bai
Shun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1615734

2,833 views

Original Research

Published on 09 Jul 2025

Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos

Ernesto G. Miranda-Morales
Daniel F. Ramos-Rosales
Alma C. Salas-Leal
Sergio M. Salas-Pacheco
Francisco X. Castellanos-Juárez
Edna M. Méndez-Hernández
Osmel La Llave-León
María S. Peñaherrera
Gerardo Quiñones-Canales
Oscar Arias-Carrión

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612544

1,534 views

Original Research

Published on 09 Jul 2025

Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism

Wei Zhou
MengYue Tang
Bo Cheng
Ling Sun
HongYu Lin
Yang Fan
Nian Liu
Shushan Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566785

1,610 views

Original Research

Published on 09 Jul 2025

Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury

Ryan P. McCann
Bethany Bowley
Monica Pessina
Qiong Yang
Hongqi Xin
Sarah A. DeVries
Mingjin Wang
Yi Zhang
Michael Chopp
Zhenggang Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1605144

2,779 views
2 citations

Mini Review

Published on 09 Jul 2025

Regulation of BBB function and pathological evolution of PD by microenvironment “spatiotemporal gradient”: unique advantages of microfluidic chips

Sixun Yu
Lingli Jiang
Min Song
Tao Yang
Ma Yuan
Xin Chen
Haifeng Shu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599509

2,804 views
2 citations

Systematic Review

Published on 08 Jul 2025

Sedentary behavior, cognition, and brain health in older adults: a systematic review

Marissa A. Gogniat
Junyeon Won
Carlos Cruz
Amaya Aranda
Aryan Verma
Swathi Gujral
Andrea M. Weinstein
Afsara B. Zaheed
Keith R. Cole
Kelsie M. Full

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1622049

3,294 views
3 citations

Original Research

Published on 08 Jul 2025

Altered automatic gaze processing in older adults

Roger Koenig-Robert
Boris Barrientos
Phoebe E. Bailey
Kiley Seymour

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592763

1,400 views

Original Research

Published on 08 Jul 2025

Efficiency of structural brain networks mediates age-associated differences in executive functioning in older adults

Geraldine Rodríguez-Nieto
Caroline Seer
Hamed Zivari Adab
Antonio Jimenez-Marin
Sima Chalavi
Amirhossein Rasooli
Jesús M. Cortés
Stefan Sunaert
Stephan P. Swinnen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1593868

1,516 views
1 citation

Original Research

Published on 07 Jul 2025

Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method

Shiyu Xiao
Xuemeng Wei
Bing Han
Xiaoqian Shi
Congzhen Wei
Rumeng Liang
Jingna Sun
Zheng Zhang
Zhengang Han
Li Shen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1561831

2,925 views
2 citations

Mini Review

Published on 04 Jul 2025

Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia

Jinhuan Yue
Peng Wang
Xiang-fa Guo
Zeyi Wei
Kaiting He
Nuo Li
Xiaoling Li
Qinhong Zhang
Xiaoqing Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547965

2,520 views
1 citation

Brief Research Report

Published on 03 Jul 2025

Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease

Neha Singh-Reilly
Ryota Satoh
Jonathan Graff-Radford
Mary M. Machulda
Val J. Lowe
Keith A. Josephs
Jennifer L. Whitwell

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1615718

1,955 views

Original Research

Published on 03 Jul 2025

GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups

Shanti Van Malderen
Melina Hehl
Stefanie Verstraelen
Robbe Breugelmans
Georg Oeltzschner
Stephan P. Swinnen
Koen Cuypers

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1626417

2,073 views

Original Research

Published on 02 Jul 2025

Serum uric acid to creatinine ratio in patients with early-onset post-stroke cognitive impairment: a retrospective cohort study

Libin Liao
Weiquan Huang
Rongchao Ma
Wentong Hu
Hui Wu
Moxi Su
Dujuan Sha

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1580722

2,061 views

Original Research

Published on 02 Jul 2025

Research hotspots and frontiers of glymphatic system and Alzheimer’s disease: a bibliometrics analysis

Shichao Liu
Lvping Zhuang
Xiaochun Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579373

3,646 views

Original Research

Published on 02 Jul 2025

Hippocampal iron patterns in aging and mild cognitive impairment

Sonja M. Kagerer
Laetitia Vionnet
Jiri M. G. van Bergen
Rafael Meyer
Anton F. Gietl
Klaas P. Pruessmann
Christoph Hock
Paul G. Unschuld

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598859

2,103 views
1 citation

Original Research

Published on 02 Jul 2025

Characterizing changes to individual-specific brain signature with age

Monireh Taimouri
Vikram Ravindra

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1493855

1,788 views
2 citations

Original Research

Published on 30 Jun 2025

Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson’s disease pathogenesis

Cheng Cheng
Huijia Yang
Lulu Tian
Yang Ni
Congcong Jia
Weidong Le
Qingshan Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612389

2,277 views
1 citation

Original Research

Published on 30 Jun 2025

Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes

Michelle Horan
Daniel Carey
Silvin Knight
A. Fagan
James F. M. Meaney
Rose Anne Kenny
Céline De Looze

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1466294

1,620 views