Frontiers in Aging Neuroscience

Original Research

Published on 09 Dec 2025

Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach

Kevin Mekulu
Faisal Aqlan
Hui Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1681124

620 views

Brief Research Report

Published on 09 Dec 2025

The cerebellar-related cognitive function is sensitive to aging: implications for early detection

Qianying Ma
Min Pu
Meijia Li
Ling Liu
Ruilin Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679443

553 views

Systematic Review

Published on 09 Dec 2025

The EEG analysis and identification of Alzheimer's disease: a review

Jinying Bi
Fei Wang
Fangzhou Hu
Shuai Han
Yuting Wang
Zhijian Fu
Xin Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1686628

911 views

Original Research

Accepted on 08 Dec 2025

Separating Cognitive and Motor Contributions to iADL Difficulties in Parkinson's Disease

Rekha Ravikumar
Marta Statucka
Melanie Cohn

Frontiers in Aging Neuroscience

161 views

Original Research

Published on 08 Dec 2025

Clinical analysis of sarcopenia prevalence and its influencing factors in patients with Parkinson’s disease

Remi Morimoto
Kazuo Kitagawa
Kenichi Todo
Mutsumi Iijima

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1718723

810 views

Original Research

Published on 08 Dec 2025

A nomogram based on coagulation markers for predicting meige syndrome risk

Yuanyuan Chen
Yuehua Sun
Xinyu Zhang
Yang Chen
Shuai Zhao
Mengyao Shi
Xuefeng Lv
Wenping Lian
Zhongquan Wang
Yongjun Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1665276

807 views

Original Research

Published on 08 Dec 2025

Cognitive impairment and dependency in activities of daily living: a cross-lagged analysis

Xuewei Fu
Shuming Ji
Jiafeng Li
Ting Chen
Xuhuan Liu
Weihong Kuang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1663237

509 views

Original Research

Published on 08 Dec 2025

The impact of neighborhood environment on physical activity among older adults: chain mediating roles of self-efficacy and outcome expectations

Lei Ying
Qingqing Yang
Jizhe Yu
Xiaoyun Liao
Wenming Fan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730899

541 views

Systematic Review

Accepted on 05 Dec 2025

The validity of visual and hearing impairment in predicting dementia and cognitive impairment in older adults: A systematic review and meta-analysis

Qingwen Gan
Yiling Yuan
Qianqian Hu
Xiaoyun Xiong
Yonghui Zhang

Frontiers in Aging Neuroscience

177 views

Original Research

Published on 05 Dec 2025

Machine learning-based early screening of mild cognitive impairment using nutrition-related biomarkers and functional indicators

Ling Yuan
Yao Zhang
Yiwen Wu
Anke Zhang
He Bai
Mengyao He
Zhaoxin Wang
Liqiang Zheng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1641690

985 views

Systematic Review

Published on 05 Dec 2025

The effect of mind–body exercise on cognitive function and neuroplasticity in elderly people with mild cognitive impairment: a systematic review and meta-analysis

Huifang Tian
Xi Yang
Jiahuan Li
Yuqi Cheng
Shui Tian
Fanfan Meng
Qinqin Zhu
Ying Shen
Tong Wang
Chuan Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1683808

761 views

Original Research

Accepted on 04 Dec 2025

Altered brain network dynamics and functional connectivity in subjective cognitive decline: An edge-centric network study

Xiaofan Wei
Baiwan Zhou
Juanling Li
Ruohong Xu
Wei Zhang

Frontiers in Aging Neuroscience

178 views

Original Research

Published on 04 Dec 2025

Peripheral CHI3L1 expression is associated with APOE ε4 status in early-onset Alzheimer’s disease

Anja Steinmaurer
Lina Breit
Elisabeth Stögmann
Theresa König

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730319

808 views

Original Research

Published on 04 Dec 2025

Assessing neurocognitive functioning among adults ageing with and without HIV at the Kenyan Coast: measurement issues and correlates

Patrick N. Mwangala
Carophine Nasambu
Ryan G. Wagner
Mihaela Duta
Gaia Scerif
Charles R. Newton
Amina Abubakar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1702869

738 views

Editorial

Published on 04 Dec 2025

Editorial: Sex-dependent modulation of neuroinflammation in the aging brain

Yu-Min Kuo
Shun-Fen Tzeng
Celia Giulietta Fernandez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1745448

668 views

Original Research

Published on 03 Dec 2025

Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson’s disease: a multisite functional magnetic resonance imaging study

Bin Qin
Yisi Tang
Huixun Qin
Wen Gao
Shusheng Liao
Mingxiu Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1695806

649 views

Review

Published on 03 Dec 2025

The ubiquitin-proteasome system in Alzheimer’s disease: mechanism of action and current status of treatment

Shanshan Jia
Quan Li
Xue Rui
Wen Qin
Wenhui Zhang
Jinjin Dou
Xiwu Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730206

925 views

Perspective

Published on 03 Dec 2025

Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions

Joël Macoir
Monica Lavoie
Guillaume Duboisdindien
Robert Laforce

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1736855

897 views

Opinion

Published on 03 Dec 2025

The mechanosensitive Piezo1 channel mechanism of Alzheimer's disease and implications for the development of therapeutic or early detection strategies

Mo Zhang
Huifang Hou
Hui Li
Xinyang Bai
Huina Song
Lu Wang
Lin-Hua Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1707659

731 views

Original Research

Published on 03 Dec 2025

Anatomically refined entorhinal cortex segmentation improves MRI-based early diagnosis of Alzheimer’s disease

Yongha Gi
Sangyoon Park
Hyungjin Lim
Jeongwon Lee
A. Hyun Jung
Seol-Hee Baek
Jong Hyun Kim
Byung-Jo Kim
Myonggeun Yoon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1682106

819 views

Original Research

Published on 03 Dec 2025

Early detection of mild cognitive impairment utilizing ocular biomarker-based risk scoring nomogram

Mohammed Seid Hussen
Bess Yin-Hung Lam
Wei Gao
Liping Zhou
Kai Yip Choi
Henry Ho-lung Chan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1669948

953 views

Original Research

Published on 03 Dec 2025

Validation of the robustness of blood-based biomarkers for predicting amyloid-β positivity in Chinese populations

Ying Wang
Liang Cui
Feng-Feng Pan
Zhen Zhang
Lin Huang
Ya Miao
Yi-Hui Guan
Qi-Hao Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1660755

918 views

Original Research

Accepted on 02 Dec 2025

Aperiodic EEG Signatures: Unveiling the Interplay between APOE ε4 and Mild Cognitive Impairment Subtypes

Joel Eyamu
Boncho Ku
Kahye Kim
Kun Ho Lee
Jaeuk Kim

Frontiers in Aging Neuroscience

304 views

Original Research

Accepted on 02 Dec 2025

Dexmedetomidine Ameliorates Cognitive and Affective Deficits by Modulating Neuroinflammation and Neurogenesis in an Alzheimer's Disease Mouse Model

Mai Li
Chanyuan An
Xin Wang
Minghe Ren
Shiyu Liu
Ruixin Chen
Yuyan Guo
Jun Wang
Yulang Fei
Dafei Ma

Frontiers in Aging Neuroscience

543 views

7,708 Publications

volumes

Volume 17 - 2025

Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach

The cerebellar-related cognitive function is sensitive to aging: implications for early detection

The EEG analysis and identification of Alzheimer's disease: a review

Separating Cognitive and Motor Contributions to iADL Difficulties in Parkinson's Disease

Clinical analysis of sarcopenia prevalence and its influencing factors in patients with Parkinson’s disease

A nomogram based on coagulation markers for predicting meige syndrome risk

Cognitive impairment and dependency in activities of daily living: a cross-lagged analysis

The impact of neighborhood environment on physical activity among older adults: chain mediating roles of self-efficacy and outcome expectations

The validity of visual and hearing impairment in predicting dementia and cognitive impairment in older adults: A systematic review and meta-analysis

Machine learning-based early screening of mild cognitive impairment using nutrition-related biomarkers and functional indicators

The effect of mind–body exercise on cognitive function and neuroplasticity in elderly people with mild cognitive impairment: a systematic review and meta-analysis

Altered brain network dynamics and functional connectivity in subjective cognitive decline: An edge-centric network study

Peripheral CHI3L1 expression is associated with APOE ε4 status in early-onset Alzheimer’s disease

Assessing neurocognitive functioning among adults ageing with and without HIV at the Kenyan Coast: measurement issues and correlates

Editorial: Sex-dependent modulation of neuroinflammation in the aging brain

Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson’s disease: a multisite functional magnetic resonance imaging study

The ubiquitin-proteasome system in Alzheimer’s disease: mechanism of action and current status of treatment

Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions

The mechanosensitive Piezo1 channel mechanism of Alzheimer's disease and implications for the development of therapeutic or early detection strategies

Anatomically refined entorhinal cortex segmentation improves MRI-based early diagnosis of Alzheimer’s disease

Early detection of mild cognitive impairment utilizing ocular biomarker-based risk scoring nomogram

Validation of the robustness of blood-based biomarkers for predicting amyloid-β positivity in Chinese populations

Aperiodic EEG Signatures: Unveiling the Interplay between APOE ε4 and Mild Cognitive Impairment Subtypes

Dexmedetomidine Ameliorates Cognitive and Affective Deficits by Modulating Neuroinflammation and Neurogenesis in an Alzheimer's Disease Mouse Model