Frontiers in Bioinformatics

Original Research

Published on 13 Feb 2026

Unveiling the potential of apigenin and kaempferol against colon cancer: an integrated network pharmacology and docking approach

Anushya Selvakumar
Perpetual Ansel Chandran
Sai Shraddha
Loganathan Chandramani Priya Dharshini
Sarath Perumal
Ramanathan Karuppasamy
Abul Kalam Azad Mandal

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1702572

282 views

Perspective

Published on 13 Feb 2026

From signal overload to shared insight: creating and structuring scientific visuals for comprehension and dialogue

Joost M. Bakker
Dirma Janse
Martijn van Overbruggen
Maarten C. A. van der Sanden

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1752027

277 views

Original Research

Accepted on 12 Feb 2026

SHACLens: A Visualization Workflow for SHACL Violation Exploration in Knowledge Graphs

Christian Alexander Steinparz
Andreas Hinterreiter
Labinot Bajraktari
Vitaly Sedlyarov
Markus J. Bauer
Thomas Zichner
Marc Streit

Frontiers in Bioinformatics

Methods

Published on 12 Feb 2026

Label-free TIMING: an efficient, reliable and scalable AI workflow for automated profiling of cell-cell interaction behaviors in nanowell arrays

Anuj S. Todkar
Shyam Reddy Kotha
Lin Bai
Saikiran Mandula
Hannah B. Wilson
Daniel D. Meyer
Rebecca Berdeaux
Badrinath Roysam
Navin Varadarajan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1711797

695 views

Editorial

Accepted on 11 Feb 2026

Editorial: Integrating Machine Learning and AI in Biological Research: Unraveling Complexities and Driving Advancements

Inimary Toby-Ogundeji
Bindu Nanduri

Frontiers in Bioinformatics

107 views

Original Research

Accepted on 09 Feb 2026

From Clinical Phenotypes to Genomic Signatures: Machine Learning Integration for Precision Tuberculosis Treatment Prediction

Li-Ping Li
Huanqing Liu
Qian Lei
Tingting Li

Frontiers in Bioinformatics

457 views

Original Research

Accepted on 09 Feb 2026

Network pharmacology refined with non-ubiquity and decoy-controlled molecular docking reveals insights into Moringa oleifera phytochemicals targeting insulin resistance

Armi Katrina Santos-Enriquez
Fabian Dayrit
Armando Jerome Jr. De Jesus
Nina Rosario L. Rojas

Frontiers in Bioinformatics

104 views

Original Research

Accepted on 04 Feb 2026

Bioinformatics Strategies and Biomarker Refinement using High-Throughput Transcriptome Data in Transplantation

Paul Keown
Karen Sherwood
Franz Fenninger
Robert Balshaw
Andreas Scherer
Zsuzsanna Hollander
Raymond Ng
Janet Wilson-McManus1
Robert McMaster
Bruce McManus

Frontiers in Bioinformatics

134 views

Original Research

Published on 04 Feb 2026

Evaluating transcriptomic integration for cyanobacterial constraint-based metabolic modelling

Thomas Pugsley
Guy Hanke
Christopher D. P. Duffy

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1715377

455 views

Original Research

Accepted on 03 Feb 2026

A Toolkit for Generating Virtual Brightfield Images of Histological and Immunohistochemical Stains from Multiplexed Data with AI-Based Channel Selection and Image Enhancement

Tristan Whitmarsh
Mohammad Al Sa’d
Eduardo Gonzalez-Solares
Alireza Molaeinezhad
Melis Irfan
Claire Mulvey
Marta Paez-Ribes
Atefeh Fatemi
Wei Cope
Kui Hua

Frontiers in Bioinformatics

149 views

Original Research

Accepted on 03 Feb 2026

Machine Learning Identifies Molecular Targets of Di(2-ethylhexyl) Phthalate in Pulmonary Arterial Hypertension

Jijia LI
Hua LI
Yingchun Jiang

Frontiers in Bioinformatics

112 views

Review

Accepted on 03 Feb 2026

Artificial Intelligence in Drug Discovery from Advanced Molecular Representation to Pipeline Applications

Weijing Tao
Xiaoyu Zhou

Frontiers in Bioinformatics

184 views

Original Research

Accepted on 03 Feb 2026

Identification of key genes in chickpea transcriptomics and the development of ChickpeaOmicsR as a comprehensive resource to advance breeding and genomic studies

Alsamman M. Alsamman
Khaled H. Mousa
Asmaa E. Abd El-Hak
Doaa A. Korkar A. Korkar
Anas M. Saedwi
Sandy Khaled
Al-Sayed Al-Soudy
Achraf El Allali
Zakaria Kehel
Morad M. Mokhtar

Frontiers in Bioinformatics

134 views

Original Research

Published on 03 Feb 2026

GPXplore: an intelligent computational framework for precise gene promoter extraction

Shruti Godara
Samarth Godara
Shbana Begam
Anil Kumar Singh

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1740722

306 views

Original Research

Accepted on 02 Feb 2026

Machine Learning for N-Dimensional Spatial Reasoning Tasks on the Web

Blake Moody
JieHyun Kim
Sanghyuk Kim
Daniel Haehn

Frontiers in Bioinformatics

116 views

Original Research

Accepted on 30 Jan 2026

Generative AI in Drug Repurposing and Biomarker Discovery: A Multimodal Approach

EMERSON RAJA JOSEPH
Saranya K
Kalaiarasi Professor

Frontiers in Bioinformatics

294 views

Original Research

Accepted on 29 Jan 2026

ZR2ViM: A Recursive Vision Mamba Model for Boundary-Preserving Medical Image Segmentation

Caijian Hua
Caorong Xiang
Liuying Li
Xia Zhou

Frontiers in Bioinformatics

191 views

Original Research

Accepted on 29 Jan 2026

Integrating Trajectory Inference and Self-Explainable Predictive Models to Explore Cell State Transitions in Breast Cancer at Single-Cell Resolution

Vanessa Verrina
Marianna Talia
Eugenio Cesario
Santina Capalbo
Domenica Scordamaglia
Rosamaria Lappano
Anna Maria Miglietta
Marcello Maggiolini
Sabrina Giordano

Frontiers in Bioinformatics

160 views

Original Research

Published on 29 Jan 2026

IRMKD: an application of instance relation matrix in plant disease recognition

Jinqing Huang
Jian Su
Tengfei Cheng

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1761574

294 views

Original Research

Published on 29 Jan 2026

Benchmarking multiple gene ontology enrichment tools reveals high biological significance, ranking, and stringency heterogeneity among datasets

Fábio Henrique Schuster de Oliveira
Felipe Acker Gomes
Bruno César Feltes

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1755664

865 views

Technology and Code

Accepted on 28 Jan 2026

Chart Builder: An Interactive Tool for User Driven Data Visualization in the Electron Microscopy Data Bank

Neli José Da Fonseca Júnior
Amudha Kumari Duraisamy
Zhe Wang
Sriram Somasundharam
Minoosadat Tayebinia
Lucas C. de Oliveira
Miao Ma
Jack Turner
Ardan Patwardhan
Gerard J. Kleywegt

Frontiers in Bioinformatics

151 views

Original Research

Accepted on 28 Jan 2026

An Efficient Computational Chemistry Approach to Generating Negative Data for Drug Discovery Pipeline Validation

Stefan Ivanov

Frontiers in Bioinformatics

165 views

Original Research

Accepted on 28 Jan 2026

SimpleKANSleepNet: A Kolmogorov–Arnold Network based Sleep Stage Classification Method

Xiaopeng Ji
Lei Wang
Yong Zhou

Frontiers in Bioinformatics

166 views

Original Research

Accepted on 28 Jan 2026

Computational Discovery of SARS-CoV-2 viral entry Inhibitors Peptides from Androctonus mauretanicus Scorpion Venom: Molecular Docking and Dynamics Simulations Targeting the Protein Spike S

REDA CHAHIR
Salaheddine Redouane
Jacob Galan
Hicham Hboub
Lahoussaine Aserrar
Salma Chakir
Ahmed Salim Lahlou
Hinde Aassila
Rachid El Fatimy
Naoual Oukkache

Frontiers in Bioinformatics

407 views

28 Publications

volumes

Unveiling the potential of apigenin and kaempferol against colon cancer: an integrated network pharmacology and docking approach

From signal overload to shared insight: creating and structuring scientific visuals for comprehension and dialogue

SHACLens: A Visualization Workflow for SHACL Violation Exploration in Knowledge Graphs

Label-free TIMING: an efficient, reliable and scalable AI workflow for automated profiling of cell-cell interaction behaviors in nanowell arrays

Editorial: Integrating Machine Learning and AI in Biological Research: Unraveling Complexities and Driving Advancements

From Clinical Phenotypes to Genomic Signatures: Machine Learning Integration for Precision Tuberculosis Treatment Prediction

Network pharmacology refined with non-ubiquity and decoy-controlled molecular docking reveals insights into Moringa oleifera phytochemicals targeting insulin resistance

Bioinformatics Strategies and Biomarker Refinement using High-Throughput Transcriptome Data in Transplantation

Evaluating transcriptomic integration for cyanobacterial constraint-based metabolic modelling

A Toolkit for Generating Virtual Brightfield Images of Histological and Immunohistochemical Stains from Multiplexed Data with AI-Based Channel Selection and Image Enhancement

Machine Learning Identifies Molecular Targets of Di(2-ethylhexyl) Phthalate in Pulmonary Arterial Hypertension

Artificial Intelligence in Drug Discovery from Advanced Molecular Representation to Pipeline Applications

Identification of key genes in chickpea transcriptomics and the development of ChickpeaOmicsR as a comprehensive resource to advance breeding and genomic studies

GPXplore: an intelligent computational framework for precise gene promoter extraction

Machine Learning for N-Dimensional Spatial Reasoning Tasks on the Web

Generative AI in Drug Repurposing and Biomarker Discovery: A Multimodal Approach

ZR2ViM: A Recursive Vision Mamba Model for Boundary-Preserving Medical Image Segmentation

Integrating Trajectory Inference and Self-Explainable Predictive Models to Explore Cell State Transitions in Breast Cancer at Single-Cell Resolution

IRMKD: an application of instance relation matrix in plant disease recognition

Benchmarking multiple gene ontology enrichment tools reveals high biological significance, ranking, and stringency heterogeneity among datasets

Chart Builder: An Interactive Tool for User Driven Data Visualization in the Electron Microscopy Data Bank

An Efficient Computational Chemistry Approach to Generating Negative Data for Drug Discovery Pipeline Validation

SimpleKANSleepNet: A Kolmogorov–Arnold Network based Sleep Stage Classification Method

Computational Discovery of SARS-CoV-2 viral entry Inhibitors Peptides from Androctonus mauretanicus Scorpion Venom: Molecular Docking and Dynamics Simulations Targeting the Protein Spike S