Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Accepted on 09 Jul 2025

Design and Synthesis of 3,4-Seco-Lupane Triterpene Derivatives: Targeting Tumor Angiogenesis and Inducing Apoptosis in Triple-Negative Breast Cancer

in Medicinal and Pharmaceutical Chemistry

Chunyu Gao
Hongbo Teng
Wenxin Zhang
Yaru Zhao
Chunguo Cui
Zerbo Patrice
Yan Zhao
Liyan Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630939

Original Research

Accepted on 09 Jul 2025

Computational Advances in the Design and Discovery of Artemis Inhibitors for Radiosensitization in Cancer Therapy

in Medicinal and Pharmaceutical Chemistry

Maryam Bashir
Usman Abdullah
Farhan Siddique
Nasir Jalal

Frontiers in Chemistry

doi 10.3389/fchem.2025.1597454

Original Research

Accepted on 07 Jul 2025

In silico design of novel dihydropteridone derivatives with oxadiazoles as potent inhibitors of MCF-7 breast cancer cells

in Medicinal and Pharmaceutical Chemistry

Mourad Aloui
Mohamed El fadili
Mohammed Er-rajy
somdutt mujwar
Hatem A abuelizz
sara er-rahmani
menana elhalaoui

Frontiers in Chemistry

doi 10.3389/fchem.2025.1590593

128 views

Original Research

Accepted on 07 Jul 2025

Integrative UHPLC-HRMS and Computational Biology Reveal Ferroptosis and Anoikis Targeting by Wenpitongluo Decoction in Cardiorenal Syndrome

in Medicinal and Pharmaceutical Chemistry

Xinxin Mao
Shuqing Shi
Chunmei Chen
Li Yumeng
Bingxuan Zhang
Qingqiao Song

Frontiers in Chemistry

doi 10.3389/fchem.2025.1617676

Original Research

Published on 07 Jul 2025

Phomaderide, a unique (6/5/4/5/6) spiro-cyclic dimer from the desert plant endophytic fungus Phoma betae A. B. Frank (Didymellaceae)

in Medicinal and Pharmaceutical Chemistry

Hao-Di Sun
Yan-Duo Wang
Hui-Qi Fang
Jian Yang
Yu-Tong Hua
Gang Ding
Lan-Ping Guo

Frontiers in Chemistry

doi 10.3389/fchem.2025.1583666

480 views

Original Research

Published on 02 Jul 2025

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

in Medicinal and Pharmaceutical Chemistry

Alexandre Bory
Alexandre Luscher
Nicole Lecoultre
Thilo Köhler
Sylvain Schnee
Katia Gindro
Jean-Luc Wolfender

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630332

575 views

Original Research

Accepted on 30 Jun 2025

Nutraceutical Potential of Moroccan Juglans regia: Phytochemical Profiling and Multi-Modal Evaluation of Bioactivities

in Medicinal and Pharmaceutical Chemistry

Drioiche Aziz
Omkulthom Al Kamaly
Soukayna Baammi
Khalid Zibouh
Rachid Amaiach
Laila Bennani
El Ouali Lalami Abdelhakim
Ahde El Imache
Fadoua EL Makhoukhi
Sevser Sahpaz

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638205

164 views

Original Research

Published on 30 Jun 2025

Metabolomics, antioxidant, and enzyme inhibitory effects of Citrus aurantium fruits

in Medicinal and Pharmaceutical Chemistry

Omayma A. Eldahshan
Salwa Bouabdallah
Rawan M. Abd El-khalek
Mahmoud A. El Hassab
Gokhan Zengin
Ahmed T. Negmeldin
Eman F. Khaleel
Wagdy M. Eldehna
Nada M. Mostafa

Frontiers in Chemistry

doi 10.3389/fchem.2025.1613827

907 views

Mini Review

Accepted on 27 Jun 2025

Application of Nano and Microformulations to Improve the Leishmanicidal Response of Quinoline Compounds: A Brief Review

in Medicinal and Pharmaceutical Chemistry

Angel Romero
Karina Gonzalez
Marcos Antonio Sabino Gutierrez

Frontiers in Chemistry

doi 10.3389/fchem.2025.1622566

165 views

Mini Review

Published on 27 Jun 2025

Strategic applications of methylene thioacetal bonds as disulfide surrogates in peptide drug discovery

in Medicinal and Pharmaceutical Chemistry

Yaqi Zhou
Dongyuan Wang
Jiean Xu
Nan Zheng

Frontiers in Chemistry

doi 10.3389/fchem.2025.1637329

901 views

Original Research

Accepted on 26 Jun 2025

Evaluation of Newly Synthesized Schiff Base Pd(II) Complexes for Prostate Cancer Treatment through In Vitro Cytotoxicity and Molecular Mechanistic Studies

in Medicinal and Pharmaceutical Chemistry

Damnjan Pantic
Nikola Mirkovic
Tatjana Vulovic
Danijela Jovanovic
Stefan Jakovljević
Petar Canovic
Milan Zaric
Radica Zivkovic Zaric
Marina Kostic
Jovana Dragojevic

Frontiers in Chemistry

doi 10.3389/fchem.2025.1636477

219 views

Original Research

Published on 26 Jun 2025

A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity

in Medicinal and Pharmaceutical Chemistry

Hussam Elddin Nabeih Khasawneh
Elryah I. Ali
Ranya Mohammed Elmagzoub
Raed Fanoukh Aboqader Al-Aouadi
Wesam Taher Almagharbeh
Ghallab Alotaibi
Stefan Bräse
Abdullah Alkhammash

Frontiers in Chemistry

doi 10.3389/fchem.2025.1606848

1,477 views

Original Research

Accepted on 25 Jun 2025

Exploring the effect and mechanism of fucoidan on liver cancer depending on network pharmacology and experimental verification

in Medicinal and Pharmaceutical Chemistry

Xinghua Li
Chengyu Yang
Liwei Wang
Ihsan Ullah
Liu Xinyue
Chunqi Feng
Qi Liu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638785

225 views

Original Research

Published on 20 Jun 2025

Ruta montana L. from Morocco: comprehensive phytochemical analysis and exploration of its antioxidant, antimicrobial, anti-inflammatory and analgesic properties

in Medicinal and Pharmaceutical Chemistry

Mohamed El Ouardi
Aziz Drioiche
Imane Tagnaout
Aicha Benouahi
Omkulthom AL kamaly
Abdelaaty Abdelaziz Shahat
El Makhoukhi Fadoua
Handaq Nadia
Sevser Sahpaz
Touriya Zair

Frontiers in Chemistry

doi 10.3389/fchem.2025.1614984

864 views

Original Research

Published on 20 Jun 2025

Seasonal changes in the essential oils of Aloysia oblanceolata Moldenke

in Medicinal and Pharmaceutical Chemistry

Paulo Vinicius L. Santos
Mateus Machado Lima
Flavia Cristina A. Lucas
Joyce Kelly do R. da Silva
José Guilherme S. Maia
Pablo Luis B. Figueiredo

Frontiers in Chemistry

doi 10.3389/fchem.2025.1564404

732 views

Original Research

Published on 11 Jun 2025

Two-dimensional QSAR-driven virtual screening for potential therapeutics against Trypanosoma cruzi

in Medicinal and Pharmaceutical Chemistry

Naseer Maliyakkal
Sunil Kumar
Ratul Bhowmik
Harish Chandra Vishwakarma
Prabha Yadav
Bijo Mathew

Frontiers in Chemistry

doi 10.3389/fchem.2025.1600945

1,039 views