Frontiers in Cardiovascular Medicine | Cardiovascular Genetics and Systems Medicine

Review

Accepted on 09 Feb 2026

Autophagy, Telomerase, and Endothelial Dysfunction in COVID-19–Induced Cardiac Injury: An Evidence-Graded Genetic and Epigenetic Synthesis

in Cardiovascular Genetics and Systems Medicine

Hari Om Singh
Gaurav Tripathi
Abdul Arif Khan
Amita Verma
Anchal Anchal

Frontiers in Cardiovascular Medicine

Original Research

Accepted on 04 Feb 2026

Characterization of the R893C NaV1.5 mutation in Brugada Syndrome

in Cardiovascular Genetics and Systems Medicine

Szabolcs Gaal
Beata Meszaros
Julianna Volko
Noemi Bilakovics
Umair Naseem Muhammad
Zoltán Pethő
Gabor Sandorfi
Gabor Menko
Orsolya Voros
Istvan Balogh

Frontiers in Cardiovascular Medicine

154 views

Case Report

Published on 30 Jan 2026

POEMS syndrome with cardiovascular lesions as the initial manifestation: a case report and literature review

in Cardiovascular Genetics and Systems Medicine

Xiuwei Tan
Gaowei Fan
Jiateng Yao
Changwei Lu
Zhaojie Qin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1716667

405 views

Review

Accepted on 23 Jan 2026

Broadening Horizons: New Links Between Cilia and Heart Development and Disease

in Cardiovascular Genetics and Systems Medicine

Wenqi Ma
Zhuofeng Zhang
Yun Ma
Chengxu Ma

Frontiers in Cardiovascular Medicine

129 views

Original Research

Published on 23 Jan 2026

Clinically validated immune-related gene markers and molecular subtypes in acute myocardial infarction revealed by peripheral blood transcriptomics

in Cardiovascular Genetics and Systems Medicine

Qingquan Zhang
Mingyan Yu
Peiran Xu
Louyuan Xu
Zhe Wang
Liang Chen
Koulong Zheng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1643959

440 views

Review

Published on 19 Jan 2026

Next generation sequencing in dilated cardiomyopathy: utility and challenges in the African context

in Cardiovascular Genetics and Systems Medicine

Minenhle Mayisela
Dineo Mpanya
Umar G. Adamu
Phelelani T. Mpangase
Zané Lombard
Joel Amoni
Nonkanyiso Mboweni
Nqoba Tsabedze

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1717936

715 views

Original Research

Published on 14 Jan 2026

Bioinformatics analyses reveal the autophagy-related feature biomarkers in dilated cardiomyopathy with heart failure

in Cardiovascular Genetics and Systems Medicine

Jiayu Ren
Zhihan Li
Yue Wang
Ying Wang
Jing Li

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1692768

647 views

Original Research

Published on 12 Jan 2026

Construction of a competitive endogenous RNA network and identification of potential regulatory axes in hypertrophic cardiomyopathy

in Cardiovascular Genetics and Systems Medicine

Rui Gao
Meilin Liu
Haoyi Yang
Lingfeng Zha
Ni Xia

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1552060

705 views

Original Research

Published on 12 Jan 2026

Hsa_circ_0005623 is an indicator for pulmonary artery hypertension associated with congenital heart disease

in Cardiovascular Genetics and Systems Medicine

Yuanhao Zhang
Yan Han
Zirui Sun
Weizhen Xing
Hao Tang
Chuanyu Gao
Yu Han

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1561069

918 views

Case Report

Published on 05 Jan 2026

A case report of a Chinese patient with obstructive hypertrophic cardiomyopathy harboring rare variants in both the MYBPC3 and DSP genes

in Cardiovascular Genetics and Systems Medicine

Xiao-Yuan Wu
Ning Ren
Jie Geng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1630263

718 views

Original Research

Published on 02 Jan 2026

A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction

in Cardiovascular Genetics and Systems Medicine

Ying-Ying Ji
Yang Wu
Ji Sun
Xiao-Xiong Lin
Xu-Miao Chen
Cheng-Cheng Ji
Li-Juan Liu
Yun-Jiu Cheng
Su-Hua Wu

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1691585

1,273 views

Case Report

Published on 18 Dec 2025

Case Report: Lethal neonatal hypertrophic cardiomyopathy from compound heterozygous MYBPC3 variants

in Cardiovascular Genetics and Systems Medicine

Jianying Wang
Lingye Hong
Yao Li
Zhengrong Mao
Yuefeng Zhu
Ming Qi
Ren Zhou
Xutao Hong

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1726463

1,004 views

Original Research

Published on 15 Dec 2025

Identification of arachidonic acid metabolism-related diagnostic markers in heart failure based on bioinformatics analysis and machine learning

in Cardiovascular Genetics and Systems Medicine

Saiqing Chen
Chunxia Zhang
Yueting Yu

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1625064

1,071 views

Case Report

Published on 20 Nov 2025

Severe cardiac valvular calcification in two Chinese brothers with mandibuloacral dysplasia type A: a case report

in Cardiovascular Genetics and Systems Medicine

Yi Guo
Xinyi Zhang
Yanfei Meng
Qiuzhe Guo
Xiaoqi Wang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1657197

1,313 views

Original Research

Published on 20 Nov 2025

Combining WGCNA and machine learning to identify mechanisms and biomarkers of hyperthyroidism and atrial fibrillation

in Cardiovascular Genetics and Systems Medicine

Linyuan Wang
Kun Yang
Ruilong Kang
Pengbo Liu
Yongzhi Deng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1694255

1,150 views

Original Research

Published on 19 Nov 2025

Single cell RNA sequencing reveals a dysbalance of proinflammatory vs. immunosuppressive dendritic cells in mouse and human aortic aneurysms

in Cardiovascular Genetics and Systems Medicine

Yi Ran
Jingpu Zhu
Ting Sun
Yixin Zhang
Chuankai Zhang
Yutao Li
Zhipeng Li
Shu Wang
Liping Li
Junjie Zheng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1713030

1,444 views

Case Report

Published on 11 Nov 2025

Case Report: A novel TTN gene variant and a concurrent rare COL4A4 gene variant in a Chinese patient with dilated cardiomyopathy

in Cardiovascular Genetics and Systems Medicine

Shan Han
Ying-Yi Zhang
Jie Geng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1668842

1,089 views

Original Research

Published on 03 Nov 2025

The analysis reveals novel hub genes and pathways associated with Tetralogy of Fallot

in Cardiovascular Genetics and Systems Medicine

Heling Wen
Zheng Huang
Yujie Mao
Wenjie Tian
Lei Peng
Yu Chen

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1604939

1,095 views

Original Research

Published on 15 Oct 2025

Comprehensive analysis of m6A methylated modification of fibrotic atria in rats induced by chronic intermittent hypoxia

in Cardiovascular Genetics and Systems Medicine

Tao Geng
Shiyu Qi
Xuan Cao
Jiao Li
Xiaodong Xia
Tianshu Gu
Hualing Wang
Pengyu Sun
Siyu Guan
Wenfeng Shangguan

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1670859

1,485 views

Case Report

Published on 08 Oct 2025

A novel LAMP2 initiation codon mutation causes Danon Disease: a case report

in Cardiovascular Genetics and Systems Medicine

Qingchuan Li
Zhihong Sun
Zeping Qiu
Yanjia Chen
Wei Jin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1699732

1,864 views

Case Report

Published on 07 Oct 2025

Case Report: Novel combinatorial factors in the WNT pathway in a pediatric case of valvular aortic stenosis from Lebanon: a brief report

in Cardiovascular Genetics and Systems Medicine

Wiam Ataya
Fathima Mohammed
Mariam Arabi
Fadi Bitar
Georges Nemer

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1614666

1,373 views

Original Research

Published on 01 Oct 2025

C5L2 gene polymorphisms and their functional interaction with metabolic-inflammatory networks in T2DM-associated CHD: insights from an integrative genetic and clinical analysis in a Chinese population

in Cardiovascular Genetics and Systems Medicine

Mengjia Liu
Fen Liu
Dilihumaer Abulaiti
Juan Yang
Yating Wang
Meng Ye
Taotao Jia
Ying Gao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1629294

9,903 views

Original Research

Published on 24 Sep 2025

Genetic relationship between Sjögren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis

in Cardiovascular Genetics and Systems Medicine

Yunanji Zhou
Hao Xiong
Qinghua Luo
Zhaohui Ding
Jun He
Lihua Wang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1554991

2,357 views

Original Research

Published on 17 Sep 2025

Integrative transcriptomic analysis reveals diagnostic biomarkers for comorbidity of coronary artery disease and obstructive sleep apnea

in Cardiovascular Genetics and Systems Medicine

Qingquan Liu
Xiaoyu Chen
Shuhan Chen
Hongzhi Gao
Meiting He
Yingting Shi
Mingzhu Zhao
Liying Yu
Huili Lin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1658016

2,519 views

511 articles

articles

Autophagy, Telomerase, and Endothelial Dysfunction in COVID-19–Induced Cardiac Injury: An Evidence-Graded Genetic and Epigenetic Synthesis

Characterization of the R893C NaV1.5 mutation in Brugada Syndrome

POEMS syndrome with cardiovascular lesions as the initial manifestation: a case report and literature review

Broadening Horizons: New Links Between Cilia and Heart Development and Disease

Clinically validated immune-related gene markers and molecular subtypes in acute myocardial infarction revealed by peripheral blood transcriptomics

Next generation sequencing in dilated cardiomyopathy: utility and challenges in the African context

Bioinformatics analyses reveal the autophagy-related feature biomarkers in dilated cardiomyopathy with heart failure

Construction of a competitive endogenous RNA network and identification of potential regulatory axes in hypertrophic cardiomyopathy

Hsa_circ_0005623 is an indicator for pulmonary artery hypertension associated with congenital heart disease

A case report of a Chinese patient with obstructive hypertrophic cardiomyopathy harboring rare variants in both the MYBPC3 and DSP genes

A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction

Case Report: Lethal neonatal hypertrophic cardiomyopathy from compound heterozygous MYBPC3 variants

Identification of arachidonic acid metabolism-related diagnostic markers in heart failure based on bioinformatics analysis and machine learning

Severe cardiac valvular calcification in two Chinese brothers with mandibuloacral dysplasia type A: a case report

Combining WGCNA and machine learning to identify mechanisms and biomarkers of hyperthyroidism and atrial fibrillation

Single cell RNA sequencing reveals a dysbalance of proinflammatory vs. immunosuppressive dendritic cells in mouse and human aortic aneurysms

Case Report: A novel TTN gene variant and a concurrent rare COL4A4 gene variant in a Chinese patient with dilated cardiomyopathy

The analysis reveals novel hub genes and pathways associated with Tetralogy of Fallot

Comprehensive analysis of m6A methylated modification of fibrotic atria in rats induced by chronic intermittent hypoxia

A novel LAMP2 initiation codon mutation causes Danon Disease: a case report

Case Report: Novel combinatorial factors in the WNT pathway in a pediatric case of valvular aortic stenosis from Lebanon: a brief report

C5L2 gene polymorphisms and their functional interaction with metabolic-inflammatory networks in T2DM-associated CHD: insights from an integrative genetic and clinical analysis in a Chinese population

Genetic relationship between Sjögren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis

Integrative transcriptomic analysis reveals diagnostic biomarkers for comorbidity of coronary artery disease and obstructive sleep apnea