Frontiers in Aging | Genetics, Genomics and Epigenomics of Aging

Original Research

Accepted on 03 Feb 2026

Gene–Gene and Gene–Environment Interactions among CYP19A1, ESR1, IL6, IL6R, IL1β, RANK and RANKL variants associated with Osteoporosis and Hip Fracture in Mexican Women

in Genetics, Genomics and Epigenomics of Aging

Antonio Miranda-Duarte
Valeria Ponce de León-Suárez
Alberto Hidalgo Bravo
Rafael Velazquez-Cruz
Esperanza Ramírez-Pérez
O. Celeste Martínez-Ramírez
Clementina Castro-Hernández
Blanca Barredo-Prieto
LEONORA CASAS-AVILA

Frontiers in Aging

107 views

Review

Accepted on 26 Jan 2026

The Tight Bond Between Fanconi Anemia and Aging

in Genetics, Genomics and Epigenomics of Aging

Marco Antonio Mejía-Barrera
Enya Enara Martínez-Torres
Ulises Juárez
Leda Torres
Moisés Ó Fiesco-Roa
Benilde García de Teresa
Juan Carlos Gómez-Verjan
Jorge Melendez-Zajgla
Alfredo Rodríguez
Silvia Sánchez

Frontiers in Aging

259 views

Editorial

Accepted on 23 Jan 2026

Editorial: Insights in Genetics, Genomics and Epigenomics of Aging:2025

in Genetics, Genomics and Epigenomics of Aging

Marcella Reale

Frontiers in Aging

735 views

Original Research

Published on 13 Jan 2026

Sex differences in APOE- and PICALM-related cognitive profiles in healthy middle-aged adults

in Genetics, Genomics and Epigenomics of Aging

Adam Bednorz
Paulina Trybek
Minh Tuan Hoang
Dorota Religa

Frontiers in Aging

doi 10.3389/fragi.2025.1694701

820 views

Original Research

Published on 12 Jan 2026

RNA transcripts in salivary extracellular vesicle cargo isolated from aged populations

in Genetics, Genomics and Epigenomics of Aging

Sicheng Wen
Chang Yu
Maxfield M. G. Kelsey
Mandy Pereira
Hannah Alaimo
Em Teixeira
Jenna Pracht
Lori A. Daiello
Jonathan Drake
John M. Sedivy

Frontiers in Aging

doi 10.3389/fragi.2025.1707720

1,049 views

Review

Published on 04 Dec 2025

The intersection of TREX1, cGAS, STING and the DNA damage theory of aging

in Genetics, Genomics and Epigenomics of Aging

Kate M. Jones
Samuel D. Chauvin
Jonathan J. Miner

Frontiers in Aging

doi 10.3389/fragi.2025.1720372

2,171 views

Brief Research Report

Published on 01 Dec 2025

Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study

in Genetics, Genomics and Epigenomics of Aging

Michael Sayer
Ding Quan Ng
Julia Trudeau
Raymond J. Chan
Munjal M. Acharya
Kord Kober
Alexandre Chan

Frontiers in Aging

doi 10.3389/fragi.2025.1667638

1,795 views

Original Research

Accepted on 21 Nov 2025

Emerging PFAS Contaminants PFNA and PFSA Amplify Epigenetic Aging: Sex-and Age-Stratified Risks in an Aging Population

in Genetics, Genomics and Epigenomics of Aging

Ya-Qian Xu
Chongyu Ding
Hui Zhang
Yulu Gong
Darong Hao
Xuetong Zhao
Kai Li

Frontiers in Aging

932 views

Editorial

Published on 14 Nov 2025

Editorial: Aging epigenome and longevity

in Genetics, Genomics and Epigenomics of Aging

Sandeep Kumar Singh
Burkhard Poeggeler

Frontiers in Aging

doi 10.3389/fragi.2025.1739913

961 views

Original Research

Published on 19 Sep 2025

Aging-dependent skin microbiome alterations across body sites in a United Kingdom cohort

in Genetics, Genomics and Epigenomics of Aging

Mary Hannah Swaney
Duncan J. Newman
Junhong Mao
Anthony C. Hilton
Tony Worthington
Min Li

Frontiers in Aging

doi 10.3389/fragi.2025.1644012

3,654 views
1 citation

Original Research

Published on 12 Sep 2025

Chromogranin a gene variants influence survival at old age through pleiotropic effects on multiple age-related traits

in Genetics, Genomics and Epigenomics of Aging

Paolina Crocco
Rossella La Grotta
Francesco De Rango
Giuseppe Passarino
Serena Dato
Giuseppina Rose

Frontiers in Aging

doi 10.3389/fragi.2025.1625070

2,148 views

Opinion

Published on 18 Aug 2025

The human biological clock and aging—a comprehensive approach integrating reductionism, holism, and geromedicine for proactive healthspan strategies

in Genetics, Genomics and Epigenomics of Aging

Teow J. Phua

Frontiers in Aging

doi 10.3389/fragi.2025.1658952

4,175 views
1 citation

Editorial

Published on 14 Aug 2025

Editorial: Interaction between genes and the environment in skin aging

in Genetics, Genomics and Epigenomics of Aging

Xiaolei Ding
Sigrid Le Clerc

Frontiers in Aging

doi 10.3389/fragi.2025.1671721

1,961 views
1 citation

Original Research

Published on 23 Jul 2025

Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression

in Genetics, Genomics and Epigenomics of Aging

Ludivine Obry
Raissa Medina-Santos
Myriam Rahmouni
Josselin Noirel
Toufik Labib
Pilar Galan
Jean-Louis Spadoni
Gaëlle Gendronneau
Randa Jdid
Sandra Courrèges

Frontiers in Aging

doi 10.3389/fragi.2025.1519799

2,698 views

Mini Review

Published on 13 May 2025

miRNA mediated mitochondrial function and gene regulation associated with Alzheimer’s disease

in Genetics, Genomics and Epigenomics of Aging

Kumudu Subasinghe
Robert Barber
Nicole Phillips

Frontiers in Aging

doi 10.3389/fragi.2025.1582812

2,641 views
2 citations

Editorial

Published on 12 May 2025

Editorial: Mechanistic theories of aging

in Genetics, Genomics and Epigenomics of Aging

John Tower

Frontiers in Aging

doi 10.3389/fragi.2025.1617783

2,072 views

Original Research

Published on 28 Feb 2025

Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age

in Genetics, Genomics and Epigenomics of Aging

Bowen Zhu
Dean Li
Guojing Han
Xue Yao
Hongqin Gu
Tao Liu
Linghua Liu
Jie Dai
Isabella Zhaotong Liu
Yanlin Liang

Frontiers in Aging

doi 10.3389/fragi.2025.1467639

2,813 views
1 citation

Original Research

Published on 23 Jan 2025

Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease

in Genetics, Genomics and Epigenomics of Aging

David Martínez-Enguita
Thomas Hillerton
Julia Åkesson
Daniel Kling
Maria Lerm
Mika Gustafsson

Frontiers in Aging

doi 10.3389/fragi.2024.1526146

5,140 views
1 citation

Review

Published on 06 Jan 2025

DNA methylation, histone acetylation in the regulation of memory and its modulation during aging

in Genetics, Genomics and Epigenomics of Aging

Padmanabh Singh
Vijay Paramanik

Frontiers in Aging

doi 10.3389/fragi.2024.1480932

6,643 views
11 citations

Review

Published on 16 Dec 2024

New insights into methods to measure biological age: a literature review

in Genetics, Genomics and Epigenomics of Aging

Aanchal Mathur
Sebastien Taurin
Sfoug Alshammary

Frontiers in Aging

doi 10.3389/fragi.2024.1395649

13,659 views
14 citations

Review

Published on 13 Dec 2024

Critical review of aging clocks and factors that may influence the pace of aging

in Genetics, Genomics and Epigenomics of Aging

Mildred Min
Caitlin Egli
Ajay S. Dulai
Raja K. Sivamani

Frontiers in Aging

doi 10.3389/fragi.2024.1487260

15,265 views
21 citations

Original Research

Published on 02 Dec 2024

Assessing the utility of epigenetic clocks for health prediction in South Korean

in Genetics, Genomics and Epigenomics of Aging

Dong Jun Kim
Joon Ho Kang
Ji-Woong Kim
Sun bin Kim
Young Kee Lee
Myeong Jae Cheon
Byung-Chul Lee

Frontiers in Aging

doi 10.3389/fragi.2024.1493406

4,728 views
5 citations

Mini Review

Published on 13 Nov 2024

The role of anti-aging approaches in managing hypogonadism in sedentary older males

in Genetics, Genomics and Epigenomics of Aging

Khaled A. Abdel-Sater

Frontiers in Aging

doi 10.3389/fragi.2024.1514438

7,035 views

Original Research

Published on 01 Nov 2024

Telomere length and cognitive changes in 7,877 older UK adults of European ancestry

in Genetics, Genomics and Epigenomics of Aging

Amy Packer
Leena Habiballa
Esteban Tato-Barcia
Gerome Breen
Helen Brooker
Anne Corbett
Ryan Arathimos
Clive Ballard
Adam Hampshire
Abbie Palmer

Frontiers in Aging

doi 10.3389/fragi.2024.1480326

2,956 views

67 articles

articles

Gene–Gene and Gene–Environment Interactions among CYP19A1, ESR1, IL6, IL6R, IL1β, RANK and RANKL variants associated with Osteoporosis and Hip Fracture in Mexican Women

The Tight Bond Between Fanconi Anemia and Aging

Editorial: Insights in Genetics, Genomics and Epigenomics of Aging:2025

Sex differences in APOE- and PICALM-related cognitive profiles in healthy middle-aged adults

RNA transcripts in salivary extracellular vesicle cargo isolated from aged populations

The intersection of TREX1, cGAS, STING and the DNA damage theory of aging

Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study

Emerging PFAS Contaminants PFNA and PFSA Amplify Epigenetic Aging: Sex-and Age-Stratified Risks in an Aging Population

Editorial: Aging epigenome and longevity

Aging-dependent skin microbiome alterations across body sites in a United Kingdom cohort

Chromogranin a gene variants influence survival at old age through pleiotropic effects on multiple age-related traits

The human biological clock and aging—a comprehensive approach integrating reductionism, holism, and geromedicine for proactive healthspan strategies

Editorial: Interaction between genes and the environment in skin aging

Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression

miRNA mediated mitochondrial function and gene regulation associated with Alzheimer’s disease

Editorial: Mechanistic theories of aging

Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age

Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease

DNA methylation, histone acetylation in the regulation of memory and its modulation during aging

New insights into methods to measure biological age: a literature review

Critical review of aging clocks and factors that may influence the pace of aging

Assessing the utility of epigenetic clocks for health prediction in South Korean

The role of anti-aging approaches in managing hypogonadism in sedentary older males

Telomere length and cognitive changes in 7,877 older UK adults of European ancestry