Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 22 Aug 2025

Natural product Erianin: mitigating FOLFOX toxicity and enhancing against colorectal cancer

in Medicinal and Pharmaceutical Chemistry

Fuqin Yang
Zeqiao Li
Haishan Zhang
Mingxiao Zhang
Zhenwei He
Xiaoqin Zheng
Yingru Zhu
Pei Long
Ruirui Ding
Zhengbin Lin

Frontiers in Chemistry

doi 10.3389/fchem.2025.1650197

526 views

Original Research

Accepted on 21 Aug 2025

Design, synthesis, and biological assessment of a novel series of coumarin-tethered thiazole derivatives as potential antibacterial agents

in Medicinal and Pharmaceutical Chemistry

Manal S Ebaid
Hanaa Farag
Mohamed Abdelraof
Abdulrahman M. Saleh
Mohamed G Thabit
Jaroslaw Dziadek
Ahmed A Youssef
Ahmed Sabt

Frontiers in Chemistry

doi 10.3389/fchem.2025.1627186

170 views

Original Research

Accepted on 21 Aug 2025

Manganese-Doped Nanotheranostic System for MRI-Guided Photothermal Therapy of Malignant Pleural Mesothelioma: In Vivo Study

in Medicinal and Pharmaceutical Chemistry

Lichang LEI
Hongjiao ZI
ShaoLei KANG
Hui DUAN
Zhenghua Zhang
Chao GAO
Ruoyun XU
Dan Han

Frontiers in Chemistry

doi 10.3389/fchem.2025.1659283

115 views

Editorial

Accepted on 21 Aug 2025

Editorial on research topic Medicinal Chemistry for Neglected Tropical Diseases Using In-vitro, In-vivo and In Silico Approaches

in Medicinal and Pharmaceutical Chemistry

Suraj N. Mali
Essa M. Saied
Cleydson Breno Rodrigues dos Santos
Jorddy Neves Cruz

Frontiers in Chemistry

doi 10.3389/fchem.2025.1689034

Opinion

Published on 21 Aug 2025

Are basic and lipophilic chain groups highly required in leishmanicidal quinolines to favor the phagolysosome accumulation?

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1655979

393 views

Original Research

Accepted on 15 Aug 2025

Activity Evaluation of Multifunctional H₂S Donors for Anti-Inflammatory, Cardioprotective, and Hepatoprotective Applications

in Medicinal and Pharmaceutical Chemistry

Donghe Wang
Yujie Meng
Yihong Liu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1643663

164 views

Original Research

Published on 11 Aug 2025

Discovery of compound 1105486 as a selective inhibitor of B4GALT1: potential for pancreatic cancer therapy

in Medicinal and Pharmaceutical Chemistry

Xu Yunyun
Mou Yiping

Frontiers in Chemistry

doi 10.3389/fchem.2025.1651402

629 views

Original Research

Published on 08 Aug 2025

Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling

in Medicinal and Pharmaceutical Chemistry

Eman F. Khaleel
Heba Abdelmegeed
Abdel-Razik H. Abdel-Razik
Manal S. Ebaid
Ninh The Son
Nguyen Xuan Ha
Hoda Atef Abdelsattar Ibrahim
Mohamed A. Abdelrahman
Abdelsamed I. Elshamy
Jarosław Dziadek

Frontiers in Chemistry

doi 10.3389/fchem.2025.1621717

987 views

Original Research

Published on 01 Aug 2025

Citrus aurantifolia essential oil: antiaging potential through integrated in vitro and in silico studies

in Medicinal and Pharmaceutical Chemistry

Yasmin A. Elkhawas
Mahmoud A. El Hassab
Omkulthom Al kamaly
Ahmed T. Negmeldin
Taghreed A. Majrashi
Wagdy M. Eldehna
Nada M. Mostafa

Frontiers in Chemistry

doi 10.3389/fchem.2025.1577871

1,351 views

Original Research

Published on 31 Jul 2025

Design and synthesis of 3,4-seco-Lupane triterpene derivatives: targeting tumor angiogenesis and inducing apoptosis in triple-negative breast cancer

in Medicinal and Pharmaceutical Chemistry

Chunyu Gao
Hongbo Teng
Wenxin Zhang
Yaru Zhao
Chunguo Cui
Zerbo Patrice
Liyan Wang
Yan Zhao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630939

1,085 views

Review

Accepted on 30 Jul 2025

Comprehensive Medicinal Chemistry Survey Highlights A Portfolio of Lead Molecules for Alzheimer's Disease Therapy

in Medicinal and Pharmaceutical Chemistry

Pravin R Bhansali
Brian Muntean
Shashank M Sonkusare
Shubhangi S Savale
Yasanandana S. Wijayasinghe
Douglas C Sloan
Ganesh U Chaturbhuj

Frontiers in Chemistry

doi 10.3389/fchem.2025.1642190

328 views

Original Research

Accepted on 28 Jul 2025

Preclinical evaluation of 6-Gingerol in modulating gut microbiota and SCFAs to mitigate Clostridium difficile-associated diarrhea in mice

in Medicinal and Pharmaceutical Chemistry

Fu-Zhi Ma
Lin Zhu
Meng Li
Xiao-Hong Yu
Ze-Wei Tang
Cong-En Zhang
Zhijie Ma

Frontiers in Chemistry

doi 10.3389/fchem.2025.1635781

221 views

Original Research

Published on 28 Jul 2025

In silico design of novel dihydropteridone derivatives with oxadiazoles as potent inhibitors of MCF-7 breast cancer cells

in Medicinal and Pharmaceutical Chemistry

Mourad Aloui
Mohamed El fadili
Mohammed Er-rajy
Somdutt Mujwar
Hatem A. Abuelizz
Sara Er-rahmani
Elhalaoui Menana

Frontiers in Chemistry

doi 10.3389/fchem.2025.1590593

1,281 views

Original Research

Published on 28 Jul 2025

Computational advances in the design and discovery of artemis inhibitors for radiosensitization in cancer therapy

in Medicinal and Pharmaceutical Chemistry

Maryam Bashir
Usman Abdullah
Sadia Nazir
Farhan Siddique
Nasir Jalal

Frontiers in Chemistry

doi 10.3389/fchem.2025.1597454

1,395 views

Mini Review

Published on 25 Jul 2025

Application of nano and microformulations to improve the leishmanicidal response of quinoline compounds: a brief review

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero
Karina N. Gonzalez
Marcos A. Sabino

Frontiers in Chemistry

doi 10.3389/fchem.2025.1622566

1,077 views

Review

Published on 23 Jul 2025

Research progress on the chemical composition of galli gigeriae endothelium corneum

in Medicinal and Pharmaceutical Chemistry

Guo-Lian Gan
Hongxin Zhou
Zhen-Bin Lin
Xiang Li
Jing-Jin Lin
Li Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1644192

1,176 views