Frontiers in Cellular Neuroscience

Original Research

Published on 22 Apr 2025

O6-methylguanine DNA methyltransferase (MGMT) expression in U1242 glioblastoma cells enhances in vitro clonogenicity, tumor implantation in vivo, and sensitivity to alisertib-carboplatin combination treatment

Müge Sak
Brian J. Williams
Andrew J. Hey
Mayur Sharma
Leslie Schier
Megan J. Wilson
Mahatma Ortega
Alyssa I. Lara
Mikaela N. Brentlinger
Norman L. Lehman

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1552015

2,768 views
2 citations

Original Research

Published on 17 Apr 2025

Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases

Adhithiya Charli
Yuan-Teng Chang
Jie Luo
Bharathi Palanisamy
Emir Malovic
Zainab Riaz
Cameron Miller
Manikandan Samidurai
Gary Zenitsky
Huajun Jin

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1549265

3,808 views
1 citation

Review

Published on 17 Apr 2025

Intestinal injury and changes of the gut microbiota after ischemic stroke

Yang Shen
Jin Wang
Yina Li
Xianhui Kang
Lijuan Gu

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1557746

3,558 views
2 citations

Original Research

Published on 17 Apr 2025

Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s disease

Daniel Tortolani
Davide Decandia
Giacomo Giacovazzo
Lucia Scipioni
Anna Panuccio
Francesca Ciaramellano
Fabiola Eugelio
Federico Fanti
Emanuele Claudio Latagliata
Livia La Barbera

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1571428

3,809 views
2 citations

Systematic Review

Published on 16 Apr 2025

Assessment of mesenchymal stem cells for the treatment of spinal cord injury: a systematic review and network meta-analysis

Runfang Wang
Yiding Wang
Fangning Yan
Jinqing Sun
Tianyu Zhang

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1532219

26,067 views
1 citation

Mini Review

Published on 15 Apr 2025

Role of glial cells in motor neuron degeneration in hereditary spastic paraplegias

Manaswini Vijayaraghavan
Sarvika Periyapalayam Murali
Gitika Thakur
Xue-Jun Li

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1553658

3,452 views
2 citations

Review

Published on 15 Apr 2025

The learning primacy hypothesis of dopamine: reconsidering dopamine’s dual functions

Charltien Long
Sotiris C. Masmanidis

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1538500

3,651 views
3 citations

Opinion

Published on 14 Apr 2025

Cases of Creutzfeldt-Jakob disease in young individuals: open questions regarding aetiology

Ilia V. Baskakov

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1571662

6,428 views
1 citation

Review

Published on 10 Apr 2025

The roles of immune factors in neurodevelopment

Chong Wang
Tingting He
Jie Qin
Jianwei Jiao
Fen Ji

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1451889

4,105 views
6 citations

Original Research

Published on 10 Apr 2025

Genetic mechanisms of dynamic functional connectivity density in diabetic retinopathy brains: a combined transcriptomic and resting-state functional magnetic resonance imaging study

Yu-Lin Zhong
Hao Liu
Xin Huang

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1476038

2,383 views
1 citation

Brief Research Report

Published on 09 Apr 2025

Activity-dependent refinement of axonal projections forms one-to-one connection pattern in the developing chick ciliary ganglion

Ryo Egawa
Hiromu Yawo
Hiroshi Kuba

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1560402

2,011 views

Original Research

Published on 09 Apr 2025

A humanized Gs-coupled DREADD for circuit and behavior modulation

Qi Zhang
Ruiqi Wang
Liang Zhang
Mengqi Li
Jianbang Lin
Xiaoyang Lu
Yixuan Tian
Yunping Lin
Taian Liu
Yefei Chen

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1577117

3,699 views

Review

Published on 07 Apr 2025

Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects

Carola Y. Förster
Sergey Shityakov
Stavros Stavrakis
Verena Scheper
Thomas Lenarz

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1523149

4,330 views
2 citations

Review

Published on 07 Apr 2025

Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment

Xiaochen Fu
Jia Li
Shoujun Yang
Jiapeng Jing
Qinzhi Zheng
Ting Zhang
Zhuo Xu

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1536028

4,945 views
4 citations

Mini Review

Published on 07 Apr 2025

Neuroimmune crosstalk in chronic neuroinflammation: microglial interactions and immune modulation

Ludmila Müller
Svetlana Di Benedetto

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1575022

6,453 views
21 citations

Original Research

Published on 07 Apr 2025

Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs

Teppei Kouga
Toru Miwa
Fan-yan Wei
Kishiko Sunami
Kazuhito Tomizawa

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1541347

3,245 views

Review

Published on 07 Apr 2025

Physiological roles of embryonic microglia and their perturbation by maternal inflammation

Tsukasa Shimamura
Masashi Kitashiba
Kazutaka Nishizawa
Yuki Hattori

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1552241

4,059 views
4 citations

Review

Published on 07 Apr 2025

CRISPR/Cas9-Based therapeutics as a promising strategy for management of Alzheimer’s disease: progress and prospects

Mohamad Sultan Khan
Nousheen Qureshi
Rehan Khan
Young-Ok Son
Tariq Maqbool

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1578138

12,056 views
13 citations

Review

Published on 04 Apr 2025

Natural killer cells in multiple sclerosis: foe or friends?

Fatemeh Aghaee
Mohammadreza Abedinpour
Saeid Anvari
Alia Saberi
Amir Fallah
Arash Bakhshi

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1500770

3,839 views
4 citations

Review

Published on 02 Apr 2025

An electrophysiologist’s guide to dorsal horn excitability and pain

Iván Rivera-Arconada
Mark L. Baccei
José A. López-García
Rita Bardoni

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1548252

4,178 views
9 citations

Editorial

Published on 01 Apr 2025

Editorial: Metabolic dysregulation in neurodegenerative diseases

Maria Jimenez-Gonzalez

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1591313

2,084 views
1 citation

Original Research

Published on 01 Apr 2025

Combined strategy of α 9-integrin transduction and AEIDGIEL peptide-functionalized fibrin gel biomaterials to promote mature DRG neurite growth

Anda Cimpean
Lars Roll
Jacqueline Reinhard
Jessica C. F. Kwok
Andreas Faissner
Fred de Winter
James W. Fawcett
Pavla Jendelová

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1568004

2,050 views

Review

Published on 31 Mar 2025

Research progress of DNA methylation on the regulation of substance use disorders and the mechanisms

Ya Liu
Xiao-Qian Wang
Peng Zhang
Abbas Haghparast
Wen-Bin He
Jian-Jun Zhang

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1566001

3,530 views
1 citation

Original Research

Published on 31 Mar 2025

A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression

Hongxia Zhao
Lingge Huang
Jian Liu
Min Feng
Yeqian Liu
Hong Li
Shan Gong
Chunming Chen
Shuiqing Zeng
Weiqiong Ren

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1553309

3,649 views
1 citation

266 Publications

volumes

O6-methylguanine DNA methyltransferase (MGMT) expression in U1242 glioblastoma cells enhances in vitro clonogenicity, tumor implantation in vivo, and sensitivity to alisertib-carboplatin combination treatment

Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases

Intestinal injury and changes of the gut microbiota after ischemic stroke

Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s disease

Assessment of mesenchymal stem cells for the treatment of spinal cord injury: a systematic review and network meta-analysis

Role of glial cells in motor neuron degeneration in hereditary spastic paraplegias

The learning primacy hypothesis of dopamine: reconsidering dopamine’s dual functions

Cases of Creutzfeldt-Jakob disease in young individuals: open questions regarding aetiology

The roles of immune factors in neurodevelopment

Genetic mechanisms of dynamic functional connectivity density in diabetic retinopathy brains: a combined transcriptomic and resting-state functional magnetic resonance imaging study

Activity-dependent refinement of axonal projections forms one-to-one connection pattern in the developing chick ciliary ganglion

A humanized Gs-coupled DREADD for circuit and behavior modulation

Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects

Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment

Neuroimmune crosstalk in chronic neuroinflammation: microglial interactions and immune modulation

Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs

Physiological roles of embryonic microglia and their perturbation by maternal inflammation

CRISPR/Cas9-Based therapeutics as a promising strategy for management of Alzheimer’s disease: progress and prospects

Natural killer cells in multiple sclerosis: foe or friends?

An electrophysiologist’s guide to dorsal horn excitability and pain

Editorial: Metabolic dysregulation in neurodegenerative diseases

Combined strategy of α 9-integrin transduction and AEIDGIEL peptide-functionalized fibrin gel biomaterials to promote mature DRG neurite growth

Research progress of DNA methylation on the regulation of substance use disorders and the mechanisms

A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression