Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Review

Published on 12 Nov 2025

Multi-targeted pharmacological actions and nanodelivery strategies of Garcinia cambogia: from molecular mechanisms to disease treatment

in Medicinal and Pharmaceutical Chemistry

Hang Zhang
Yurou Cao
Xubin Chen
Jingxin Chen

Frontiers in Chemistry

doi 10.3389/fchem.2025.1692386

2,092 views

Original Research

Published on 07 Nov 2025

Elucidating the phytochemical profile of Sophorae Flavescentis Radix-Astragali Radix herb pair: an integrated LC-QTOF-MS/MS, pharmacological activity, and network pharmacology study on anti-hepatocellular carcinoma effects

in Medicinal and Pharmaceutical Chemistry

Yidi Yin
Jiameng Qu
Lanzhuo Qu
Zhiyuan Li
Huarong Xu
Qing Li

Frontiers in Chemistry

doi 10.3389/fchem.2025.1687098

1,801 views

Original Research

Published on 10 Oct 2025

Antibacterial effects of coniferyl alcohol-derived dehydrogenation polymer on chlamydial infection in vitro

in Medicinal and Pharmaceutical Chemistry

Anna Pfundner
Tamara Weinmayer
Nora Geissler
Ana Kovacevic
Dragica Spasojevic
Ksenija Radotic
Marijana Stojanovic
Irma Schabussova
Ursula Wiedermann
Aleksandra Inic-Kanada

Frontiers in Chemistry

doi 10.3389/fchem.2025.1654478

2,645 views

Correction

Published on 09 Oct 2025

Correction: Membrane-targeting antibacterial isoniazid schiff base against S. aureus and biofilms

in Medicinal and Pharmaceutical Chemistry

Yaguang Liu
Lianzhi Hu
Binbin Liu
Zheng Qu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1706525

987 views

Original Research

Published on 09 Oct 2025

Elucidating multifaceted targets of Marein in cerebral ischemia-reperfusion injury

in Medicinal and Pharmaceutical Chemistry

Weidan Luo
Jian Wang
Ying Fan
Meng Yuan
Wanying Xie
Yang Su
Xingchun Wang
Yi Zhong
Yibo Zhang
Jiaxin Zhan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1651873

3,185 views

Review

Published on 02 Oct 2025

Targeting RNA-binding proteins with small molecules: perspectives and challenges

in Medicinal and Pharmaceutical Chemistry

Olivier Mpungi Konde
Williams Balela Balela
Tania Bishola Tshitenge

Frontiers in Chemistry

doi 10.3389/fchem.2025.1649692

4,580 views

Mini Review

Published on 01 Oct 2025

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine

in Medicinal and Pharmaceutical Chemistry

Yuanyuan Wu
Hui Huang
Xianglong Zhao
Junhao Lin
Jialiang Guo
Zhengjin Jiang
Kesara Ar-Sanork
Tao Deng
Dongsheng Xu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1694998

3,151 views

Review

Published on 01 Oct 2025

Comprehensive medicinal chemistry survey highlights a portfolio of lead molecules for Alzheimer’s disease therapy

in Medicinal and Pharmaceutical Chemistry

Pravin R. Bhansali
Shashank M. Sonkusare
Shubhangi S. Savale
Yasanandana S. Wijayasinghe
Yini Liao
Douglas C. Sloan
Ganesh U. Chaturbhuj
Brian S. Muntean

Frontiers in Chemistry

doi 10.3389/fchem.2025.1642190

21,840 views

Original Research

Published on 24 Sep 2025

Polybrominated diphenyl ether profiles in adipose tissues of breast cancer patients and their carcinogenic potential investigation based on network toxicology and molecular docking

in Medicinal and Pharmaceutical Chemistry

Qihao Zhao
Xi Liu
Haoyi Chen
Yingming Jin
Qian Chen
Yiteng Huang
Lin Peng

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630283

3,787 views

Original Research

Published on 22 Sep 2025

Reversed phase HPLC analysis of mobocertinib and its impurities and studies on the structure and biological activity of a new degradation product

in Medicinal and Pharmaceutical Chemistry

Ronghua Ni
Jisu Qin
Wenyi Wu
Jinqiu Xu
Qunfeng Luo
Liangliang Cai

Frontiers in Chemistry

doi 10.3389/fchem.2025.1659507

3,714 views

Original Research

Published on 16 Sep 2025

Design, synthesis, antiproliferative assessments, and computational studies of new quinolin-2(1H)-ones as dual EGFR/HER-2 inhibitors

in Medicinal and Pharmaceutical Chemistry

Lamya H. Al-Wahaibi
Hesham A. Abou-Zied
Martin Nieger
Stefan Bräse
Bahaa G. M. Youssif
Hendawy N. Tawfeek

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638489

3,630 views
1 citation

Mini Review

Published on 15 Sep 2025

Quinolines: the role of substitution site in antileishmanial activity

in Medicinal and Pharmaceutical Chemistry

Orlando G. Elso
Guadalupe García Liñares

Frontiers in Chemistry

doi 10.3389/fchem.2025.1645334

4,359 views
1 citation

Original Research

Published on 11 Sep 2025

Manganese-doped nanotheranostic system for MRI-guided photothermal therapy of malignant pleural mesothelioma: in vivo study

in Medicinal and Pharmaceutical Chemistry

Lichang Lei
Hongjiao Zi
ShaoLei Kang
Hui Duan
Zhenghua Zhang
Chao Gao
Ruoyun Xu
Dan Han

Frontiers in Chemistry

doi 10.3389/fchem.2025.1659283

2,970 views

Editorial

Published on 09 Sep 2025

Editorial: Quinoline as lead structures for the development of leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero
Gustavo Benaim

Frontiers in Chemistry

doi 10.3389/fchem.2025.1694616

1,924 views

Original Research

Published on 09 Sep 2025

Membrane-targeting antibacterial isoniazid schiff base against S. aureus and biofilms

in Medicinal and Pharmaceutical Chemistry

Yaguang Liu
Lianzhi Hu
Binbin Liu
Zheng Qu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1654358

2,616 views
1 citation

Original Research

Published on 05 Sep 2025

Activity evaluation of multifunctional H2S donors for anti-inflammatory, cardioprotective, and hepatoprotective applications

in Medicinal and Pharmaceutical Chemistry

Donghe Wang
Yujie Meng
Yihong Liu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1643663

2,084 views

Original Research

Published on 05 Sep 2025

Design, synthesis, and biological assessment of a novel series of coumarin-tethered thiazole derivatives as potential antibacterial agents

in Medicinal and Pharmaceutical Chemistry

Manal S. Ebaid
Hanaa Farag
Mohamed Abdelraof
Abdulrahman M. Saleh
Mohamed G. Thabit
Jarosław Dziadek
Ahmed A. Youssef
Ahmed Sabt

Frontiers in Chemistry

doi 10.3389/fchem.2025.1627186

3,603 views
4 citations

Original Research

Published on 04 Sep 2025

Nutraceutical potential of moroccan Juglans regia: phytochemical profiling and multi-modal evaluation of bioactivities

in Medicinal and Pharmaceutical Chemistry

Aziz Drioiche
Omkulthom Al kamaly
Soukayna Baammi
Khalid Zibouh
Rachid Amaiach
Laila Bennani
El Ouali Lalami Abdelhakim
Ahde El Imache
Fadoua EL Makhoukhi
Sevser Sahpaz

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638205

3,202 views
1 citation

Original Research

Published on 03 Sep 2025

UHPLC-HRMS analysis combined with feature-based molecular networking methods for systematic identification of chemicals in AnShenDingZhiLing and its absorbed metabolites

in Medicinal and Pharmaceutical Chemistry

Tai Han
Deqing Ni
Wanqing Zhu
Dan Fang
An Kang
Yumiao Wu
Jichao Sun

Frontiers in Chemistry

doi 10.3389/fchem.2025.1647159

2,606 views

Editorial

Published on 01 Sep 2025

Editorial: Medicinal chemistry for neglected tropical diseases using in-vitro, in-vivo and in silico approaches

in Medicinal and Pharmaceutical Chemistry

Suraj N. Mali
Essa M. Saied
Cleydson Breno Rodrigues dos Santos
Jorddy Neves Cruz

Frontiers in Chemistry

doi 10.3389/fchem.2025.1689034

1,913 views

Original Research

Published on 28 Aug 2025

Preclinical evaluation of 6-Gingerol in modulating gut microbiota and SCFAs to mitigate Clostridium difficile-associated diarrhea in mice

in Medicinal and Pharmaceutical Chemistry

Fu-Zhi Ma
Lin Zhu
Meng Li
Ze-Wei Tang
Xiao-Hong Yu
Cong-En Zhang
Zhi-Jie Ma

Frontiers in Chemistry

doi 10.3389/fchem.2025.1635781

2,932 views
1 citation

Original Research

Published on 22 Aug 2025

Natural product Erianin: mitigating FOLFOX toxicity and enhancing against colorectal cancer

in Medicinal and Pharmaceutical Chemistry

Fuqin Yang
Zeqiao Li
Haishan Zhang
Mingxiao Zhang
Zhenwei He
Xiaoqin Zheng
Yingru Zhu
Pei Long
Ruirui Ding
Zhengbin Lin

Frontiers in Chemistry

doi 10.3389/fchem.2025.1650197

3,987 views
1 citation

Opinion

Published on 21 Aug 2025

Are basic and lipophilic chain groups highly required in leishmanicidal quinolines to favor the phagolysosome accumulation?

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1655979

1,426 views
1 citation

Original Research

Published on 11 Aug 2025

Discovery of compound 1105486 as a selective inhibitor of B4GALT1: potential for pancreatic cancer therapy

in Medicinal and Pharmaceutical Chemistry

Xu Yunyun
Mou Yiping

Frontiers in Chemistry

doi 10.3389/fchem.2025.1651402

3,162 views

944 articles

articles

Multi-targeted pharmacological actions and nanodelivery strategies of Garcinia cambogia: from molecular mechanisms to disease treatment

Elucidating the phytochemical profile of Sophorae Flavescentis Radix-Astragali Radix herb pair: an integrated LC-QTOF-MS/MS, pharmacological activity, and network pharmacology study on anti-hepatocellular carcinoma effects

Antibacterial effects of coniferyl alcohol-derived dehydrogenation polymer on chlamydial infection in vitro

Correction: Membrane-targeting antibacterial isoniazid schiff base against S. aureus and biofilms

Elucidating multifaceted targets of Marein in cerebral ischemia-reperfusion injury

Targeting RNA-binding proteins with small molecules: perspectives and challenges

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine

Comprehensive medicinal chemistry survey highlights a portfolio of lead molecules for Alzheimer’s disease therapy

Polybrominated diphenyl ether profiles in adipose tissues of breast cancer patients and their carcinogenic potential investigation based on network toxicology and molecular docking

Reversed phase HPLC analysis of mobocertinib and its impurities and studies on the structure and biological activity of a new degradation product

Design, synthesis, antiproliferative assessments, and computational studies of new quinolin-2(1H)-ones as dual EGFR/HER-2 inhibitors

Quinolines: the role of substitution site in antileishmanial activity

Manganese-doped nanotheranostic system for MRI-guided photothermal therapy of malignant pleural mesothelioma: in vivo study

Editorial: Quinoline as lead structures for the development of leishmanicidal agents

Membrane-targeting antibacterial isoniazid schiff base against S. aureus and biofilms

Activity evaluation of multifunctional H2S donors for anti-inflammatory, cardioprotective, and hepatoprotective applications

Design, synthesis, and biological assessment of a novel series of coumarin-tethered thiazole derivatives as potential antibacterial agents

Nutraceutical potential of moroccan Juglans regia: phytochemical profiling and multi-modal evaluation of bioactivities

UHPLC-HRMS analysis combined with feature-based molecular networking methods for systematic identification of chemicals in AnShenDingZhiLing and its absorbed metabolites

Editorial: Medicinal chemistry for neglected tropical diseases using in-vitro, in-vivo and in silico approaches

Preclinical evaluation of 6-Gingerol in modulating gut microbiota and SCFAs to mitigate Clostridium difficile-associated diarrhea in mice

Natural product Erianin: mitigating FOLFOX toxicity and enhancing against colorectal cancer

Are basic and lipophilic chain groups highly required in leishmanicidal quinolines to favor the phagolysosome accumulation?

Discovery of compound 1105486 as a selective inhibitor of B4GALT1: potential for pancreatic cancer therapy