volumes

Volume 4 - 2025

Original Research

Published on 12 May 2025

Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation

Marika Attili
Sonia Valentini
Maria Pesavento
Marco Ballarotto
Viviana Scognamiglio
Alfredo Pontecorvi
Antonio Macchiarulo
Fulvio Saccoccia
Fabiola Moretti

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1576640

2,842 views

Original Research

Published on 23 Apr 2025

Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation

Carla Luciana Padilla Franzotti
Nicolas Palopoli
Juliana Palma
Gustavo Pierdominici-Sottile

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1538350

1,409 views

Editorial

Published on 03 Apr 2025

Editorial: New developments in bioinorganic and bioorganic chemistry

Isabel Correia
Sylvia M. Draper

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1586841

1,623 views

Mini Review

Published on 28 Feb 2025

Multifaceted roles of STING in tumors: from molecular mechanisms to therapeutic strategies

Aashiq Hussain
Linchun Wen
Rui Wang

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1549003

1,836 views

Review

Published on 25 Feb 2025

Biology and pharmacological inhibition of homeodomain-interacting protein kinases

Adam Štefek
Kamil Paruch

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1441138

2,191 views

Editorial

Published on 14 Feb 2025

Editorial: Bioluminescence and fluorescence molecular imaging in chemical biology

Sung Bae Kim
Giuseppe Sancataldo

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1568300

1,154 views

Editorial

Published on 07 Feb 2025

Editorial: Structure-function relationship of enzymes through a chemical lens

Justin M. Miller
Adam Offenbacher

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1565931

1,650 views

Original Research

Published on 03 Feb 2025

Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions

Aviva Levina
Debbie C. Crans
Peter A. Lay

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1547323

1,638 views

Volume 3 - 2024

Methods

Published on 21 Jan 2025

Evaluation of the microenvironment formed by interferon-β

Mai Yamagishi
Yutaka Hori
Nobutake Suzuki
Yu Peng
Yoshie Harada
Takashi Funatsu
Osamu Ohara
Yoshitaka Shirasaki

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1425571

1,767 views

Original Research

Published on 06 Jan 2025

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Claudia Testi
Roberta Piacentini
Alessandro Perrone
Chiara Bartoli
Daniele Leso
Domitilla Pavia
Elisa Pistolesi
Flavio Scipione
Irene Cotronea
Marco Adinolfi Falcone

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1517163

2,255 views
2 citations

Review

Published on 20 Dec 2024

Cysteine-rich zinc finger proteins and the nuclear factor kappa-B pathway

Andrew T. Stoltzfus
Sarah L. J. Michel

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1503390

1,981 views
1 citation

Original Research

Published on 11 Oct 2024

Molecular interactions at the interface: polyoxometalates of the Anderson-Evans type and lipid membranes

Alina A. Pashkovskaya
Nadiia I. Gumerova
Annette Rompel
Elena E. Pohl

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1454558

2,554 views

Original Research

Published on 10 Sep 2024

Acylfulvenes covalently interact with thioredoxin as an additional cancer target

Laura Slappendel
Xiaodan Liu
Michael R. Macarthur
Charles M. Sharpless
Shana J. Sturla

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1462351

1,472 views

Original Research

Published on 06 Sep 2024

Exploring polyoxometalate speciation: the interplay of concentration, ionic strength, and buffer composition

Maja Ždrnja
Nadiia I. Gumerova
Annette Rompel

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1444359

2,963 views
1 citation

Review

Published on 19 Aug 2024

Bioluminescence from the bright and dark sides

Sung-Bae Kim
Tadaomi Furuta

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1459397

5,721 views
4 citations

Original Research

Published on 13 Aug 2024

Expanding the applications of a bioluminescent mouse infection model of acute African trypanosomiasis

Diego Benítez
Cecilia Ortíz
Estefania Dibello
Marcelo A. Comini

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1433511

2,399 views
3 citations

Original Research

Published on 12 Aug 2024

Guanidinium and spermidinium decavanadates: as small biomimetic models to understand non-covalent interactions between decavanadate and arginine and lysine side chains in proteins

Luis F. Paredes-Pérez
Angel Mendoza
Amalia García-García
Laura E. Serrano-De la Rosa
Miguel A. Méndez-Rojas
Francisco J. Melendez
María Eugenia Castro
Enrique González-Vergara

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1451167

4,167 views
2 citations

Original Research

Published on 05 Aug 2024

Structural and kinetic characterization of DUSP5 with a Di-phosphorylated tripeptide substrate from the ERK activation loop

Andrea Imhoff
Noreena L. Sweeney
Robert D. Bongard
Raulia Syrlybaeva
Ankan Gupta
Edgar Del Carpio
Marat R. Talipov
Costanza Garcia-Keller
Debbie C. Crans
Ramani Ramchandran

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1385560

2,719 views
6 citations

Original Research

Published on 31 Jul 2024

Generation of lysolipin derivatives by genetic engineering

Helene Robertsen
Sabrina Rohrer
Andreas Kulik
Wolfgang Wohlleben
Yvonne Mast

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1445095

2,316 views
2 citations

Original Research

Published on 29 Jul 2024

Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants

Jacob L. Capener
James D. Vasta
Vittorio L. Katis
Ani Michaud
Michael T. Beck
Sabrina C. D. Daglish
Sarit Cohen-Kedar
Efrat Shaham Barda
Stefanie Howell
Iris Dotan

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1447622

2,547 views
2 citations

Original Research

Published on 23 Jul 2024

In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering

Yvett Sosa
Bhav Kapur
Jessica Hurtak
Laura J. Kingsley
Hao Wu
Stefanie Gruber
Herbert Nar
Saad Khattabi
Jesus Seco Moral
Maria Fátima Lucas

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1425501

4,067 views

Original Research

Published on 22 Jul 2024

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

Rick Janssens
Rien van Haperen
Michael van der Reijden
Alex Maas
Jingsong Wang
Frank Grosveld
Dubravka Drabek

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1408621

4,559 views

Mini Review

Published on 12 Jul 2024

The chemistry of Formycin biosynthesis

Nigel G. J. Richards
James H. Naismith

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1428646

2,854 views
2 citations

Original Research

Published on 10 Jul 2024

A switch and a failsafe: KatG’s mechanism for preservation of catalase activity using a conformationally dynamic Arg and an active-site Trp

Hui Xu
Jessica R. Kenneson
Laura E. Minton
Douglas C. Goodwin

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1431412

2,780 views
1 citation