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Original Research

Published on 24 Oct 2024

Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultrafiltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability study in uremic hemodialysis patients

in Cardiovascular Pharmacology and Drug Discovery

  • Ming-Chen Cao
  • Xin Huang
  • Bo-Hao Tang
  • Hai-Yan Shi
  • Yi Zheng
  • Wei Zhao
Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultrafiltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability study in uremic hemodialysis patients
Frontiers in Cardiovascular Medicine
doi 10.3389/fcvm.2024.1461181
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