Frontiers in Chemical Biology

Original Research

Published on 23 Jul 2024

In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering

in Theoretical Modeling, Structure Prediction & Design

Yvett Sosa
Bhav Kapur
Jessica Hurtak
Laura J. Kingsley
Hao Wu
Stefanie Gruber
Herbert Nar
Saad Khattabi
Jesus Seco Moral
Maria Fátima Lucas

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1425501

1,799 views

Original Research

Published on 22 Jul 2024

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

in Structure, Spectroscopy & Imaging

Rick Janssens
Rien van Haperen
Michael van der Reijden
Alex Maas
Jingsong Wang
Frank Grosveld
Dubravka Drabek

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1408621

1,833 views

Mini Review

Published on 12 Jul 2024

The chemistry of Formycin biosynthesis

in Molecular Sciences

Nigel G. J. Richards
James H. Naismith

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1428646

733 views

Original Research

Published on 10 Jul 2024

A switch and a failsafe: KatG’s mechanism for preservation of catalase activity using a conformationally dynamic Arg and an active-site Trp

in Molecular Sciences

Hui Xu
Jessica R. Kenneson
Laura E. Minton
Douglas C. Goodwin

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1431412

1,065 views

Original Research

Published on 05 Jul 2024

Solution chemistry and anti-proliferative activity against glioblastoma cells of a vanadium(V) complex with two bioactive ligands

in Bioinorganic Chemistry

Aviva Levina
Gonzalo Scalese
Dinorah Gambino
Debbie C. Crans
Peter A. Lay

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1394645

722 views
2 citations

Original Research

Published on 17 Jun 2024

Development of bioluminescent reporter Trypanosoma cruzi and bioassay for compound screening

in Structure, Spectroscopy & Imaging

Cristina Quiroga
Marcelo Incerti
Diego Benitez
Eduardo Manta
Andrea Medeiros
Marcelo A. Comini

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1423430

1,134 views

Review

Published on 06 Jun 2024

Advances in human glutamine-hydrolyzing synthetases and their therapeutic potential

in Molecular Sciences

Wen Zhu
Alanya J. Nardone
Lucciano A. Pearce

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1410435

1,634 views
1 citation

Mini Review

Published on 30 May 2024

Keto-enol tautomerism in the development of new drugs

in Structure, Spectroscopy & Imaging

Ana Paula Araujo de Oliveira
Camila Anchau Wegermann
Ana Maria Da Costa Ferreira

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1400642

1,978 views

Original Research

Published on 22 May 2024

Effect of pH on the thermostability and redox properties of cytochrome c552 from Wolinella succinogenes

in Structure, Spectroscopy & Imaging

Vitor H. Mordido
Marta S. P. Carepo
Cristina M. Cordas
Navendu Paul
Jörg Simon
Isabel Moura
Sofia R. Pauleta

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1398105

761 views

Mini Review

Published on 09 May 2024

A mini review of mycotoxin’s occurrence in food in South America in the last 5 years: research gaps and challenges in a climate change era

in Quantitative and Analytical Techniques

Claudia Foerster
Andrea Müller-Sepúlveda
Marina Venturini Copetti
Andrea Alejandra Arrúa
Liliam Monsalve
María Laura Ramirez
Adriana M. Torres

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1400481

1,974 views
1 citation

Original Research

Published on 07 May 2024

An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme

in Molecular Sciences

Lauren B. Coco
Caren L. Freel Meyers

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1389620

818 views

Review

Published on 25 Apr 2024

A review of hydrazide-hydrazone metal complexes’ antitumor potential

in Bioinorganic Chemistry

Nádia Ribeiro
Isabel Correia

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1398873

2,816 views
2 citations

Mini Review

Published on 10 Apr 2024

Recent food alerts and analytical advances related to the contamination of tropane and pyrrolizidine alkaloids in food

in Quantitative and Analytical Techniques

Natalia Casado
Judith Gañán
Sonia Morante-Zarcero
Isabel Sierra

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1360027

1,387 views
2 citations

Mini Review

Published on 05 Apr 2024

Putting the sting back in STING therapy: novel delivery vehicles for improved STING activation

in Molecular Sciences

Sina Khorsandi
Kristin Huntoon
Jacques Lux

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1386220

1,021 views

Original Research

Published on 25 Mar 2024

Impact of different spacers on the conjugation between Anderson-Evans polyoxometalates and peptides

in Bioinorganic Chemistry

Haihong Yu
Claudia Honisch
Mattia Frigo
Nicola Balice
Valeria Tagliavini
Xue Zhao
Elisabetta Stramiglio
Ambra Campofelice
Simona Serratì
Amalia Azzariti

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1377357

1,192 views

Original Research

Published on 18 Mar 2024

An in vivo BSL-2 model for henipavirus infection based on bioluminescence imaging of recombinant Cedar virus replication in mice

in Molecular Sciences

Celeste Huaman
Caitlyn Clouse
Madeline Rader
Lianying Yan
Shuangyi Bai
Bronwyn M. Gunn
Moushimi Amaya
Eric D. Laing
Christopher C. Broder
Brian C. Schaefer

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1363498

1,877 views
2 citations

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Articles

In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

The chemistry of Formycin biosynthesis

A switch and a failsafe: KatG’s mechanism for preservation of catalase activity using a conformationally dynamic Arg and an active-site Trp

Solution chemistry and anti-proliferative activity against glioblastoma cells of a vanadium(V) complex with two bioactive ligands

Development of bioluminescent reporter Trypanosoma cruzi and bioassay for compound screening

Advances in human glutamine-hydrolyzing synthetases and their therapeutic potential

Keto-enol tautomerism in the development of new drugs

Effect of pH on the thermostability and redox properties of cytochrome c552 from Wolinella succinogenes

A mini review of mycotoxin’s occurrence in food in South America in the last 5 years: research gaps and challenges in a climate change era

An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme

A review of hydrazide-hydrazone metal complexes’ antitumor potential

Recent food alerts and analytical advances related to the contamination of tropane and pyrrolizidine alkaloids in food

Putting the sting back in STING therapy: novel delivery vehicles for improved STING activation

Impact of different spacers on the conjugation between Anderson-Evans polyoxometalates and peptides

An in vivo BSL-2 model for henipavirus infection based on bioluminescence imaging of recombinant Cedar virus replication in mice