Frontiers in Cardiovascular Medicine | Cardiovascular Pharmacology and Drug Discovery

Original Research

Accepted on 29 Dec 2025

Network Pharmacological Analysis, Mendelian Randomization Analysis and Animal Experimental reveal the mechanism of Wenxin Granules in inhibiting heart failure after myocardial infarction: Apoptosis and Inflammation

in Cardiovascular Pharmacology and Drug Discovery

Fuyuan Zhang
Baohua Li
Ruikang Liu
Yiying Liu
Xuanchun Huang
Jun Li

Frontiers in Cardiovascular Medicine

Original Research

Accepted on 18 Dec 2025

Protosappanin A protects against pathological cardiac hypertrophy by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis via activation of the Nrf2 signaling pathway

in Cardiovascular Pharmacology and Drug Discovery

Qing He
Yun Zheng
Xiaoli Yan
Shanshan Lv
Bo Yu

Frontiers in Cardiovascular Medicine

174 views

Brief Research Report

Accepted on 15 Dec 2025

Plasma Pharmacokinetic of the combination of potassium chloride extended-release tablets and potassium citrate granules in patients with cardiovascular emergencies

in Cardiovascular Pharmacology and Drug Discovery

Xinmei Li
Minghong Qu
Haizhi Li
Te Li

Frontiers in Cardiovascular Medicine

149 views

Original Research

Accepted on 09 Dec 2025

Helianthus Annuus L. Ameliorates Atherosclerosis-Induced Myocardial Infarction via inhibiting inflammation and oxidative stress

in Cardiovascular Pharmacology and Drug Discovery

Mengjue Li
Jianbing Wang
Lina Chen
Shenqing Cui
Bowen Jiang
Haoran Sun
Yunxia Zhu

Frontiers in Cardiovascular Medicine

194 views

Review

Published on 09 Dec 2025

Cardiovascular safety pharmacology: beyond arrhythmic risk assessment

in Cardiovascular Pharmacology and Drug Discovery

Raafat Fares
Pascal Champéroux

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1623644

584 views

Clinical Trial

Published on 08 Dec 2025

Assessing the cardiovascular and potassium lowering effects of levalbuterol compared to albuterol: a randomized control trial

in Cardiovascular Pharmacology and Drug Discovery

Baraa Shebli
Mike Ghabally
Muhammad Besher Shabouk
Ahmad Yamen Arnaout
Mohamed Besher Zeina
Mahmoud Malhis

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1463999

682 views

Review

Published on 21 Nov 2025

Targeting the Notch signaling pathway: molecular mechanisms and therapeutic strategies for cardiac repair after myocardial infarction

in Cardiovascular Pharmacology and Drug Discovery

ZhiCheng Zhang
FengQun Xie
Jie Cheng
Xinyue Liu
Xinran Wang
Jun Long
QiMao Feng
Dongping Yuan

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1669362

974 views

Mini Review

Published on 27 Oct 2025

The role of cardiac lymphatic dysfunction in the progression of myocarditis

in Cardiovascular Pharmacology and Drug Discovery

Shreya Kurup
Daniel A. Hu
Tsutomu Kume

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1659309

1,369 views

Review

Published on 23 Oct 2025

Nanoparticle-based drug delivery systems targeting inflammatory immune mechanisms in acute myocardial infarction: current advances and perspectives

in Cardiovascular Pharmacology and Drug Discovery

Yuxuan Li
Peng Li
Wujiao Wang
Yuanyuan Zhang
Sinai Li
Dong Li
Qian Lin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1657300

1,740 views

Review

Published on 05 Sep 2025

Medicinal plants administered to control hypertension in Ethiopia: ethnomedicine, pharmacology, nutraceutical, phytochemistry, toxicology, and policy perspectives

in Cardiovascular Pharmacology and Drug Discovery

Dejen Nureye
Getnet Tadege
Silesh Dubale
Dereje Kebebe
Sultan Suleman
Elvine Pami Nguelefack-Mbuyo

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1514911

5,390 views

Original Research

Published on 12 Aug 2025

Effects of angiotensin receptor–neprilysin inhibition on myocardial energy metabolism and prognosis in patients with acute myocardial infarction complicated by heart failure

in Cardiovascular Pharmacology and Drug Discovery

Caiming Cheng
Yu Nie
Di Chen
Yan Yang
Shunji Liang
Qin Yu

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1550624

2,131 views

Original Research

Published on 12 Aug 2025

Salidroside ameliorates abnormalities in electrophysiological indices induced by perfusion of the heart with low-potassium solutions

in Cardiovascular Pharmacology and Drug Discovery

Ruoning Yang
Chi Yan
Yifeng Zhou
Wenyuan Li
Gongxin Wang
Huan Li
Fei Lin
Guoliang Hao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1628940

2,209 views

Case Report

Published on 23 Jul 2025

Treatment of infective endocarditis caused by Enterococcus faecalis with a combination of penicillin G and ceftriaxone: a case report and literature review

in Cardiovascular Pharmacology and Drug Discovery

Li Jiang
Zhiqiang Lin
Shuifa Wu
Tingting Chen

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1539372

3,646 views

Review

Published on 14 Jul 2025

The role of Nrf2 signaling pathway in diabetic cardiomyopathy: from pathogenesis to traditional Chinese medicine interventions

in Cardiovascular Pharmacology and Drug Discovery

Huixian Gu
Junchang Liu
Jie Jiang
Hongyan Ma
Siyu Wu
Longfei Sun
Lan Yao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1492499

3,376 views
1 citation

Systematic Review

Published on 10 Jul 2025

A systematic review and network meta-analysis of cardiovascular safety of benzbromarone compared to febuxostat and allopurinol in patients with gout

in Cardiovascular Pharmacology and Drug Discovery

Ting-Syuan Lin
Yen-Liang Lin
Chiu-Hao Hsu
Song-Chou Hsieh
Wen-Yi Shau
Wei-Shiung Yang
Chi-Ling Chen

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1541307

3,997 views
1 citation

Original Research

Published on 04 Jul 2025

Herb pair of Astragali Radix-Descurainiae Semen attenuate heart failure through the myosin VI-Tom1 complex mediated autophagy

in Cardiovascular Pharmacology and Drug Discovery

Mengyue Wang
Songlin Ni
Tong Wang
Mo Sun
Qiaolan Wu
Xiaolin Wu
Guangying Lu
Peiwei Su
Zu Gao
Qian Chen

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1599746

2,341 views

Review

Published on 01 Jul 2025

The therapeutic effects of natural organosulfur compounds on atherosclerosis and their potential mechanisms: a comprehensive review

in Cardiovascular Pharmacology and Drug Discovery

Yuanyuan Tang
De Lv
Yijing Tao
Juan Wang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1599154

3,052 views
2 citations

Brief Research Report

Published on 30 Jun 2025

Clinical outcomes of pharmacological therapies for heart failure in Black vs. White populations: a meta-analysis of randomized controlled trials of heart failure treatment

in Cardiovascular Pharmacology and Drug Discovery

Yujia Li
Huilin Tang
Wenxi Huang
Wei-Han Chen
Shao-Hsuan Chang
Jiang Bian
Mustafa M. Ahmed
Stephen E. Kimmel
Jingchuan Guo

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1482311

1,807 views

Original Research

Published on 30 Jun 2025

CLU, FOS, and CXCL8 as diagnostic biomarkers for heart failure progression post-acute myocardial infarction: an integrated RNA-Seq and multi-machine learning study

in Cardiovascular Pharmacology and Drug Discovery

Jingjing Wei
Peng Yu
Yucai Hu
Lijie Qiao
Bin Li
Haitao Li
Shiyang Xie
Zhengwei Dong
Aolong Wang
Yilin Zhang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1611668

2,438 views
1 citation

Correction

Published on 27 Jun 2025

Correction: Adverse events associated with amlodipine: a pharmacovigilance study using the FDA adverse event reporting system

in Cardiovascular Pharmacology and Drug Discovery

Jiazhen Jiang
Qian Zhong
Xinyu Zhou
Lisi Zhou
Jiyuan Zheng
Bingshuo Liu
Xingwei Di

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1636315

1,191 views

Editorial

Published on 27 Jun 2025

Editorial: Therapeutic strategies to lower residual dyslipidemic CV risk beyond LDL-C and statins

in Cardiovascular Pharmacology and Drug Discovery

Raffaele De Caterina
Matthew Budoff
William E. Boden

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1597062

1,682 views

Systematic Review

Published on 26 May 2025

Methods and validity indicators for measuring adherence and persistence to aspirin in secondary cardiovascular prevention: a systematic review

in Cardiovascular Pharmacology and Drug Discovery

Rauf Nouni-García
Elisabeth Ramirez-Familia
Adriana López-Pineda
Amanda Esquerdo-Arroyo
Álvaro Carbonell-Soliva
María Martínez-Muñóz
Antonio F. Compañ Rosique
Jose A. Quesada
Concepción Carratalá-Munuera
Vicente F. Gil-Guillén

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1570331

2,286 views
1 citation

Review

Published on 26 May 2025

Chinese medicine targets cellular autophagy against cardiovascular diseases: research progress and future prospects

in Cardiovascular Pharmacology and Drug Discovery

Zhengyu Chen
Jinjin Dou
Xiwu Zhang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1585407

2,405 views

Original Research

Published on 23 May 2025

Yellow Wine Polyphenolic Compounds protect against myocardial ischemia-reperfusion injury in rats by activating Nrf2 nuclear translocation to regulate the balance of mitochondrial fission and fusion

in Cardiovascular Pharmacology and Drug Discovery

Lili Xu
Jiedong Zhou
Haifei Lou
Haodi Gu
Haixia Xu
Zuoquan Zhong
Hui Lin
Chengjian Jiang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1506388

2,112 views

119 articles

articles

Network Pharmacological Analysis, Mendelian Randomization Analysis and Animal Experimental reveal the mechanism of Wenxin Granules in inhibiting heart failure after myocardial infarction: Apoptosis and Inflammation

Protosappanin A protects against pathological cardiac hypertrophy by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis via activation of the Nrf2 signaling pathway

Plasma Pharmacokinetic of the combination of potassium chloride extended-release tablets and potassium citrate granules in patients with cardiovascular emergencies

Helianthus Annuus L. Ameliorates Atherosclerosis-Induced Myocardial Infarction via inhibiting inflammation and oxidative stress

Cardiovascular safety pharmacology: beyond arrhythmic risk assessment

Assessing the cardiovascular and potassium lowering effects of levalbuterol compared to albuterol: a randomized control trial

Targeting the Notch signaling pathway: molecular mechanisms and therapeutic strategies for cardiac repair after myocardial infarction

The role of cardiac lymphatic dysfunction in the progression of myocarditis

Nanoparticle-based drug delivery systems targeting inflammatory immune mechanisms in acute myocardial infarction: current advances and perspectives

Medicinal plants administered to control hypertension in Ethiopia: ethnomedicine, pharmacology, nutraceutical, phytochemistry, toxicology, and policy perspectives

Effects of angiotensin receptor–neprilysin inhibition on myocardial energy metabolism and prognosis in patients with acute myocardial infarction complicated by heart failure

Salidroside ameliorates abnormalities in electrophysiological indices induced by perfusion of the heart with low-potassium solutions

Treatment of infective endocarditis caused by Enterococcus faecalis with a combination of penicillin G and ceftriaxone: a case report and literature review

The role of Nrf2 signaling pathway in diabetic cardiomyopathy: from pathogenesis to traditional Chinese medicine interventions

A systematic review and network meta-analysis of cardiovascular safety of benzbromarone compared to febuxostat and allopurinol in patients with gout

Herb pair of Astragali Radix-Descurainiae Semen attenuate heart failure through the myosin VI-Tom1 complex mediated autophagy

The therapeutic effects of natural organosulfur compounds on atherosclerosis and their potential mechanisms: a comprehensive review

Clinical outcomes of pharmacological therapies for heart failure in Black vs. White populations: a meta-analysis of randomized controlled trials of heart failure treatment

CLU, FOS, and CXCL8 as diagnostic biomarkers for heart failure progression post-acute myocardial infarction: an integrated RNA-Seq and multi-machine learning study

Correction: Adverse events associated with amlodipine: a pharmacovigilance study using the FDA adverse event reporting system

Editorial: Therapeutic strategies to lower residual dyslipidemic CV risk beyond LDL-C and statins

Methods and validity indicators for measuring adherence and persistence to aspirin in secondary cardiovascular prevention: a systematic review

Chinese medicine targets cellular autophagy against cardiovascular diseases: research progress and future prospects

Yellow Wine Polyphenolic Compounds protect against myocardial ischemia-reperfusion injury in rats by activating Nrf2 nuclear translocation to regulate the balance of mitochondrial fission and fusion