Frontiers in Chemical Biology

Review

Published on 10 Feb 2026

Zinc-dependent aminopeptidases: new perspectives on structure, function, and biomedical applications

in Bioinorganic Chemistry

Saleem Bhat

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1752191

429 views

Original Research

Accepted on 09 Feb 2026

Roscovitine Derivative Optimization via Molecular Dynamics Reveals Potent and Selective CDK5 Binders

in Theoretical Modeling, Structure Prediction & Design

Lorenzo Botta
Giovanni Carotenuto
Manuel Arcieri
Elena Di Nisio
Valerio Perticaroli
Tiziana Castrignanò
Raffaele Saladino
Rodolfo Negri

Frontiers in Chemical Biology

Original Research

Published on 05 Feb 2026

Design, synthesis, reactivity, and biological activity of nitroimidazole derivatives and their copper(II) coordination compounds

in Bioinorganic Chemistry

Walter Fugarolas
Lorena Reyes-Carmona
Bruno Landeros-Rivera
Argelia Almaguer-Flores
Norah Barba-Behrens

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1736242

433 views

Original Research

Accepted on 04 Feb 2026

Ligand-directed assembly of an iminodiacetate-hybridized molybdenum-red isopolyoxomolybdate MoV10MoVI3

in Bioinorganic Chemistry

Ingrid Gregorovic
Emir Al-Sayed
Nadiia I. Gumerova
Judith Füllborn-Ott
Ingo Ott
Gerald Giester
Annette Rompel

Frontiers in Chemical Biology

Mini Review

Published on 30 Jan 2026

Ferritin-metallodrugs nanocomposites: light and shadow of drugs loading methods

in Bioinorganic Chemistry

Rosanna Lucignano
Giarita Ferraro

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1740075

276 views

Original Research

Published on 30 Jan 2026

Redox potential fine tuning of ferrocene-peptide conjugates

in Bioinorganic Chemistry

Alessia Difino
Barbara Biondi
Annalisa Bisello
Roberta Cardena
Luana Lastella
Marko Šimić
Beatrice Calderaro
Fernando Formaggio
Marzio Rancan
Saverio Santi

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1736812

403 views

Perspective

Published on 28 Jan 2026

Protein metalation by anticancer metal-based drugs revealed through the integration of ESI-MS and XRD measurements. State of the art and open issues

in Bioinorganic Chemistry

Antonello Merlino
Tiziano Marzo
Luigi Messori

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1758486

283 views

Mini Review

Published on 22 Jan 2026

Anticancer drugs based on metal complexes of 2-imine-8-hydroxyquinolines

in Bioinorganic Chemistry

Leonor Côrte-Real
Nádia Ribeiro
Isabel Correia

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1734289

411 views

Perspective

Published on 15 Jan 2026

From simple to complex: multiscale modeling of metal-mediated protein interactions to uncover mechanistic insights into the action of inorganic drugs

in Bioinorganic Chemistry

Lorenzo Chiaverini
Lidia Ciccone
Alessandro Marrone
Luca Famlonga
Davide Piroddu
Nicolò Tonali
Iogann Tolbatov
Jürgen Gailer
Tiziano Marzo
Luigi Messori

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1764819

471 views

Review

Published on 12 Jan 2026

Receptor-targeted technetium-99m radiopharmaceuticals: increasing access to molecular imaging in healthcare

in Bioinorganic Chemistry

Michelle T. Ma

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1729615

627 views

Perspective

Published on 05 Jan 2026

Tailoring LC approaches to address the chemical biology of toxic metals in humans

in Bioinorganic Chemistry

Jürgen Gailer

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1729141

340 views

Specialty Grand Challenge

Published on 19 Dec 2025

Grand challenges in bioanalytical chemistry

in Quantitative and Analytical Techniques

George Barisas
Deborah A. Roess

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1746545

1,003 views

Mini Review

Published on 19 Dec 2025

The importance of ferric reductases for iron uptake in humans

in Bioinorganic Chemistry

Hitomi Sawai

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1724624

1,090 views

Mini Review

Published on 18 Dec 2025

Metallacrowns: an ideal platform for accessing lanthanide luminescence

in Structure, Spectroscopy & Imaging

Soroush Naseri
Vincent L. Pecoraro

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1726839

673 views

Original Research

Published on 08 Dec 2025

In silico study of structure-based screening of inhibitors to block PrPC conversion and amyloid aggregation

in Theoretical Modeling, Structure Prediction & Design

Kamakshi Ruhela
Subham
Shailendra S. Maurya
Hemlata Dwivedi-Agnihotri
Sumit K. Chaturvedi

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1736396

777 views

Brief Research Report

Published on 05 Dec 2025

An evaluation of high-field asymmetric-waveform ion mobility spectrometry coupled to electron-transfer/higher-energy collision dissociation for ADP-ribosylation proteomics

in Quantitative and Analytical Techniques

Taku Kasai
Gabriel Shlayen
Yuto Nakamura
Masanori Aikawa
Sasha A. Singh

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1709253

715 views

Original Research

Published on 26 Nov 2025

Drug repurposing for Chagas disease: overcoming the hit-to-preclinical candidate stage

in Molecular Sciences

Claudia Veira
Belén Dávila
Elva Serna
Nilda Portillo
Gloria Yaluff
Guzmán Álvarez
Hugo Cerecetto
Elena Aguilera

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1662907

698 views

Specialty Grand Challenge

Published on 24 Nov 2025

Grand challenges in chemical biology from the perspective of organic chemical synthesis

in Organic Chemical Synthesis

Marco Francescato
Hang Liao
Luca Gentilucci

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1731631

1,851 views

Original Research

Published on 20 Nov 2025

Copper complexes containing o-phenylenediamine-based pentadentate ligands catalyze TEMPO-mediated alcohol oxidation

in Structure, Spectroscopy & Imaging

Yuji Mikata
Miyu Akedo
Yutaka Ohsedo
Sunao Shoji
Takashi Matsuo
Attawit Jehdaramarn
Preeyanuch Sangtrirutnugul
Yasuhiro Funahashi

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1688400

880 views

Mini Review

Published on 20 Oct 2025

Metals in medicine: unlocking new avenues for neurodegenerative disease treatment

in Bioinorganic Chemistry

Kuan Teng Tan
Kok Whye Cheong
Lai Chun Wong
Hélène C. Bertrand
Nurul Huda Abd Karim
Yie Kie Chong
May Lee Low

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1696058

2,090 views

Original Research

Published on 17 Oct 2025

Quantifying antioxidant activity of hydrophobic compounds using metal-mediated DNA damage

in Bioinorganic Chemistry

Andrea A. E. Gaertner
Nathan R. Perron
Heeren M. G. Anderholm
Daniel C. Whitehead
Julia L. Brumaghim

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1677610

1,055 views

Perspective

Published on 29 Sep 2025

X-ray structures of metal-protein adducts at body temperature: concepts, examples and perspectives

in Bioinorganic Chemistry

Antonello Merlino

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1670177

883 views

Correction

Published on 19 Sep 2025

Correction: An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme

in Molecular Sciences

Lauren B. Coco
Caren L. Freel Meyers

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1670585

618 views

Editorial

Published on 19 Sep 2025

Editorial: Linking chemistry to biology and medicine via metal ions: developed from the 16th international symposium on applied bioinorganic chemistry

in Bioinorganic Chemistry

Christina N. Banti
Debbie C. Crans
Ana Maria Da Costa Ferreira
Sotiris K. Hadjikakou

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1695257

1,233 views

84 articles

articles

Zinc-dependent aminopeptidases: new perspectives on structure, function, and biomedical applications

Roscovitine Derivative Optimization via Molecular Dynamics Reveals Potent and Selective CDK5 Binders

Design, synthesis, reactivity, and biological activity of nitroimidazole derivatives and their copper(II) coordination compounds

Ligand-directed assembly of an iminodiacetate-hybridized molybdenum-red isopolyoxomolybdate MoV10MoVI3

Ferritin-metallodrugs nanocomposites: light and shadow of drugs loading methods

Redox potential fine tuning of ferrocene-peptide conjugates

Protein metalation by anticancer metal-based drugs revealed through the integration of ESI-MS and XRD measurements. State of the art and open issues

Anticancer drugs based on metal complexes of 2-imine-8-hydroxyquinolines

From simple to complex: multiscale modeling of metal-mediated protein interactions to uncover mechanistic insights into the action of inorganic drugs

Receptor-targeted technetium-99m radiopharmaceuticals: increasing access to molecular imaging in healthcare

Tailoring LC approaches to address the chemical biology of toxic metals in humans

Grand challenges in bioanalytical chemistry

The importance of ferric reductases for iron uptake in humans

Metallacrowns: an ideal platform for accessing lanthanide luminescence

In silico study of structure-based screening of inhibitors to block PrPC conversion and amyloid aggregation

An evaluation of high-field asymmetric-waveform ion mobility spectrometry coupled to electron-transfer/higher-energy collision dissociation for ADP-ribosylation proteomics

Drug repurposing for Chagas disease: overcoming the hit-to-preclinical candidate stage

Grand challenges in chemical biology from the perspective of organic chemical synthesis

Copper complexes containing o-phenylenediamine-based pentadentate ligands catalyze TEMPO-mediated alcohol oxidation

Metals in medicine: unlocking new avenues for neurodegenerative disease treatment

Quantifying antioxidant activity of hydrophobic compounds using metal-mediated DNA damage

X-ray structures of metal-protein adducts at body temperature: concepts, examples and perspectives

Correction: An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme

Editorial: Linking chemistry to biology and medicine via metal ions: developed from the 16th international symposium on applied bioinorganic chemistry