Frontiers in Bioengineering and Biotechnology

Systematic Review

Published on 18 Jun 2021

Clinical Studies and Pre-clinical Animal Models on Facial Nerve Preservation, Reconstruction, and Regeneration Following Cerebellopontine Angle Tumor Surgery–A Systematic Review and Future Perspectives

in Cell and Gene Therapy

Isabel C. Hostettler
Narayan Jayashankar
Christos Bikis
Stefan Wanderer
Edin Nevzati
Ravindran Karuppiah
Vicknes Waran
Daniel Kalbermatten
Luigi Mariani
Serge Marbacher

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.659413

9,448 views
10 citations

Original Research

Published on 09 Jun 2021

Fabrication and Characterization of a Biomaterial Based on Extracellular-Vesicle Functionalized Graphene Oxide

in Cell and Gene Therapy

Julia Driscoll
Anuradha Moirangthem
Irene K. Yan
Tushar Patel

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.686510

5,351 views
10 citations

Original Research

Published on 07 Jun 2021

New Multiscale Characterization Methodology for Effective Determination of Isolation–Structure–Function Relationship of Extracellular Vesicles

in Cell and Gene Therapy

Thanh Huyen Phan
Shiva Kamini Divakarla
Jia Hao Yeo
Qingyu Lei
Priyanka Tharkar
Taisa Nogueira Pansani
Kathryn G. Leslie
Maggie Tong
Victoria A. Coleman
Åsa Jämting

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.669537

24,145 views
11 citations

Original Research

Published on 28 May 2021

Protein Arginine Methyltransferase 5 Promotes Esophageal Squamous Cell Carcinoma Proliferation and Metastasis via LKB1/AMPK/mTOR Signaling Pathway

in Cell and Gene Therapy

Yu-ru Chen
Hua-ni Li
Lian-jun Zhang
Chong Zhang
Jin-guang He

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.645375

4,982 views
14 citations

Original Research

Published on 26 May 2021

A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells

in Cell and Gene Therapy

Aliosha I. Figueroa-Valdés
Catalina de la Fuente
Yessia Hidalgo
Ana María Vega-Letter
Rafael Tapia-Limonchi
Maroun Khoury
Francisca Alcayaga-Miranda

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.619930

15,388 views
24 citations

Original Research

Published on 25 May 2021

Measuring and Modeling Oxygen Transport and Consumption in 3D Hydrogels Containing Chondrocytes and Stem Cells of Different Tissue Origins

in Cell and Gene Therapy

Simon F. Carroll
Conor T. Buckley
Daniel J. Kelly

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.591126

6,481 views
11 citations

Editorial

Published on 24 May 2021

Editorial: Bone and Cartilage Regeneration With Extracellular Vesicles

in Cell and Gene Therapy

Roberta Tasso
Susanne Grässel
Frank Zaucke

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.692836

3,643 views

Review

Published on 13 May 2021

Mesenchymal Stromal Cells and Their Secretome: New Therapeutic Perspectives for Skeletal Muscle Regeneration

in Cell and Gene Therapy

Martina Sandonà
Lorena Di Pietro
Federica Esposito
Alessia Ventura
Antonietta Rosa Silini
Ornella Parolini
Valentina Saccone

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.652970

21,137 views
94 citations

Mini Review

Published on 23 Apr 2021

Is Extracellular Vesicle-Based Therapy the Next Answer for Cartilage Regeneration?

in Cell and Gene Therapy

Émilie Velot
Henning Madry
Jagadeesh K. Venkatesan
Arnaud Bianchi
Magali Cucchiarini

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.645039

10,079 views
23 citations

Brief Research Report

Published on 13 Apr 2021

Raman Fingerprint of Extracellular Vesicles and Conditioned Media for the Reproducibility Assessment of Cell-Free Therapeutics

in Cell and Gene Therapy

Cristiano Carlomagno
Chiara Giannasi
Stefania Niada
Marzia Bedoni
Alice Gualerzi
Anna Teresa Brini

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.640617

7,299 views
27 citations

Review

Published on 30 Mar 2021

The Importance of Proper Oxygenation in 3D Culture

in Cell and Gene Therapy

Hubert M. Tse
Graeme Gardner
Juan Dominguez-Bendala
Christopher A. Fraker

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.634403

15,747 views
46 citations

Review

Published on 18 Mar 2021

The Limitless Future of RNA Therapeutics

in Cell and Gene Therapy

Tulsi Ram Damase
Roman Sukhovershin
Christian Boada
Francesca Taraballi
Roderic I. Pettigrew
John P. Cooke

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.628137

184,378 views
504 citations

Systematic Review

Published on 17 Mar 2021

Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation

in Cell and Gene Therapy

Piers Wilkinson
Ilya Y. Bozo
Thomas Braxton
Peter Just
Elena Jones
Roman V. Deev
Peter V. Giannoudis
Georg A. Feichtinger

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.626315

6,474 views
9 citations

Original Research

Published on 09 Mar 2021

Optimizing Granulocyte Colony-Stimulating Factor Transcript for Enhanced Expression in Escherichia coli

in Cell and Gene Therapy

Sonal Datta

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.630367

7,042 views
3 citations

Original Research

Published on 25 Feb 2021

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells

in Cell and Gene Therapy

Corina A. Ghebes
Jess Morhayim
Marion Kleijer
Merve Koroglu
Stefan J. Erkeland
Remco Hoogenboezem
Eric Bindels
Floris P. J. van Alphen
Maartje van den Biggelaar
Martijn A. Nolte

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.640419

8,020 views
17 citations

Original Research

Published on 15 Feb 2021

miR-103a-3p and miR-22-5p Are Reliable Reference Genes in Extracellular Vesicles From Cartilage, Adipose Tissue, and Bone Marrow Cells

in Cell and Gene Therapy

Enrico Ragni
Alessandra Colombini
Paola De Luca
Francesca Libonati
Marco Viganò
Carlotta Perucca Orfei
Luigi Zagra
Laura de Girolamo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.632440

8,812 views
26 citations

Review

Published on 12 Feb 2021

Increased Mesenchymal Stem Cell Functionalization in Three-Dimensional Manufacturing Settings for Enhanced Therapeutic Applications

in Cell and Gene Therapy

Dimitrios Kouroupis
Diego Correa

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.621748

24,409 views
118 citations

Review

Published on 05 Feb 2021

Extracellular Vesicles From Perinatal Cells for Anti-inflammatory Therapy

in Cell and Gene Therapy

Anna Cargnoni
Andrea Papait
Alice Masserdotti
Anna Pasotti
Francesca Romana Stefani
Antonietta Rosa Silini
Ornella Parolini

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.637737

8,479 views
30 citations

Original Research

Published on 05 Feb 2021

Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells

in Cell and Gene Therapy

Carola Schmitz
Ekaterina Potekhina
Teresa Irianto
Vsevolod V. Belousov
Antonina Lavrentieva

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.611837

12,733 views
48 citations

Original Research

Published on 04 Feb 2021

Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside

in Cell and Gene Therapy

Ilia Y. Bozo
Alexey Y. Drobyshev
Nikolay A. Redko
Vladimir S. Komlev
Artur A. Isaev
Roman V. Deev

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.599300

7,090 views
27 citations

Original Research

Published on 21 Jan 2021

Scalable Production of Equine Platelet Lysate for Multipotent Mesenchymal Stromal Cell Culture

in Cell and Gene Therapy

A. Hagen
H. Lehmann
S. Aurich
N. Bauer
M. Melzer
J. Moellerberndt
V. Patané
C. L. Schnabel
J. Burk

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.613621

7,110 views
22 citations

Review

Published on 20 Jan 2021

Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration

in Cell and Gene Therapy

Marietta Herrmann
Solvig Diederichs
Svitlana Melnik
Jana Riegger
Drenka Trivanović
Shushan Li
Zsuzsa Jenei-Lanzl
Rolf E. Brenner
Markus Huber-Lang
Frank Zaucke

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.624096

10,514 views
39 citations

Original Research

Published on 15 Jan 2021

Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems

in Cell and Gene Therapy

Marline Kirsch
Jessica Rach
Wiebke Handke
Axel Seltsam
Iliyana Pepelanova
Sarah Strauß
Peter Vogt
Thomas Scheper
Antonina Lavrentieva

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.598389

12,898 views
40 citations

Original Research

Published on 15 Jan 2021

Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway

in Cell and Gene Therapy

Chenyu Liang
Yang Liu
Huifeng Xu
Junling Huang
Yi Shen
Faxiu Chen
Ming Luo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.615850

11,270 views
63 citations

319 articles

articles

Clinical Studies and Pre-clinical Animal Models on Facial Nerve Preservation, Reconstruction, and Regeneration Following Cerebellopontine Angle Tumor Surgery–A Systematic Review and Future Perspectives

Fabrication and Characterization of a Biomaterial Based on Extracellular-Vesicle Functionalized Graphene Oxide

New Multiscale Characterization Methodology for Effective Determination of Isolation–Structure–Function Relationship of Extracellular Vesicles

Protein Arginine Methyltransferase 5 Promotes Esophageal Squamous Cell Carcinoma Proliferation and Metastasis via LKB1/AMPK/mTOR Signaling Pathway

A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells

Measuring and Modeling Oxygen Transport and Consumption in 3D Hydrogels Containing Chondrocytes and Stem Cells of Different Tissue Origins

Editorial: Bone and Cartilage Regeneration With Extracellular Vesicles

Mesenchymal Stromal Cells and Their Secretome: New Therapeutic Perspectives for Skeletal Muscle Regeneration

Is Extracellular Vesicle-Based Therapy the Next Answer for Cartilage Regeneration?

Raman Fingerprint of Extracellular Vesicles and Conditioned Media for the Reproducibility Assessment of Cell-Free Therapeutics

The Importance of Proper Oxygenation in 3D Culture

The Limitless Future of RNA Therapeutics

Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation

Optimizing Granulocyte Colony-Stimulating Factor Transcript for Enhanced Expression in Escherichia coli

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells

miR-103a-3p and miR-22-5p Are Reliable Reference Genes in Extracellular Vesicles From Cartilage, Adipose Tissue, and Bone Marrow Cells

Increased Mesenchymal Stem Cell Functionalization in Three-Dimensional Manufacturing Settings for Enhanced Therapeutic Applications

Extracellular Vesicles From Perinatal Cells for Anti-inflammatory Therapy

Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells

Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside

Scalable Production of Equine Platelet Lysate for Multipotent Mesenchymal Stromal Cell Culture

Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration

Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems

Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway