Frontiers in Cardiovascular Medicine | Cardiovascular Pharmacology and Drug Discovery

Original Research

Published on 16 May 2025

Treatment adherence, persistence, and effectiveness of fixed dose combination versus free combination therapy of rosuvastatin–ezetimibe as a lipid-lowering therapy

in Cardiovascular Pharmacology and Drug Discovery

Mihail Samnaliev
Irfan Khan
Praveen Potukuchi
Kelly Lee
Genevieve Garon
Charlie Nicholls

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1461416

4,340 views
2 citations

Original Research

Published on 12 May 2025

Genetic and clinical determinants of MACE and haemorrhage in antiplatelet therapy: insights from pharmacogenomic analysis

in Cardiovascular Pharmacology and Drug Discovery

Yubo Wang
Shuangli Yuan
Muyun Li
Wenling Feng
Jing Li
Wenwen Chen
Aliye Berdi
Yulian Kou
Yuan Yuan
Jun Zhao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1572389

2,123 views
1 citation

Original Research

Published on 09 May 2025

Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via regulating intracellular calcium cycle

in Cardiovascular Pharmacology and Drug Discovery

Xiaojie Ruan
Wei Zhao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1546325

2,289 views
2 citations

Original Research

Published on 06 May 2025

Adverse events associated with amlodipine: a pharmacovigilance study using the FDA adverse event reporting system

in Cardiovascular Pharmacology and Drug Discovery

Jiazhen Jiang
Qian Zhong
Xinyu Zhou
Lisi Zhou
Jiyuan Zheng
Bingshuo Liu
Xingwei Di

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1504671

15,291 views
1 citation

Original Research

Published on 01 May 2025

Drug-induced cardiac arrest: a pharmacovigilance study from 2004–2024 based on FAERS database

in Cardiovascular Pharmacology and Drug Discovery

Gaocan Ren
Pingping Huang
Jinhui Zhang
Jin Liu
Zian Yan
Xiaochang Ma

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1498700

4,520 views
1 citation

Original Research

Published on 28 Apr 2025

From knowledge silos to integrated insights: building a cardiovascular medication knowledge graph for enhanced medication knowledge retrieval, relationship discovery, and reasoning

in Cardiovascular Pharmacology and Drug Discovery

Hongzhen Cui
Xiaoyue Zhu
Wei Zhang
Meihua Piao
Yunfeng Peng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1526247

2,975 views
2 citations

Original Research

Published on 22 Apr 2025

Mechanism of Ershen Zhenwu Decoction in ameliorating chronic heart failure via JNK/MAPK-regulated apoptosis: insights from network pharmacology and experimental validation

in Cardiovascular Pharmacology and Drug Discovery

Yulong Liu
Xinyue Wang
Maomao Zhang
Dan Cheng
Zhenpeng Zhu
Lan Ge
Xiaoyu Cheng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1561963

3,395 views

Original Research

Published on 22 Apr 2025

Integrating network pharmacology and experimental validation to investigate the mechanism of Gualou Xiebai Banxia decoction against myocardial ischemia

in Cardiovascular Pharmacology and Drug Discovery

Wanjun Zhu
Ping Shao
Ying Ren
Wenxuan Liu
Xiaorui Han
Kexin Zeng
Chunmei Dai
Feifei Liu

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1512791

3,169 views

Brief Research Report

Published on 14 Mar 2025

Cross-Sectional analysis of demographic and clinical characteristics of patients in the United States using icosapent ethyl

in Cardiovascular Pharmacology and Drug Discovery

Peter P. Toth
John R. Nelson
Handrean Soran
Om P. Ganda
Nathan D. Wong
Hakima Hannachi
David Abrahamson
Josh Hartman
Sierra Luciano
Sephy Philip

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1411233

2,241 views

Original Research

Published on 20 Feb 2025

A comprehensive study on the impact of Ligustrum vicaryi L. fruit polysaccharide on myocardial fibrosis through animal experiments, network pharmacology and molecular docking

in Cardiovascular Pharmacology and Drug Discovery

Shuling Liu
Meifang Liu
Jianan Wang
Ruixue Rong
Yanwei Gao
Xiaoqi Li
Xin Liu
Shaojian Li

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1470761

3,320 views

Original Research

Published on 13 Feb 2025

Network pharmacology to unveil the blood components and mechanisms of Tongmai Yangxin Pills in treating elderly coronary heart disease

in Cardiovascular Pharmacology and Drug Discovery

Yue Zhang
Chao-Hui Li
Yi-Zhi Yan
Jie-Yun Lin
Shan-Shan Zhu
Si-Jie Tan
Peng Zeng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1475546

4,503 views
2 citations

Systematic Review

Published on 15 Jan 2025

Efficacy and safety of cardiac myosin inhibitors for symptomatic hypertrophic cardiomyopathy: a meta-analysis of randomized controlled trials

in Cardiovascular Pharmacology and Drug Discovery

Anas Abunada
Madiha Shah
Ateesh Kumar
Syeda Lamiya Mir
Dinesh Kumar
Saboor Ahmed
Muhammad Tanzeel
Vikash Kumar
Aashish Meghjiani
Muhammad Basit Ali Siddiqui

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1477487

5,784 views
2 citations

Review

Published on 15 Jan 2025

Chinese and western medicine treatment of myocardial fibrosis drugs

in Cardiovascular Pharmacology and Drug Discovery

Yuxi Zhu
Fangmei Zhang
Zhongcheng Li
Yu Zhou
Yi Shu
Jian Ruan
Guo Chen

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1477601

4,169 views
2 citations

Systematic Review

Published on 14 Jan 2025

Comparative efficacy of different drugs in acute heart failure with renal dysfunction: a systematic review and network meta-analysis

in Cardiovascular Pharmacology and Drug Discovery

Qianyu Lv
Qian Wu
Yingtian Yang
Lanlan Li
Xuejiao Ye
Shihan Wang
Yanfei Lv
Manshi Wang
Yushan Li

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1444068

3,567 views

Editorial

Published on 07 Jan 2025

Editorial: Novel treatments for cardiovascular diseases by targeting inflammation, oxidative stress, and cell death

in Cardiovascular Pharmacology and Drug Discovery

Dong Fan
Li Wang
Abhijit Chakraborty
Cheng-Lin Zhang
Feng Hua Yang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1538222

1,985 views
1 citation

Original Research

Published on 06 Jan 2025

Effects of different doses of remimazolam on the quality of sedation and cardiac function in elderly patients: a double-blind randomised controlled study

in Cardiovascular Pharmacology and Drug Discovery

Liu Minghong
Qizhu Feng
Huichun Chen
Ju Li
Jun Shi

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1453608

2,570 views
3 citations

Review

Published on 03 Dec 2024

Traditional Chinese medicine for cardiovascular disease: efficacy and safety

in Cardiovascular Pharmacology and Drug Discovery

Youwei Lin
Yuanshan Han
Yuhong Wang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1419169

5,035 views
8 citations

Systematic Review

Published on 22 Nov 2024

Exploring research trends and hotspots on PCSK9 inhibitor studies: a bibliometric and visual analysis spanning 2007 to 2023

in Cardiovascular Pharmacology and Drug Discovery

Ping Lai
Shuquan Xu
Ziyou Liu
Jiayuan Ling
Kejun Tian
Jianwei Yan
Dong Chen
Yiming Zhong
Jinhua Xue

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1474472

3,917 views

Original Research

Published on 29 Oct 2024

Metabolomics revealed pharmacodynamic effects of aspirin and indobufen in patients after percutaneous transluminal angioplasty surgery

in Cardiovascular Pharmacology and Drug Discovery

Shaobo Sun
Kang Xun
Damei Li
Renjie Bao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1433643

1,703 views

Original Research

Published on 24 Oct 2024

Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultraﬁltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability study in uremic hemodialysis patients

in Cardiovascular Pharmacology and Drug Discovery

Ming-Chen Cao
Xin Huang
Bo-Hao Tang
Hai-Yan Shi
Yi Zheng
Wei Zhao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1461181

1,961 views
1 citation

Review

Published on 18 Oct 2024

Research progress of sea buckthorn (Hippophae rhamnoides L.) in prevention and treatment of cardiovascular disease

in Cardiovascular Pharmacology and Drug Discovery

Yumeng Chen
Weiwei He
Hanjing Cao
Zhenzhen Wang
Jiping Liu
Bin Wang
Chuan Wang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1477636

10,122 views
9 citations

Systematic Review

Published on 25 Sep 2024

The efficacy and safety of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors combined with statins in patients with hypercholesterolemia: a network meta-analysis

in Cardiovascular Pharmacology and Drug Discovery

Dong Liu
Jin Zhang
Xiaoyu Zhang
Fengli Jiang
Yiping Wu
Beibei Yang
Xinghuan Li
Xiongxiong Fan
Han Li
Yu Sun

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1454918

5,830 views
2 citations

Original Research

Published on 24 Sep 2024

Causal relationship between novel antidiabetic drugs and ischemic stroke: a drug-targeted Mendelian randomization study

in Cardiovascular Pharmacology and Drug Discovery

Zongliang Yu
Xinyi Liu
Xue Feng
Xiaonan Zhang
Rui Gao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1449185

4,257 views
2 citations

Review

Published on 23 Sep 2024

A comprehensive review of finerenone—a third-generation non-steroidal mineralocorticoid receptor antagonist

in Cardiovascular Pharmacology and Drug Discovery

Shuhui Zhai
Baisheng Ma
Weiwei Chen
Qini Zhao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1476029

17,847 views
11 citations

119 articles

articles

Treatment adherence, persistence, and effectiveness of fixed dose combination versus free combination therapy of rosuvastatin–ezetimibe as a lipid-lowering therapy

Genetic and clinical determinants of MACE and haemorrhage in antiplatelet therapy: insights from pharmacogenomic analysis

Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via regulating intracellular calcium cycle

Adverse events associated with amlodipine: a pharmacovigilance study using the FDA adverse event reporting system

Drug-induced cardiac arrest: a pharmacovigilance study from 2004–2024 based on FAERS database

From knowledge silos to integrated insights: building a cardiovascular medication knowledge graph for enhanced medication knowledge retrieval, relationship discovery, and reasoning

Mechanism of Ershen Zhenwu Decoction in ameliorating chronic heart failure via JNK/MAPK-regulated apoptosis: insights from network pharmacology and experimental validation

Integrating network pharmacology and experimental validation to investigate the mechanism of Gualou Xiebai Banxia decoction against myocardial ischemia

Cross-Sectional analysis of demographic and clinical characteristics of patients in the United States using icosapent ethyl

A comprehensive study on the impact of Ligustrum vicaryi L. fruit polysaccharide on myocardial fibrosis through animal experiments, network pharmacology and molecular docking

Network pharmacology to unveil the blood components and mechanisms of Tongmai Yangxin Pills in treating elderly coronary heart disease

Efficacy and safety of cardiac myosin inhibitors for symptomatic hypertrophic cardiomyopathy: a meta-analysis of randomized controlled trials

Chinese and western medicine treatment of myocardial fibrosis drugs

Comparative efficacy of different drugs in acute heart failure with renal dysfunction: a systematic review and network meta-analysis

Editorial: Novel treatments for cardiovascular diseases by targeting inflammation, oxidative stress, and cell death

Effects of different doses of remimazolam on the quality of sedation and cardiac function in elderly patients: a double-blind randomised controlled study

Traditional Chinese medicine for cardiovascular disease: efficacy and safety

Exploring research trends and hotspots on PCSK9 inhibitor studies: a bibliometric and visual analysis spanning 2007 to 2023

Metabolomics revealed pharmacodynamic effects of aspirin and indobufen in patients after percutaneous transluminal angioplasty surgery

Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultraﬁltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability study in uremic hemodialysis patients

Research progress of sea buckthorn (Hippophae rhamnoides L.) in prevention and treatment of cardiovascular disease

The efficacy and safety of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors combined with statins in patients with hypercholesterolemia: a network meta-analysis

Causal relationship between novel antidiabetic drugs and ischemic stroke: a drug-targeted Mendelian randomization study

A comprehensive review of finerenone—a third-generation non-steroidal mineralocorticoid receptor antagonist