Frontiers in Cell and Developmental Biology

Original Research

Published on 29 Dec 2025

Integration of peripheral blood-based systemic inflammatory indices and retinal imaging using interpretable machine learning for predicting anti-VEGF treatment response in macular edema secondary to retinal vein occlusion

in Molecular and Cellular Pathology

Jiajun Li
Yao Lu
Qianzi Jin
Siqi Wu
Xiangzhong Xu
Qin Jiang
Keran Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1732963

1,133 views

Review

Published on 23 Dec 2025

Fibroblast PI3K/AKT signaling and extracellular matrix homeostasis: mechanisms, targets, and delivery challenges

in Signaling

Chunyun Fang
Zitao Zeng
Bin Ni
Xiaochun Wen
Zhipeng Fang
Junrong Zou
Guoxi Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1681875

1,959 views

Review

Published on 19 Dec 2025

Recent advances in the role of CARM1 in skeletal muscle development, metabolism, and homeostasis maintenance

in Cellular Biochemistry

Xiaojing Xie
Menghuan Li
Yue Zhang
Zhenwei Bao
Xuejie Yi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1709515

1,210 views

Brief Research Report

Published on 19 Dec 2025

Therapy to teratology: chronic paternal antioxidant supplementation alters offspring placental architecture and craniofacial morphogenesis in a mouse model

in Chromosome and Chromatin Biology

Destani D. Derrico
Katherine Z. Scaturro
Erin E. Murray
Eliezar Guillen
Nathan S. Truss
Katherine A. Fairly
Samantha L. Higgins
Sanat S. Bhadsavle
Michael C. Golding

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1697843

2,044 views

Original Research

Published on 19 Dec 2025

Association of fibronectin 1 deregulation with tyrosine kinase inhibitor resistance in chronic myeloid leukemia

in Molecular and Cellular Pathology

Lina Tiedemann
Sivahari Prasad Gorantla
Philine Ahlf
Lucie Sophie Schmidt
Christiane Pott
Merit Litterst
Vicki Waetzig
Inga Nagel
Johanna Ruemenapp
Nikolas von Bubnoff

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1725857

1,125 views

Original Research

Published on 19 Dec 2025

Sexual dimorphism in the DNA methylation pattern after immune stimulation in the zebrafish (Danio rerio) gonads

in Chromosome and Chromatin Biology

M. Salazar
M. Caballero-Huertas
T. A. van Gelderen
M. N. Krabbe
M. Gut
S. Heath
A. Esteve
L. Ribas

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1720219

1,418 views

Original Research

Published on 18 Dec 2025

Cecal growth factors promote enteric neurosphere formation and hindgut colonization in the avian model

in Embryonic Development

Ádám Soós
Emőke Szőcs
Viktória Halasy
Zsanna Gecse
Fruzsina Mógor
Csenge Jurenka
Katalin Kocsis
Jitka Mucksová
Jiří Hejnar
Nándor Nagy

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1681844

1,441 views

Original Research

Published on 18 Dec 2025

Disruption of Swell1/VRAC function impairs initial hemodynamics and activates compensatory leukotriene signaling in zebrafish circulation development

in Embryonic Development

Yen-Tzu Tseng
Chia-Teng Chang
Wei-Chun HuangFu
I.-Hsuan Liu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1719544

1,381 views

Methods

Published on 18 Dec 2025

Optimized protocols for generating half-sized embryos from separated first two blastomeres in green sea urchin and Xenopus laevis

in Embryonic Development

Eugeny E. Orlov
Polina S. Timoshina
Elena A. Parshina
Fedor M. Eroshkin
Maria A. Bannikova
Andrey G. Zaraisky

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1730288

1,369 views

Original Research

Published on 18 Dec 2025

Inflammation centered muscle signature of sarcopenia from postmenopausal women in Shanghai China

in Stem Cell Research

Yongqian Fan
Shangjin Lin
Ming Ling
Tao Cui
Cong Chen
Fengjian Yang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1726045

1,190 views

Mini Review

Published on 18 Dec 2025

METTL5 in physiology and pathology: mechanisms and implications

in Cancer Cell Biology

Chunhong Li
Xiulin Jiang
Yixiao Yuan
Qiang Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1708541

1,359 views

Review

Published on 18 Dec 2025

The role of ADAR1 in human pathophysiology

in Molecular and Cellular Pathology

Jiahao Li
Yushan Xiao
Xiaofeng Li
Yan Dai

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1672970

1,594 views

Original Research

Published on 18 Dec 2025

Osteoprogenitor cells from non-regenerative bone show greater resistance to cellular stress than those from regenerative bone

in Stem Cell Research

Joshua Broussard
Sylvia Culpepper
Tyrel Long
Alexander J. Trostle
Robert J. Tower
Mimi C. Sammarco
Jennifer Simkin

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1684670

1,382 views

Original Research

Published on 18 Dec 2025

Targeted peptide modification of mesenchymal stem cells enhances their therapeutic efficacy in the treatment of idiopathic pulmonary fibrosis

in Stem Cell Research

Zelin Lei
Rui Jia
Yixuan Ren
Yirun Zhao
Yun Wang
Wenqian Cao
Xue Bai
Yali Peng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1710750

1,626 views

Mini Review

Published on 18 Dec 2025

Metabolic reprogramming in bone metastasis of human cancers

in Cancer Cell Biology

Tianda Li
Ziyi Wang
Haitao Yang
Yihan Kang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1711592

1,307 views

Review

Published on 17 Dec 2025

The role of MMPs in intracerebral hemorrhage

in Molecular and Cellular Pathology

Xiaofei Guan
Meiren Li
Huimin Li
Zeqin Guo
Muhammad Saad Ullah
Xiaoqun Liu
Moxin Wu
Wenmin Yu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1667228

1,835 views

Review

Published on 17 Dec 2025

Ferroptosis at the intersection of osteoarthritis and bone metabolism: mechanistic links and therapeutic prospects

in Cell Death and Survival

Jing Xiao
Yan Zhu
Jingjing Chen
Yujie Hong
Yang Cao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1722435

1,790 views

Review

Published on 17 Dec 2025

R-loops and small RNA regulatory interactions: mechanisms and clinical perspectives

in Cellular Biochemistry

Si-Yao Wang
Ya-Ni Liu
Si-Qiao Zhao
Wen Liu
Jin-Long Hu
Fan Yang
Sheng Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1727548

1,171 views

Original Research

Published on 16 Dec 2025

Microglia response and function in a chronic model of photoreceptor damage

in Molecular and Cellular Pathology

Deepa Raghavan
Olivia Jeakle
Yasmeen Berry
Majd Victor
Ryan Thummel

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1699271

1,537 views

Review

Published on 16 Dec 2025

Endoplasmic reticulum stress in non-small cell lung cancer: a review of therapeutic agents, mechanistic insights, and implications for therapy

in Cancer Cell Biology

Qiong Luo
Xinxin Gao
Peng Meng
Xiao Qi
Wen Wang
Shan Li
Linlin Duan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1693023

1,717 views

Original Research

Published on 16 Dec 2025

Low-dose letrozole-HMG regimen reverses letrozole-induced endometrial impairment and improves frozen embryo transfer outcomes

in Molecular and Cellular Reproduction

Zhonglin Xiao
Feng Wang
Yali Yang
Tianxia Xiao
Jie Chen
Mengxia Li
Haizhen Liao
Chiawei Chu
Xiujun Fan
Jian V. Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1725350

1,384 views

Original Research

Published on 16 Dec 2025

Image-text guided fundus vessel segmentation via attention mechanism and gated residual learning

in Molecular and Cellular Pathology

Jianguo Xu
Qingyou Liu
Jianxin Shen
Rong Tan
Sukun Tian
Wei Chi
Weihua Yang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1710343

907 views

Original Research

Published on 16 Dec 2025

Multi-omics analysis reveals a protective role of endogenous proline in sheep oocyte vitrification and its therapeutic application

in Embryonic Development

Airixiati Dilixiati
Xi Zhao
Aikebaier Aihemaiti
Weijian Li
Chen Fan
Guodong Zhao
Abulizi Wusiman
Xuguang Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1714529

1,379 views

Review

Published on 16 Dec 2025

Aging-associated mechanisms and metabolic vulnerabilities in esophageal carcinoma: an integrative review

in Cancer Cell Biology

Qiwei Liu
Zhiyu Xie
Wei Li
Mengxiang Li
Yijun Qi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1714824

1,487 views

13,020 articles

articles

Integration of peripheral blood-based systemic inflammatory indices and retinal imaging using interpretable machine learning for predicting anti-VEGF treatment response in macular edema secondary to retinal vein occlusion

Fibroblast PI3K/AKT signaling and extracellular matrix homeostasis: mechanisms, targets, and delivery challenges

Recent advances in the role of CARM1 in skeletal muscle development, metabolism, and homeostasis maintenance

Therapy to teratology: chronic paternal antioxidant supplementation alters offspring placental architecture and craniofacial morphogenesis in a mouse model

Association of fibronectin 1 deregulation with tyrosine kinase inhibitor resistance in chronic myeloid leukemia

Sexual dimorphism in the DNA methylation pattern after immune stimulation in the zebrafish (Danio rerio) gonads

Cecal growth factors promote enteric neurosphere formation and hindgut colonization in the avian model

Disruption of Swell1/VRAC function impairs initial hemodynamics and activates compensatory leukotriene signaling in zebrafish circulation development

Optimized protocols for generating half-sized embryos from separated first two blastomeres in green sea urchin and Xenopus laevis

Inflammation centered muscle signature of sarcopenia from postmenopausal women in Shanghai China

METTL5 in physiology and pathology: mechanisms and implications

The role of ADAR1 in human pathophysiology

Osteoprogenitor cells from non-regenerative bone show greater resistance to cellular stress than those from regenerative bone

Targeted peptide modification of mesenchymal stem cells enhances their therapeutic efficacy in the treatment of idiopathic pulmonary fibrosis

Metabolic reprogramming in bone metastasis of human cancers

The role of MMPs in intracerebral hemorrhage

Ferroptosis at the intersection of osteoarthritis and bone metabolism: mechanistic links and therapeutic prospects

R-loops and small RNA regulatory interactions: mechanisms and clinical perspectives

Microglia response and function in a chronic model of photoreceptor damage

Endoplasmic reticulum stress in non-small cell lung cancer: a review of therapeutic agents, mechanistic insights, and implications for therapy

Low-dose letrozole-HMG regimen reverses letrozole-induced endometrial impairment and improves frozen embryo transfer outcomes

Image-text guided fundus vessel segmentation via attention mechanism and gated residual learning

Multi-omics analysis reveals a protective role of endogenous proline in sheep oocyte vitrification and its therapeutic application

Aging-associated mechanisms and metabolic vulnerabilities in esophageal carcinoma: an integrative review