Frontiers in Aging Neuroscience

Original Research

Published on 30 Jun 2025

Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes

Michelle Horan
Daniel Carey
Silvin Knight
A. Fagan
James F. M. Meaney
Rose Anne Kenny
Céline De Looze

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1466294

1,626 views

Editorial

Published on 27 Jun 2025

Editorial: Advances in Parkinson's Disease Research: Exploring Biomarkers and Therapeutic Strategies for Halting Disease Progression

Anastasia Bougea
Yildiz Degirmenci

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640566

2,173 views
1 citation

Original Research

Published on 27 Jun 2025

Age-sex differences in Alzheimer’s and related dementias burden and risk factors in east and Southeast Asia: results from the 2021 GBD study

Tengyu Zhao
Pengyu Pan
Yuhan Zhou
Xinyue Zhang
Quan Li
Yanyan Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1562148

3,849 views
1 citation

Original Research

Published on 26 Jun 2025

Metformin improves age-related visual cortex dysfunction in mice by reducing noise correlation in the primary visual cortex

Xiaoming Liu
Yifeng Zhou
Jiachen Liu
Guangwei Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1572653

1,434 views

Original Research

Published on 26 Jun 2025

Regional network covariance patterns of white matter integrity related to cardiorespiratory fitness in healthy aging

Samantha G. Smith
Pradyumna K. Bharadwaj
David A. Raichlen
Matthew D. Grilli
Jessica R. Andrews-Hanna
Georg A. Hishaw
Matthew J. Huentelman
Theodore P. Trouard
Gene E. Alexander

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1542458

1,674 views

Original Research

Published on 26 Jun 2025

Reduced synaptic tagging by complement protein C3 is associated with elevated extracellular matrix in the middle-aged cerebellum of mice

Henning Peter Düsedau
Carla Cangalaya
Stoyan Stoyanov
Alexander Dityatev
Ildiko Rita Dunay

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1616390

2,215 views

Review

Published on 25 Jun 2025

Necroptosis in vascular cognitive impairment: mechanisms and therapeutic potential

Shufei Wei
Lin Cheng
Chunxiao Shen
Zefen Li
Jiahui Teng
Liangliang Wang
Xiaorong Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599773

2,356 views

Original Research

Published on 25 Jun 2025

Predicting amyloid status in mild cognitive impairment: the role of semantic intrusions combined with plasma biomarkers

Yao Lu
Liang Cui
Lin Huang
Fang Xie
Qi-Hao Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1624513

2,108 views

Original Research

Published on 25 Jun 2025

Voxel- and surface-based morphometry in the cortical thickness and cortical and subcortical gray matter volume in patients with mild-to-moderate Alzheimer’s disease

Kaidi Li
Dingling Xie
Zhengyong Zhang
Chunyu Fu
Chunyang Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1546977

2,394 views

Original Research

Published on 25 Jun 2025

Modeling heterogeneity in cognitive trajectories in the Framingham Heart Study

Yuan Fang
Jiachen Chen
Jesse Mez
Claudia L. Satizabal
Michael L. Alosco
Wei Qiao Qiu
Margaret F. Doyle
Joanne M. Murabito
Kathryn L. Lunetta

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1471154

2,040 views
1 citation

Original Research

Published on 24 Jun 2025

A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling

Jiahui Li
Yuan Xu
Gianfranco Balboni
Ying Xia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587219

2,429 views
1 citation

Original Research

Published on 24 Jun 2025

Cognitive function changes and DTI-ALPS index in postmenopausal women

Ningning Liu
Yue Zhang
Weiqing Fu
Huijun Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1593366

2,207 views

Original Research

Published on 23 Jun 2025

α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid

Jacob Raber
Alexandra Pederson
Emily Bunnell
Nora Mattek
Nora E. Gray
Steven G. Kohama
Alison R. Weiss
Joseph F. Quinn
Henryk F. Urbanski

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599402

2,252 views

Editorial

Published on 23 Jun 2025

Editorial: A comprehensive look at biomarkers in neurodegenerative diseases: from early diagnosis to treatment response assessment

Riccardo Pascuzzo
Fulvia Palesi
Yi-Min Wan
Federico Angelo Cazzaniga

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1642793

1,719 views
1 citation

Brief Research Report

Published on 23 Jun 2025

Exploration of the effects of Tai Chi practice on lower limb corticomuscular coherence during balance-demanding virtual reality conditions in older adults

Yang Hu
Elizabeth T. Hsiao-Wecksler
Manuel E. Hernandez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1554000

2,687 views
1 citation

Study Protocol

Published on 23 Jun 2025

Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol

Louis Bherer
Tudor Vrinceanu
Emma Gabrielle Dupuy
Mathieu Gayda
Thomas Vincent
Pierre-Olivier Magnan
Hanieh Mohammadi
Claudine Gauthier
Christine Gagnon
Simon Duchesne

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1605128

3,574 views

Original Research

Published on 23 Jun 2025

Sensorimotor dysfunction and postural instability in older adults with type 2 diabetes mellitus: the role of proprioception and neuropathy

Saleh M. Kardm
Abdulmohsen Saeed Kardm
Ziad Ahmed Alanazi
Hani Hassan Alnakhli
Batool Abdulelah Alkhamis
Ravi Shankar Reddy

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1615399

2,999 views
1 citation

Original Research

Published on 20 Jun 2025

The correlation between muscle strength, inhibitory function, and cognitive function in older adults with cognitive impairment: evidence from resting-state electroencephalography

Mi Hu
Xing Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1574275

2,576 views

Original Research

Published on 20 Jun 2025

Exploring the sensitivity of episodic and spatial memory tests to healthy and pathological cognitive aging

Gina Michallat-Bragg
Megan Bennett
Bethany Iona Flewitt
Sayed Kazmi
Sarah Jane Smith
Christine Wells
Annabel Hollins
Charlotte Ash
Sarah Thwaites
Wendy Neil

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547834

3,171 views

Original Research

Published on 19 Jun 2025

Functional cognitive performance augments cognitive screening data in older adults

Timothy S. Marks
Gordon Muir Giles
Dorothy Farrar Edwards

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1535146

2,962 views
1 citation

Original Research

Published on 19 Jun 2025

The effect of periodontal status in the associations between socioeconomic status and cognitive performance: a mediation analysis in older adults

Heming Zhang
Hongxia Xiang
Lin Zhang
Zhiyang Chen
Wei Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1524268

2,972 views

Original Research

Published on 18 Jun 2025

Elevated monocyte-to-high-density lipoprotein ratio is associated with increased risk of cognitive impairment and severe cerebral small vessel disease burden

Yueshan Zhao
Meixi Li
Juan Zhang
Chao Wang
Mengyao Zhao
Qishuo Yang
Tianjun Wang
Peiyuan Lv

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1588488

2,455 views
1 citation

Original Research

Published on 18 Jun 2025

Hemodynamic changes and their relationship with white matter hyperintensities in CSVD patients with cognitive impairment: a 4D flow study

Jiajun Cao
Chang Yuan
Zhenpeng Zhang
Xiaoying Zhao
Yukun Zhang
Peipei Chang
Qingwei Song
Bingwei Zhang
Rui Hu
Yanwei Miao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1578288

2,684 views

Original Research

Published on 18 Jun 2025

Relationship between executive function and dual-task walking in people with Parkinson's disease

Jun-Hong Zhou
Ray-Yau Wang
Yo-Tsen Liu
Shih-Jung Cheng
Hsin-Hsuan Liu
Yea-Ru Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1585524

2,873 views