Frontiers in Aging Neuroscience

Original Research

Published on 28 Apr 2025

NTN-1 attenuates amyloid-β-mediated microglial neuroinflammation and memory impairment via the NF-κB pathway and NLRP3 inflammasome in a rat model of Alzheimer's disease

Tianhang Wang
Yanchen Liu
Yidan Lu
Lijun Chi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1516399

3,269 views
5 citations

Original Research

Published on 28 Apr 2025

Handgrip strength and risk of cognitive impairment across different glucose metabolism statuses: insights from the CHARLS study

Shiqi Wang
Liangchen Li
Jia Yu
Xianli Sun
Jianqiao Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566652

6,965 views
2 citations

Original Research

Published on 28 Apr 2025

Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer’s disease

Sean B. Ostlund
Grace Chen
Alisa Kosheleff
Lindsay M Lueptow
Irina Zhuravka
Sally A. Frautschy
Hoa A. Lam
Nigel T. Maidment

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1572956

3,281 views
3 citations

Original Research

Published on 28 Apr 2025

A cross-sectional study of how high-frequency hearing loss impacts cognitive functions in middle-aged-to-older adults

Dona M. P. Jayakody
Paul McIlhiney
Inge Stegeman
Robert H. Eikelboom

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1560307

3,401 views
2 citations

Systematic Review

Published on 28 Apr 2025

Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review

Xinming Yang
Bo Li
Linna Wu
Ying Cui

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1515327

6,785 views
3 citations

Brief Research Report

Published on 28 Apr 2025

Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease

Hóngyi Zhào
Wei Wei
Fang Lv
Jie Shen
Yonghua Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569582

3,006 views

Original Research

Published on 25 Apr 2025

Bioinformatics-driven exploration of key genes and mechanisms underlying oxidative stress in traumatic brain injury

Bin Ren
Jifang Liang
Leifang Yang
Xiaocong Wei
Min Guo
Hong Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1531317

2,927 views
2 citations

Original Research

Published on 25 Apr 2025

Activation of GLP-1R modulates the spontaneous discharge of nigral dopaminergic neurons and motor behavior in mice with chronic MPTP Parkinson's disease

Wen-Hong Liu
Cui Liu
Yan Xue
Xiang-Rong Sun
Xin-Yi Chen
Lei Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1529919

3,148 views
2 citations

Original Research

Published on 25 Apr 2025

Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss

Chenyang Yuan
Tianyu Ma
Mengting Liu
Li Jiang
Gongrui Tang
Qi Hu
Tianhong Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1526519

3,695 views

Original Research

Published on 25 Apr 2025

Lower CALLY index levels indicate higher poor functional outcome risk in acute ischemic stroke patients treated with endovascular thrombectomy

Yunnan Lu
Xiaohua Zhu
Yaojia Xu
Yongxin Li
Qingyong Dai
Xia Chang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587861

3,871 views
6 citations

Mini Review

Published on 25 Apr 2025

The potential and challenges of TREM2-targeted therapy in Alzheimer’s disease: insights from the INVOKE-2 study

Ya-nan Ma
Xiqi Hu
Kenji Karako
Peipei Song
Wei Tang
Ying Xia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576020

9,320 views
16 citations

Review

Published on 24 Apr 2025

Neuroprotective effects of electroacupuncture in ischemic stroke: from mechanisms to clinical implications

Jinxi Zhu
Xinyi Ge
Yulong Cao
Renjie Xiao
Xiao Deng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1562925

6,518 views
3 citations

Original Research

Published on 23 Apr 2025

Machine learning models based on location-radiomics enable the accurate prediction of early neurological function deterioration for acute stroke in elderly patients

Xiaoming Fu
Chuanyang Zhang
Hongjie Huang
Changcheng Li
Miaomiao Li
XiaoRan Li
Zhijun Gao
Mingyang Peng
Hui Xu
Wenli Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1582687

2,658 views
1 citation

Systematic Review

Published on 23 Apr 2025

Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention

Giulia Marafioti
Laura Culicetto
Desirèe Latella
Angela Marra
Angelo Quartarone
Viviana Lo Buono

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549134

5,710 views
5 citations

Original Research

Published on 23 Apr 2025

# Language processing characteristics in normal pressure hydrocephalus: insights from eye-tracking analysis of incorrect responses

Ji-Yeong Kim
Jiho Lee
Nayeon Kim
Ki-Su Park
Janghyeok Yoon
Kyunghun Kang
Ji-Wan Ha

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1527962

3,155 views
1 citation

Original Research

Published on 23 Apr 2025

The synergistic extract of Zophobas atratus and Tenebrio molitor regulates neuroplasticity and oxidative stress in a scopolamine-induced cognitive impairment model

Ngoc Buu Tran
Haesung Lee
Myoung-Geun Ji
Long Ngo Hoang
Sook-Jeong Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566621

3,228 views
1 citation

Review

Published on 23 Apr 2025

The role of quantitative EEG biomarkers in Alzheimer’s disease and mild cognitive impairment: applications and insights

Yue Yuan
Yang Zhao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1522552

12,027 views
21 citations

Original Research

Published on 22 Apr 2025

Early identification of mild cognitive impairment: an innovative model using ocular biomarkers

Lingjing Zhang
Yanwei Wang
Yuming Liu
Zi Ye
Zhaohui Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1492804

3,678 views
1 citation

Original Research

Published on 22 Apr 2025

Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy

Li Zhao
Lingyun Liu
Miao Lin
Linyun Xie
Hui Hong
Qingze Zeng
Shuyue Wang
Ruiting Zhang
Zhenhua Zhao
Peiyu Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549072

4,074 views

Original Research

Published on 22 Apr 2025

Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease

Han Liu
Wenhui Zheng
Jie Geng
Xia Zhou
Yu Xia
Yan Liu
Gang Zhang
Xiaoqun Zhu
Daping Lv
Zhongwu Sun

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1538850

3,139 views
1 citation

Systematic Review

Published on 22 Apr 2025

Comparative efficacy of rTMS on different targets in Alzheimer’s disease: a systematic review and meta-analysis

Yushu Zhang
Ke Dong
Jiajia Yang
Qifan Guo
Yan Zhao
Xiaoxia Zhu
Dongxu Liu
Peng Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1536573

5,286 views
2 citations

Original Research

Published on 17 Apr 2025

Reduced composite dietary antioxidant index increases the risk of Parkinson’s disease and all-cause mortality in Parkinson’s disease patients: evidence from the NHANES database

Fei Huang
Jingwen Hao
Chanjuan Chen
Qun Liu
Dan He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1510654

3,939 views

Editorial

Published on 16 Apr 2025

Editorial: Similarities and differences between cellular and molecular mechanisms of normal brain aging and neurodegeneration

Anamaria Jurcau

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602391

2,108 views

Original Research

Published on 16 Apr 2025

The impact of BST1 rs4698412 variant on Parkinson’s disease progression in a longitudinal study

Hao-Ling Xu
Yu Yang
Li-Na Chen
Yun-Jing Li
Guo-En Cai
Ying-Qing Wang
Yan-Hong Weng
Xiao-Ling Lin
Jing Jian
Xiao-Chun Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1570347

2,782 views
1 citation

7,808 Publications

volumes

Volume 17 - 2025

NTN-1 attenuates amyloid-β-mediated microglial neuroinflammation and memory impairment via the NF-κB pathway and NLRP3 inflammasome in a rat model of Alzheimer's disease

Handgrip strength and risk of cognitive impairment across different glucose metabolism statuses: insights from the CHARLS study

Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer’s disease

A cross-sectional study of how high-frequency hearing loss impacts cognitive functions in middle-aged-to-older adults

Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review

Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease

Bioinformatics-driven exploration of key genes and mechanisms underlying oxidative stress in traumatic brain injury

Activation of GLP-1R modulates the spontaneous discharge of nigral dopaminergic neurons and motor behavior in mice with chronic MPTP Parkinson's disease

Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss

Lower CALLY index levels indicate higher poor functional outcome risk in acute ischemic stroke patients treated with endovascular thrombectomy

The potential and challenges of TREM2-targeted therapy in Alzheimer’s disease: insights from the INVOKE-2 study

Neuroprotective effects of electroacupuncture in ischemic stroke: from mechanisms to clinical implications

Machine learning models based on location-radiomics enable the accurate prediction of early neurological function deterioration for acute stroke in elderly patients

Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention

# Language processing characteristics in normal pressure hydrocephalus: insights from eye-tracking analysis of incorrect responses

The synergistic extract of Zophobas atratus and Tenebrio molitor regulates neuroplasticity and oxidative stress in a scopolamine-induced cognitive impairment model

The role of quantitative EEG biomarkers in Alzheimer’s disease and mild cognitive impairment: applications and insights

Early identification of mild cognitive impairment: an innovative model using ocular biomarkers

Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy

Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease

Comparative efficacy of rTMS on different targets in Alzheimer’s disease: a systematic review and meta-analysis

Reduced composite dietary antioxidant index increases the risk of Parkinson’s disease and all-cause mortality in Parkinson’s disease patients: evidence from the NHANES database

Editorial: Similarities and differences between cellular and molecular mechanisms of normal brain aging and neurodegeneration

The impact of BST1 rs4698412 variant on Parkinson’s disease progression in a longitudinal study