Frontiers in Bioinformatics | Integrative Bioinformatics

Original Research

Published on 26 Jun 2025

Identification of immune and major depressive disorder-related diagnostic markers for early nonalcoholic fatty liver disease by WGCNA and machine learning

in Integrative Bioinformatics

Yuyun Jia
Yanping Cao
Qin Yin
Xueqian Li
Xiu Wen

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1594971

306 views

Original Research

Published on 25 Jun 2025

Integrated single-cell and bulk RNA dequencing to identify and validate prognostic genes related to T Cell senescence in acute myeloid leukemia

in Integrative Bioinformatics

Mengyao Sha
Jun Chen
Haifeng Hou
Huaihui Dou
Yan Zhang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1606284

301 views

Original Research

Published on 18 Jun 2025

Temporal GeneTerrain: advancing precision medicine through dynamic gene expression visualization

in Integrative Bioinformatics

Ehsan Saghapour
Rahul Sharma
Delower Hossain
Kevin Song
Zhandos Sembay
Jake Y. Chen

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1602850

670 views

Original Research

Accepted on 17 Jun 2025

Using Deep Neural Networks and LASSO Regression to Predict miRNA Expression Changes Based on mRNA Data

in Integrative Bioinformatics

Franz Leonard Böge
Helena U Zacharias
Stefanie Christine Becker
Klaus Jung

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1566162

224 views

Original Research

Published on 19 May 2025

Integrative multi-omics study identifies sex-specific molecular signatures and immune modulation in bladder cancer

in Integrative Bioinformatics

Yizhou Wang
Priyanka Bhandary
Kevin Griffin
Jason H. Moore
Xue Li
Zhiping Paul Wang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1575790

1,480 views

Original Research

Accepted on 13 May 2025

NeSyDPP4-QSAR: Discovering DPP-4 Inhibitors for Diabetes Treatment with a Neuro-symbolic AI Approach

in Integrative Bioinformatics

Delower Hossain
Ehsan Saghapour
Jake Y Chen

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1603133

386 views

Original Research

Published on 28 Mar 2025

Identification of key hub genes in pancreatic ductal adenocarcinoma: an integrative bioinformatics study

in Integrative Bioinformatics

Kankana Bhattacharjee
Avik Sengupta
Rahul Kumar
Aryya Ghosh

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1536783

1,646 views

Review

Published on 24 Feb 2025

Reliable machine learning models in genomic medicine using conformal prediction

in Integrative Bioinformatics

Christina Papangelou
Konstantinos Kyriakidis
Pantelis Natsiavas
Ioanna Chouvarda
Andigoni Malousi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1507448

2,529 views
1 citation

Original Research

Published on 28 Jan 2025

DNA methylation biomarker analysis from low-survival-rate cancers based on genetic functional approaches

in Integrative Bioinformatics

Yi-Hsuan Tsai
Prasenjit Mitra
David Taniar
Tun-Wen Pai

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1523524

1,502 views

Methods

Published on 23 Jan 2025

A novel lossless encoding algorithm for data compression–genomics data as an exemplar

in Integrative Bioinformatics

Anas Al-okaily
Abdelghani Tbakhi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2024.1489704

1,278 views

Original Research

Published on 15 Jan 2025

Developing a ceRNA-based lncRNA-miRNA-mRNA regulatory network to uncover roles in skeletal muscle development

in Integrative Bioinformatics

Wang Wenlun
Yu Chaohang
Huang Yan
Li Wenbin
Zhou Nanqing
Hu Qianmin
Wu Shengcai
Yuan Qing
Yu Shirui
Zhang Feng

Frontiers in Bioinformatics

doi 10.3389/fbinf.2024.1494717

2,575 views

Brief Research Report

Published on 09 Jan 2025

Detection of reproducible liver cancer specific ligand-receptor signaling in blood

in Integrative Bioinformatics

Aram Safrastyan
Damian Wollny

Frontiers in Bioinformatics

doi 10.3389/fbinf.2024.1332782

1,150 views

Editorial

Published on 07 Jan 2025

Editorial: Multi-omics approaches in the study of human disease mechanisms

in Integrative Bioinformatics

Dapeng Wang
Giuseppe Agapito

Frontiers in Bioinformatics

doi 10.3389/fbinf.2024.1546680

1,612 views
1 citation

Technology and Code

Published on 20 Dec 2024

PRONAME: a user-friendly pipeline to process long-read nanopore metabarcoding data by generating high-quality consensus sequences

in Integrative Bioinformatics

Benjamin Dubois
Mathieu Delitte
Salomé Lengrand
Claude Bragard
Anne Legrève
Frédéric Debode

Frontiers in Bioinformatics

doi 10.3389/fbinf.2024.1483255

4,007 views
2 citations

Original Research

Published on 04 Oct 2024

Discovery of plasma biomarkers related to blood-brain barrier dysregulation in Alzheimer’s disease

in Integrative Bioinformatics

Yuet Ruh Dan
Keng-Hwee Chiam

Frontiers in Bioinformatics

doi 10.3389/fbinf.2024.1463001

3,057 views

Editorial

Published on 09 Aug 2024

Editorial: Big data and artificial intelligence for genomics and therapeutics – Proceedings of the 19th Annual Meeting of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS)

in Integrative Bioinformatics

Huixiao Hong
Inimary Toby-Ogundeji
Robert J. Doerksen
Zhaohui Steve Qin

Frontiers in Bioinformatics

doi 10.3389/fbinf.2024.1470107

1,304 views