Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Mini Review

Published on 30 May 2025

Current developments of metal- and metalloid-based quinoline compounds as leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Edgar Del Carpio
Lino Hernández
Vito Lubes
Francisco Jourdan
Hugo Cerecetto
Gonzalo Scalese
Dinorah Gambino
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1586044

1,328 views
1 citation

Original Research

Published on 30 May 2025

Neuraminidase as a novel therapeutic management strategy for Alzheimer’s disease: evidenced through molecular docking, molecular dynamic simulation and gene expression analysis

in Medicinal and Pharmaceutical Chemistry

Sami I. Alzarea
Omar Awad Alsaidan
Hassan H. Alhassan
Abdulaziz Ibrahim Alzarea
Tariq G. Alsahli
Metab Alharbi
Muhammad Afzal
Mohammad Jaffar Sadiq Mantargi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1574702

1,099 views

Original Research

Published on 30 May 2025

Black ginseng under forest as a natural antidepressant: insights into its active components and mechanisms

in Medicinal and Pharmaceutical Chemistry

Yixuan Sui
Yiying Tan
Yajing Li
Xiaochen Gao
Han Lu
Jiaming Shen
Xuesheng Hu
Lei Wang
Liting Zhao
Jiaming Sun

Frontiers in Chemistry

doi 10.3389/fchem.2025.1619060

1,029 views

Original Research

Published on 27 May 2025

Network pharmacology and molecular dynamics simulation reveal antineoplastic potential of Antarctic sponge-derived suberitenones

in Medicinal and Pharmaceutical Chemistry

Prasenjit Bhowmik
Rahul Mallick
Asim K. Duttaroy

Frontiers in Chemistry

doi 10.3389/fchem.2025.1545834

1,484 views

Original Research

Published on 21 May 2025

Synthesis and characterization of thymol-derived phenoxy acetamide derivatives using DFT, molecular docking, and parasitological investigations

in Medicinal and Pharmaceutical Chemistry

Ahmed R. Rabee
Saied M. Soliman
Hamida Abdel-Hamid
Esraa A. Moneer
Sara H. Akl
Yahya H. Shahin
Aliaa A. Masoud
Doaa Ahmad Ghareeb
Mariusz Jaremko
Abdul-Hamid Emwas

Frontiers in Chemistry

doi 10.3389/fchem.2025.1579923

11,339 views

Original Research

Accepted on 20 May 2025

Phomaderide, a Unique (6/5/4/5/6) Spiro-Cyclic Dimmer from the Desert Plant Endophytic Fungus Phoma betae A. B. Frank (Didymellaceae)

in Medicinal and Pharmaceutical Chemistry

Haodi Sun
Yan-Duo Wang
Hui-Qi Fang
Jian Yang
Yutong Hua
Gang Ding
Lanping Guo

Frontiers in Chemistry

doi 10.3389/fchem.2025.1583666

272 views

Original Research

Published on 19 May 2025

Engineering of antimicrobial peptide Brevinin-1pl: arginine, lysine, and histidine substitutions enhance antimicrobial-anticancer efficacy with reduced cytotoxicity

in Medicinal and Pharmaceutical Chemistry

Jingkai Wang
Fanli Zeng
Xiaoling Chen
Tao Wang
Lei Wang
Mei Zhou
Yangyang Jiang
Tianbao Chen
Yongfei Fang
Jinwei Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1579097

1,869 views

Original Research

Published on 13 May 2025

Chronic alcohol intake disrupts cytochrome P450 enzyme activity in alcoholic fatty liver disease: insights into metabolic alterations and therapeutic targets

in Medicinal and Pharmaceutical Chemistry

Qian Zhu
Xuefeng Xie
Ling Fang
Cheng Huang
Jun Li

Frontiers in Chemistry

doi 10.3389/fchem.2025.1509785

1,424 views

Original Research

Published on 12 May 2025

Identification of novel potential hypoxia-inducible factor-1α inhibitors through machine learning and computational simulations

in Medicinal and Pharmaceutical Chemistry

Yuxiang He
Shuning Diao
Shengzhen Hou
Taiying Li
Wenhui Meng
Jinping Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1585882

1,288 views

Original Research

Published on 12 May 2025

Development of nifedipine isosteres: an integrated approach to the design, synthesis, and biological assessment of calcium channel blockers

in Medicinal and Pharmaceutical Chemistry

Yasser M. Zohny
Samir M. Awad
Omar Alsaidan
Maha A. Rabie

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581037

1,466 views

Original Research

Published on 08 May 2025

Mechanism of hedysari radix praeparata cum melle and curcumae rhizoma herb pair in colitis-associated colorectal cancer through the MAPK/NF-κB signaling pathway: an investigation in vivo and in vitro

in Medicinal and Pharmaceutical Chemistry

Ting Liu
Yugui Zhang
Feiyun Gao
Zhuanhong Zhang
Maomao Wang
Cui Ma
Yanjun Wang
Dingcai Ma
Zhe Wang
Xingke Yan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1551722

1,627 views

Original Research

Published on 08 May 2025

Discovery of a novel binding pocket in PPARγ for partial agonists: structure-based virtual screening identifies ginsenoside Rg5 as a partial agonist promoting beige adipogenesis

in Medicinal and Pharmaceutical Chemistry

Zhen Wang
Kexin Shui
Zehui Zhang
Yihan Chen
Nanfei Yang
Shiliang Ji
Pingping Shen
Qiang Tian

Frontiers in Chemistry

doi 10.3389/fchem.2025.1579445

2,430 views

Original Research

Published on 06 May 2025

Design, synthesis, and biological investigation of new thiazole-based derivatives as multi-targeted inhibitors endowed with antiproliferative, antioxidant, and antibacterial properties

in Medicinal and Pharmaceutical Chemistry

Hesham A. M. Gomaa
Asmaa M. Atta
Mohamed E. Shaker
Sami I. Alzarea
Tariq G. Alsahli
Eid Alatwi
Arafa Musa
Fatma A. M. Mohamed
Hayat Ali Alzahrani
Aliaa M. Mohassab

Frontiers in Chemistry

doi 10.3389/fchem.2025.1595997

5,009 views

Original Research

Published on 29 Apr 2025

Proposal of a new chemical marker for the quality control of the herb Scleromitrion diffusum

in Medicinal and Pharmaceutical Chemistry

Tao Zheng
Chu-Chu Zhong
Grace Gar-Lee Yue
Dong-Min Jiang
Man-Ho Tong
Hiu-Yan Wong
Kwan-Ho Wong
Meng-Hua Wu
David Tai-Wai Lau
Hui Cao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1600769

1,259 views

Review

Published on 29 Apr 2025

Modification of biopharmaceutical parameters of flavonoids: a review

in Medicinal and Pharmaceutical Chemistry

Amir Taldaev
Artem A. Svotin
Semyon I. Obukhov
Roman P. Terekhov
Irina A. Selivanova

Frontiers in Chemistry

doi 10.3389/fchem.2025.1602967

1,574 views

Original Research

Published on 25 Apr 2025

Chemical profile of Rhododendron luteum Sweet leaf supercritical CO2 extracts and their anti-inflammatory and antidiabetic potential

in Medicinal and Pharmaceutical Chemistry

Lena Łyko
Renata Nowak
Marta Olech
Urszula Gawlik
Agnieszka Krajewska
Danuta Kalemba
Andriy Prokopiv

Frontiers in Chemistry

doi 10.3389/fchem.2025.1576852

1,340 views