Frontiers in Bioengineering and Biotechnology | Organoids and Organ-On-A-Chip

Review

Accepted on 04 Jul 2025

Bridging the Gap: The Role of 3D Cell Cultures in Mimicking Tumor Microenvironment for Enhanced Drug Testing Accuracy

in Organoids and Organ-On-A-Chip

Yan Zhou
Fei-Yuan Yu
Min Guo
Yao Tang
Qian Xu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1498141

118 views

Review

Accepted on 30 Jun 2025

Organoid scaffold materials：research and application

in Organoids and Organ-On-A-Chip

Ziwei Zhang
Maoshu Zhu
Haiqing Luo
Zq Q
Fanwei Zeng

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1637456

178 views

Original Research

Published on 25 Jun 2025

Development and application of a stepwise-assembled modular biomimetic lung chip for analyzing formaldehyde-induced cellular ferroptosis

in Organoids and Organ-On-A-Chip

Siyu Chen
Zezhi Li
Quanping Yan
Chenfeng Hua
Pingping Shang
Kejian Liu
Junwei Zhao
Guangxiang Jin
Xiang Li
Fuwei Xie

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1570270

692 views

Methods

Published on 12 Jun 2025

Methods for processing and analyzing images of vascularized micro-organ and tumor systems

in Organoids and Organ-On-A-Chip

Stephanie J. Hachey
Christopher J. Hatch
Daniela Gaebler
Alexander G. Forsythe
Makena L. Ewald
Alexander L. Chopra
Zhangying Chen
Kapil Thapa
Melvin Hodanu
Jennifer S. Fang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1585003

1,092 views

Perspective

Published on 11 Jun 2025

More than just life and death: advances in imaging and analysis for 3D-bioprinted tissues

in Organoids and Organ-On-A-Chip

Erin R. Spiller
Daniela F. Duarte Campos

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1600077

1,107 views

Original Research

Accepted on 30 May 2025

Lung-Resident SARS-CoV-2 Peptide-Specific Immune Responses in Perfused 3D Human Lung Explant Models

in Organoids and Organ-On-A-Chip

Kayla Goliwas
Anthony Wood
Scott Simmons
Saad A Khan
Rabisa Khan
Yong Wang
Rekha Ramachandran
Joel Berry
Mohammad Athar
James Mobley

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1587080

335 views

Mini Review

Published on 17 Apr 2025

Developments in gastrointestinal organoid cultures to recapitulate tissue environments

in Organoids and Organ-On-A-Chip

Madeline R. Kuhn
Emma A. Wolcott
Ellen M. Langer

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1521044

1,918 views
1 citation

Original Research

Published on 09 Apr 2025

A hybrid computational model of cancer spheroid growth with ribose-induced collagen stiffening

in Organoids and Organ-On-A-Chip

Margherita Botticelli
John Metzcar
Thomas Phillips
Susan Cox
Pradeep Keshavanarayana
Fabian Spill

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1515962

1,594 views

Review

Published on 01 Apr 2025

Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier

in Organoids and Organ-On-A-Chip

Nina Truong
Abir Zahra
Ryan C. V. Lintao
Rahul Chauhan
Giovana Fernanda Bento
Manuel Vidal Jr.
Sungjin Kim
Po Yi Lam
Thomas Conrads
Kelly Conrads

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1568389

2,301 views

Review

Published on 31 Mar 2025

Host-microbe-cancer interactions on-a-chip

in Organoids and Organ-On-A-Chip

Mauricio G. C. Sousa
Danielle S. K. Brasino
Madeline Krieger
Duygu A. Dindar
Rebekka Duhen
Zhenzhen Zhang
Cristiane Miranda Franca
Luiz E. Bertassoni

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1505963

2,263 views

Perspective

Published on 20 Mar 2025

Bioengineering ethics for the age of microphysiological systems

in Organoids and Organ-On-A-Chip

Maxence Gaillard

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1497060

1,075 views

Review

Published on 11 Mar 2025

Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling

in Organoids and Organ-On-A-Chip

Lito Papamichail
Lena S. Koch
Devin Veerman
Kerensa Broersen
Andries D. van der Meer

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1515340

5,308 views
2 citations

Mini Review

Published on 27 Jan 2025

In silico modelling of organ-on-a-chip devices: an overview

in Organoids and Organ-On-A-Chip

Yue Wang
Lucia Marucci
Martin E. Homer

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1520795

2,466 views

Review

Published on 07 Jan 2025

The utilisation of biliary organoids for biomedical applications

in Organoids and Organ-On-A-Chip

Zhongwen Lei
Yijun Yang
Yang Xiang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1501829

1,975 views
1 citation

Review

Published on 07 Jan 2025

Microfluidic organ-on-chip systems for periodontal research: advances and future directions

in Organoids and Organ-On-A-Chip

Gopu Sriram
Hardik Makkar

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1490453

3,400 views
1 citation

Methods

Published on 18 Dec 2024

Rapid and reproducible generation of glioblastoma spheroids for high-throughput drug screening

in Organoids and Organ-On-A-Chip

Christian Bach
Annegret Glasow
Rainer Baran-Schmidt
Henry Oppermann
Christoph Bach
Jürgen Meixensberger
Erdem Güresir
Frank Gaunitz

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1471012

2,060 views