Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 08 Aug 2025

Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling

in Medicinal and Pharmaceutical Chemistry

Eman F. Khaleel
Heba Abdelmegeed
Abdel-Razik H. Abdel-Razik
Manal S. Ebaid
Ninh The Son
Nguyen Xuan Ha
Hoda Atef Abdelsattar Ibrahim
Mohamed A. Abdelrahman
Abdelsamed I. Elshamy
Jarosław Dziadek

Frontiers in Chemistry

doi 10.3389/fchem.2025.1621717

2,528 views
1 citation

Original Research

Published on 01 Aug 2025

Citrus aurantifolia essential oil: antiaging potential through integrated in vitro and in silico studies

in Medicinal and Pharmaceutical Chemistry

Yasmin A. Elkhawas
Mahmoud A. El Hassab
Omkulthom Al kamaly
Ahmed T. Negmeldin
Taghreed A. Majrashi
Wagdy M. Eldehna
Nada M. Mostafa

Frontiers in Chemistry

doi 10.3389/fchem.2025.1577871

3,788 views
1 citation

Original Research

Published on 31 Jul 2025

Design and synthesis of 3,4-seco-Lupane triterpene derivatives: targeting tumor angiogenesis and inducing apoptosis in triple-negative breast cancer

in Medicinal and Pharmaceutical Chemistry

Chunyu Gao
Hongbo Teng
Wenxin Zhang
Yaru Zhao
Chunguo Cui
Zerbo Patrice
Liyan Wang
Yan Zhao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630939

2,631 views

Original Research

Published on 28 Jul 2025

In silico design of novel dihydropteridone derivatives with oxadiazoles as potent inhibitors of MCF-7 breast cancer cells

in Medicinal and Pharmaceutical Chemistry

Mourad Aloui
Mohamed El fadili
Mohammed Er-rajy
Somdutt Mujwar
Hatem A. Abuelizz
Sara Er-rahmani
Elhalaoui Menana

Frontiers in Chemistry

doi 10.3389/fchem.2025.1590593

2,348 views
1 citation

Original Research

Published on 28 Jul 2025

Computational advances in the design and discovery of artemis inhibitors for radiosensitization in cancer therapy

in Medicinal and Pharmaceutical Chemistry

Maryam Bashir
Usman Abdullah
Sadia Nazir
Farhan Siddique
Nasir Jalal

Frontiers in Chemistry

doi 10.3389/fchem.2025.1597454

2,882 views
3 citations

Mini Review

Published on 25 Jul 2025

Application of nano and microformulations to improve the leishmanicidal response of quinoline compounds: a brief review

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero
Karina N. Gonzalez
Marcos A. Sabino

Frontiers in Chemistry

doi 10.3389/fchem.2025.1622566

1,962 views
2 citations

Review

Published on 23 Jul 2025

Research progress on the chemical composition of galli gigeriae endothelium corneum

in Medicinal and Pharmaceutical Chemistry

Guo-Lian Gan
Hongxin Zhou
Zhen-Bin Lin
Xiang Li
Jing-Jin Lin
Li Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1644192

3,020 views
1 citation

Original Research

Published on 21 Jul 2025

Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome

in Medicinal and Pharmaceutical Chemistry

Xinxin Mao
Shuqing Shi
Chunmei Chen
Yumeng Li
Bingxuan Zhang
Qingqiao Song

Frontiers in Chemistry

doi 10.3389/fchem.2025.1617676

2,762 views
1 citation

Original Research

Published on 18 Jul 2025

MicroRNA-31 mediated inhibition of keratin 6 by PSORI-CM01: a novel approach to psoriasis amelioration

in Medicinal and Pharmaceutical Chemistry

Shilei Wang
Jingkai Wang
Helin Pan
Ruogu Yang
Fanli Zeng
Yongfei Fang
Jinwei Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1636529

2,320 views

Original Research

Published on 17 Jul 2025

Evaluation of newly synthesized schiff base Pd(II) complexes for prostate cancer treatment through in vitro cytotoxicity and molecular mechanistic studies

in Medicinal and Pharmaceutical Chemistry

Damnjan Pantic
Nikola Mirkovic
Tatjana Vulovic
Danijela Jovanovic
Stefan Jakovljevic
Petar Canovic
Milan Zaric
Radica Zivkovic Zaric
Marina Kostic
Jovana Dragojevic

Frontiers in Chemistry

doi 10.3389/fchem.2025.1636477

3,154 views
2 citations

Original Research

Published on 16 Jul 2025

Exploring the effect and mechanism of fucoidan on liver cancer depending on network pharmacology and experimental verification

in Medicinal and Pharmaceutical Chemistry

Xinghua Li
Chengyu Yang
Liwei Wang
Ihsan Ullah
Xinyue Liu
Chunqi Feng
Qi Liu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638785

3,097 views
1 citation

Original Research

Published on 07 Jul 2025

Phomaderide, a unique (6/5/4/5/6) spiro-cyclic dimer from the desert plant endophytic fungus Phoma betae A. B. Frank (Didymellaceae)

in Medicinal and Pharmaceutical Chemistry

Hao-Di Sun
Yan-Duo Wang
Hui-Qi Fang
Jian Yang
Yu-Tong Hua
Gang Ding
Lan-Ping Guo

Frontiers in Chemistry

doi 10.3389/fchem.2025.1583666

2,103 views

Original Research

Published on 02 Jul 2025

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

in Medicinal and Pharmaceutical Chemistry

Alexandre Bory
Alexandre Luscher
Nicole Lecoultre
Thilo Köhler
Sylvain Schnee
Katia Gindro
Jean-Luc Wolfender

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630332

2,759 views

Original Research

Published on 30 Jun 2025

Metabolomics, antioxidant, and enzyme inhibitory effects of Citrus aurantium fruits

in Medicinal and Pharmaceutical Chemistry

Omayma A. Eldahshan
Salwa Bouabdallah
Rawan M. Abd El-khalek
Mahmoud A. El Hassab
Gokhan Zengin
Ahmed T. Negmeldin
Eman F. Khaleel
Wagdy M. Eldehna
Nada M. Mostafa

Frontiers in Chemistry

doi 10.3389/fchem.2025.1613827

3,332 views

Mini Review

Published on 27 Jun 2025

Strategic applications of methylene thioacetal bonds as disulfide surrogates in peptide drug discovery

in Medicinal and Pharmaceutical Chemistry

Yaqi Zhou
Dongyuan Wang
Jiean Xu
Nan Zheng

Frontiers in Chemistry

doi 10.3389/fchem.2025.1637329

3,687 views
2 citations

Original Research

Published on 26 Jun 2025

A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity

in Medicinal and Pharmaceutical Chemistry

Hussam Elddin Nabeih Khasawneh
Elryah I. Ali
Ranya Mohammed Elmagzoub
Raed Fanoukh Aboqader Al-Aouadi
Wesam Taher Almagharbeh
Ghallab Alotaibi
Stefan Bräse
Abdullah Alkhammash

Frontiers in Chemistry

doi 10.3389/fchem.2025.1606848

4,218 views
2 citations

Original Research

Published on 20 Jun 2025

Ruta montana L. from Morocco: comprehensive phytochemical analysis and exploration of its antioxidant, antimicrobial, anti-inflammatory and analgesic properties

in Medicinal and Pharmaceutical Chemistry

Mohamed El Ouardi
Aziz Drioiche
Imane Tagnaout
Aicha Benouahi
Omkulthom AL kamaly
Abdelaaty Abdelaziz Shahat
El Makhoukhi Fadoua
Handaq Nadia
Sevser Sahpaz
Touriya Zair

Frontiers in Chemistry

doi 10.3389/fchem.2025.1614984

3,099 views
3 citations

Original Research

Published on 20 Jun 2025

Seasonal changes in the essential oils of Aloysia oblanceolata Moldenke

in Medicinal and Pharmaceutical Chemistry

Paulo Vinicius L. Santos
Mateus Machado Lima
Flavia Cristina A. Lucas
Joyce Kelly do R. da Silva
José Guilherme S. Maia
Pablo Luis B. Figueiredo

Frontiers in Chemistry

doi 10.3389/fchem.2025.1564404

1,742 views
2 citations

Original Research

Published on 11 Jun 2025

Two-dimensional QSAR-driven virtual screening for potential therapeutics against Trypanosoma cruzi

in Medicinal and Pharmaceutical Chemistry

Naseer Maliyakkal
Sunil Kumar
Ratul Bhowmik
Harish Chandra Vishwakarma
Prabha Yadav
Bijo Mathew

Frontiers in Chemistry

doi 10.3389/fchem.2025.1600945

2,943 views
2 citations

Original Research

Published on 09 Jun 2025

HIF1A acts as target of XiHuang Pill in the treatment of papillary thyroid cancer by regulating dedifferentiation

in Medicinal and Pharmaceutical Chemistry

Xu-Zhe Yu
Wei-Li Zhu
Hua-Chun Qian
Chun-Jiang Sun

Frontiers in Chemistry

doi 10.3389/fchem.2025.1607067

2,963 views
1 citation

Original Research

Published on 09 Jun 2025

Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective TIM-3 inhibitor for NSCLC immunotherapy

in Medicinal and Pharmaceutical Chemistry

Xinxin Ying
Yangyong Lou
Yueming Wu
Weiwei Hu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1622511

2,703 views

Correction

Published on 09 Jun 2025

Correction: Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

in Medicinal and Pharmaceutical Chemistry

Yongzhi He
Jiachun Lu
Yushan Luo
Rizhao Pang
Xiaoming Hu
Lijuan Ding
Hua Xiao
Yunyun Wang
Wenchun Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1636136

1,610 views

Mini Review

Published on 30 May 2025

A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Romina E. Avanzo
Guadalupe García Liñares
Noris Rodríguez
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1608340

3,764 views
5 citations

Mini Review

Published on 30 May 2025

Current developments of metal- and metalloid-based quinoline compounds as leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Edgar Del Carpio
Lino Hernández
Vito Lubes
Francisco Jourdan
Hugo Cerecetto
Gonzalo Scalese
Dinorah Gambino
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1586044

2,927 views
4 citations

944 articles

articles

Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling

Citrus aurantifolia essential oil: antiaging potential through integrated in vitro and in silico studies

Design and synthesis of 3,4-seco-Lupane triterpene derivatives: targeting tumor angiogenesis and inducing apoptosis in triple-negative breast cancer

In silico design of novel dihydropteridone derivatives with oxadiazoles as potent inhibitors of MCF-7 breast cancer cells

Computational advances in the design and discovery of artemis inhibitors for radiosensitization in cancer therapy

Application of nano and microformulations to improve the leishmanicidal response of quinoline compounds: a brief review

Research progress on the chemical composition of galli gigeriae endothelium corneum

Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome

MicroRNA-31 mediated inhibition of keratin 6 by PSORI-CM01: a novel approach to psoriasis amelioration

Evaluation of newly synthesized schiff base Pd(II) complexes for prostate cancer treatment through in vitro cytotoxicity and molecular mechanistic studies

Exploring the effect and mechanism of fucoidan on liver cancer depending on network pharmacology and experimental verification

Phomaderide, a unique (6/5/4/5/6) spiro-cyclic dimer from the desert plant endophytic fungus Phoma betae A. B. Frank (Didymellaceae)

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

Metabolomics, antioxidant, and enzyme inhibitory effects of Citrus aurantium fruits

Strategic applications of methylene thioacetal bonds as disulfide surrogates in peptide drug discovery

A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity

Ruta montana L. from Morocco: comprehensive phytochemical analysis and exploration of its antioxidant, antimicrobial, anti-inflammatory and analgesic properties

Seasonal changes in the essential oils of Aloysia oblanceolata Moldenke

Two-dimensional QSAR-driven virtual screening for potential therapeutics against Trypanosoma cruzi

HIF1A acts as target of XiHuang Pill in the treatment of papillary thyroid cancer by regulating dedifferentiation

Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective TIM-3 inhibitor for NSCLC immunotherapy

Correction: Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents

Current developments of metal- and metalloid-based quinoline compounds as leishmanicidal agents