Frontiers in Cellular Neuroscience

Original Research

Published on 07 Oct 2025

Dual role of Lyz2-positive myeloid cells in traumatic brain injury: acute anti-inflammatory effects vs. chronic neurological deterioration

in Cellular Neuropathology

Hua-Zheng Yan
Yi-Wan Fang
Shi-Yu Zhou
Jian-Xiong Gao
Ming-Ming Bian
Yao-Mei Xu
Lin Zhang
Nan Zhang
He-Zuo Lü

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1642410

2,430 views

Original Research

Published on 03 Oct 2025

Rotenone accelerates endogenous α-synuclein spreading and enhances neurodegeneration in an intra-striatal α-synuclein preformed fibril injected mouse model of Parkinson’s disease

in Non-Neuronal Cells

Engila Khan
Nada Radwan
Mustafa T. Ardah
Tohru Kitada
M. Emdadul Haque

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1624593

3,044 views

Original Research

Published on 02 Oct 2025

Microglia-containing neural organoids as brain microphysiological systems for long-term culture

in Non-Neuronal Cells

Alex Rittenhouse
Caroline Krall
Jesse Plotkin
Dowlette-Mary Alam El Din
Breanne Kincaid
Jason Laird
Lena Smirnova

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1616470

5,328 views

Brief Research Report

Published on 01 Oct 2025

GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus

in Cellular Neurophysiology

Olga Netsyk
Sergiy V. Korol
Bryndis Birnir
Zhe Jin

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1638550

2,660 views

Original Research

Published on 30 Sep 2025

THC reverses SIV-induced senescence in astrocytes: possible compensatory mechanism against HIV associated brain injury?

in Cellular Neuropathology

Alison R. Van Zandt
Miranda D. Horn
Tiffany A. Peterson
Sarah Y. Dickinson
Elise M. Frost
Andrew G. MacLean

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1642917

2,481 views
1 citation

Original Research

Published on 25 Sep 2025

A mutational hotspot in TUBB2A associated with impaired heterodimer formation and severe brain developmental disorders

in Cellular Neuropathology

Gabriele Di Pasquale
Jacopo Colella
Carola P. Di Cataldo
Miguel A. Soler
Sara Fortuna
Emma Mizrahi-Powell
Mathilde Nizon
Benjamin Cognè
Valentina Turchetti
Giuseppe D. Mangano

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1664953

2,910 views

Review

Published on 25 Sep 2025

The role of small GTPases in Alzheimer’s disease tau pathologies

in Cellular Neuropathology

Peter Hoegy
Yan-Hua Chen
Qun Lu

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1650400

2,247 views

Brief Research Report

Published on 25 Sep 2025

Brain-derived neurotrophic factor prevents LPS-induced dysregulation of GABAergic interneuron markers in mouse hippocampus

in Cellular Neuropathology

Sara Rezaei
Mounira Banasr
Thomas D. Prevot
Yashika Bansal
Erica Vieira
Etienne Sibille

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1675003

2,475 views

Original Research

Published on 24 Sep 2025

Sex-specific interneuron vulnerability after traumatic brain injury correlates with neurotrophic signaling and chloride homeostasis, independent of behavioral and network outcomes

in Cellular Neuropathology

Amandine Consumi
Cécile Marcourt
Tayam Tnaimou
Jérôme Laurin
Michael K. E. Schäfer
Christophe Pellegrino
Claudio Rivera

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1572213

2,030 views

Brief Research Report

Published on 23 Sep 2025

Endothelin-1 triggers oxidative stress and cytokine release in human microglia cells through ETRB-dependent mechanisms

in Non-Neuronal Cells

Yaritza Inostroza-Nieves
Shakira Bou
José Alvarado
Diego Capo-Ruiz
Jessica Garcia
Jean P. Moliere
Claudia P. Arenas

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1677457

1,401 views

Original Research

Published on 23 Sep 2025

Lactate infusion increases circulating pro-brain-derived neurotrophic factor levels in humans

in Cellular Neuropathology

Julia Röja
Nicolas Fiori Ameller
Jonathan Grip
William Apró
Marcus Moberg

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1644843

4,175 views

Review

Published on 18 Sep 2025

Spatiotemporal crosstalk among mitochondrial dynamics, NLRP3 inflammasome activation, and histone lactylation drives α-synuclein pathology in prodromal Parkinson’s disease

in Cellular Neuropathology

Peizhu Lv
Xia Chen
Shiping Liu
Yu Zhang
Yan Bai
Shun Wang
Yulin Wang

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1636185

4,876 views

Original Research

Published on 16 Sep 2025

Boldine as a neuroprotective agent against motor neuron degeneration in models of amyotrophic lateral sclerosis

in Cellular Neuropathology

Carlos A. Toro
Wei Zhao
Patricio Garcia Silva
Daniela Retamal-Santibáñez
Fabiola Rojas
Jiangping Pan
Nicholas Johnson
Yorley Duarte
Christopher P. Cardozo
Juan C. Sáez

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1640590

2,687 views

Original Research

Published on 15 Sep 2025

Distinct reduction in relative microglial glucose uptake compared to astrocytes and neurons upon isolation from the brain environment

in Non-Neuronal Cells

Sebastian T. Kunte
Johannes Gnörich
Philipp Beumers
Laura M. Bartos
Stephan Wagner
Karin Wind-Mark
Adrien Holzgreve
Dennis Pötter
Rudolf A. Werner
Sibylle Ziegler

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1572431

2,108 views

Original Research

Published on 12 Sep 2025

Establishment of human Leber’s hereditary optic neuropathy model using iPSC-derived retinal organoids

in Cellular Neuropathology

Kota Aoshima
Yuya Takagi
Michinori Funato
Yoshiki Kuse
Shinsuke Nakamura
Masamitsu Shimazawa

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1635775

3,070 views

Review

Published on 10 Sep 2025

Alzheimer’s disease: where do we stand now and what are the strategic interventions?

in Cellular Neuropathology

Andrea González
Stephanie Geywitz
Ricardo B. Maccioni

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1655342

3,480 views

Review

Published on 10 Sep 2025

Schwann cells in the inner ear: development, disease, and regeneration

in Cellular Neuropathology

Drew J. Montigny
Judith S. Kempfle

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1662274

2,903 views

Methods

Published on 08 Sep 2025

A customized affordable multiplexed immunofluorescence method visualizes early changes in the mouse brain microenvironment upon laser cytoreduction

in Cellular Neuropathology

Santhosh Shanmugam Anandhan
Jeremy Spence
Farhana Begum
Nimrat Kaur
Dana Henderson
Sabine Hombach-Klonisch
Thomas Klonisch

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1553058

2,556 views

Original Research

Published on 05 Sep 2025

Growth hormone reduces retinal inflammation and preserves microglial morphology after optic nerve crush in male rats

in Cellular Neuropathology

Jerusa E. Balderas-Márquez
David Epardo
Lourdes Siqueiros-Márquez
Martha Carranza
Maricela Luna
José Luis Quintanar
Carlos Arámburo
Carlos G. Martínez-Moreno

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1636399

2,870 views

Original Research

Published on 03 Sep 2025

Nodal Na+ and Ca2+ flux dynamics in cortical myelinated axons

in Cellular Neurophysiology

Oron Kotler
Kenichi Miyazaki
Yana Khrapunsky
William N. Ross
Ilya A. Fleidervish

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1662730

2,213 views

Original Research

Published on 03 Sep 2025

Early olfactory dysfunction in experimental autoimmune encephalomyelitis reflects transient brain barrier breach and initiation of neuroinflammation in the olfactory bulb

in Cellular Neuropathology

Andjela Stekic
Milorad Dragic
Ivana Stevanovic
Marina Zaric Kontic
Marija Adzic Bukvic
Sanja Dacic
Milica Ninkovic
Nadezda Nedeljkovic

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1656777

2,376 views

Review

Published on 02 Sep 2025

Vascular endothelial growth factor: a key factor in the onset and treatment of depression

in Non-Neuronal Cells

Jing Wang
Fanhao Meng
Long Wang
Zeguang Li

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1645437

2,692 views
2 citations

Review

Published on 02 Sep 2025

Research progress of kinesin family in neurological diseases

in Cellular Neuropathology

Shuyi Liu
Jialing Chen
Liping Shi
Yuan Deng
Zhengbo Wang

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1527305

2,387 views

Review

Published on 01 Sep 2025

NcRNAs: a potential treatment for spinal cord injury

in Cellular Neuropathology

Jie Bao
Wenhui Zhi
Sheng Qi
Haolong Mo
Ruzhuan Liu
Chunhui Guo

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1645639

1,912 views

6,216 articles

articles

Dual role of Lyz2-positive myeloid cells in traumatic brain injury: acute anti-inflammatory effects vs. chronic neurological deterioration

Rotenone accelerates endogenous α-synuclein spreading and enhances neurodegeneration in an intra-striatal α-synuclein preformed fibril injected mouse model of Parkinson’s disease

Microglia-containing neural organoids as brain microphysiological systems for long-term culture

GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus

THC reverses SIV-induced senescence in astrocytes: possible compensatory mechanism against HIV associated brain injury?

A mutational hotspot in TUBB2A associated with impaired heterodimer formation and severe brain developmental disorders

The role of small GTPases in Alzheimer’s disease tau pathologies

Brain-derived neurotrophic factor prevents LPS-induced dysregulation of GABAergic interneuron markers in mouse hippocampus

Sex-specific interneuron vulnerability after traumatic brain injury correlates with neurotrophic signaling and chloride homeostasis, independent of behavioral and network outcomes

Endothelin-1 triggers oxidative stress and cytokine release in human microglia cells through ETRB-dependent mechanisms

Lactate infusion increases circulating pro-brain-derived neurotrophic factor levels in humans

Spatiotemporal crosstalk among mitochondrial dynamics, NLRP3 inflammasome activation, and histone lactylation drives α-synuclein pathology in prodromal Parkinson’s disease

Boldine as a neuroprotective agent against motor neuron degeneration in models of amyotrophic lateral sclerosis

Distinct reduction in relative microglial glucose uptake compared to astrocytes and neurons upon isolation from the brain environment

Establishment of human Leber’s hereditary optic neuropathy model using iPSC-derived retinal organoids

Alzheimer’s disease: where do we stand now and what are the strategic interventions?

Schwann cells in the inner ear: development, disease, and regeneration

A customized affordable multiplexed immunofluorescence method visualizes early changes in the mouse brain microenvironment upon laser cytoreduction

Growth hormone reduces retinal inflammation and preserves microglial morphology after optic nerve crush in male rats

Nodal Na+ and Ca2+ flux dynamics in cortical myelinated axons

Early olfactory dysfunction in experimental autoimmune encephalomyelitis reflects transient brain barrier breach and initiation of neuroinflammation in the olfactory bulb

Vascular endothelial growth factor: a key factor in the onset and treatment of depression

Research progress of kinesin family in neurological diseases

NcRNAs: a potential treatment for spinal cord injury