Frontiers in Cellular Neuroscience

Review

Published on 12 Nov 2025

Aquaporin-4 in glioblastoma: a nexus of glymphatic dysfunction, edema, immune evasion, and treatment resistance

in Non-Neuronal Cells

Leandro Castañeyra-Ruiz
Ibrahim González-Marrero
Luis H. García-Abad
Emilio Gonzalez-Arnay
Marcial Camacho
Emilia Ma Carmona-Calero
Seunghyun Lee
Celine Thao-Quyen Tran
Brian W. Hanak
Michael Muhonen

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1685491

2,259 views
2 citations

Editorial

Published on 10 Nov 2025

Editorial: New approaches to overcome the blood-brain barrier for the treatment of CNS disorders

in Non-Neuronal Cells

Mikko Gynther
Gert Fricker
Sabrina Petralla

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1730250

1,087 views

Mini Review

Published on 30 Oct 2025

Ontogeny and colonization of embryonic border-associated macrophages and their role in neurodevelopment

in Non-Neuronal Cells

Ashley M. Otero
Adrienne M. Antonson

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1677414

1,959 views

Review

Published on 29 Oct 2025

The role of brain mechanisms in diabetic peripheral neuropathy: recent advances and comprehensive analysis

in Non-Neuronal Cells

Min Wei
Ye Jiang
Jiayin Shou
Guogang Xing
Min Li

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1637357

2,419 views

Original Research

Published on 03 Oct 2025

Rotenone accelerates endogenous α-synuclein spreading and enhances neurodegeneration in an intra-striatal α-synuclein preformed fibril injected mouse model of Parkinson’s disease

in Non-Neuronal Cells

Engila Khan
Nada Radwan
Mustafa T. Ardah
Tohru Kitada
M. Emdadul Haque

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1624593

3,601 views

Original Research

Published on 02 Oct 2025

Microglia-containing neural organoids as brain microphysiological systems for long-term culture

in Non-Neuronal Cells

Alex Rittenhouse
Caroline Krall
Jesse Plotkin
Dowlette-Mary Alam El Din
Breanne Kincaid
Jason Laird
Lena Smirnova

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1616470

6,419 views
1 citation

Brief Research Report

Published on 23 Sep 2025

Endothelin-1 triggers oxidative stress and cytokine release in human microglia cells through ETRB-dependent mechanisms

in Non-Neuronal Cells

Yaritza Inostroza-Nieves
Shakira Bou
José Alvarado
Diego Capo-Ruiz
Jessica Garcia
Jean P. Moliere
Claudia P. Arenas

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1677457

1,707 views

Original Research

Published on 15 Sep 2025

Distinct reduction in relative microglial glucose uptake compared to astrocytes and neurons upon isolation from the brain environment

in Non-Neuronal Cells

Sebastian T. Kunte
Johannes Gnörich
Philipp Beumers
Laura M. Bartos
Stephan Wagner
Karin Wind-Mark
Adrien Holzgreve
Dennis Pötter
Rudolf A. Werner
Sibylle Ziegler

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1572431

2,406 views

Review

Published on 02 Sep 2025

Vascular endothelial growth factor: a key factor in the onset and treatment of depression

in Non-Neuronal Cells

Jing Wang
Fanhao Meng
Long Wang
Zeguang Li

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1645437

3,247 views
2 citations

Original Research

Published on 01 Sep 2025

APOE genotype-dependent differences in human astrocytic energy metabolism

in Non-Neuronal Cells

Vanessa Budny
Chantal Bodenmann
Kathrin J. Zürcher
Maik Krüger
Sherida M. de Leeuw
Rebecca Z. Weber
Ruslan Rust
Luca Ravotto
Iván Ruminot
L. Felipe Barros

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1603657

4,346 views

Perspective

Published on 13 Aug 2025

Underestimation of mitochondrial respiratory capacity in gray matter voxels of the human brain map due to limited OXPHOS and TCA cycle in astrocytes

in Non-Neuronal Cells

Christos Chinopoulos

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1661231

1,892 views

Review

Published on 06 Aug 2025

Astrocyte alterations in α-synucleinopathies

in Non-Neuronal Cells

Manuela Rodríguez-Castañeda
Ana Campos-Ríos
Jose Antonio Lamas
Ana Covelo

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1650326

2,243 views
3 citations

Original Research

Published on 29 Jul 2025

Validation of Hv1 channel functions in BV2 microglial cells using small molecule modulators

in Non-Neuronal Cells

Ashutosh Sharma
Nandini B. Kale
Priyanka Yadav
Shivani Yadav
Madhavi Ranawat
Valmik S. Shinde
Aravind Singh Kshatri

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1624224

3,462 views
1 citation

Review

Published on 22 Jul 2025

Walking on the tightrope: the shared roles of the bridging pericytes in the brain

in Non-Neuronal Cells

Audrey Chagnot
Axel Montagne

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1615579

3,052 views
1 citation

Original Research

Published on 21 Jul 2025

Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach

in Non-Neuronal Cells

Farida Tripodi
Elisa Maffioli
Silvia Sacchi
Valentina Rabattoni
Zoraide Motta
Claudia Bearzi
Gabriella Tedeschi
Loredano Pollegioni
Paola Coccetti

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1616911

2,561 views
1 citation

Original Research

Published on 08 Jul 2025

AhR regulation of amyloid beta-induced inflammation in astrocyte cells

in Non-Neuronal Cells

Emmanuel Ojo
Temitope Adu
Raheem F. H. AI Aameri
Shelley A. Tischkau

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1618209

2,853 views
1 citation

Methods

Published on 19 Jun 2025

Establishment of an AI-supported scoring system for neuroglial cells

in Non-Neuronal Cells

Annika Bitsch
Manfred Henrich
Svenja Susanne Erika Körber
Kathrin Büttner
Christiane Herden

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1584422

1,470 views
1 citation

Editorial

Published on 10 Jun 2025

Editorial: The legacy of Sherrington and Adrian Nobel Prize: non-neuronal cells in information processing

in Non-Neuronal Cells

Wuhyun Koh
Zhuofan Lei

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1634743

1,643 views

Editorial

Published on 09 Jun 2025

Editorial: Non-neuronal cells in neurodegenerative diseases and psychiatric disorders

in Non-Neuronal Cells

Enrique Estudillo
Gilberto Pérez-Sánchez
Lenin Pavón
Adriana Jiménez

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1623523

2,307 views

Original Research

Published on 22 May 2025

Investigating the use of cuprizone and lysolecithin to model demyelination ex vivo in sagittal rat brain organotypic slice cultures

in Non-Neuronal Cells

Brooke Hawker
Bronwen Connor
Amy McCaughey-Chapman

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1609806

3,216 views

Review

Published on 15 May 2025

Astrocyte regulation of behavioral outputs: the versatile roles of calcium

in Non-Neuronal Cells

Gillian Imrie
Isabella Farhy-Tselnicker

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1606265

4,302 views
8 citations

Original Research

Published on 24 Apr 2025

Circulating CD4+, CD8+, and double-negative T cells in ischemic stroke and stroke-associated infection: a prospective case-control study

in Non-Neuronal Cells

Magdalena Telec
Magdalena Frydrychowicz
Radosław Kazmierski
Izabela Wojtasz
Grzegorz Dworacki
Wojciech Kozubski
Maria Łukasik

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1547905

2,567 views
3 citations

Original Research

Published on 23 Apr 2025

Topographic relationship between glial cells and neovessels of the epiretinal membrane in proliferative diabetic retinopathy depends on the phase of angiogenesis

in Non-Neuronal Cells

Svetlana V. Sdobnikova
Sergey S. Makhotin
Alexander V. Revishchin
Veronika Y. Sysoeva
Galina V. Pavlova
Lyubov E. Sdobnikova

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1571596

2,277 views

Mini Review

Published on 15 Apr 2025

Role of glial cells in motor neuron degeneration in hereditary spastic paraplegias

in Non-Neuronal Cells

Manaswini Vijayaraghavan
Sarvika Periyapalayam Murali
Gitika Thakur
Xue-Jun Li

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1553658

3,766 views
2 citations

1,091 articles

articles

Aquaporin-4 in glioblastoma: a nexus of glymphatic dysfunction, edema, immune evasion, and treatment resistance

Editorial: New approaches to overcome the blood-brain barrier for the treatment of CNS disorders

Ontogeny and colonization of embryonic border-associated macrophages and their role in neurodevelopment

The role of brain mechanisms in diabetic peripheral neuropathy: recent advances and comprehensive analysis

Rotenone accelerates endogenous α-synuclein spreading and enhances neurodegeneration in an intra-striatal α-synuclein preformed fibril injected mouse model of Parkinson’s disease

Microglia-containing neural organoids as brain microphysiological systems for long-term culture

Endothelin-1 triggers oxidative stress and cytokine release in human microglia cells through ETRB-dependent mechanisms

Distinct reduction in relative microglial glucose uptake compared to astrocytes and neurons upon isolation from the brain environment

Vascular endothelial growth factor: a key factor in the onset and treatment of depression

APOE genotype-dependent differences in human astrocytic energy metabolism

Underestimation of mitochondrial respiratory capacity in gray matter voxels of the human brain map due to limited OXPHOS and TCA cycle in astrocytes

Astrocyte alterations in α-synucleinopathies

Validation of Hv1 channel functions in BV2 microglial cells using small molecule modulators

Walking on the tightrope: the shared roles of the bridging pericytes in the brain

Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach

AhR regulation of amyloid beta-induced inflammation in astrocyte cells

Establishment of an AI-supported scoring system for neuroglial cells

Editorial: The legacy of Sherrington and Adrian Nobel Prize: non-neuronal cells in information processing

Editorial: Non-neuronal cells in neurodegenerative diseases and psychiatric disorders

Investigating the use of cuprizone and lysolecithin to model demyelination ex vivo in sagittal rat brain organotypic slice cultures

Astrocyte regulation of behavioral outputs: the versatile roles of calcium

Circulating CD4+, CD8+, and double-negative T cells in ischemic stroke and stroke-associated infection: a prospective case-control study

Topographic relationship between glial cells and neovessels of the epiretinal membrane in proliferative diabetic retinopathy depends on the phase of angiogenesis

Role of glial cells in motor neuron degeneration in hereditary spastic paraplegias