Frontiers in Chemical Biology

Perspective

Published on 04 Sep 2025

Lessons from metals-containing drugs in diagnostic, and theranostic applications for future development of metal-containing non-conventional therapeutics: vanadium compounds for intratumor administration

in Bioinorganic Chemistry

Adam R. Miller
Debbie C. Crans

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1639340

1,876 views
1 citation

Original Research

Published on 14 Aug 2025

Preliminary investigation of Ru(II) complexes bearing nile red chromophores for photodynamic therapy

in Bioinorganic Chemistry

Claire Condon
Oriol Careta-Borràs
Judit Fodor
Amani B. Al Riyami
Xiao Xiao
Jianzhang Zhao
Carme Nogués
Sylvia M. Draper

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1620562

1,513 views

Original Research

Published on 12 Aug 2025

Carboxymethyl cellulose hydrogel doped with zinc-aspirinate as a multifunctional material: photoprotection, epithelial regeneration, and biocompatibility

in Bioinorganic Chemistry

Christina N. Banti
Fotakis Lezos
Antonios Hatzidimitriou
Sotiris K. Hadjikakou

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1639096

1,511 views

Editorial

Published on 15 Jul 2025

Editorial: Insights in theoretical modelling, structure prediction and design

in Theoretical Modeling, Structure Prediction & Design

Andrea Ilari
Veronica Morea
Adriana Erica Miele

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1653901

1,056 views

Brief Research Report

Published on 24 Jun 2025

Boronic acid-modified cell-penetrating peptide exhibits superior performance over natural TAT peptide

in Structure, Spectroscopy & Imaging

Pritam Ghosh

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1610127

2,338 views
3 citations

Specialty Grand Challenge

Published on 18 Jun 2025

Specialty grand challenges in theoretical modeling, structure prediction and design

in Theoretical Modeling, Structure Prediction & Design

Cécile Exertier
Andrea Ilari

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1635423

1,896 views

Original Research

Published on 17 Jun 2025

How vanadium and manganese compounds impact cardiac mitochondrial function

in Bioinorganic Chemistry

Connor C. Dolan
Luke A. Whitcomb
Edgar Del Carpio
Lilliana Rose
Adam J. Chicco
Debbie C. Crans

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1602602

2,090 views

Original Research

Published on 14 May 2025

Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis

in Theoretical Modeling, Structure Prediction & Design

Cécile Exertier
Lorenzo Antonelli
Vittorio Brufani
Gianni Colotti
Andrea Ilari
Annarita Fiorillo

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1605579

2,329 views

Original Research

Published on 12 May 2025

Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation

in Theoretical Modeling, Structure Prediction & Design

Marika Attili
Sonia Valentini
Maria Pesavento
Marco Ballarotto
Viviana Scognamiglio
Alfredo Pontecorvi
Antonio Macchiarulo
Fulvio Saccoccia
Fabiola Moretti

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1576640

3,159 views

Original Research

Published on 23 Apr 2025

Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation

in Theoretical Modeling, Structure Prediction & Design

Carla Luciana Padilla Franzotti
Nicolas Palopoli
Juliana Palma
Gustavo Pierdominici-Sottile

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1538350

1,579 views

Editorial

Published on 03 Apr 2025

Editorial: New developments in bioinorganic and bioorganic chemistry

in Bioinorganic Chemistry

Isabel Correia
Sylvia M. Draper

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1586841

1,868 views

Mini Review

Published on 28 Feb 2025

Multifaceted roles of STING in tumors: from molecular mechanisms to therapeutic strategies

in Molecular Sciences

Aashiq Hussain
Linchun Wen
Rui Wang

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1549003

2,064 views
1 citation

Review

Published on 25 Feb 2025

Biology and pharmacological inhibition of homeodomain-interacting protein kinases

in Molecular Sciences

Adam Štefek
Kamil Paruch

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1441138

2,523 views

Editorial

Published on 14 Feb 2025

Editorial: Bioluminescence and fluorescence molecular imaging in chemical biology

in Structure, Spectroscopy & Imaging

Sung Bae Kim
Giuseppe Sancataldo

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1568300

1,297 views

Editorial

Published on 07 Feb 2025

Editorial: Structure-function relationship of enzymes through a chemical lens

in Molecular Sciences

Justin M. Miller
Adam Offenbacher

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1565931

1,925 views

Original Research

Published on 03 Feb 2025

Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions

in Bioinorganic Chemistry

Aviva Levina
Debbie C. Crans
Peter A. Lay

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1547323

1,886 views

Methods

Published on 21 Jan 2025

Evaluation of the microenvironment formed by interferon-β

in Structure, Spectroscopy & Imaging

Mai Yamagishi
Yutaka Hori
Nobutake Suzuki
Yu Peng
Yoshie Harada
Takashi Funatsu
Osamu Ohara
Yoshitaka Shirasaki

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1425571

2,016 views

Original Research

Published on 06 Jan 2025

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

in Theoretical Modeling, Structure Prediction & Design

Claudia Testi
Roberta Piacentini
Alessandro Perrone
Chiara Bartoli
Daniele Leso
Domitilla Pavia
Elisa Pistolesi
Flavio Scipione
Irene Cotronea
Marco Adinolfi Falcone

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1517163

2,422 views
2 citations

Review

Published on 20 Dec 2024

Cysteine-rich zinc finger proteins and the nuclear factor kappa-B pathway

in Bioinorganic Chemistry

Andrew T. Stoltzfus
Sarah L. J. Michel

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1503390

2,298 views
1 citation

Original Research

Published on 11 Oct 2024

Molecular interactions at the interface: polyoxometalates of the Anderson-Evans type and lipid membranes

in Bioinorganic Chemistry

Alina A. Pashkovskaya
Nadiia I. Gumerova
Annette Rompel
Elena E. Pohl

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1454558

2,876 views
1 citation

Original Research

Published on 10 Sep 2024

Acylfulvenes covalently interact with thioredoxin as an additional cancer target

in Molecular Sciences

Laura Slappendel
Xiaodan Liu
Michael R. Macarthur
Charles M. Sharpless
Shana J. Sturla

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1462351

1,698 views

Original Research

Published on 06 Sep 2024

Exploring polyoxometalate speciation: the interplay of concentration, ionic strength, and buffer composition

in Bioinorganic Chemistry

Maja Ždrnja
Nadiia I. Gumerova
Annette Rompel

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1444359

3,341 views
1 citation

Review

Published on 19 Aug 2024

Bioluminescence from the bright and dark sides

in Quantitative and Analytical Techniques

Sung-Bae Kim
Tadaomi Furuta

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1459397

6,205 views
4 citations

Original Research

Published on 13 Aug 2024

Expanding the applications of a bioluminescent mouse infection model of acute African trypanosomiasis

in Structure, Spectroscopy & Imaging

Diego Benítez
Cecilia Ortíz
Estefania Dibello
Marcelo A. Comini

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1433511

2,621 views
4 citations

84 articles

articles

Lessons from metals-containing drugs in diagnostic, and theranostic applications for future development of metal-containing non-conventional therapeutics: vanadium compounds for intratumor administration

Preliminary investigation of Ru(II) complexes bearing nile red chromophores for photodynamic therapy

Carboxymethyl cellulose hydrogel doped with zinc-aspirinate as a multifunctional material: photoprotection, epithelial regeneration, and biocompatibility

Editorial: Insights in theoretical modelling, structure prediction and design

Boronic acid-modified cell-penetrating peptide exhibits superior performance over natural TAT peptide

Specialty grand challenges in theoretical modeling, structure prediction and design

How vanadium and manganese compounds impact cardiac mitochondrial function

Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis

Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation

Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation

Editorial: New developments in bioinorganic and bioorganic chemistry

Multifaceted roles of STING in tumors: from molecular mechanisms to therapeutic strategies

Biology and pharmacological inhibition of homeodomain-interacting protein kinases

Editorial: Bioluminescence and fluorescence molecular imaging in chemical biology

Editorial: Structure-function relationship of enzymes through a chemical lens

Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions

Evaluation of the microenvironment formed by interferon-β

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Cysteine-rich zinc finger proteins and the nuclear factor kappa-B pathway

Molecular interactions at the interface: polyoxometalates of the Anderson-Evans type and lipid membranes

Acylfulvenes covalently interact with thioredoxin as an additional cancer target

Exploring polyoxometalate speciation: the interplay of concentration, ionic strength, and buffer composition

Bioluminescence from the bright and dark sides

Expanding the applications of a bioluminescent mouse infection model of acute African trypanosomiasis