Frontiers in Cell and Developmental Biology

Review

Published on 26 Mar 2021

Structural and Functional Significance of the Endoplasmic Reticulum Unfolded Protein Response Transducers and Chaperones at the Mitochondria–ER Contacts: A Cancer Perspective

in Signaling

Giuseppina Amodio
Valentina Pagliara
Ornella Moltedo
Paolo Remondelli

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.641194

9,340 views
22 citations

Review

Published on 25 Mar 2021

Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy

in Signaling

Dazhong Xu
Cen Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.646687

8,626 views
21 citations

Mini Review

Published on 25 Mar 2021

Ghrelin-Mediated Regeneration and Plasticity After Nervous System Injury

in Signaling

Irina Stoyanova
David Lutz

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.595914

6,861 views
22 citations

Review

Published on 23 Mar 2021

The Dual Role of STAT1 in Ovarian Cancer: Insight Into Molecular Mechanisms and Application Potentials

in Signaling

Xin Li
Fanchen Wang
Xiaolin Xu
Jinguo Zhang
Guoxiong Xu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.636595

11,223 views
41 citations

Hypothesis and Theory

Published on 23 Mar 2021

Reconciling VEGF With VPF: The Importance of Increased Vascular Permeability for Stroma Formation in Tumors, Healing Wounds, and Chronic Inflammation

in Signaling

Harold F. Dvorak

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.660609

5,349 views
26 citations

Review

Published on 19 Mar 2021

The Role of the Signaling Pathways Involved in the Effects of Hydrogen Sulfide on Endoplasmic Reticulum Stress

in Signaling

Shizhen Zhao
Xinping Li
Ping Lu
Xiaotian Li
Mingfei Sun
Honggang Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.646723

4,749 views
13 citations

Original Research

Published on 16 Mar 2021

lncRNA Gm16410 Mediates PM2.5-Induced Macrophage Activation via PI3K/AKT Pathway

in Signaling

Jingbin Xu
Henggui Xu
Kexin Ma
Yue Wang
Ben Niu
Li Zhang
Fasheng Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.618045

4,921 views
17 citations

Original Research

Published on 15 Mar 2021

Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts

in Signaling

Mahmood Yaseen Hachim
Noha Mousaad Elemam
Rakhee K. Ramakrishnan
Khuloud Bajbouj
Ronald Olivenstein
Ibrahim Yaseen Hachim
Saba Al Heialy
Qutayba Hamid
Hauke Busch
Rifat Hamoudi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.641404

9,010 views
25 citations

Mini Review

Published on 15 Mar 2021

Mechanistic Target of Rapamycin Inhibitors in Renal Cell Carcinoma: Potential, Limitations, and Perspectives

in Signaling

Seraina Faes
Nicolas Demartines
Olivier Dormond

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.636037

8,523 views
36 citations

Review

Published on 15 Mar 2021

How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy

in Signaling

Christopher E. Rudd

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.626095

14,682 views
49 citations

Original Research

Published on 15 Mar 2021

Pharmacologic Inhibition of ADAM10 Attenuates Brain Tissue Loss, Axonal Injury and Pro-inflammatory Gene Expression Following Traumatic Brain Injury in Mice

in Signaling

Dominik Appel
Regina Hummel
Martin Weidemeier
Kristina Endres
Christina Gölz
Michael K. E. Schäfer

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.661462

9,240 views
24 citations

Original Research

Published on 12 Mar 2021

Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage in Drosophila

in Signaling

Yu-Hsien Lin
Houda Ouns Maaroufi
Lucie Kucerova
Lenka Rouhova
Tomas Filip
Michal Zurovec

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.651367

6,080 views
8 citations

Review

Published on 11 Mar 2021

Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects

in Signaling

H. Yesid Estupiñán
Anna Berglöf
Rula Zain
C. I. Edvard Smith

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.630942

83,852 views
239 citations

Mini Review

Published on 11 Mar 2021

Playing the Whack-A-Mole Game: ERK5 Activation Emerges Among the Resistance Mechanisms to RAF-MEK1/2-ERK1/2- Targeted Therapy

in Signaling

Alessandro Tubita
Ignazia Tusa
Elisabetta Rovida

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.647311

8,354 views
21 citations

Mini Review

Published on 11 Mar 2021

Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression

in Signaling

Fei Huang
Xiaojun Wu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.649103

42,730 views
170 citations

Original Research

Published on 11 Mar 2021

Immune Profiling Reveals Molecular Classification and Characteristic in Urothelial Bladder Cancer

in Signaling

Li Yang
Aitian Li
Fengsen Liu
Qitai Zhao
Shaofei Ji
Wen Zhu
Weina Yu
Ru Zhang
Yaqing Liu
Wencai Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.596484

5,119 views
10 citations

Review

Published on 11 Mar 2021

Activating Mutation of SHP2 Establishes a Tumorigenic Phonotype Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms

in Signaling

Lei Dong
Da Han
Xinyi Meng
Mengchuan Xu
Chuwen Zheng
Qin Xia

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.630712

11,822 views
22 citations

Review

Published on 09 Mar 2021

The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia

in Signaling

Soudeh Ghafouri-Fard
Atefe Abak
Mahdi Mohaqiq
Hamed Shoorei
Mohammad Taheri

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.634512

5,239 views
11 citations

Mini Review

Published on 05 Mar 2021

P2X7 Receptor in Hematological Malignancies

in Signaling

Elena De Marchi
Anna Pegoraro
Elena Adinolfi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.645605

5,973 views
17 citations

Review

Published on 05 Mar 2021

Regulation of Age-Related Protein Toxicity

in Signaling

Anita Pras
Ellen A. A. Nollen

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.637084

8,265 views
18 citations

Original Research

Published on 04 Mar 2021

SARAF and Orai1 Contribute to Endothelial Cell Activation and Angiogenesis

in Signaling

Isabel Galeano-Otero
Raquel Del Toro
Abdel-Majid Khatib
Juan Antonio Rosado
Antonio Ordóñez-Fernández
Tarik Smani

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.639952

8,172 views
23 citations

Original Research

Published on 04 Mar 2021

CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism

in Signaling

Wen-Li Huang
Tuersunayi Abudureheman
Jing Xia
Lei Chu
Hang Zhou
Wei-Wei Zheng
Neng Zhou
Rong-Yi Shi
Ming-Hao Li
Jian-Min Zhu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.641271

10,771 views
27 citations

Mini Review

Published on 04 Mar 2021

Functional Importance of Transient Receptor Potential (TRP) Channels in Neurological Disorders

in Signaling

Kihwan Lee
Youn Yi Jo
Gehoon Chung
Jung Hoon Jung
Yong Ho Kim
Chul-Kyu Park

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.611773

11,088 views
41 citations

Mini Review

Published on 02 Mar 2021

In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes

in Signaling

Ulises Ahumada-Castro
Galdo Bustos
Eduardo Silva-Pavez
Andrea Puebla-Huerta
Alenka Lovy
César Cárdenas

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.629522

12,853 views
42 citations

1,291 articles

articles

Structural and Functional Significance of the Endoplasmic Reticulum Unfolded Protein Response Transducers and Chaperones at the Mitochondria–ER Contacts: A Cancer Perspective

Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy

Ghrelin-Mediated Regeneration and Plasticity After Nervous System Injury

The Dual Role of STAT1 in Ovarian Cancer: Insight Into Molecular Mechanisms and Application Potentials

Reconciling VEGF With VPF: The Importance of Increased Vascular Permeability for Stroma Formation in Tumors, Healing Wounds, and Chronic Inflammation

The Role of the Signaling Pathways Involved in the Effects of Hydrogen Sulfide on Endoplasmic Reticulum Stress

lncRNA Gm16410 Mediates PM2.5-Induced Macrophage Activation via PI3K/AKT Pathway

Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts

Mechanistic Target of Rapamycin Inhibitors in Renal Cell Carcinoma: Potential, Limitations, and Perspectives

How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy

Pharmacologic Inhibition of ADAM10 Attenuates Brain Tissue Loss, Axonal Injury and Pro-inflammatory Gene Expression Following Traumatic Brain Injury in Mice

Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage in Drosophila

Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects

Playing the Whack-A-Mole Game: ERK5 Activation Emerges Among the Resistance Mechanisms to RAF-MEK1/2-ERK1/2- Targeted Therapy

Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression

Immune Profiling Reveals Molecular Classification and Characteristic in Urothelial Bladder Cancer

Activating Mutation of SHP2 Establishes a Tumorigenic Phonotype Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms

The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia

P2X7 Receptor in Hematological Malignancies

Regulation of Age-Related Protein Toxicity

SARAF and Orai1 Contribute to Endothelial Cell Activation and Angiogenesis

CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism

Functional Importance of Transient Receptor Potential (TRP) Channels in Neurological Disorders

In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes