Frontiers in Bioengineering and Biotechnology

Brief Research Report

Published on 13 Apr 2021

Raman Fingerprint of Extracellular Vesicles and Conditioned Media for the Reproducibility Assessment of Cell-Free Therapeutics

in Cell and Gene Therapy

Cristiano Carlomagno
Chiara Giannasi
Stefania Niada
Marzia Bedoni
Alice Gualerzi
Anna Teresa Brini

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.640617

5,967 views
21 citations

Review

Published on 30 Mar 2021

The Importance of Proper Oxygenation in 3D Culture

in Cell and Gene Therapy

Hubert M. Tse
Graeme Gardner
Juan Dominguez-Bendala
Christopher A. Fraker

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.634403

12,631 views
30 citations

Review

Published on 18 Mar 2021

The Limitless Future of RNA Therapeutics

in Cell and Gene Therapy

Tulsi Ram Damase
Roman Sukhovershin
Christian Boada
Francesca Taraballi
Roderic I. Pettigrew
John P. Cooke

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.628137

159,130 views
422 citations

Systematic Review

Published on 17 Mar 2021

Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation

in Cell and Gene Therapy

Piers Wilkinson
Ilya Y. Bozo
Thomas Braxton
Peter Just
Elena Jones
Roman V. Deev
Peter V. Giannoudis
Georg A. Feichtinger

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.626315

5,248 views
6 citations

Original Research

Published on 09 Mar 2021

Optimizing Granulocyte Colony-Stimulating Factor Transcript for Enhanced Expression in Escherichia coli

in Cell and Gene Therapy

Sonal Datta

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.630367

5,905 views
1 citation

Original Research

Published on 25 Feb 2021

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells

in Cell and Gene Therapy

Corina A. Ghebes
Jess Morhayim
Marion Kleijer
Merve Koroglu
Stefan J. Erkeland
Remco Hoogenboezem
Eric Bindels
Floris P. J. van Alphen
Maartje van den Biggelaar
Martijn A. Nolte

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.640419

6,648 views
13 citations

Original Research

Published on 15 Feb 2021

miR-103a-3p and miR-22-5p Are Reliable Reference Genes in Extracellular Vesicles From Cartilage, Adipose Tissue, and Bone Marrow Cells

in Cell and Gene Therapy

Enrico Ragni
Alessandra Colombini
Paola De Luca
Francesca Libonati
Marco Viganò
Carlotta Perucca Orfei
Luigi Zagra
Laura de Girolamo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.632440

7,445 views
21 citations

Review

Published on 12 Feb 2021

Increased Mesenchymal Stem Cell Functionalization in Three-Dimensional Manufacturing Settings for Enhanced Therapeutic Applications

in Cell and Gene Therapy

Dimitrios Kouroupis
Diego Correa

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.621748

19,797 views
85 citations

Original Research

Published on 05 Feb 2021

Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells

in Cell and Gene Therapy

Carola Schmitz
Ekaterina Potekhina
Teresa Irianto
Vsevolod V. Belousov
Antonina Lavrentieva

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.611837

10,545 views
41 citations

Review

Published on 05 Feb 2021

Extracellular Vesicles From Perinatal Cells for Anti-inflammatory Therapy

in Cell and Gene Therapy

Anna Cargnoni
Andrea Papait
Alice Masserdotti
Anna Pasotti
Francesca Romana Stefani
Antonietta Rosa Silini
Ornella Parolini

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.637737

7,037 views
24 citations

Original Research

Published on 04 Feb 2021

Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside

in Cell and Gene Therapy

Ilia Y. Bozo
Alexey Y. Drobyshev
Nikolay A. Redko
Vladimir S. Komlev
Artur A. Isaev
Roman V. Deev

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.599300

5,764 views
24 citations

Original Research

Published on 21 Jan 2021

Scalable Production of Equine Platelet Lysate for Multipotent Mesenchymal Stromal Cell Culture

in Cell and Gene Therapy

A. Hagen
H. Lehmann
S. Aurich
N. Bauer
M. Melzer
J. Moellerberndt
V. Patané
C. L. Schnabel
J. Burk

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.613621

5,504 views
20 citations

Review

Published on 20 Jan 2021

Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration

in Cell and Gene Therapy

Marietta Herrmann
Solvig Diederichs
Svitlana Melnik
Jana Riegger
Drenka Trivanović
Shushan Li
Zsuzsa Jenei-Lanzl
Rolf E. Brenner
Markus Huber-Lang
Frank Zaucke

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.624096

8,458 views
31 citations

Original Research

Published on 15 Jan 2021

Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems

in Cell and Gene Therapy

Marline Kirsch
Jessica Rach
Wiebke Handke
Axel Seltsam
Iliyana Pepelanova
Sarah Strauß
Peter Vogt
Thomas Scheper
Antonina Lavrentieva

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.598389

10,723 views
35 citations

Original Research

Published on 15 Jan 2021

Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway

in Cell and Gene Therapy

Chenyu Liang
Yang Liu
Huifeng Xu
Junling Huang
Yi Shen
Faxiu Chen
Ming Luo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.615850

9,429 views
45 citations

Mini Review

Published on 13 Jan 2021

Non-viral Gene Therapy for Osteoarthritis

in Cell and Gene Therapy

Ilona Uzieliene
Ursule Kalvaityte
Eiva Bernotiene
Ali Mobasheri

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.618399

13,485 views
32 citations

Navigation group

Articles

Raman Fingerprint of Extracellular Vesicles and Conditioned Media for the Reproducibility Assessment of Cell-Free Therapeutics

The Importance of Proper Oxygenation in 3D Culture

The Limitless Future of RNA Therapeutics

Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation

Optimizing Granulocyte Colony-Stimulating Factor Transcript for Enhanced Expression in Escherichia coli

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells

miR-103a-3p and miR-22-5p Are Reliable Reference Genes in Extracellular Vesicles From Cartilage, Adipose Tissue, and Bone Marrow Cells

Increased Mesenchymal Stem Cell Functionalization in Three-Dimensional Manufacturing Settings for Enhanced Therapeutic Applications

Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells

Extracellular Vesicles From Perinatal Cells for Anti-inflammatory Therapy

Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside

Scalable Production of Equine Platelet Lysate for Multipotent Mesenchymal Stromal Cell Culture

Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration

Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems

Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway

Non-viral Gene Therapy for Osteoarthritis