Frontiers in Cell and Developmental Biology

Original Research

Published on 14 Nov 2025

IGF1R promotes radiation-induced HSCs activation by regulating DNA-PKcs-mediated DNA damage repair

in Molecular and Cellular Pathology

Jiguo Lin
Gang Zhao
Jie Feng
Chaonan Sun
Chang Liu
Jiajing Li
Yannan Shen
Yunyun Cheng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1678654

1,003 views

Review

Published on 14 Nov 2025

Super enhancers as key drivers of gene regulatory networks in normal and malignant hematopoiesis

in Epigenomics and Epigenetics

Ying Cheng
Guangxin Pei
Hengchao Zhang
Yan Hou
Lei Sun
Hongdi Xu
Yuning Lv
Xiuyun Wu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1674470

1,221 views

Mini Review

Published on 14 Nov 2025

Liquid-liquid phase separation in super enhancer-driven oncogenesis: mechanisms, immune evasion, and therapeutic implications

in Epigenomics and Epigenetics

Ruoxi Yu
Deyu Sun
Chuang Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1645325

1,136 views

Review

Published on 14 Nov 2025

Unravelling targeted therapy in prostate cancer: from molecular mechanisms to translational opportunities

in Cancer Cell Biology

Litong Wu
Junfeng Qiu
Zhiming Hong
Quan Wang
Qixin Li
Wenbin Zhou

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1685857

1,487 views

Original Research

Published on 14 Nov 2025

EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration

in Molecular and Cellular Pathology

Runa Sugiyama
Anna S. Sedukhina
Eri Sato
Ayako Yamaura
Kimino Minagawa
Sookhee Pae
Ena Imai
Ankita Chawla
Ziran Xu
Mihika Chakraborty

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1695627

1,059 views

Brief Research Report

Published on 13 Nov 2025

Tissue-resident macrophages co-develop with myocardial tissue in human induced pluripotent stem cell-derived organoids

in Embryonic Development

Anna Frederike Rockel
Tobias Brunnbauer
Nicole Wagner
Brenda Gerull
Süleyman Ergün
Philipp Wörsdörfer

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1629988

1,942 views

Original Research

Published on 13 Nov 2025

Knocking down tumor suppressor gene PTPRG enhances axonal regeneration of dorsal root ganglion neurons

in Cell Growth and Division

Qian Zhao
Lan Zhang
Peng Yang
Jingjing Li
Sheng Yi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1698864

837 views

Mini Review

Published on 13 Nov 2025

Mechanisms of metabolic reprogramming in abdominal aortic aneurysm

in Cell Death and Survival

Xiaodong Wu
Jianpeng Li
Qiaoyue Ju
Yuqi Zeng
Junjie Cao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1718220

1,034 views

Original Research

Published on 13 Nov 2025

Artesunate alleviates kidney fibrosis by restoring klotho protein and suppressing Wnt/β-catenin signalling pathway

in Cellular Biochemistry

Goran H. Mohammad
Julius Kieswich
Abhishek Kumar
Kieran McCafferty
Ramyangshu Chakraborty
Christoph Thiemermann
Magdi M. Yaqoob

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1688753

1,294 views

Correction

Published on 13 Nov 2025

Correction: Molecular puzzle of insulin: structural assembly pathways and their role in diabetes

in Cellular Biochemistry

Edyta Urbaniak
Sara Henry
Maciej Lalowski
Malgorzata Borowiak

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1737821

549 views

Original Research

Published on 12 Nov 2025

MASE-GC: a multi-omics autoencoder and stacking ensemble framework for gastric cancer classification

in Cancer Cell Biology

Di Liu
Zhongguang Che
Guannan Xu
Ye Huang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1704237

1,010 views

Mini Review

Published on 12 Nov 2025

HLA-G regulation through trogocytosis: intercellular membrane transfer mechanisms and immune dysregulation in Systemic Lupus Erythematosus

in Membrane Traffic and Organelle Dynamics

Abhibroto Karmakar
Uma Kumar
Rachana Kamath
Hargurdas Singh
Mukhyaprana M. Prabhu
Subhradip Karmakar

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1664622

1,539 views

Mini Review

Published on 12 Nov 2025

Functionalized peptide hydrogels: enabling dynamic stage-adaptive modulation for wound healing

in Cell Adhesion and Migration

Xi-Kun Ma
Qi Peng
Gui-Hua Miao
Xiu-Zhen Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1710175

1,366 views

Review

Published on 12 Nov 2025

Advances in the role of extracellular vesicles in circulating microRNA biomarker discovery for lung cancer

in Cancer Cell Biology

Ayaz Belkozhayev
Minnatallah Al-Yozbaki
Yeldar Ashirbekov
Kantemir Satken
Arman Abaildayev
Askar Yeleussizov
Nurlan Jainakbayev
Kamalidin Sharipov
Cornelia M. Wilson

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1676530

1,979 views

Correction

Published on 11 Nov 2025

Correction: Dysregulation of decidual NK cell proliferation by impaired decidual cells: a potential contributor to excessive trophoblast invasion in placenta accreta spectrum

in Stem Cell Research

You-Zhen Liu
Hsin-Hung Lin
Meng-Shiue Wu
Jin-Chung Shih
Thai-Yen Ling

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1696297

621 views

Review

Published on 11 Nov 2025

Advances in understanding the role of inflammatory factors and immune cells in the pathology of epilepsy, mediated by neuroimmune interactions within the gut-brain axis

in Signaling

Lijia Zhang
Rongjiang Xu
Hao Huang
Juan Yang
Changyin Yu
Haiqing Zhang
Zucai Xu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1650909

1,482 views

Original Research

Published on 11 Nov 2025

Decoding HuH-7: a comprehensive genetic and molecular portrait of a widely used hepatocellular carcinoma model

in Cellular Biochemistry

Dario Dourado Luis
Thomas Liehr
Stefanie Kankel
Anja Weise
Constanze Pentzold
Eva M. Buhl
Katharina S. Hardt
Diandra T. Keller
Sarah K. Schröder-Lange
Ralf Weiskirchen

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1648639

1,379 views

Review

Published on 11 Nov 2025

Multiple entanglements of different cell death pathways, in which caspase-8 and BID interact with cardiolipin*, have been identified

in Cell Death and Survival

Patrice X. Petit

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1667611

1,626 views

Original Research

Published on 11 Nov 2025

Proximity-based proteomics (BioID) uncovers the Rho GTPase interactome in kidney podocytes

in Cellular Biochemistry

Sajida Ibrahim
Jun Matsuda
Zachary W. Nurcombe
Jonathan Boulais
Lamine Aoudjit
Emily Foxman
Cyril Kazan
Soichiro Suzuki
Simon Leclerc
Naoyuki Shimada

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1625950

1,467 views

Original Research

Published on 11 Nov 2025

Protocatechuic aldehyde ameliorates high glucose-induced podocyte injury by attenuating inflammation, oxidative stress, and apoptosis via suppression of endoplasmic reticulum stress through the GSK3β/Nrf2 pathway

in Cellular Biochemistry

Yishu Wang
Haifeng Wang
Yang Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1693955

1,126 views

Brief Research Report

Published on 10 Nov 2025

Deficiency for MicroRNA-582 does not impact dilated cardiomyopathy or heart failure induced by pressure overload in vivo

in Molecular and Cellular Pathology

Simone Martini
Inka Dobberstein
Nesrin Schmiedel
Lucia Sophie Kilian
Jakob Christoph Voran
Frauke Senger
Ashraf Yusuf Rangrez
Derk Frank
Christian Kuhn
Norbert Frey

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1661965

934 views

Original Research

Published on 10 Nov 2025

Decoding IL-1 receptor 1 and 2 expression profiles across organs in sepsis

in Molecular and Cellular Pathology

Chuyi Tan
Weiqin Wang
Han Ma
Huan Chen
Huali Zhang
Yue Peng
Yiying Yang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1675870

1,374 views

Editorial

Published on 10 Nov 2025

Editorial: The fertilization success from the Oocyte’s perspective, volume II

in Molecular and Cellular Reproduction

Marcela A. Michaut
Joanna M. G. Souza-Fabjan
Rafael A. Fissore

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1728990

835 views

Original Research

Published on 10 Nov 2025

Anti-diabetic effects of Dachaihu decoction combined with Sanghuangporus vaninii: insights from network pharmacology, intestinal flora, and liver metabolomics

in Cellular Biochemistry

Juntao Huang
Yanfa Lin
Zifeng Huang
Tiantian Li
Xiaodong Ge
Bin Liu
Zirui Huang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1707392

1,046 views

12,823 articles

articles

IGF1R promotes radiation-induced HSCs activation by regulating DNA-PKcs-mediated DNA damage repair

Super enhancers as key drivers of gene regulatory networks in normal and malignant hematopoiesis

Liquid-liquid phase separation in super enhancer-driven oncogenesis: mechanisms, immune evasion, and therapeutic implications

Unravelling targeted therapy in prostate cancer: from molecular mechanisms to translational opportunities

EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration

Tissue-resident macrophages co-develop with myocardial tissue in human induced pluripotent stem cell-derived organoids

Knocking down tumor suppressor gene PTPRG enhances axonal regeneration of dorsal root ganglion neurons

Mechanisms of metabolic reprogramming in abdominal aortic aneurysm

Artesunate alleviates kidney fibrosis by restoring klotho protein and suppressing Wnt/β-catenin signalling pathway

Correction: Molecular puzzle of insulin: structural assembly pathways and their role in diabetes

MASE-GC: a multi-omics autoencoder and stacking ensemble framework for gastric cancer classification

HLA-G regulation through trogocytosis: intercellular membrane transfer mechanisms and immune dysregulation in Systemic Lupus Erythematosus

Functionalized peptide hydrogels: enabling dynamic stage-adaptive modulation for wound healing

Advances in the role of extracellular vesicles in circulating microRNA biomarker discovery for lung cancer

Correction: Dysregulation of decidual NK cell proliferation by impaired decidual cells: a potential contributor to excessive trophoblast invasion in placenta accreta spectrum

Advances in understanding the role of inflammatory factors and immune cells in the pathology of epilepsy, mediated by neuroimmune interactions within the gut-brain axis

Decoding HuH-7: a comprehensive genetic and molecular portrait of a widely used hepatocellular carcinoma model

Multiple entanglements of different cell death pathways, in which caspase-8 and BID interact with cardiolipin*, have been identified

Proximity-based proteomics (BioID) uncovers the Rho GTPase interactome in kidney podocytes

Protocatechuic aldehyde ameliorates high glucose-induced podocyte injury by attenuating inflammation, oxidative stress, and apoptosis via suppression of endoplasmic reticulum stress through the GSK3β/Nrf2 pathway

Deficiency for MicroRNA-582 does not impact dilated cardiomyopathy or heart failure induced by pressure overload in vivo

Decoding IL-1 receptor 1 and 2 expression profiles across organs in sepsis

Editorial: The fertilization success from the Oocyte’s perspective, volume II

Anti-diabetic effects of Dachaihu decoction combined with Sanghuangporus vaninii: insights from network pharmacology, intestinal flora, and liver metabolomics