Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 02 Jul 2025

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

in Medicinal and Pharmaceutical Chemistry

Alexandre Bory
Alexandre Luscher
Nicole Lecoultre
Thilo Köhler
Sylvain Schnee
Katia Gindro
Jean-Luc Wolfender

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630332

415 views

Original Research

Accepted on 30 Jun 2025

Nutraceutical Potential of Moroccan Juglans regia: Phytochemical Profiling and Multi-Modal Evaluation of Bioactivities

in Medicinal and Pharmaceutical Chemistry

Drioiche Aziz
Omkulthom Al Kamaly
Soukayna Baammi
Khalid Zibouh
Rachid Amaiach
Laila Bennani
El Ouali Lalami Abdelhakim
Ahde El Imache
Fadoua EL Makhoukhi
Sevser Sahpaz

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638205

141 views

Original Research

Published on 30 Jun 2025

Metabolomics, antioxidant, and enzyme inhibitory effects of Citrus aurantium fruits

in Medicinal and Pharmaceutical Chemistry

Omayma A. Eldahshan
Salwa Bouabdallah
Rawan M. Abd El-khalek
Mahmoud A. El Hassab
Gokhan Zengin
Ahmed T. Negmeldin
Eman F. Khaleel
Wagdy M. Eldehna
Nada M. Mostafa

Frontiers in Chemistry

doi 10.3389/fchem.2025.1613827

840 views

Mini Review

Accepted on 27 Jun 2025

Application of Nano and Microformulations to Improve the Leishmanicidal Response of Quinoline Compounds: A Brief Review

in Medicinal and Pharmaceutical Chemistry

Angel Romero
Karina Gonzalez
Marcos Antonio Sabino Gutierrez

Frontiers in Chemistry

doi 10.3389/fchem.2025.1622566

146 views

Mini Review

Published on 27 Jun 2025

Strategic applications of methylene thioacetal bonds as disulfide surrogates in peptide drug discovery

in Medicinal and Pharmaceutical Chemistry

Yaqi Zhou
Dongyuan Wang
Jiean Xu
Nan Zheng

Frontiers in Chemistry

doi 10.3389/fchem.2025.1637329

805 views

Original Research

Accepted on 26 Jun 2025

Evaluation of Newly Synthesized Schiff Base Pd(II) Complexes for Prostate Cancer Treatment through In Vitro Cytotoxicity and Molecular Mechanistic Studies

in Medicinal and Pharmaceutical Chemistry

Damnjan Pantic
Nikola Mirkovic
Tatjana Vulovic
Danijela Jovanovic
Stefan Jakovljević
Petar Canovic
Milan Zaric
Radica Zivkovic Zaric
Marina Kostic
Jovana Dragojevic

Frontiers in Chemistry

doi 10.3389/fchem.2025.1636477

190 views

Original Research

Published on 26 Jun 2025

A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity

in Medicinal and Pharmaceutical Chemistry

Hussam Elddin Nabeih Khasawneh
Elryah I. Ali
Ranya Mohammed Elmagzoub
Raed Fanoukh Aboqader Al-Aouadi
Wesam Taher Almagharbeh
Ghallab Alotaibi
Stefan Bräse
Abdullah Alkhammash

Frontiers in Chemistry

doi 10.3389/fchem.2025.1606848

1,166 views

Original Research

Accepted on 25 Jun 2025

Exploring the effect and mechanism of fucoidan on liver cancer depending on network pharmacology and experimental verification

in Medicinal and Pharmaceutical Chemistry

Xinghua Li
Chengyu Yang
Liwei Wang
Ihsan Ullah
Liu Xinyue
Chunqi Feng
Qi Liu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638785

202 views

Original Research

Published on 20 Jun 2025

Ruta montana L. from Morocco: comprehensive phytochemical analysis and exploration of its antioxidant, antimicrobial, anti-inflammatory and analgesic properties

in Medicinal and Pharmaceutical Chemistry

Mohamed El Ouardi
Aziz Drioiche
Imane Tagnaout
Aicha Benouahi
Omkulthom AL kamaly
Abdelaaty Abdelaziz Shahat
El Makhoukhi Fadoua
Handaq Nadia
Sevser Sahpaz
Touriya Zair

Frontiers in Chemistry

doi 10.3389/fchem.2025.1614984

770 views

Original Research

Published on 20 Jun 2025

Seasonal changes in the essential oils of Aloysia oblanceolata Moldenke

in Medicinal and Pharmaceutical Chemistry

Paulo Vinicius L. Santos
Mateus Machado Lima
Flavia Cristina A. Lucas
Joyce Kelly do R. da Silva
José Guilherme S. Maia
Pablo Luis B. Figueiredo

Frontiers in Chemistry

doi 10.3389/fchem.2025.1564404

649 views

Original Research

Published on 11 Jun 2025

Two-dimensional QSAR-driven virtual screening for potential therapeutics against Trypanosoma cruzi

in Medicinal and Pharmaceutical Chemistry

Naseer Maliyakkal
Sunil Kumar
Ratul Bhowmik
Harish Chandra Vishwakarma
Prabha Yadav
Bijo Mathew

Frontiers in Chemistry

doi 10.3389/fchem.2025.1600945

980 views

Original Research

Published on 09 Jun 2025

HIF1A acts as target of XiHuang Pill in the treatment of papillary thyroid cancer by regulating dedifferentiation

in Medicinal and Pharmaceutical Chemistry

Xu-Zhe Yu
Wei-Li Zhu
Hua-Chun Qian
Chun-Jiang Sun

Frontiers in Chemistry

doi 10.3389/fchem.2025.1607067

1,081 views

Correction

Published on 09 Jun 2025

Correction: Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

in Medicinal and Pharmaceutical Chemistry

Yongzhi He
Jiachun Lu
Yushan Luo
Rizhao Pang
Xiaoming Hu
Lijuan Ding
Hua Xiao
Yunyun Wang
Wenchun Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1636136

753 views

Original Research

Published on 09 Jun 2025

Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective TIM-3 inhibitor for NSCLC immunotherapy

in Medicinal and Pharmaceutical Chemistry

Xinxin Ying
Yangyong Lou
Yueming Wu
Weiwei Hu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1622511

1,082 views

Mini Review

Published on 30 May 2025

Current developments of metal- and metalloid-based quinoline compounds as leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Edgar Del Carpio
Lino Hernández
Vito Lubes
Francisco Jourdan
Hugo Cerecetto
Gonzalo Scalese
Dinorah Gambino
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1586044

1,362 views
1 citation

Mini Review

Published on 30 May 2025

A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Romina E. Avanzo
Guadalupe García Liñares
Noris Rodríguez
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1608340

1,223 views
1 citation